Amino acid dipepetide frequency for Microbacterium ginsengisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.922AlaAla: 23.922 ± 0.293
0.714AlaCys: 0.714 ± 0.029
8.647AlaAsp: 8.647 ± 0.128
7.381AlaGlu: 7.381 ± 0.113
4.086AlaPhe: 4.086 ± 0.069
12.736AlaGly: 12.736 ± 0.131
2.803AlaHis: 2.803 ± 0.068
6.17AlaIle: 6.17 ± 0.087
2.554AlaLys: 2.554 ± 0.065
14.98AlaLeu: 14.98 ± 0.182
2.521AlaMet: 2.521 ± 0.056
2.218AlaAsn: 2.218 ± 0.053
7.073AlaPro: 7.073 ± 0.111
4.118AlaGln: 4.118 ± 0.081
10.057AlaArg: 10.057 ± 0.15
8.127AlaSer: 8.127 ± 0.102
8.233AlaThr: 8.233 ± 0.112
12.251AlaVal: 12.251 ± 0.147
1.996AlaTrp: 1.996 ± 0.054
2.513AlaTyr: 2.513 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.689CysAla: 0.689 ± 0.028
0.055CysCys: 0.055 ± 0.008
0.309CysAsp: 0.309 ± 0.022
0.231CysGlu: 0.231 ± 0.019
0.15CysPhe: 0.15 ± 0.014
0.555CysGly: 0.555 ± 0.029
0.106CysHis: 0.106 ± 0.011
0.19CysIle: 0.19 ± 0.015
0.045CysLys: 0.045 ± 0.007
0.424CysLeu: 0.424 ± 0.022
0.071CysMet: 0.071 ± 0.009
0.122CysAsn: 0.122 ± 0.013
0.292CysPro: 0.292 ± 0.022
0.132CysGln: 0.132 ± 0.017
0.346CysArg: 0.346 ± 0.024
0.324CysSer: 0.324 ± 0.022
0.342CysThr: 0.342 ± 0.024
0.421CysVal: 0.421 ± 0.021
0.061CysTrp: 0.061 ± 0.009
0.109CysTyr: 0.109 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
9.957AspAla: 9.957 ± 0.131
0.225AspCys: 0.225 ± 0.015
4.493AspAsp: 4.493 ± 0.093
4.214AspGlu: 4.214 ± 0.091
1.536AspPhe: 1.536 ± 0.038
5.807AspGly: 5.807 ± 0.093
1.219AspHis: 1.219 ± 0.042
2.416AspIle: 2.416 ± 0.061
0.964AspLys: 0.964 ± 0.038
6.252AspLeu: 6.252 ± 0.094
0.776AspMet: 0.776 ± 0.032
0.848AspAsn: 0.848 ± 0.031
4.139AspPro: 4.139 ± 0.073
1.538AspGln: 1.538 ± 0.043
4.439AspArg: 4.439 ± 0.095
2.272AspSer: 2.272 ± 0.054
2.918AspThr: 2.918 ± 0.062
5.672AspVal: 5.672 ± 0.082
0.885AspTrp: 0.885 ± 0.033
1.221AspTyr: 1.221 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.509GluAla: 6.509 ± 0.102
0.21GluCys: 0.21 ± 0.017
2.194GluAsp: 2.194 ± 0.051
2.358GluGlu: 2.358 ± 0.061
1.5GluPhe: 1.5 ± 0.044
3.598GluGly: 3.598 ± 0.071
1.249GluHis: 1.249 ± 0.042
2.683GluIle: 2.683 ± 0.054
1.318GluLys: 1.318 ± 0.05
5.913GluLeu: 5.913 ± 0.1
0.737GluMet: 0.737 ± 0.032
1.142GluAsn: 1.142 ± 0.039
2.703GluPro: 2.703 ± 0.068
1.96GluGln: 1.96 ± 0.053
5.114GluArg: 5.114 ± 0.1
2.519GluSer: 2.519 ± 0.054
2.994GluThr: 2.994 ± 0.068
4.471GluVal: 4.471 ± 0.088
0.771GluTrp: 0.771 ± 0.032
