Amino acid dipepetide frequency for Gemmobacter aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.969AlaAla: 19.969 ± 0.24	1.166AlaCys: 1.166 ± 0.035	7.833AlaAsp: 7.833 ± 0.103	9.049AlaGlu: 9.049 ± 0.097	4.612AlaPhe: 4.612 ± 0.069	12.528AlaGly: 12.528 ± 0.138	2.547AlaHis: 2.547 ± 0.048	6.044AlaIle: 6.044 ± 0.081	3.213AlaLys: 3.213 ± 0.073	14.75AlaLeu: 14.75 ± 0.156	4.173AlaMet: 4.173 ± 0.063	2.666AlaAsn: 2.666 ± 0.055	6.676AlaPro: 6.676 ± 0.1	3.954AlaGln: 3.954 ± 0.066	10.839AlaArg: 10.839 ± 0.118	5.244AlaSer: 5.244 ± 0.074	6.424AlaThr: 6.424 ± 0.075	9.122AlaVal: 9.122 ± 0.1	1.523AlaTrp: 1.523 ± 0.041	2.466AlaTyr: 2.466 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.06CysAla: 1.06 ± 0.034	0.1CysCys: 0.1 ± 0.011	0.603CysAsp: 0.603 ± 0.023	0.43CysGlu: 0.43 ± 0.022	0.309CysPhe: 0.309 ± 0.016	0.99CysGly: 0.99 ± 0.032	0.289CysHis: 0.289 ± 0.018	0.37CysIle: 0.37 ± 0.018	0.162CysLys: 0.162 ± 0.012	0.87CysLeu: 0.87 ± 0.025	0.177CysMet: 0.177 ± 0.013	0.202CysAsn: 0.202 ± 0.014	0.532CysPro: 0.532 ± 0.025	0.221CysGln: 0.221 ± 0.014	0.622CysArg: 0.622 ± 0.023	0.382CysSer: 0.382 ± 0.018	0.459CysThr: 0.459 ± 0.024	0.623CysVal: 0.623 ± 0.027	0.111CysTrp: 0.111 ± 0.009	0.184CysTyr: 0.184 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.097AspAla: 7.097 ± 0.091	0.48AspCys: 0.48 ± 0.022	3.23AspAsp: 3.23 ± 0.092	3.293AspGlu: 3.293 ± 0.072	2.333AspPhe: 2.333 ± 0.051	5.687AspGly: 5.687 ± 0.119	1.428AspHis: 1.428 ± 0.038	2.76AspIle: 2.76 ± 0.054	1.237AspLys: 1.237 ± 0.036	6.947AspLeu: 6.947 ± 0.078	1.486AspMet: 1.486 ± 0.037	1.017AspAsn: 1.017 ± 0.036	4.005AspPro: 4.005 ± 0.062	1.761AspGln: 1.761 ± 0.041	5.545AspArg: 5.545 ± 0.077	1.888AspSer: 1.888 ± 0.051	2.774AspThr: 2.774 ± 0.104	3.91AspVal: 3.91 ± 0.062	1.246AspTrp: 1.246 ± 0.036	1.448AspTyr: 1.448 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.594GluAla: 8.594 ± 0.104	0.369GluCys: 0.369 ± 0.02	3.058GluAsp: 3.058 ± 0.058	2.834GluGlu: 2.834 ± 0.065	1.727GluPhe: 1.727 ± 0.038	5.438GluGly: 5.438 ± 0.081	0.918GluHis: 0.918 ± 0.029	3.206GluIle: 3.206 ± 0.051	1.716GluLys: 1.716 ± 0.05	4.459GluLeu: 4.459 ± 0.067	1.682GluMet: 1.682 ± 0.036	1.469GluAsn: 1.469 ± 0.041	2.59GluPro: 2.59 ± 0.063	1.565GluGln: 1.565 ± 0.044	4.189GluArg: 4.189 ± 0.069	1.906GluSer: 1.906 ± 0.04	3.565GluThr: 3.565 ± 0.055	4.332GluVal: 4.332 ± 0.058	0.771GluTrp: 0.771 ± 0.026	0.998GluTyr: 0.998 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.631PheAla: 4.631 ± 0.07	0.455PheCys: 0.455 ± 0.022	2.793PheAsp: 2.793 ± 0.055	1.906PheGlu: 1.906 ± 0.041	1.357PhePhe: 1.357 ± 0.04	3.86PheGly: 3.86 ± 0.064	0.762PheHis: 0.762 ± 0.027	1.582PheIle: 1.582 ± 0.04	0.74PheLys: 0.74 ± 0.028	3.601PheLeu: 3.601 ± 0.061	0.778PheMet: 0.778 ± 0.028	0.929PheAsn: 0.929 ± 0.03	1.672PhePro: 1.672 ± 0.037	0.885PheGln: 0.885 ± 0.03	2.581PheArg: 2.581 ± 0.052	1.836PheSer: 1.836 ± 0.048	2.083PheThr: 2.083 ± 0.049	2.655PheVal: 2.655 ± 0.049	0.591PheTrp: 0.591 ± 0.021	0.821PheTyr: 0.821 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.367GlyAla: 11.367 ± 0.11	0.917GlyCys: 0.917 ± 0.028	4.915GlyAsp: 4.915 ± 0.121	4.728GlyGlu: 4.728 ± 0.072	3.899GlyPhe: 3.899 ± 0.068	8.695GlyGly: 8.695 ± 0.169	2.147GlyHis: 2.147 ± 0.048	4.583GlyIle: 4.583 ± 0.063	2.772GlyLys: 2.772 ± 0.058	9.932GlyLeu: 9.932 ± 0.115	2.823GlyMet: 2.823 ± 0.056	2.381GlyAsn: 2.381 ± 0.116	4.161GlyPro: 4.161 ± 0.065	3.338GlyGln: 3.338 ± 0.049	7.237GlyArg: 7.237 ± 0.098	4.069GlySer: 4.069 ± 0.068	4.876GlyThr: 4.876 ± 0.087	6.58GlyVal: 6.58 ± 0.076	1.682GlyTrp: 1.682 ± 0.039	2.218GlyTyr: 2.218 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.489HisAla: 2.489 ± 0.044	0.252HisCys: 0.252 ± 0.016	1.321HisAsp: 1.321 ± 0.035	1.031HisGlu: 1.031 ± 0.034	0.774HisPhe: 0.774 ± 0.028	2.034HisGly: 2.034 ± 0.044	0.546HisHis: 0.546 ± 0.029	0.85HisIle: 0.85 ± 0.028	0.404HisLys: 0.404 ± 0.02	2.232HisLeu: 2.232 ± 0.056	0.49HisMet: 0.49 ± 0.021	0.379HisAsn: 0.379 ± 0.018	1.536HisPro: 1.536 ± 0.041	0.519HisGln: 0.519 ± 0.023	1.555HisArg: 1.555 ± 0.038	0.872HisSer: 0.872 ± 0.026	0.7HisThr: 0.7 ± 0.029	1.57HisVal: 1.57 ± 0.041	0.367HisTrp: 0.367 ± 0.02	0.531HisTyr: 0.531 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.011IleAla: 7.011 ± 0.098	0.546IleCys: 0.546 ± 0.024	3.402IleAsp: 3.402 ± 0.052	3.145IleGlu: 3.145 ± 0.051	1.557IlePhe: 1.557 ± 0.044	4.979IleGly: 4.979 ± 0.071	0.958IleHis: 0.958 ± 0.029	1.911IleIle: 1.911 ± 0.046	1.027IleLys: 1.027 ± 0.033	5.052IleLeu: 5.052 ± 0.069	0.947IleMet: 0.947 ± 0.027	1.179IleAsn: 1.179 ± 0.036	2.323IlePro: 2.323 ± 0.046	0.976IleGln: 0.976 ± 0.033	3.599IleArg: 3.599 ± 0.067	2.389IleSer: 2.389 ± 0.05	2.787IleThr: 2.787 ± 0.053	3.818IleVal: 3.818 ± 0.058	0.681IleTrp: 0.681 ± 0.025	1.002IleTyr: 1.002 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.708LysAla: 3.708 ± 0.056	0.168LysCys: 0.168 ± 0.01	1.457LysAsp: 1.457 ± 0.04	1.239LysGlu: 1.239 ± 0.036	0.743LysPhe: 0.743 ± 0.028	2.672LysGly: 2.672 ± 0.052	0.486LysHis: 0.486 ± 0.021	1.246LysIle: 1.246 ± 0.039	0.928LysLys: 0.928 ± 0.033	2.264LysLeu: 2.264 ± 0.05	0.696LysMet: 0.696 ± 0.025	0.603LysAsn: 0.603 ± 0.026	1.629LysPro: 1.629 ± 0.046	0.635LysGln: 0.635 ± 0.025	1.812LysArg: 1.812 ± 0.048	1.392LysSer: 1.392 ± 0.043	1.58LysThr: 1.58 ± 0.036	2.06LysVal: 2.06 ± 0.051	0.341LysTrp: 0.341 ± 0.018	0.505LysTyr: 0.505 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.914LeuAla: 14.914 ± 0.154	0.949LeuCys: 0.949 ± 0.028	5.855LeuAsp: 5.855 ± 0.078	4.792LeuGlu: 4.792 ± 0.075	3.553LeuPhe: 3.553 ± 0.069	8.631LeuGly: 8.631 ± 0.093	1.868LeuHis: 1.868 ± 0.044	5.135LeuIle: 5.135 ± 0.068	3.0LeuLys: 3.0 ± 0.058	8.472LeuLeu: 8.472 ± 0.112	2.781LeuMet: 2.781 ± 0.051	2.463LeuAsn: 2.463 ± 0.045	6.108LeuPro: 6.108 ± 0.094	2.42LeuGln: 2.42 ± 0.05	7.466LeuArg: 7.466 ± 0.089	6.356LeuSer: 6.356 ± 0.08	6.078LeuThr: 6.078 ± 0.068	6.997LeuVal: 6.997 ± 0.094	1.481LeuTrp: 1.481 ± 0.041	1.821LeuTyr: 1.821 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.875MetAla: 3.875 ± 0.058	0.173MetCys: 0.173 ± 0.014	1.436MetAsp: 1.436 ± 0.036	1.373MetGlu: 1.373 ± 0.037	0.758MetPhe: 0.758 ± 0.026	2.398MetGly: 2.398 ± 0.049	0.456MetHis: 0.456 ± 0.023	1.531MetIle: 1.531 ± 0.042	0.986MetLys: 0.986 ± 0.031	2.425MetLeu: 2.425 ± 0.049	0.742MetMet: 0.742 ± 0.031	0.773MetAsn: 0.773 ± 0.025	1.577MetPro: 1.577 ± 0.042	0.921MetGln: 0.921 ± 0.027	1.993MetArg: 1.993 ± 0.037	1.388MetSer: 1.388 ± 0.04	2.107MetThr: 2.107 ± 0.048	1.95MetVal: 1.95 ± 0.044	0.239MetTrp: 0.239 ± 0.016	0.309MetTyr: 0.309 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.885AsnAla: 2.885 ± 0.05	0.217AsnCys: 0.217 ± 0.011	1.585AsnAsp: 1.585 ± 0.12	0.994AsnGlu: 0.994 ± 0.032	0.87AsnPhe: 0.87 ± 0.027	2.314AsnGly: 2.314 ± 0.065	0.47AsnHis: 0.47 ± 0.021	1.105AsnIle: 1.105 ± 0.031	0.496AsnLys: 0.496 ± 0.023	2.431AsnLeu: 2.431 ± 0.047	0.6AsnMet: 0.6 ± 0.024	0.527AsnAsn: 0.527 ± 0.022	1.826AsnPro: 1.826 ± 0.041	0.543AsnGln: 0.543 ± 0.025	1.783AsnArg: 1.783 ± 0.04	0.921AsnSer: 0.921 ± 0.029	1.169AsnThr: 1.169 ± 0.034	1.604AsnVal: 1.604 ± 0.04	0.393AsnTrp: 0.393 ± 0.02	0.519AsnTyr: 0.519 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.269ProAla: 7.269 ± 0.115	0.4ProCys: 0.4 ± 0.021	4.219ProAsp: 4.219 ± 0.074	4.209ProGlu: 4.209 ± 0.066	2.074ProPhe: 2.074 ± 0.042	5.427ProGly: 5.427 ± 0.076	1.109ProHis: 1.109 ± 0.033	2.008ProIle: 2.008 ± 0.044	1.416ProLys: 1.416 ± 0.05	4.914ProLeu: 4.914 ± 0.073	1.406ProMet: 1.406 ± 0.033	1.129ProAsn: 1.129 ± 0.034	2.729ProPro: 2.729 ± 0.061	1.476ProGln: 1.476 ± 0.036	3.318ProArg: 3.318 ± 0.062	2.309ProSer: 2.309 ± 0.045	2.251ProThr: 2.251 ± 0.048	4.988ProVal: 4.988 ± 0.075	0.742ProTrp: 0.742 ± 0.027	1.118ProTyr: 1.118 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.057GlnAla: 4.057 ± 0.065	0.203GlnCys: 0.203 ± 0.013	1.453GlnAsp: 1.453 ± 0.035	1.266GlnGlu: 1.266 ± 0.033	0.929GlnPhe: 0.929 ± 0.031	2.669GlnGly: 2.669 ± 0.054	0.475GlnHis: 0.475 ± 0.023	1.748GlnIle: 1.748 ± 0.043	0.872GlnLys: 0.872 ± 0.025	2.277GlnLeu: 2.277 ± 0.049	0.98GlnMet: 0.98 ± 0.029	0.73GlnAsn: 0.73 ± 0.024	1.521GlnPro: 1.521 ± 0.036	0.783GlnGln: 0.783 ± 0.029	1.955GlnArg: 1.955 ± 0.047	1.452GlnSer: 1.452 ± 0.04	1.538GlnThr: 1.538 ± 0.043	2.295GlnVal: 2.295 ± 0.046	0.381GlnTrp: 0.381 ± 0.02	0.459GlnTyr: 0.459 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.953ArgAla: 9.953 ± 0.104	0.477ArgCys: 0.477 ± 0.023	4.549ArgAsp: 4.549 ± 0.072	3.857ArgGlu: 3.857 ± 0.059	3.008ArgPhe: 3.008 ± 0.05	5.382ArgGly: 5.382 ± 0.084	1.777ArgHis: 1.777 ± 0.045	4.47ArgIle: 4.47 ± 0.071	2.038ArgLys: 2.038 ± 0.045	8.694ArgLeu: 8.694 ± 0.104	2.27ArgMet: 2.27 ± 0.047	1.687ArgAsn: 1.687 ± 0.034	4.136ArgPro: 4.136 ± 0.072	2.309ArgGln: 2.309 ± 0.041	5.837ArgArg: 5.837 ± 0.077	3.065ArgSer: 3.065 ± 0.061	3.213ArgThr: 3.213 ± 0.05	5.288ArgVal: 5.288 ± 0.078	1.005ArgTrp: 1.005 ± 0.029	1.447ArgTyr: 1.447 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.473SerAla: 5.473 ± 0.075	0.384SerCys: 0.384 ± 0.02	2.667SerAsp: 2.667 ± 0.054	2.284SerGlu: 2.284 ± 0.042	1.876SerPhe: 1.876 ± 0.049	5.194SerGly: 5.194 ± 0.083	0.978SerHis: 0.978 ± 0.031	2.133SerIle: 2.133 ± 0.049	1.028SerLys: 1.028 ± 0.035	4.534SerLeu: 4.534 ± 0.065	1.118SerMet: 1.118 ± 0.034	1.075SerAsn: 1.075 ± 0.035	2.493SerPro: 2.493 ± 0.048	1.231SerGln: 1.231 ± 0.033	3.201SerArg: 3.201 ± 0.052	2.064SerSer: 2.064 ± 0.049	2.195SerThr: 2.195 ± 0.044	3.575SerVal: 3.575 ± 0.058	0.572SerTrp: 0.572 ± 0.027	1.05SerTyr: 1.05 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.526ThrAla: 6.526 ± 0.085	0.46ThrCys: 0.46 ± 0.022	3.061ThrAsp: 3.061 ± 0.057	2.915ThrGlu: 2.915 ± 0.051	1.964ThrPhe: 1.964 ± 0.042	5.893ThrGly: 5.893 ± 0.095	1.069ThrHis: 1.069 ± 0.031	2.688ThrIle: 2.688 ± 0.059	1.143ThrLys: 1.143 ± 0.035	5.806ThrLeu: 5.806 ± 0.073	1.223ThrMet: 1.223 ± 0.031	1.214ThrAsn: 1.214 ± 0.038	3.365ThrPro: 3.365 ± 0.057	1.321ThrGln: 1.321 ± 0.039	3.617ThrArg: 3.617 ± 0.055	2.225ThrSer: 2.225 ± 0.047	2.638ThrThr: 2.638 ± 0.06	4.339ThrVal: 4.339 ± 0.07	0.669ThrTrp: 0.669 ± 0.025	1.163ThrTyr: 1.163 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.866ValAla: 9.866 ± 0.103	0.629ValCys: 0.629 ± 0.023	3.919ValAsp: 3.919 ± 0.06	4.361ValGlu: 4.361 ± 0.068	2.829ValPhe: 2.829 ± 0.058	5.413ValGly: 5.413 ± 0.077	1.339ValHis: 1.339 ± 0.037	4.431ValIle: 4.431 ± 0.059	2.083ValLys: 2.083 ± 0.051	7.685ValLeu: 7.685 ± 0.098	2.171ValMet: 2.171 ± 0.047	1.913ValAsn: 1.913 ± 0.037	3.776ValPro: 3.776 ± 0.06	1.975ValGln: 1.975 ± 0.043	4.553ValArg: 4.553 ± 0.068	3.628ValSer: 3.628 ± 0.066	5.073ValThr: 5.073 ± 0.075	5.716ValVal: 5.716 ± 0.083	1.076ValTrp: 1.076 ± 0.032	1.431ValTyr: 1.431 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.595TrpAla: 1.595 ± 0.041	0.151TrpCys: 0.151 ± 0.012	0.802TrpAsp: 0.802 ± 0.025	0.632TrpGlu: 0.632 ± 0.024	0.552TrpPhe: 0.552 ± 0.023	1.098TrpGly: 1.098 ± 0.032	0.354TrpHis: 0.354 ± 0.019	0.656TrpIle: 0.656 ± 0.023	0.44TrpLys: 0.44 ± 0.021	1.697TrpLeu: 1.697 ± 0.04	0.426TrpMet: 0.426 ± 0.019	0.415TrpAsn: 0.415 ± 0.019	0.791TrpPro: 0.791 ± 0.028	0.618TrpGln: 0.618 ± 0.025	1.219TrpArg: 1.219 ± 0.035	0.739TrpSer: 0.739 ± 0.024	0.788TrpThr: 0.788 ± 0.026	0.995TrpVal: 0.995 ± 0.032	0.239TrpTrp: 0.239 ± 0.014	0.261TrpTyr: 0.261 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.459TyrAla: 2.459 ± 0.048	0.2TyrCys: 0.2 ± 0.013	1.415TyrAsp: 1.415 ± 0.035	1.048TyrGlu: 1.048 ± 0.036	0.797TyrPhe: 0.797 ± 0.03	2.017TyrGly: 2.017 ± 0.048	0.477TyrHis: 0.477 ± 0.023	0.831TyrIle: 0.831 ± 0.031	0.463TyrLys: 0.463 ± 0.018	2.099TyrLeu: 2.099 ± 0.042	0.44TyrMet: 0.44 ± 0.021	0.503TyrAsn: 0.503 ± 0.02	1.062TyrPro: 1.062 ± 0.031	0.591TyrGln: 0.591 ± 0.024	1.542TyrArg: 1.542 ± 0.034	0.999TyrSer: 0.999 ± 0.029	1.001TyrThr: 1.001 ± 0.03	1.45TyrVal: 1.45 ± 0.035	0.358TyrTrp: 0.358 ± 0.02	0.481TyrTyr: 0.481 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3480 proteins (1136179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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