Amino acid dipepetide frequency for Streptococcus satellite phage Javan70

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.253AlaAla: 1.253 ± 0.695
0.0AlaCys: 0.0 ± 0.0
4.385AlaAsp: 4.385 ± 1.237
6.89AlaGlu: 6.89 ± 2.05
2.819AlaPhe: 2.819 ± 1.16
2.505AlaGly: 2.505 ± 1.285
0.94AlaHis: 0.94 ± 0.377
5.637AlaIle: 5.637 ± 1.54
4.698AlaLys: 4.698 ± 1.671
6.89AlaLeu: 6.89 ± 1.165
1.253AlaMet: 1.253 ± 0.619
2.192AlaAsn: 2.192 ± 0.886
2.505AlaPro: 2.505 ± 0.892
1.879AlaGln: 1.879 ± 0.531
3.445AlaArg: 3.445 ± 0.901
3.758AlaSer: 3.758 ± 1.096
4.698AlaThr: 4.698 ± 1.002
2.192AlaVal: 2.192 ± 0.618
0.626AlaTrp: 0.626 ± 0.472
3.445AlaTyr: 3.445 ± 0.783
0.0AlaXaa: 0.0 ± 0.0
Cys
0.313CysAla: 0.313 ± 0.274
0.313CysCys: 0.313 ± 0.3
0.626CysAsp: 0.626 ± 0.457
0.313CysGlu: 0.313 ± 0.345
0.0CysPhe: 0.0 ± 0.0
0.313CysGly: 0.313 ± 0.283
0.313CysHis: 0.313 ± 0.3
0.313CysIle: 0.313 ± 0.324
0.626CysLys: 0.626 ± 0.473
0.94CysLeu: 0.94 ± 0.533
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.313CysGln: 0.313 ± 0.239
0.313CysArg: 0.313 ± 0.296
0.0CysSer: 0.0 ± 0.0
0.313CysThr: 0.313 ± 0.304
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.313CysTyr: 0.313 ± 0.331
0.0CysXaa: 0.0 ± 0.0
Asp
1.879AspAla: 1.879 ± 0.739
0.94AspCys: 0.94 ± 0.542
4.071AspAsp: 4.071 ± 1.318
6.264AspGlu: 6.264 ± 1.423
3.445AspPhe: 3.445 ± 1.092
2.192AspGly: 2.192 ± 0.887
0.313AspHis: 0.313 ± 0.239
6.264AspIle: 6.264 ± 1.327
4.698AspLys: 4.698 ± 0.926
6.577AspLeu: 6.577 ± 1.63
2.192AspMet: 2.192 ± 0.639
2.505AspAsn: 2.505 ± 0.544
0.313AspPro: 0.313 ± 0.283
0.626AspGln: 0.626 ± 0.494
2.192AspArg: 2.192 ± 0.856
1.566AspSer: 1.566 ± 0.578
3.758AspThr: 3.758 ± 0.938
1.879AspVal: 1.879 ± 0.701
0.0AspTrp: 0.0 ± 0.0
3.132AspTyr: 3.132 ± 0.606
0.0AspXaa: 0.0 ± 0.0
Glu
6.577GluAla: 6.577 ± 1.848
0.94GluCys: 0.94 ± 0.394
5.951GluAsp: 5.951 ± 1.306
8.456GluGlu: 8.456 ± 1.845
2.819GluPhe: 2.819 ± 0.703
2.505GluGly: 2.505 ± 0.86
2.505GluHis: 2.505 ± 0.788
8.456GluIle: 8.456 ± 1.465
7.83GluLys: 7.83 ± 1.077
12.527GluLeu: 12.527 ± 2.003
1.879GluMet: 1.879 ± 0.715
5.951GluAsn: 5.951 ± 1.682
2.505GluPro: 2.505 ± 0.848
4.385GluGln: 4.385 ± 1.475
7.516GluArg: 7.516 ± 2.09
2.819GluSer: 2.819 ± 0.838
4.698GluThr: 4.698 ± 0.959
5.637GluVal: 5.637 ± 1.33
0.313GluTrp: 0.313 ± 0.296
3.132GluTyr: 3.132 ± 1.264
0.0GluXaa: 0.0 ± 0.0
Phe
0.626PheAla: 0.626 ± 0.406
0.313PheCys: 0.313 ± 0.331
3.132PheAsp: 3.132 ± 0.883
2.819PheGlu: 2.819 ± 0.713
1.879PhePhe: 1.879 ± 0.659
2.192PheGly: 2.192 ± 0.704
0.626PheHis: 0.626 ± 0.444
2.192PheIle: 2.192 ± 0.763
2.819PheLys: 2.819 ± 0.863
4.071PheLeu: 4.071 ± 1.195
0.94PheMet: 0.94 ± 0.537
3.445PheAsn: 3.445 ± 1.1
0.94PhePro: 0.94 ± 0.579
0.94PheGln: 0.94 ± 0.399
1.879PheArg: 1.879 ± 0.509
3.758PheSer: 3.758 ± 0.885
1.566PheThr: 1.566 ± 0.56
0.94PheVal: 0.94 ± 0.435
0.626PheTrp: 0.626 ± 0.344
0.94PheTyr: 0.94 ± 0.569
0.0PheXaa: 0.0 ± 0.0
Gly
2.819GlyAla: 2.819 ± 1.113
0.313GlyCys: 0.313 ± 0.296
2.192GlyAsp: 2.192 ± 0.767
1.879GlyGlu: 1.879 ± 0.782
2.192GlyPhe: 2.192 ± 0.935
1.253GlyGly: 1.253 ± 0.477
1.253GlyHis: 1.253 ± 0.546
5.011GlyIle: 5.011 ± 1.066
3.132GlyLys: 3.132 ± 1.126
3.758GlyLeu: 3.758 ± 1.391
1.253GlyMet: 1.253 ± 0.568
0.0GlyAsn: 0.0 ± 0.0
0.0GlyPro: 0.0 ± 0.0
3.132GlyGln: 3.132 ± 1.118
3.758GlyArg: 3.758 ± 0.995
0.626GlySer: 0.626 ± 0.381
2.505GlyThr: 2.505 ± 0.906
3.445GlyVal: 3.445 ± 1.06
0.626GlyTrp: 0.626 ± 0.368
2.819GlyTyr: 2.819 ± 0.59
0.0GlyXaa: 0.0 ± 0.0
His
0.94HisAla: 0.94 ± 0.888
0.0HisCys: 0.0 ± 0.0
0.94HisAsp: 0.94 ± 0.495
0.626HisGlu: 0.626 ± 0.6
0.0HisPhe: 0.0 ± 0.0
1.253HisGly: 1.253 ± 0.599
0.626HisHis: 0.626 ± 0.382
1.253HisIle: 1.253 ± 0.867
2.192HisLys: 2.192 ± 0.983
1.566HisLeu: 1.566 ± 0.488
0.0HisMet: 0.0 ± 0.0
1.566HisAsn: 1.566 ± 0.903
0.313HisPro: 0.313 ± 0.324
0.94HisGln: 0.94 ± 0.415
0.94HisArg: 0.94 ± 0.633
0.0HisSer: 0.0 ± 0.0
0.626HisThr: 0.626 ± 0.375
0.626HisVal: 0.626 ± 0.354
0.313HisTrp: 0.313 ± 0.239
1.253HisTyr: 1.253 ± 0.865
0.0HisXaa: 0.0 ± 0.0
Ile
6.577IleAla: 6.577 ± 1.144
0.94IleCys: 0.94 ± 0.522
5.951IleAsp: 5.951 ± 1.137
8.456IleGlu: 8.456 ± 2.18
2.819IlePhe: 2.819 ± 0.932
2.819IleGly: 2.819 ± 0.81
0.313IleHis: 0.313 ± 0.296
4.698IleIle: 4.698 ± 0.921
8.769IleLys: 8.769 ± 1.523
7.516IleLeu: 7.516 ± 1.623
0.94IleMet: 0.94 ± 0.527
3.758IleAsn: 3.758 ± 1.082
3.445IlePro: 3.445 ± 1.021
2.192IleGln: 2.192 ± 0.747
2.819IleArg: 2.819 ± 0.951
3.132IleSer: 3.132 ± 0.766
5.324IleThr: 5.324 ± 0.959
1.879IleVal: 1.879 ± 0.751
0.94IleTrp: 0.94 ± 0.434
1.566IleTyr: 1.566 ± 0.672
0.0IleXaa: 0.0 ± 0.0