1.028GluTyr: 1.028 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.534PheAla: 4.534 ± 0.07
0.141PheCys: 0.141 ± 0.012
2.277PheAsp: 2.277 ± 0.052
1.585PheGlu: 1.585 ± 0.048
0.999PhePhe: 0.999 ± 0.038
3.378PheGly: 3.378 ± 0.068
0.548PheHis: 0.548 ± 0.026
1.111PheIle: 1.111 ± 0.038
0.387PheLys: 0.387 ± 0.021
2.784PheLeu: 2.784 ± 0.066
0.386PheMet: 0.386 ± 0.024
0.583PheAsn: 0.583 ± 0.03
1.384PhePro: 1.384 ± 0.042
0.748PheGln: 0.748 ± 0.034
1.748PheArg: 1.748 ± 0.047
1.698PheSer: 1.698 ± 0.042
2.168PheThr: 2.168 ± 0.049
2.882PheVal: 2.882 ± 0.071
0.45PheTrp: 0.45 ± 0.02
0.656PheTyr: 0.656 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
11.401GlyAla: 11.401 ± 0.14
0.557GlyCys: 0.557 ± 0.026
5.172GlyAsp: 5.172 ± 0.078
4.742GlyGlu: 4.742 ± 0.076
3.27GlyPhe: 3.27 ± 0.061
7.696GlyGly: 7.696 ± 0.127
1.842GlyHis: 1.842 ± 0.049
4.709GlyIle: 4.709 ± 0.073
1.974GlyLys: 1.974 ± 0.057
8.628GlyLeu: 8.628 ± 0.1
1.874GlyMet: 1.874 ± 0.048
1.61GlyAsn: 1.61 ± 0.048
3.554GlyPro: 3.554 ± 0.07
2.461GlyGln: 2.461 ± 0.06
6.34GlyArg: 6.34 ± 0.09
5.169GlySer: 5.169 ± 0.092
5.784GlyThr: 5.784 ± 0.106
8.465GlyVal: 8.465 ± 0.122
1.631GlyTrp: 1.631 ± 0.051
2.246GlyTyr: 2.246 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.591HisAla: 2.591 ± 0.069
0.113HisCys: 0.113 ± 0.012
1.399HisAsp: 1.399 ± 0.044
1.095HisGlu: 1.095 ± 0.032
0.523HisPhe: 0.523 ± 0.024
1.963HisGly: 1.963 ± 0.056
0.529HisHis: 0.529 ± 0.027
0.761HisIle: 0.761 ± 0.032
0.271HisLys: 0.271 ± 0.018
1.964HisLeu: 1.964 ± 0.044
0.292HisMet: 0.292 ± 0.019
0.335HisAsn: 0.335 ± 0.021
1.567HisPro: 1.567 ± 0.053
0.465HisGln: 0.465 ± 0.024
1.61HisArg: 1.61 ± 0.048
0.953HisSer: 0.953 ± 0.031
1.055HisThr: 1.055 ± 0.036
1.754HisVal: 1.754 ± 0.05
0.245HisTrp: 0.245 ± 0.017
0.409HisTyr: 0.409 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.517IleAla: 7.517 ± 0.103
0.243IleCys: 0.243 ± 0.016
3.672IleAsp: 3.672 ± 0.067
2.678IleGlu: 2.678 ± 0.068
1.115IlePhe: 1.115 ± 0.043
4.806IleGly: 4.806 ± 0.09
0.685IleHis: 0.685 ± 0.029
1.751IleIle: 1.751 ± 0.061
0.732IleLys: 0.732 ± 0.032
3.483IleLeu: 3.483 ± 0.07
0.56IleMet: 0.56 ± 0.027
0.86IleAsn: 0.86 ± 0.033
2.378IlePro: 2.378 ± 0.054
0.98IleGln: 0.98 ± 0.038
2.495IleArg: 2.495 ± 0.053
2.315IleSer: 2.315 ± 0.05
2.803IleThr: 2.803 ± 0.061
5.055IleVal: 5.055 ± 0.079
0.507IleTrp: 0.507 ± 0.027
0.762IleTyr: 0.762 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
2.363LysAla: 2.363 ± 0.065
0.064LysCys: 0.064 ± 0.009
1.019LysAsp: 1.019 ± 0.042
0.82LysGlu: 0.82 ± 0.042
0.423LysPhe: 0.423 ± 0.025
1.486LysGly: 1.486 ± 0.05
0.335LysHis: 0.335 ± 0.022
0.908LysIle: 0.908 ± 0.038
0.705LysLys: 0.705 ± 0.042
1.758LysLeu: 1.758 ± 0.05
0.296LysMet: 0.296 ± 0.017
0.483LysAsn: 0.483 ± 0.028
1.097LysPro: 1.097 ± 0.042
0.62LysGln: 0.62 ± 0.028
1.372LysArg: 1.372 ± 0.045
1.071LysSer: 1.071 ± 0.035
1.194LysThr: 1.194 ± 0.038
1.642LysVal: 1.642 ± 0.044
0.217LysTrp: 0.217 ± 0.016
0.408LysTyr: 0.408 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
15.409LeuAla: 15.409 ± 0.171
0.486LeuCys: 0.486 ± 0.025
6.612LeuAsp: 6.612 ± 0.099
4.722LeuGlu: 4.722 ± 0.082
2.865LeuPhe: 2.865 ± 0.064
9.123LeuGly: 9.123 ± 0.121
1.89LeuHis: 1.89 ± 0.048
4.36LeuIle: 4.36 ± 0.08
1.541LeuLys: 1.541 ± 0.05
10.078LeuLeu: 10.078 ± 0.149
1.488LeuMet: 1.488 ± 0.047
1.556LeuAsn: 1.556 ± 0.042
5.412LeuPro: 5.412 ± 0.09
2.464LeuGln: 2.464 ± 0.056
7.623LeuArg: 7.623 ± 0.12
5.672LeuSer: 5.672 ± 0.087
6.585LeuThr: 6.585 ± 0.092
9.857LeuVal: 9.857 ± 0.153
1.356LeuTrp: 1.356 ± 0.048
1.629LeuTyr: 1.629 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
1.906MetAla: 1.906 ± 0.051
0.093MetCys: 0.093 ± 0.011
0.666MetAsp: 0.666 ± 0.031
0.447MetGlu: 0.447 ± 0.024
0.502MetPhe: 0.502 ± 0.024
1.191MetGly: 1.191 ± 0.04
0.3MetHis: 0.3 ± 0.021
0.762MetIle: 0.762 ± 0.029
0.346MetLys: 0.346 ± 0.018
1.638MetLeu: 1.638 ± 0.048
0.299MetMet: 0.299 ± 0.022
0.451MetAsn: 0.451 ± 0.023
1.042MetPro: 1.042 ± 0.033
0.462MetGln: 0.462 ± 0.022
1.285MetArg: 1.285 ± 0.044
1.499MetSer: 1.499 ± 0.041
1.685MetThr: 1.685 ± 0.043
1.215MetVal: 1.215 ± 0.042
0.198MetTrp: 0.198 ± 0.014
0.249MetTyr: 0.249 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.334AsnAla: 2.334 ± 0.057
0.111AsnCys: 0.111 ± 0.012
1.014AsnAsp: 1.014 ± 0.038
0.838AsnGlu: 0.838 ± 0.034
0.577AsnPhe: 0.577 ± 0.026
1.735AsnGly: 1.735 ± 0.054
0.31AsnHis: 0.31 ± 0.021
0.807AsnIle: 0.807 ± 0.036
0.375AsnLys: 0.375 ± 0.025
1.939AsnLeu: 1.939 ± 0.048
0.295AsnMet: 0.295 ± 0.018
0.43AsnAsn: 0.43 ± 0.025
1.538AsnPro: 1.538 ± 0.044
0.528AsnGln: 0.528 ± 0.029
1.132AsnArg: 1.132 ± 0.035
0.863AsnSer: 0.863 ± 0.032
1.118AsnThr: 1.118 ± 0.041
1.664AsnVal: 1.664 ± 0.05
0.281AsnTrp: 0.281 ± 0.018
0.44AsnTyr: 0.44 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.698ProAla: 7.698 ± 0.105
0.222ProCys: 0.222 ± 0.019
3.813ProAsp: 3.813 ± 0.072
3.249ProGlu: 3.249 ± 0.061
1.722ProPhe: 1.722 ± 0.045
4.96ProGly: 4.96 ± 0.083
1.177ProHis: 1.177 ± 0.037
2.207ProIle: 2.207 ± 0.049
0.922ProLys: 0.922 ± 0.036
4.944ProLeu: 4.944 ± 0.083
0.792ProMet: 0.792 ± 0.031
0.956ProAsn: 0.956 ± 0.04
2.248ProPro: 2.248 ± 0.062
1.472ProGln: 1.472 ± 0.047
3.637ProArg: 3.637 ± 0.074
3.147ProSer: 3.147 ± 0.065
3.582ProThr: 3.582 ± 0.081
5.113ProVal: 5.113 ± 0.082
0.868ProTrp: 0.868 ± 0.036
0.989ProTyr: 0.989 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.603GlnAla: 3.603 ± 0.086
0.131GlnCys: 0.131 ± 0.013
1.155GlnAsp: 1.155 ± 0.041
1.109GlnGlu: 1.109 ± 0.044
0.848GlnPhe: 0.848 ± 0.033
2.037GlnGly: 2.037 ± 0.055
0.608GlnHis: 0.608 ± 0.027
1.463GlnIle: 1.463 ± 0.048
0.666GlnLys: 0.666 ± 0.031
3.175GlnLeu: 3.175 ± 0.068
0.444GlnMet: 0.444 ± 0.02
0.674GlnAsn: 0.674 ± 0.034
1.475GlnPro: 1.475 ± 0.048
1.235GlnGln: 1.235 ± 0.048
2.353GlnArg: 2.353 ± 0.058
1.466GlnSer: 1.466 ± 0.046
1.679GlnThr: 1.679 ± 0.053
2.453GlnVal: 2.453 ± 0.055
0.436GlnTrp: 0.436 ± 0.024
0.569GlnTyr: 0.569 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
9.715ArgAla: 9.715 ± 0.138
0.29ArgCys: 0.29 ± 0.022
4.452ArgAsp: 4.452 ± 0.091
4.109ArgGlu: 4.109 ± 0.081
2.371ArgPhe: 2.371 ± 0.056
5.818ArgGly: 5.818 ± 0.091
1.666ArgHis: 1.666 ± 0.052
3.587ArgIle: 3.587 ± 0.065
1.244ArgLys: 1.244 ± 0.046
7.517ArgLeu: 7.517 ± 0.115
1.586ArgMet: 1.586 ± 0.047
1.217ArgAsn: 1.217 ± 0.038
3.635ArgPro: 3.635 ± 0.071
2.012ArgGln: 2.012 ± 0.055
6.986ArgArg: 6.986 ± 0.111
3.913ArgSer: 3.913 ± 0.065
4.444ArgThr: 4.444 ± 0.079
6.478ArgVal: 6.478 ± 0.109
1.199ArgTrp: 1.199 ± 0.042
1.548ArgTyr: 1.548 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
7.465SerAla: 7.465 ± 0.106
0.265SerCys: 0.265 ± 0.016
3.231SerAsp: 3.231 ± 0.063
2.311SerGlu: 2.311 ± 0.054
1.787SerPhe: 1.787 ± 0.045
5.742SerGly: 5.742 ± 0.1
0.997SerHis: 0.997 ± 0.035
2.547SerIle: 2.547 ± 0.051
0.946SerLys: 0.946 ± 0.034
5.43SerLeu: 5.43 ± 0.078
1.062SerMet: 1.062 ± 0.033
1.052SerAsn: 1.052 ± 0.039
3.222SerPro: 3.222 ± 0.067
1.422SerGln: 1.422 ± 0.038
3.71SerArg: 3.71 ± 0.065
3.51SerSer: 3.51 ± 0.095
3.826SerThr: 3.826 ± 0.085
4.877SerVal: 4.877 ± 0.079
0.878SerTrp: 0.878 ± 0.033
1.14SerTyr: 1.14 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
8.39ThrAla: 8.39 ± 0.115
0.314ThrCys: 0.314 ± 0.02
3.686ThrAsp: 3.686 ± 0.066
2.779ThrGlu: 2.779 ± 0.06
1.961ThrPhe: 1.961 ± 0.053
6.186ThrGly: 6.186 ± 0.094
1.186ThrHis: 1.186 ± 0.034
2.959ThrIle: 2.959 ± 0.066
1.088ThrLys: 1.088 ± 0.043
6.263ThrLeu: 6.263 ± 0.093
0.859ThrMet: 0.859 ± 0.031
1.17ThrAsn: 1.17 ± 0.05
4.242ThrPro: 4.242 ± 0.081
1.575ThrGln: 1.575 ± 0.046
4.033ThrArg: 4.033 ± 0.077
3.813ThrSer: 3.813 ± 0.076
4.102ThrThr: 4.102 ± 0.073
6.198ThrVal: 6.198 ± 0.096
0.905ThrTrp: 0.905 ± 0.034
1.242ThrTyr: 1.242 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
12.941ValAla: 12.941 ± 0.163
0.527ValCys: 0.527 ± 0.026
5.968ValAsp: 5.968 ± 0.084
4.637ValGlu: 4.637 ± 0.088
2.998ValPhe: 2.998 ± 0.071
7.316ValGly: 7.316 ± 0.106
1.813ValHis: 1.813 ± 0.05
4.612ValIle: 4.612 ± 0.078
1.564ValLys: 1.564 ± 0.046
9.702ValLeu: 9.702 ± 0.129
1.334ValMet: 1.334 ± 0.041
1.747ValAsn: 1.747 ± 0.044
4.939ValPro: 4.939 ± 0.08
2.273ValGln: 2.273 ± 0.051
6.613ValArg: 6.613 ± 0.104
5.126ValSer: 5.126 ± 0.088
6.403ValThr: 6.403 ± 0.104
9.611ValVal: 9.611 ± 0.138
1.296ValTrp: 1.296 ± 0.04
1.563ValTyr: 1.563 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.664TrpAla: 1.664 ± 0.048
0.099TrpCys: 0.099 ± 0.012
0.691TrpAsp: 0.691 ± 0.03
0.664TrpGlu: 0.664 ± 0.029
0.555TrpPhe: 0.555 ± 0.026
1.088TrpGly: 1.088 ± 0.033
0.334TrpHis: 0.334 ± 0.02
0.719TrpIle: 0.719 ± 0.032
0.284TrpLys: 0.284 ± 0.021
1.742TrpLeu: 1.742 ± 0.056
0.312TrpMet: 0.312 ± 0.019
0.436TrpAsn: 0.436 ± 0.021
0.714TrpPro: 0.714 ± 0.029
0.528TrpGln: 0.528 ± 0.027
1.304TrpArg: 1.304 ± 0.034
0.906TrpSer: 0.906 ± 0.034
0.875TrpThr: 0.875 ± 0.033
1.259TrpVal: 1.259 ± 0.039
0.391TrpTrp: 0.391 ± 0.024
0.289TrpTyr: 0.289 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.493TyrAla: 2.493 ± 0.05
0.115TyrCys: 0.115 ± 0.012
1.317TyrAsp: 1.317 ± 0.042
1.001TyrGlu: 1.001 ± 0.036
0.661TyrPhe: 0.661 ± 0.031
1.906TyrGly: 1.906 ± 0.047
0.295TyrHis: 0.295 ± 0.019
0.678TyrIle: 0.678 ± 0.028
0.354TyrLys: 0.354 ± 0.021
2.111TyrLeu: 2.111 ± 0.054
0.254TyrMet: 0.254 ± 0.017
0.438TyrAsn: 0.438 ± 0.021
1.064TyrPro: 1.064 ± 0.044
0.587TyrGln: 0.587 ± 0.027
1.592TyrArg: 1.592 ± 0.039
1.055TyrSer: 1.055 ± 0.038
1.16TyrThr: 1.16 ± 0.042
1.647TyrVal: 1.647 ± 0.042
0.284TyrTrp: 0.284 ± 0.017
0.417TyrTyr: 0.417 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2779 proteins (879300 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski