Amino acid dipepetide frequency for Halogranum gelatinilyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.016AlaAla: 13.016 ± 0.191	0.687AlaCys: 0.687 ± 0.025	9.704AlaAsp: 9.704 ± 0.103	8.125AlaGlu: 8.125 ± 0.106	3.896AlaPhe: 3.896 ± 0.064	9.242AlaGly: 9.242 ± 0.103	1.767AlaHis: 1.767 ± 0.042	4.142AlaIle: 4.142 ± 0.07	2.078AlaLys: 2.078 ± 0.047	10.277AlaLeu: 10.277 ± 0.118	1.997AlaMet: 1.997 ± 0.044	2.505AlaAsn: 2.505 ± 0.05	3.746AlaPro: 3.746 ± 0.063	2.285AlaGln: 2.285 ± 0.041	5.996AlaArg: 5.996 ± 0.077	5.459AlaSer: 5.459 ± 0.071	7.134AlaThr: 7.134 ± 0.101	10.949AlaVal: 10.949 ± 0.141	1.145AlaTrp: 1.145 ± 0.035	2.554AlaTyr: 2.554 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.57CysAla: 0.57 ± 0.024	0.082CysCys: 0.082 ± 0.009	0.587CysAsp: 0.587 ± 0.024	0.53CysGlu: 0.53 ± 0.022	0.19CysPhe: 0.19 ± 0.011	0.779CysGly: 0.779 ± 0.032	0.186CysHis: 0.186 ± 0.013	0.252CysIle: 0.252 ± 0.014	0.117CysLys: 0.117 ± 0.011	0.595CysLeu: 0.595 ± 0.025	0.114CysMet: 0.114 ± 0.01	0.164CysAsn: 0.164 ± 0.014	0.51CysPro: 0.51 ± 0.025	0.166CysGln: 0.166 ± 0.012	0.46CysArg: 0.46 ± 0.019	0.382CysSer: 0.382 ± 0.019	0.405CysThr: 0.405 ± 0.021	0.473CysVal: 0.473 ± 0.019	0.07CysTrp: 0.07 ± 0.008	0.191CysTyr: 0.191 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.787AspAla: 9.787 ± 0.125	0.615AspCys: 0.615 ± 0.024	7.833AspAsp: 7.833 ± 0.125	8.008AspGlu: 8.008 ± 0.103	2.287AspPhe: 2.287 ± 0.048	8.025AspGly: 8.025 ± 0.12	1.752AspHis: 1.752 ± 0.046	3.292AspIle: 3.292 ± 0.071	1.19AspLys: 1.19 ± 0.037	7.042AspLeu: 7.042 ± 0.09	1.278AspMet: 1.278 ± 0.039	1.529AspAsn: 1.529 ± 0.037	4.085AspPro: 4.085 ± 0.074	1.519AspGln: 1.519 ± 0.042	5.464AspArg: 5.464 ± 0.078	3.947AspSer: 3.947 ± 0.067	4.293AspThr: 4.293 ± 0.064	7.956AspVal: 7.956 ± 0.101	1.021AspTrp: 1.021 ± 0.032	2.228AspTyr: 2.228 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.072GluAla: 8.072 ± 0.107	0.479GluCys: 0.479 ± 0.025	5.063GluAsp: 5.063 ± 0.079	6.617GluGlu: 6.617 ± 0.104	2.915GluPhe: 2.915 ± 0.059	5.354GluGly: 5.354 ± 0.079	1.873GluHis: 1.873 ± 0.048	3.159GluIle: 3.159 ± 0.065	2.08GluLys: 2.08 ± 0.066	7.371GluLeu: 7.371 ± 0.087	1.878GluMet: 1.878 ± 0.042	2.194GluAsn: 2.194 ± 0.049	3.534GluPro: 3.534 ± 0.067	2.763GluGln: 2.763 ± 0.058	6.582GluArg: 6.582 ± 0.094	4.819GluSer: 4.819 ± 0.076	6.45GluThr: 6.45 ± 0.1	5.763GluVal: 5.763 ± 0.081	1.114GluTrp: 1.114 ± 0.033	2.381GluTyr: 2.381 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.797PheAla: 3.797 ± 0.068	0.258PheCys: 0.258 ± 0.017	3.307PheAsp: 3.307 ± 0.062	3.043PheGlu: 3.043 ± 0.056	1.156PhePhe: 1.156 ± 0.039	3.541PheGly: 3.541 ± 0.064	0.645PheHis: 0.645 ± 0.022	1.096PheIle: 1.096 ± 0.036	0.546PheLys: 0.546 ± 0.023	3.004PheLeu: 3.004 ± 0.061	0.53PheMet: 0.53 ± 0.023	0.77PheAsn: 0.77 ± 0.026	1.393PhePro: 1.393 ± 0.033	0.87PheGln: 0.87 ± 0.03	1.83PheArg: 1.83 ± 0.046	1.883PheSer: 1.883 ± 0.042	2.027PheThr: 2.027 ± 0.044	3.498PheVal: 3.498 ± 0.055	0.39PheTrp: 0.39 ± 0.018	0.902PheTyr: 0.902 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.5GlyAla: 7.5 ± 0.101	0.729GlyCys: 0.729 ± 0.029	6.931GlyAsp: 6.931 ± 0.097	6.688GlyGlu: 6.688 ± 0.086	3.332GlyPhe: 3.332 ± 0.061	7.71GlyGly: 7.71 ± 0.111	1.675GlyHis: 1.675 ± 0.037	3.912GlyIle: 3.912 ± 0.075	2.071GlyLys: 2.071 ± 0.048	7.811GlyLeu: 7.811 ± 0.11	1.703GlyMet: 1.703 ± 0.041	2.079GlyAsn: 2.079 ± 0.059	3.258GlyPro: 3.258 ± 0.059	2.19GlyGln: 2.19 ± 0.043	4.935GlyArg: 4.935 ± 0.077	5.413GlySer: 5.413 ± 0.092	5.706GlyThr: 5.706 ± 0.08	8.134GlyVal: 8.134 ± 0.105	1.126GlyTrp: 1.126 ± 0.036	2.766GlyTyr: 2.766 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.989HisAla: 1.989 ± 0.041	0.196HisCys: 0.196 ± 0.013	1.775HisAsp: 1.775 ± 0.044	1.689HisGlu: 1.689 ± 0.044	0.565HisPhe: 0.565 ± 0.026	1.881HisGly: 1.881 ± 0.043	0.537HisHis: 0.537 ± 0.025	0.729HisIle: 0.729 ± 0.023	0.318HisLys: 0.318 ± 0.018	1.645HisLeu: 1.645 ± 0.04	0.297HisMet: 0.297 ± 0.019	0.457HisAsn: 0.457 ± 0.02	1.189HisPro: 1.189 ± 0.036	0.503HisGln: 0.503 ± 0.022	1.296HisArg: 1.296 ± 0.036	0.899HisSer: 0.899 ± 0.032	1.106HisThr: 1.106 ± 0.031	1.919HisVal: 1.919 ± 0.043	0.239HisTrp: 0.239 ± 0.014	0.602HisTyr: 0.602 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	3.966IleAla: 3.966 ± 0.066	0.235IleCys: 0.235 ± 0.014	3.31IleAsp: 3.31 ± 0.064	3.48IleGlu: 3.48 ± 0.067	0.921IlePhe: 0.921 ± 0.029	3.276IleGly: 3.276 ± 0.069	0.8IleHis: 0.8 ± 0.03	1.268IleIle: 1.268 ± 0.041	0.706IleLys: 0.706 ± 0.026	2.916IleLeu: 2.916 ± 0.068	0.46IleMet: 0.46 ± 0.023	0.922IleAsn: 0.922 ± 0.036	2.058IlePro: 2.058 ± 0.044	1.064IleGln: 1.064 ± 0.037	2.389IleArg: 2.389 ± 0.05	2.023IleSer: 2.023 ± 0.053	2.22IleThr: 2.22 ± 0.056	3.328IleVal: 3.328 ± 0.067	0.258IleTrp: 0.258 ± 0.016	0.838IleTyr: 0.838 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	1.945LysAla: 1.945 ± 0.049	0.138LysCys: 0.138 ± 0.011	1.192LysAsp: 1.192 ± 0.035	1.539LysGlu: 1.539 ± 0.049	0.59LysPhe: 0.59 ± 0.021	1.533LysGly: 1.533 ± 0.037	0.498LysHis: 0.498 ± 0.024	0.779LysIle: 0.779 ± 0.032	0.665LysLys: 0.665 ± 0.03	1.998LysLeu: 1.998 ± 0.049	0.419LysMet: 0.419 ± 0.018	0.646LysAsn: 0.646 ± 0.028	1.025LysPro: 1.025 ± 0.032	0.898LysGln: 0.898 ± 0.035	1.784LysArg: 1.784 ± 0.043	1.217LysSer: 1.217 ± 0.037	1.401LysThr: 1.401 ± 0.043	1.383LysVal: 1.383 ± 0.038	0.277LysTrp: 0.277 ± 0.019	0.64LysTyr: 0.64 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.321LeuAla: 11.321 ± 0.135	0.578LeuCys: 0.578 ± 0.025	8.004LeuAsp: 8.004 ± 0.102	5.762LeuGlu: 5.762 ± 0.081	3.353LeuPhe: 3.353 ± 0.071	8.031LeuGly: 8.031 ± 0.121	1.673LeuHis: 1.673 ± 0.04	2.542LeuIle: 2.542 ± 0.057	1.747LeuLys: 1.747 ± 0.049	9.034LeuLeu: 9.034 ± 0.135	1.351LeuMet: 1.351 ± 0.041	1.994LeuAsn: 1.994 ± 0.046	4.345LeuPro: 4.345 ± 0.075	2.248LeuGln: 2.248 ± 0.05	5.699LeuArg: 5.699 ± 0.064	5.884LeuSer: 5.884 ± 0.079	5.741LeuThr: 5.741 ± 0.071	9.687LeuVal: 9.687 ± 0.13	0.934LeuTrp: 0.934 ± 0.033	2.332LeuTyr: 2.332 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.794MetAla: 1.794 ± 0.044	0.105MetCys: 0.105 ± 0.011	1.282MetAsp: 1.282 ± 0.039	1.062MetGlu: 1.062 ± 0.035	0.517MetPhe: 0.517 ± 0.024	1.405MetGly: 1.405 ± 0.04	0.357MetHis: 0.357 ± 0.017	0.531MetIle: 0.531 ± 0.021	0.517MetLys: 0.517 ± 0.019	1.542MetLeu: 1.542 ± 0.042	0.305MetMet: 0.305 ± 0.017	0.659MetAsn: 0.659 ± 0.023	0.804MetPro: 0.804 ± 0.03	0.565MetGln: 0.565 ± 0.024	1.117MetArg: 1.117 ± 0.034	1.562MetSer: 1.562 ± 0.04	1.531MetThr: 1.531 ± 0.038	1.334MetVal: 1.334 ± 0.036	0.156MetTrp: 0.156 ± 0.011	0.391MetTyr: 0.391 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.5AsnAla: 2.5 ± 0.05	0.209AsnCys: 0.209 ± 0.017	1.755AsnAsp: 1.755 ± 0.041	1.794AsnGlu: 1.794 ± 0.045	0.761AsnPhe: 0.761 ± 0.028	2.091AsnGly: 2.091 ± 0.05	0.517AsnHis: 0.517 ± 0.028	1.018AsnIle: 1.018 ± 0.034	0.515AsnLys: 0.515 ± 0.023	2.113AsnLeu: 2.113 ± 0.047	0.475AsnMet: 0.475 ± 0.019	0.606AsnAsn: 0.606 ± 0.028	1.682AsnPro: 1.682 ± 0.038	0.685AsnGln: 0.685 ± 0.028	1.665AsnArg: 1.665 ± 0.036	1.152AsnSer: 1.152 ± 0.037	1.359AsnThr: 1.359 ± 0.035	2.326AsnVal: 2.326 ± 0.046	0.309AsnTrp: 0.309 ± 0.019	0.716AsnTyr: 0.716 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.433ProAla: 4.433 ± 0.062	0.234ProCys: 0.234 ± 0.015	4.317ProAsp: 4.317 ± 0.076	4.401ProGlu: 4.401 ± 0.064	1.678ProPhe: 1.678 ± 0.042	3.554ProGly: 3.554 ± 0.046	0.885ProHis: 0.885 ± 0.029	1.624ProIle: 1.624 ± 0.037	0.955ProLys: 0.955 ± 0.028	3.846ProLeu: 3.846 ± 0.064	0.854ProMet: 0.854 ± 0.029	1.196ProAsn: 1.196 ± 0.034	2.104ProPro: 2.104 ± 0.049	1.082ProGln: 1.082 ± 0.031	2.253ProArg: 2.253 ± 0.047	2.736ProSer: 2.736 ± 0.052	3.539ProThr: 3.539 ± 0.075	4.22ProVal: 4.22 ± 0.059	0.559ProTrp: 0.559 ± 0.025	1.14ProTyr: 1.14 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.581GlnAla: 2.581 ± 0.053	0.197GlnCys: 0.197 ± 0.013	1.352GlnAsp: 1.352 ± 0.04	1.794GlnGlu: 1.794 ± 0.043	1.182GlnPhe: 1.182 ± 0.033	1.742GlnGly: 1.742 ± 0.046	0.526GlnHis: 0.526 ± 0.023	0.954GlnIle: 0.954 ± 0.032	0.67GlnLys: 0.67 ± 0.026	2.696GlnLeu: 2.696 ± 0.049	0.594GlnMet: 0.594 ± 0.022	0.768GlnAsn: 0.768 ± 0.031	1.252GlnPro: 1.252 ± 0.033	1.153GlnGln: 1.153 ± 0.04	1.978GlnArg: 1.978 ± 0.047	1.78GlnSer: 1.78 ± 0.049	1.92GlnThr: 1.92 ± 0.044	1.963GlnVal: 1.963 ± 0.044	0.401GlnTrp: 0.401 ± 0.02	0.908GlnTyr: 0.908 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.11ArgAla: 6.11 ± 0.081	0.399ArgCys: 0.399 ± 0.019	5.017ArgAsp: 5.017 ± 0.076	6.086ArgGlu: 6.086 ± 0.088	2.341ArgPhe: 2.341 ± 0.051	4.448ArgGly: 4.448 ± 0.065	1.251ArgHis: 1.251 ± 0.033	2.608ArgIle: 2.608 ± 0.052	1.488ArgLys: 1.488 ± 0.043	6.221ArgLeu: 6.221 ± 0.092	1.273ArgMet: 1.273 ± 0.03	1.615ArgAsn: 1.615 ± 0.037	2.508ArgPro: 2.508 ± 0.048	1.931ArgGln: 1.931 ± 0.043	4.788ArgArg: 4.788 ± 0.083	3.285ArgSer: 3.285 ± 0.059	3.858ArgThr: 3.858 ± 0.063	5.541ArgVal: 5.541 ± 0.082	0.766ArgTrp: 0.766 ± 0.036	1.809ArgTyr: 1.809 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.148SerAla: 5.148 ± 0.074	0.317SerCys: 0.317 ± 0.018	4.428SerAsp: 4.428 ± 0.074	4.394SerGlu: 4.394 ± 0.078	2.027SerPhe: 2.027 ± 0.05	5.414SerGly: 5.414 ± 0.088	1.067SerHis: 1.067 ± 0.03	2.136SerIle: 2.136 ± 0.05	1.27SerLys: 1.27 ± 0.034	5.48SerLeu: 5.48 ± 0.094	1.06SerMet: 1.06 ± 0.03	1.4SerAsn: 1.4 ± 0.04	2.693SerPro: 2.693 ± 0.052	1.567SerGln: 1.567 ± 0.042	3.338SerArg: 3.338 ± 0.053	3.139SerSer: 3.139 ± 0.071	3.857SerThr: 3.857 ± 0.073	5.384SerVal: 5.384 ± 0.077	0.632SerTrp: 0.632 ± 0.024	1.49SerTyr: 1.49 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.117ThrAla: 7.117 ± 0.104	0.358ThrCys: 0.358 ± 0.017	5.524ThrAsp: 5.524 ± 0.089	4.654ThrGlu: 4.654 ± 0.079	2.226ThrPhe: 2.226 ± 0.044	5.777ThrGly: 5.777 ± 0.071	1.224ThrHis: 1.224 ± 0.031	2.422ThrIle: 2.422 ± 0.05	1.239ThrLys: 1.239 ± 0.035	6.294ThrLeu: 6.294 ± 0.07	0.972ThrMet: 0.972 ± 0.032	1.614ThrAsn: 1.614 ± 0.044	3.595ThrPro: 3.595 ± 0.073	1.574ThrGln: 1.574 ± 0.048	3.487ThrArg: 3.487 ± 0.048	3.232ThrSer: 3.232 ± 0.074	4.735ThrThr: 4.735 ± 0.089	7.631ThrVal: 7.631 ± 0.125	0.658ThrTrp: 0.658 ± 0.027	1.715ThrTyr: 1.715 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	11.436ValAla: 11.436 ± 0.147	0.7ValCys: 0.7 ± 0.025	8.412ValAsp: 8.412 ± 0.102	7.655ValGlu: 7.655 ± 0.098	3.176ValPhe: 3.176 ± 0.058	8.646ValGly: 8.646 ± 0.136	1.679ValHis: 1.679 ± 0.044	2.767ValIle: 2.767 ± 0.055	1.642ValLys: 1.642 ± 0.047	8.43ValLeu: 8.43 ± 0.111	1.38ValMet: 1.38 ± 0.032	2.083ValAsn: 2.083 ± 0.046	4.081ValPro: 4.081 ± 0.062	2.108ValGln: 2.108 ± 0.045	5.5ValArg: 5.5 ± 0.064	5.46ValSer: 5.46 ± 0.088	6.312ValThr: 6.312 ± 0.086	10.677ValVal: 10.677 ± 0.134	0.889ValTrp: 0.889 ± 0.023	2.372ValTyr: 2.372 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.995TrpAla: 0.995 ± 0.031	0.089TrpCys: 0.089 ± 0.008	0.777TrpAsp: 0.777 ± 0.03	0.84TrpGlu: 0.84 ± 0.03	0.487TrpPhe: 0.487 ± 0.025	0.831TrpGly: 0.831 ± 0.028	0.24TrpHis: 0.24 ± 0.016	0.379TrpIle: 0.379 ± 0.02	0.28TrpLys: 0.28 ± 0.015	1.247TrpLeu: 1.247 ± 0.039	0.225TrpMet: 0.225 ± 0.014	0.385TrpAsn: 0.385 ± 0.02	0.453TrpPro: 0.453 ± 0.02	0.454TrpGln: 0.454 ± 0.02	0.822TrpArg: 0.822 ± 0.029	0.632TrpSer: 0.632 ± 0.025	0.878TrpThr: 0.878 ± 0.032	0.909TrpVal: 0.909 ± 0.03	0.222TrpTrp: 0.222 ± 0.013	0.404TrpTyr: 0.404 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.625TyrAla: 2.625 ± 0.051	0.219TyrCys: 0.219 ± 0.014	2.582TyrAsp: 2.582 ± 0.054	2.297TyrGlu: 2.297 ± 0.054	0.886TyrPhe: 0.886 ± 0.031	2.389TyrGly: 2.389 ± 0.045	0.677TyrHis: 0.677 ± 0.023	0.828TyrIle: 0.828 ± 0.028	0.474TyrLys: 0.474 ± 0.021	2.703TyrLeu: 2.703 ± 0.057	0.368TyrMet: 0.368 ± 0.019	0.66TyrAsn: 0.66 ± 0.025	1.295TyrPro: 1.295 ± 0.035	0.789TyrGln: 0.789 ± 0.027	1.96TyrArg: 1.96 ± 0.043	1.34TyrSer: 1.34 ± 0.036	1.574TyrThr: 1.574 ± 0.037	2.328TyrVal: 2.328 ± 0.048	0.384TyrTrp: 0.384 ± 0.02	0.84TyrTyr: 0.84 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3752 proteins (1098223 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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