Lys
8.143LysAla: 8.143 ± 1.857
0.0LysCys: 0.0 ± 0.0
3.445LysAsp: 3.445 ± 0.974
12.841LysGlu: 12.841 ± 2.453
1.879LysPhe: 1.879 ± 0.561
3.445LysGly: 3.445 ± 1.413
1.253LysHis: 1.253 ± 0.558
7.83LysIle: 7.83 ± 1.555
6.89LysLys: 6.89 ± 1.544
8.143LysLeu: 8.143 ± 1.643
2.505LysMet: 2.505 ± 0.928
2.819LysAsn: 2.819 ± 0.841
3.445LysPro: 3.445 ± 0.995
6.577LysGln: 6.577 ± 1.253
8.143LysArg: 8.143 ± 1.315
4.385LysSer: 4.385 ± 1.056
5.324LysThr: 5.324 ± 1.2
4.071LysVal: 4.071 ± 1.198
1.566LysTrp: 1.566 ± 0.633
1.566LysTyr: 1.566 ± 0.827
0.0LysXaa: 0.0 ± 0.0
Leu
8.456LeuAla: 8.456 ± 1.354
0.0LeuCys: 0.0 ± 0.0
6.577LeuAsp: 6.577 ± 1.576
11.901LeuGlu: 11.901 ± 2.182
4.071LeuPhe: 4.071 ± 1.259
3.132LeuGly: 3.132 ± 1.049
0.94LeuHis: 0.94 ± 0.539
6.264LeuIle: 6.264 ± 1.363
7.83LeuLys: 7.83 ± 1.645
9.396LeuLeu: 9.396 ± 1.618
1.879LeuMet: 1.879 ± 0.784
4.071LeuAsn: 4.071 ± 1.352
4.698LeuPro: 4.698 ± 1.486
5.951LeuGln: 5.951 ± 1.385
4.071LeuArg: 4.071 ± 1.159
5.637LeuSer: 5.637 ± 1.001
6.577LeuThr: 6.577 ± 1.59
5.951LeuVal: 5.951 ± 1.374
0.94LeuTrp: 0.94 ± 0.441
4.071LeuTyr: 4.071 ± 1.232
0.0LeuXaa: 0.0 ± 0.0
Met
3.132MetAla: 3.132 ± 1.054
0.0MetCys: 0.0 ± 0.0
1.566MetAsp: 1.566 ± 0.676
2.505MetGlu: 2.505 ± 0.728
0.94MetPhe: 0.94 ± 0.469
0.313MetGly: 0.313 ± 0.324
0.313MetHis: 0.313 ± 0.387
1.253MetIle: 1.253 ± 0.6
2.505MetLys: 2.505 ± 1.198
1.879MetLeu: 1.879 ± 0.677
0.626MetMet: 0.626 ± 0.398
1.566MetAsn: 1.566 ± 0.558
0.313MetPro: 0.313 ± 0.376
0.94MetGln: 0.94 ± 0.68
0.94MetArg: 0.94 ± 0.49
0.626MetSer: 0.626 ± 0.472
2.819MetThr: 2.819 ± 0.624
0.94MetVal: 0.94 ± 0.565
0.313MetTrp: 0.313 ± 0.331
0.313MetTyr: 0.313 ± 0.318
0.0MetXaa: 0.0 ± 0.0
Asn
3.132AsnAla: 3.132 ± 0.951
0.313AsnCys: 0.313 ± 0.345
1.253AsnAsp: 1.253 ± 0.638
4.698AsnGlu: 4.698 ± 1.5
1.566AsnPhe: 1.566 ± 0.539
3.132AsnGly: 3.132 ± 0.824
0.94AsnHis: 0.94 ± 0.368
2.192AsnIle: 2.192 ± 1.016
4.385AsnLys: 4.385 ± 1.007
4.698AsnLeu: 4.698 ± 1.008
1.879AsnMet: 1.879 ± 0.681
2.505AsnAsn: 2.505 ± 0.697
3.132AsnPro: 3.132 ± 1.015
1.879AsnGln: 1.879 ± 0.832
1.879AsnArg: 1.879 ± 0.879
2.819AsnSer: 2.819 ± 0.624
3.132AsnThr: 3.132 ± 0.964
2.192AsnVal: 2.192 ± 0.715
0.0AsnTrp: 0.0 ± 0.0
2.192AsnTyr: 2.192 ± 0.833
0.0AsnXaa: 0.0 ± 0.0
Pro
1.566ProAla: 1.566 ± 0.896
0.0ProCys: 0.0 ± 0.0
0.94ProAsp: 0.94 ± 0.448
4.698ProGlu: 4.698 ± 1.354
1.879ProPhe: 1.879 ± 0.679
0.313ProGly: 0.313 ± 0.327
0.0ProHis: 0.0 ± 0.0
2.192ProIle: 2.192 ± 0.868
3.758ProLys: 3.758 ± 0.74
2.192ProLeu: 2.192 ± 0.787
0.313ProMet: 0.313 ± 0.345
1.879ProAsn: 1.879 ± 1.164
0.94ProPro: 0.94 ± 0.469
1.566ProGln: 1.566 ± 1.11
3.445ProArg: 3.445 ± 0.943
0.626ProSer: 0.626 ± 0.366
2.505ProThr: 2.505 ± 0.6
1.566ProVal: 1.566 ± 0.479
0.0ProTrp: 0.0 ± 0.0
1.879ProTyr: 1.879 ± 0.768
0.0ProXaa: 0.0 ± 0.0
Gln
3.132GlnAla: 3.132 ± 0.885
0.0GlnCys: 0.0 ± 0.0
2.819GlnAsp: 2.819 ± 1.016
3.758GlnGlu: 3.758 ± 0.942
0.94GlnPhe: 0.94 ± 0.659
2.505GlnGly: 2.505 ± 1.047
0.94GlnHis: 0.94 ± 0.415
1.566GlnIle: 1.566 ± 0.667
5.324GlnLys: 5.324 ± 1.186
5.637GlnLeu: 5.637 ± 1.399
0.94GlnMet: 0.94 ± 0.456
0.626GlnAsn: 0.626 ± 0.444
1.253GlnPro: 1.253 ± 0.584
3.132GlnGln: 3.132 ± 0.939
1.566GlnArg: 1.566 ± 0.598
3.132GlnSer: 3.132 ± 0.98
4.698GlnThr: 4.698 ± 1.164
3.132GlnVal: 3.132 ± 1.343
0.313GlnTrp: 0.313 ± 0.327
1.879GlnTyr: 1.879 ± 0.851
0.0GlnXaa: 0.0 ± 0.0
Arg
3.132ArgAla: 3.132 ± 1.423
0.313ArgCys: 0.313 ± 0.296
0.626ArgAsp: 0.626 ± 0.431
2.819ArgGlu: 2.819 ± 0.795
1.879ArgPhe: 1.879 ± 0.731
3.132ArgGly: 3.132 ± 0.771
1.879ArgHis: 1.879 ± 0.883
4.385ArgIle: 4.385 ± 1.223
5.951ArgLys: 5.951 ± 1.48
5.011ArgLeu: 5.011 ± 0.676
1.566ArgMet: 1.566 ± 0.588
4.071ArgAsn: 4.071 ± 1.211
1.879ArgPro: 1.879 ± 0.62
3.132ArgGln: 3.132 ± 0.862
2.192ArgArg: 2.192 ± 0.885
1.253ArgSer: 1.253 ± 0.461
2.505ArgThr: 2.505 ± 0.791
2.192ArgVal: 2.192 ± 0.938
0.94ArgTrp: 0.94 ± 0.61
4.071ArgTyr: 4.071 ± 0.841
0.0ArgXaa: 0.0 ± 0.0
Ser
1.253SerAla: 1.253 ± 0.51
0.313SerCys: 0.313 ± 0.324
2.505SerAsp: 2.505 ± 0.814
4.698SerGlu: 4.698 ± 1.541
1.879SerPhe: 1.879 ± 0.584
2.192SerGly: 2.192 ± 1.015
0.313SerHis: 0.313 ± 0.296
4.698SerIle: 4.698 ± 1.098
3.758SerLys: 3.758 ± 0.816
5.951SerLeu: 5.951 ± 0.899
1.566SerMet: 1.566 ± 0.767
2.819SerAsn: 2.819 ± 0.713
0.94SerPro: 0.94 ± 0.468
2.192SerGln: 2.192 ± 0.477
1.879SerArg: 1.879 ± 0.991
1.253SerSer: 1.253 ± 0.52
1.879SerThr: 1.879 ± 0.631
1.879SerVal: 1.879 ± 0.569
0.313SerTrp: 0.313 ± 0.296
2.819SerTyr: 2.819 ± 1.041
0.0SerXaa: 0.0 ± 0.0
Thr
3.758ThrAla: 3.758 ± 1.039
0.313ThrCys: 0.313 ± 0.345
2.192ThrAsp: 2.192 ± 0.625
5.637ThrGlu: 5.637 ± 1.257
1.566ThrPhe: 1.566 ± 0.631
5.324ThrGly: 5.324 ± 1.379
0.94ThrHis: 0.94 ± 0.622
4.071ThrIle: 4.071 ± 0.666
6.577ThrLys: 6.577 ± 1.36
6.89ThrLeu: 6.89 ± 1.562
1.253ThrMet: 1.253 ± 0.55
1.566ThrAsn: 1.566 ± 1.18
2.505ThrPro: 2.505 ± 0.763
2.505ThrGln: 2.505 ± 0.731
2.192ThrArg: 2.192 ± 0.712
3.445ThrSer: 3.445 ± 1.033
5.011ThrThr: 5.011 ± 1.756
4.385ThrVal: 4.385 ± 1.252
0.94ThrTrp: 0.94 ± 0.46
2.505ThrTyr: 2.505 ± 1.142
0.0ThrXaa: 0.0 ± 0.0
Val
4.071ValAla: 4.071 ± 0.758
0.0ValCys: 0.0 ± 0.0
3.445ValAsp: 3.445 ± 0.986
3.758ValGlu: 3.758 ± 1.089
2.505ValPhe: 2.505 ± 1.101
1.253ValGly: 1.253 ± 0.696
0.0ValHis: 0.0 ± 0.0
3.445ValIle: 3.445 ± 0.902
5.011ValLys: 5.011 ± 1.213
4.071ValLeu: 4.071 ± 0.886
0.94ValMet: 0.94 ± 0.477
1.566ValAsn: 1.566 ± 0.905
0.94ValPro: 0.94 ± 0.7
1.879ValGln: 1.879 ± 0.762
1.566ValArg: 1.566 ± 0.654
2.505ValSer: 2.505 ± 0.845
3.445ValThr: 3.445 ± 0.661
2.819ValVal: 2.819 ± 1.191
0.626ValTrp: 0.626 ± 0.352
3.132ValTyr: 3.132 ± 0.809
0.0ValXaa: 0.0 ± 0.0
Trp
0.94TrpAla: 0.94 ± 0.55
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.566TrpGlu: 1.566 ± 0.718
0.313TrpPhe: 0.313 ± 0.327
0.0TrpGly: 0.0 ± 0.0
0.313TrpHis: 0.313 ± 0.345
0.0TrpIle: 0.0 ± 0.0
0.626TrpLys: 0.626 ± 0.478
1.879TrpLeu: 1.879 ± 0.736
0.0TrpMet: 0.0 ± 0.0
0.313TrpAsn: 0.313 ± 0.327
0.313TrpPro: 0.313 ± 0.239
0.313TrpGln: 0.313 ± 0.3
0.313TrpArg: 0.313 ± 0.279
0.626TrpSer: 0.626 ± 0.375
0.94TrpThr: 0.94 ± 0.547
0.94TrpVal: 0.94 ± 0.471
0.0TrpTrp: 0.0 ± 0.0
0.313TrpTyr: 0.313 ± 0.387
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.313TyrAla: 0.313 ± 0.239
0.313TyrCys: 0.313 ± 0.324
2.505TyrAsp: 2.505 ± 1.089
2.819TyrGlu: 2.819 ± 0.753
1.253TyrPhe: 1.253 ± 0.515
2.192TyrGly: 2.192 ± 0.992
1.253TyrHis: 1.253 ± 0.503
3.132TyrIle: 3.132 ± 0.915
6.89TyrLys: 6.89 ± 1.472
2.819TyrLeu: 2.819 ± 0.928
1.566TyrMet: 1.566 ± 0.766
4.698TyrAsn: 4.698 ± 1.211
1.879TyrPro: 1.879 ± 0.739
2.819TyrGln: 2.819 ± 0.999
1.879TyrArg: 1.879 ± 0.788
3.132TyrSer: 3.132 ± 0.69
1.253TyrThr: 1.253 ± 0.699
0.313TyrVal: 0.313 ± 0.283
0.313TyrTrp: 0.313 ± 0.283
3.445TyrTyr: 3.445 ± 1.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 19 proteins (3194 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski