Amino acid dipepetide frequency for Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.292AlaAla: 6.292 ± 0.418
2.282AlaCys: 2.282 ± 0.362
2.835AlaAsp: 2.835 ± 0.546
3.388AlaGlu: 3.388 ± 0.7
3.526AlaPhe: 3.526 ± 0.569
4.564AlaGly: 4.564 ± 0.651
1.245AlaHis: 1.245 ± 0.309
3.319AlaIle: 3.319 ± 0.615
3.112AlaLys: 3.112 ± 0.66
6.915AlaLeu: 6.915 ± 0.997
2.213AlaMet: 2.213 ± 0.181
5.67AlaAsn: 5.67 ± 0.62
3.526AlaPro: 3.526 ± 1.137
1.798AlaGln: 1.798 ± 0.732
2.766AlaArg: 2.766 ± 0.243
6.569AlaSer: 6.569 ± 0.582
5.324AlaThr: 5.324 ± 0.546
5.67AlaVal: 5.67 ± 0.954
0.761AlaTrp: 0.761 ± 0.155
4.08AlaTyr: 4.08 ± 0.239
0.0AlaXaa: 0.0 ± 0.0
Cys
2.005CysAla: 2.005 ± 0.382
0.83CysCys: 0.83 ± 0.245
2.005CysAsp: 2.005 ± 0.311
0.83CysGlu: 0.83 ± 0.178
1.106CysPhe: 1.106 ± 0.329
2.144CysGly: 2.144 ± 0.412
0.207CysHis: 0.207 ± 0.205
1.66CysIle: 1.66 ± 0.68
1.66CysLys: 1.66 ± 0.307
2.766CysLeu: 2.766 ± 0.685
0.553CysMet: 0.553 ± 0.162
2.144CysAsn: 2.144 ± 0.407
0.761CysPro: 0.761 ± 0.144
0.622CysGln: 0.622 ± 0.12
1.383CysArg: 1.383 ± 0.275
1.66CysSer: 1.66 ± 0.323
2.351CysThr: 2.351 ± 0.277
3.25CysVal: 3.25 ± 0.544
0.346CysTrp: 0.346 ± 0.158
2.144CysTyr: 2.144 ± 0.495
0.0CysXaa: 0.0 ± 0.0
Asp
4.356AspAla: 4.356 ± 0.978
2.074AspCys: 2.074 ± 0.374
2.144AspAsp: 2.144 ± 0.375
1.729AspGlu: 1.729 ± 0.369
2.42AspPhe: 2.42 ± 0.341
3.941AspGly: 3.941 ± 0.303
0.899AspHis: 0.899 ± 0.245
2.766AspIle: 2.766 ± 0.7
1.936AspLys: 1.936 ± 0.346
5.463AspLeu: 5.463 ± 0.606
1.314AspMet: 1.314 ± 0.187
2.282AspAsn: 2.282 ± 0.432
2.42AspPro: 2.42 ± 0.322
1.59AspGln: 1.59 ± 0.214
1.729AspArg: 1.729 ± 0.342
4.08AspSer: 4.08 ± 0.563
3.181AspThr: 3.181 ± 0.741
5.601AspVal: 5.601 ± 1.011
0.622AspTrp: 0.622 ± 0.276
2.973AspTyr: 2.973 ± 0.495
0.0AspXaa: 0.0 ± 0.0
Glu
3.665GluAla: 3.665 ± 0.381
1.245GluCys: 1.245 ± 0.467
3.042GluAsp: 3.042 ± 0.477
1.798GluGlu: 1.798 ± 0.392
2.282GluPhe: 2.282 ± 0.329
2.766GluGly: 2.766 ± 0.419
1.037GluHis: 1.037 ± 0.411
1.314GluIle: 1.314 ± 0.228
2.074GluLys: 2.074 ± 0.504
3.319GluLeu: 3.319 ± 0.31
0.346GluMet: 0.346 ± 0.215
1.936GluAsn: 1.936 ± 0.38
1.867GluPro: 1.867 ± 0.297
1.383GluGln: 1.383 ± 0.199
1.867GluArg: 1.867 ± 0.508
2.213GluSer: 2.213 ± 0.332
2.351GluThr: 2.351 ± 0.21
4.011GluVal: 4.011 ± 0.703
0.622GluTrp: 0.622 ± 0.153
1.521GluTyr: 1.521 ± 0.354
0.0GluXaa: 0.0 ± 0.0
Phe
3.25PheAla: 3.25 ± 0.192
1.798PheCys: 1.798 ± 0.34
2.558PheAsp: 2.558 ± 0.422
1.729PheGlu: 1.729 ± 0.306
1.729PhePhe: 1.729 ± 0.356
2.282PheGly: 2.282 ± 0.49
0.691PheHis: 0.691 ± 0.448
3.526PheIle: 3.526 ± 0.745
2.074PheLys: 2.074 ± 0.582
3.042PheLeu: 3.042 ± 0.555
0.968PheMet: 0.968 ± 0.243
3.181PheAsn: 3.181 ± 0.475
1.245PhePro: 1.245 ± 0.42
2.005PheGln: 2.005 ± 0.599
1.245PheArg: 1.245 ± 0.156
2.904PheSer: 2.904 ± 0.416
3.457PheThr: 3.457 ± 0.397
5.67PheVal: 5.67 ± 0.613
0.553PheTrp: 0.553 ± 0.225
2.628PheTyr: 2.628 ± 0.157
0.0PheXaa: 0.0 ± 0.0
Gly
4.564GlyAla: 4.564 ± 0.575
1.936GlyCys: 1.936 ± 0.296
3.665GlyAsp: 3.665 ± 0.819
2.558GlyGlu: 2.558 ± 0.205
2.973GlyPhe: 2.973 ± 0.522
3.457GlyGly: 3.457 ± 0.737
1.59GlyHis: 1.59 ± 0.309
3.526GlyIle: 3.526 ± 0.361
3.388GlyLys: 3.388 ± 0.336
4.495GlyLeu: 4.495 ± 0.533
1.106GlyMet: 1.106 ± 0.302
2.282GlyAsn: 2.282 ± 0.617
1.66GlyPro: 1.66 ± 0.362
1.521GlyGln: 1.521 ± 0.241
2.074GlyArg: 2.074 ± 0.613
4.702GlySer: 4.702 ± 0.441
4.425GlyThr: 4.425 ± 1.253
6.085GlyVal: 6.085 ± 0.705
0.415GlyTrp: 0.415 ± 0.143
2.628GlyTyr: 2.628 ± 1.172
0.0GlyXaa: 0.0 ± 0.0
His
1.314HisAla: 1.314 ± 0.307
0.484HisCys: 0.484 ± 0.158
0.83HisAsp: 0.83 ± 0.274
0.83HisGlu: 0.83 ± 0.279
0.83HisPhe: 0.83 ± 0.338
1.245HisGly: 1.245 ± 0.333
0.0HisHis: 0.0 ± 0.0
1.452HisIle: 1.452 ± 0.22
0.83HisLys: 0.83 ± 0.214
1.521HisLeu: 1.521 ± 0.387
0.277HisMet: 0.277 ± 0.171
0.899HisAsn: 0.899 ± 0.24
1.037HisPro: 1.037 ± 0.31
0.761HisGln: 0.761 ± 0.121
0.761HisArg: 0.761 ± 0.327
1.729HisSer: 1.729 ± 0.442
1.936HisThr: 1.936 ± 0.336
2.074HisVal: 2.074 ± 0.287
0.207HisTrp: 0.207 ± 0.111
1.245HisTyr: 1.245 ± 0.342
0.0HisXaa: 0.0 ± 0.0
Ile
4.425IleAla: 4.425 ± 0.281
1.106IleCys: 1.106 ± 0.163
2.835IleAsp: 2.835 ± 0.36
1.59IleGlu: 1.59 ± 0.273
1.729IlePhe: 1.729 ± 0.289
3.042IleGly: 3.042 ± 0.475
0.484IleHis: 0.484 ± 0.141
1.66IleIle: 1.66 ± 0.584
2.42IleLys: 2.42 ± 0.403
4.287IleLeu: 4.287 ± 0.6
0.277IleMet: 0.277 ± 0.113
2.697IleAsn: 2.697 ± 0.518
2.697IlePro: 2.697 ± 0.224
1.037IleGln: 1.037 ± 0.225
1.936IleArg: 1.936 ± 0.553
2.973IleSer: 2.973 ± 0.397
3.112IleThr: 3.112 ± 0.633
4.564IleVal: 4.564 ± 0.793
0.761IleTrp: 0.761 ± 0.207
1.936IleTyr: 1.936 ± 0.547
0.0IleXaa: 0.0 ± 0.0
Lys
3.872LysAla: 3.872 ± 0.568
1.383LysCys: 1.383 ± 0.272
2.904LysAsp: 2.904 ± 0.665
1.936LysGlu: 1.936 ± 0.296
2.835LysPhe: 2.835 ± 0.541
3.526LysGly: 3.526 ± 0.952
1.867LysHis: 1.867 ± 0.573
2.558LysIle: 2.558 ± 0.519
2.835LysLys: 2.835 ± 0.494
5.601LysLeu: 5.601 ± 1.006
1.59LysMet: 1.59 ± 0.605
2.351LysAsn: 2.351 ± 0.23
3.526LysPro: 3.526 ± 0.378
2.351LysGln: 2.351 ± 0.894
2.558LysArg: 2.558 ± 0.424
2.282LysSer: 2.282 ± 0.264
2.766LysThr: 2.766 ± 0.279
3.042LysVal: 3.042 ± 0.368
0.83LysTrp: 0.83 ± 0.25
2.489LysTyr: 2.489 ± 0.534
0.069LysXaa: 0.069 ± 0.048
Leu
6.846LeuAla: 6.846 ± 0.648
3.388LeuCys: 3.388 ± 0.597
3.872LeuAsp: 3.872 ± 0.404
3.042LeuGlu: 3.042 ± 0.585
4.356LeuPhe: 4.356 ± 0.426
3.941LeuGly: 3.941 ± 0.685
2.973LeuHis: 2.973 ± 0.435
3.112LeuIle: 3.112 ± 0.497
5.463LeuLys: 5.463 ± 1.079
9.266LeuLeu: 9.266 ± 1.241
2.074LeuMet: 2.074 ± 0.483
5.117LeuAsn: 5.117 ± 0.517
3.526LeuPro: 3.526 ± 0.539
3.872LeuGln: 3.872 ± 0.336
4.218LeuArg: 4.218 ± 0.68
7.537LeuSer: 7.537 ± 0.546
7.744LeuThr: 7.744 ± 0.974
7.537LeuVal: 7.537 ± 0.983
1.314LeuTrp: 1.314 ± 0.305
3.596LeuTyr: 3.596 ± 0.47
0.0LeuXaa: 0.0 ± 0.0
Met
1.59MetAla: 1.59 ± 0.791
0.83MetCys: 0.83 ± 0.253
0.899MetAsp: 0.899 ± 0.286
1.106MetGlu: 1.106 ± 0.257
0.968MetPhe: 0.968 ± 0.432
1.106MetGly: 1.106 ± 0.213
0.83MetHis: 0.83 ± 0.208
0.553MetIle: 0.553 ± 0.145
0.691MetLys: 0.691 ± 0.238
3.457MetLeu: 3.457 ± 0.61
0.622MetMet: 0.622 ± 0.337
0.691MetAsn: 0.691 ± 0.258
0.83MetPro: 0.83 ± 0.259
1.037MetGln: 1.037 ± 0.368
0.899MetArg: 0.899 ± 0.692
1.383MetSer: 1.383 ± 0.142
1.452MetThr: 1.452 ± 0.381
1.798MetVal: 1.798 ± 0.269
0.069MetTrp: 0.069 ± 0.197
0.899MetTyr: 0.899 ± 0.237
0.0MetXaa: 0.0 ± 0.0
Asn
4.702AsnAla: 4.702 ± 0.359
1.867AsnCys: 1.867 ± 0.257
2.628AsnAsp: 2.628 ± 0.304
1.729AsnGlu: 1.729 ± 0.163
2.835AsnPhe: 2.835 ± 0.727
3.941AsnGly: 3.941 ± 0.75
0.484AsnHis: 0.484 ± 0.215
2.005AsnIle: 2.005 ± 0.413
3.319AsnLys: 3.319 ± 0.419
4.287AsnLeu: 4.287 ± 0.918
1.106AsnMet: 1.106 ± 0.277
2.489AsnAsn: 2.489 ± 0.5
1.59AsnPro: 1.59 ± 0.258
1.521AsnGln: 1.521 ± 0.588
1.729AsnArg: 1.729 ± 0.249
4.425AsnSer: 4.425 ± 0.403
2.835AsnThr: 2.835 ± 0.227
4.909AsnVal: 4.909 ± 0.766
1.175AsnTrp: 1.175 ± 0.388
2.628AsnTyr: 2.628 ± 0.757
0.0AsnXaa: 0.0 ± 0.0
Pro
3.042ProAla: 3.042 ± 0.927
1.452ProCys: 1.452 ± 0.295
1.798ProAsp: 1.798 ± 0.248
2.005ProGlu: 2.005 ± 0.367
1.66ProPhe: 1.66 ± 0.163
2.144ProGly: 2.144 ± 0.508
0.691ProHis: 0.691 ± 0.247
2.351ProIle: 2.351 ± 0.997
1.798ProLys: 1.798 ± 0.641
4.909ProLeu: 4.909 ± 0.858
0.691ProMet: 0.691 ± 0.384
2.074ProAsn: 2.074 ± 0.319
1.729ProPro: 1.729 ± 0.972
2.144ProGln: 2.144 ± 0.404
1.729ProArg: 1.729 ± 0.671
2.558ProSer: 2.558 ± 0.968
3.112ProThr: 3.112 ± 0.331
3.042ProVal: 3.042 ± 0.51
0.691ProTrp: 0.691 ± 0.153
1.452ProTyr: 1.452 ± 0.251
0.0ProXaa: 0.0 ± 0.0
Gln
2.766GlnAla: 2.766 ± 0.288
0.691GlnCys: 0.691 ± 0.293
1.936GlnAsp: 1.936 ± 0.358
1.59GlnGlu: 1.59 ± 1.136
1.521GlnPhe: 1.521 ± 0.25
2.074GlnGly: 2.074 ± 0.286
0.277GlnHis: 0.277 ± 0.139
1.245GlnIle: 1.245 ± 0.354
1.452GlnLys: 1.452 ± 0.79
4.011GlnLeu: 4.011 ± 0.616
0.83GlnMet: 0.83 ± 0.148
1.245GlnAsn: 1.245 ± 0.235
1.383GlnPro: 1.383 ± 0.601
1.383GlnGln: 1.383 ± 0.511
1.175GlnArg: 1.175 ± 0.649
3.457GlnSer: 3.457 ± 0.584
2.351GlnThr: 2.351 ± 0.255
3.25GlnVal: 3.25 ± 0.388
0.346GlnTrp: 0.346 ± 0.094
1.245GlnTyr: 1.245 ± 0.419
0.0GlnXaa: 0.0 ± 0.0
Arg
3.042ArgAla: 3.042 ± 0.457
0.83ArgCys: 0.83 ± 0.516
2.282ArgAsp: 2.282 ± 0.455
0.968ArgGlu: 0.968 ± 0.208
1.452ArgPhe: 1.452 ± 0.379
1.936ArgGly: 1.936 ± 0.316
1.175ArgHis: 1.175 ± 0.292
1.59ArgIle: 1.59 ± 0.454
2.074ArgLys: 2.074 ± 0.442
3.803ArgLeu: 3.803 ± 0.957
0.622ArgMet: 0.622 ± 0.139
2.282ArgAsn: 2.282 ± 0.35
1.383ArgPro: 1.383 ± 1.118
1.59ArgGln: 1.59 ± 0.243
1.521ArgArg: 1.521 ± 0.463
2.766ArgSer: 2.766 ± 1.2
1.798ArgThr: 1.798 ± 0.302
3.319ArgVal: 3.319 ± 0.445
0.207ArgTrp: 0.207 ± 0.366
2.351ArgTyr: 2.351 ± 0.441
0.0ArgXaa: 0.0 ± 0.0
Ser
5.947SerAla: 5.947 ± 0.926
1.936SerCys: 1.936 ± 0.457
5.255SerAsp: 5.255 ± 0.679
3.319SerGlu: 3.319 ± 0.497
3.457SerPhe: 3.457 ± 0.321
3.941SerGly: 3.941 ± 0.566
1.383SerHis: 1.383 ± 0.546
2.351SerIle: 2.351 ± 0.641
5.255SerLys: 5.255 ± 0.551
6.292SerLeu: 6.292 ± 0.693
1.59SerMet: 1.59 ± 0.524
3.319SerAsn: 3.319 ± 0.837
1.798SerPro: 1.798 ± 0.38
2.558SerGln: 2.558 ± 0.745
2.42SerArg: 2.42 ± 0.93
6.915SerSer: 6.915 ± 1.736
4.495SerThr: 4.495 ± 0.278
7.606SerVal: 7.606 ± 0.325
1.175SerTrp: 1.175 ± 0.16
3.872SerTyr: 3.872 ± 0.168
0.0SerXaa: 0.0 ± 0.0
Thr
4.149ThrAla: 4.149 ± 0.683
1.037ThrCys: 1.037 ± 0.288
3.112ThrAsp: 3.112 ± 0.387
3.042ThrGlu: 3.042 ± 0.305
3.112ThrPhe: 3.112 ± 0.485
5.947ThrGly: 5.947 ± 1.314
1.66ThrHis: 1.66 ± 0.264
3.042ThrIle: 3.042 ± 0.345
2.628ThrLys: 2.628 ± 0.56
6.638ThrLeu: 6.638 ± 0.489
1.729ThrMet: 1.729 ± 0.368
2.973ThrAsn: 2.973 ± 0.502
3.941ThrPro: 3.941 ± 0.419
2.282ThrGln: 2.282 ± 0.792
1.521ThrArg: 1.521 ± 0.296
5.393ThrSer: 5.393 ± 0.78
6.016ThrThr: 6.016 ± 1.116
6.223ThrVal: 6.223 ± 0.491
0.83ThrTrp: 0.83 ± 0.16
3.457ThrTyr: 3.457 ± 0.625
0.0ThrXaa: 0.0 ± 0.0
Val
5.947ValAla: 5.947 ± 0.495
3.319ValCys: 3.319 ± 0.467
4.702ValAsp: 4.702 ± 0.895
6.085ValGlu: 6.085 ± 1.046
3.803ValPhe: 3.803 ± 0.124
4.702ValGly: 4.702 ± 0.419
1.66ValHis: 1.66 ± 0.224
5.393ValIle: 5.393 ± 0.43
6.154ValLys: 6.154 ± 1.155
7.26ValLeu: 7.26 ± 0.748
2.42ValMet: 2.42 ± 0.541
4.909ValAsn: 4.909 ± 0.749
3.457ValPro: 3.457 ± 0.375
3.803ValGln: 3.803 ± 0.429
2.766ValArg: 2.766 ± 0.22
6.361ValSer: 6.361 ± 0.582
5.601ValThr: 5.601 ± 0.475
8.643ValVal: 8.643 ± 1.2
0.83ValTrp: 0.83 ± 0.223
4.149ValTyr: 4.149 ± 0.347
0.0ValXaa: 0.0 ± 0.0
Trp
1.106TrpAla: 1.106 ± 0.275
0.553TrpCys: 0.553 ± 0.181
0.761TrpAsp: 0.761 ± 0.253
0.277TrpGlu: 0.277 ± 0.113
1.245TrpPhe: 1.245 ± 0.182
0.138TrpGly: 0.138 ± 0.097
0.207TrpHis: 0.207 ± 0.072
0.415TrpIle: 0.415 ± 0.156
0.761TrpLys: 0.761 ± 0.248
1.314TrpLeu: 1.314 ± 0.213
0.207TrpMet: 0.207 ± 0.145
0.83TrpAsn: 0.83 ± 0.202
0.691TrpPro: 0.691 ± 0.283
0.069TrpGln: 0.069 ± 0.241
0.622TrpArg: 0.622 ± 0.289
0.968TrpSer: 0.968 ± 0.33
0.553TrpThr: 0.553 ± 0.138
0.899TrpVal: 0.899 ± 0.233
0.138TrpTrp: 0.138 ± 0.19
0.277TrpTyr: 0.277 ± 0.285
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.973TyrAla: 2.973 ± 0.667
1.452TyrCys: 1.452 ± 0.197
3.457TyrAsp: 3.457 ± 0.379
1.106TyrGlu: 1.106 ± 0.213
2.697TyrPhe: 2.697 ± 0.297
2.213TyrGly: 2.213 ± 0.467
0.899TyrHis: 0.899 ± 0.259
1.729TyrIle: 1.729 ± 0.413
3.25TyrLys: 3.25 ± 0.654
4.149TyrLeu: 4.149 ± 0.537
1.106TyrMet: 1.106 ± 0.219
2.835TyrAsn: 2.835 ± 0.391
2.005TyrPro: 2.005 ± 0.704
0.899TyrGln: 0.899 ± 0.369
2.074TyrArg: 2.074 ± 0.228
4.011TyrSer: 4.011 ± 0.343
3.872TyrThr: 3.872 ± 0.494
4.771TyrVal: 4.771 ± 0.619
0.069TyrTrp: 0.069 ± 0.162
2.697TyrTyr: 2.697 ± 0.5
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.069XaaTrp: 0.069 ± 0.048
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (14463 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski