Amino acid dipepetide frequency for Bifidobacterium aquikefiri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.164AlaAla: 10.164 ± 0.163
0.951AlaCys: 0.951 ± 0.042
5.778AlaAsp: 5.778 ± 0.097
4.905AlaGlu: 4.905 ± 0.094
3.443AlaPhe: 3.443 ± 0.081
7.407AlaGly: 7.407 ± 0.11
2.301AlaHis: 2.301 ± 0.061
6.077AlaIle: 6.077 ± 0.091
4.363AlaLys: 4.363 ± 0.088
9.649AlaLeu: 9.649 ± 0.125
2.684AlaMet: 2.684 ± 0.058
3.117AlaAsn: 3.117 ± 0.068
3.269AlaPro: 3.269 ± 0.078
4.624AlaGln: 4.624 ± 0.081
5.249AlaArg: 5.249 ± 0.099
7.376AlaSer: 7.376 ± 0.109
5.639AlaThr: 5.639 ± 0.103
7.346AlaVal: 7.346 ± 0.119
1.232AlaTrp: 1.232 ± 0.043
2.508AlaTyr: 2.508 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.894CysAla: 0.894 ± 0.036
0.117CysCys: 0.117 ± 0.014
0.517CysAsp: 0.517 ± 0.029
0.471CysGlu: 0.471 ± 0.029
0.298CysPhe: 0.298 ± 0.024
0.903CysGly: 0.903 ± 0.038
0.175CysHis: 0.175 ± 0.017
0.598CysIle: 0.598 ± 0.029
0.252CysLys: 0.252 ± 0.018
0.728CysLeu: 0.728 ± 0.033
0.216CysMet: 0.216 ± 0.019
0.276CysAsn: 0.276 ± 0.021
0.393CysPro: 0.393 ± 0.024
0.238CysGln: 0.238 ± 0.017
0.43CysArg: 0.43 ± 0.03
0.581CysSer: 0.581 ± 0.031
0.513CysThr: 0.513 ± 0.032
0.683CysVal: 0.683 ± 0.032
0.104CysTrp: 0.104 ± 0.013
0.202CysTyr: 0.202 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
6.288AspAla: 6.288 ± 0.124
0.464AspCys: 0.464 ± 0.024
4.155AspAsp: 4.155 ± 0.109
4.275AspGlu: 4.275 ± 0.091
2.166AspPhe: 2.166 ± 0.061
4.746AspGly: 4.746 ± 0.127
1.179AspHis: 1.179 ± 0.045
3.734AspIle: 3.734 ± 0.083
2.288AspLys: 2.288 ± 0.064
4.925AspLeu: 4.925 ± 0.094
1.529AspMet: 1.529 ± 0.048
2.082AspAsn: 2.082 ± 0.062
3.09AspPro: 3.09 ± 0.068
1.804AspGln: 1.804 ± 0.062
2.861AspArg: 2.861 ± 0.079
4.332AspSer: 4.332 ± 0.088
3.321AspThr: 3.321 ± 0.079
4.683AspVal: 4.683 ± 0.111
0.874AspTrp: 0.874 ± 0.035
1.732AspTyr: 1.732 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
5.066GluAla: 5.066 ± 0.096
0.369GluCys: 0.369 ± 0.022
3.124GluAsp: 3.124 ± 0.073
2.95GluGlu: 2.95 ± 0.078
1.853GluPhe: 1.853 ± 0.055
3.389GluGly: 3.389 ± 0.069
1.944GluHis: 1.944 ± 0.067
3.104GluIle: 3.104 ± 0.066
2.228GluLys: 2.228 ± 0.069
5.103GluLeu: 5.103 ± 0.105
1.468GluMet: 1.468 ± 0.045
1.965GluAsn: 1.965 ± 0.06
2.029GluPro: 2.029 ± 0.056
2.765GluGln: 2.765 ± 0.06
3.679GluArg: 3.679 ± 0.092
4.122GluSer: 4.122 ± 0.083
3.104GluThr: 3.104 ± 0.066
3.181GluVal: 3.181 ± 0.08
0.578GluTrp: 0.578 ± 0.03
1.461GluTyr: 1.461 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.604PheAla: 3.604 ± 0.085
0.32PheCys: 0.32 ± 0.025
2.432PheAsp: 2.432 ± 0.051
1.882PheGlu: 1.882 ± 0.059
1.276PhePhe: 1.276 ± 0.047
3.247PheGly: 3.247 ± 0.08
0.789PheHis: 0.789 ± 0.034
2.29PheIle: 2.29 ± 0.08
1.329PheLys: 1.329 ± 0.047
2.784PheLeu: 2.784 ± 0.072
0.887PheMet: 0.887 ± 0.033
1.485PheAsn: 1.485 ± 0.048
1.47PhePro: 1.47 ± 0.049
1.112PheGln: 1.112 ± 0.039
1.489PheArg: 1.489 ± 0.05
2.814PheSer: 2.814 ± 0.068
2.419PheThr: 2.419 ± 0.059
2.596PheVal: 2.596 ± 0.073
0.507PheTrp: 0.507 ± 0.026
0.852PheTyr: 0.852 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
6.479GlyAla: 6.479 ± 0.116
0.632GlyCys: 0.632 ± 0.029
3.987GlyAsp: 3.987 ± 0.09
3.862GlyGlu: 3.862 ± 0.089
3.205GlyPhe: 3.205 ± 0.076
5.251GlyGly: 5.251 ± 0.155
1.712GlyHis: 1.712 ± 0.049
5.649GlyIle: 5.649 ± 0.106
3.857GlyLys: 3.857 ± 0.087
6.855GlyLeu: 6.855 ± 0.111
2.176GlyMet: 2.176 ± 0.068
2.879GlyAsn: 2.879 ± 0.071
2.197GlyPro: 2.197 ± 0.059
2.463GlyGln: 2.463 ± 0.063
3.776GlyArg: 3.776 ± 0.084
6.164GlySer: 6.164 ± 0.124
4.915GlyThr: 4.915 ± 0.117
5.476GlyVal: 5.476 ± 0.108
1.068GlyTrp: 1.068 ± 0.041
2.463GlyTyr: 2.463 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
2.472HisAla: 2.472 ± 0.072
0.219HisCys: 0.219 ± 0.018
1.776HisAsp: 1.776 ± 0.055
1.442HisGlu: 1.442 ± 0.05
0.762HisPhe: 0.762 ± 0.037
2.056HisGly: 2.056 ± 0.06
0.79HisHis: 0.79 ± 0.033
1.494HisIle: 1.494 ± 0.049
0.775HisLys: 0.775 ± 0.032
1.831HisLeu: 1.831 ± 0.053
0.638HisMet: 0.638 ± 0.032
0.843HisAsn: 0.843 ± 0.033
1.243HisPro: 1.243 ± 0.043
0.817HisGln: 0.817 ± 0.034
1.723HisArg: 1.723 ± 0.06
1.489HisSer: 1.489 ± 0.054
1.371HisThr: 1.371 ± 0.043
1.887HisVal: 1.887 ± 0.053
0.356HisTrp: 0.356 ± 0.024
0.686HisTyr: 0.686 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
7.034IleAla: 7.034 ± 0.111
0.571IleCys: 0.571 ± 0.032
4.159IleAsp: 4.159 ± 0.079
3.499IleGlu: 3.499 ± 0.081
2.033IlePhe: 2.033 ± 0.061
4.861IleGly: 4.861 ± 0.112
1.398IleHis: 1.398 ± 0.046
3.745IleIle: 3.745 ± 0.083
1.87IleLys: 1.87 ± 0.051
5.103IleLeu: 5.103 ± 0.114
1.373IleMet: 1.373 ± 0.052
2.1IleAsn: 2.1 ± 0.057
3.237IlePro: 3.237 ± 0.064
1.872IleGln: 1.872 ± 0.052
3.325IleArg: 3.325 ± 0.078
4.571IleSer: 4.571 ± 0.082
3.902IleThr: 3.902 ± 0.095
5.244IleVal: 5.244 ± 0.089
0.641IleTrp: 0.641 ± 0.035
1.358IleTyr: 1.358 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.477LysAla: 4.477 ± 0.09
0.177LysCys: 0.177 ± 0.016
2.547LysAsp: 2.547 ± 0.077
2.204LysGlu: 2.204 ± 0.067
1.055LysPhe: 1.055 ± 0.044
2.73LysGly: 2.73 ± 0.063
1.079LysHis: 1.079 ± 0.042
2.25LysIle: 2.25 ± 0.063
1.878LysLys: 1.878 ± 0.068
3.493LysLeu: 3.493 ± 0.087
0.924LysMet: 0.924 ± 0.038
1.71LysAsn: 1.71 ± 0.059
2.092LysPro: 2.092 ± 0.046
1.773LysGln: 1.773 ± 0.048
2.347LysArg: 2.347 ± 0.076
2.943LysSer: 2.943 ± 0.071
2.691LysThr: 2.691 ± 0.076
2.989LysVal: 2.989 ± 0.07
0.426LysTrp: 0.426 ± 0.023
1.011LysTyr: 1.011 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
9.237LeuAla: 9.237 ± 0.145
0.901LeuCys: 0.901 ± 0.04
5.539LeuAsp: 5.539 ± 0.102
4.272LeuGlu: 4.272 ± 0.081
3.11LeuPhe: 3.11 ± 0.083
6.996LeuGly: 6.996 ± 0.119
2.285LeuHis: 2.285 ± 0.061
5.401LeuIle: 5.401 ± 0.108
3.721LeuLys: 3.721 ± 0.079
8.098LeuLeu: 8.098 ± 0.156
2.214LeuMet: 2.214 ± 0.073
3.474LeuAsn: 3.474 ± 0.067
4.363LeuPro: 4.363 ± 0.081
3.248LeuGln: 3.248 ± 0.076
4.985LeuArg: 4.985 ± 0.111
6.925LeuSer: 6.925 ± 0.112
5.4LeuThr: 5.4 ± 0.105
6.312LeuVal: 6.312 ± 0.116
1.111LeuTrp: 1.111 ± 0.047
2.129LeuTyr: 2.129 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.378MetAla: 2.378 ± 0.067
0.222MetCys: 0.222 ± 0.018
1.289MetAsp: 1.289 ± 0.044
1.021MetGlu: 1.021 ± 0.046
0.869MetPhe: 0.869 ± 0.04
1.719MetGly: 1.719 ± 0.06
0.659MetHis: 0.659 ± 0.034
1.468MetIle: 1.468 ± 0.056
1.094MetLys: 1.094 ± 0.041
2.584MetLeu: 2.584 ± 0.071
0.649MetMet: 0.649 ± 0.032
1.19MetAsn: 1.19 ± 0.047
1.393MetPro: 1.393 ± 0.044
1.028MetGln: 1.028 ± 0.034
1.555MetArg: 1.555 ± 0.055
2.09MetSer: 2.09 ± 0.057
1.804MetThr: 1.804 ± 0.054
1.858MetVal: 1.858 ± 0.06
0.295MetTrp: 0.295 ± 0.021
0.544MetTyr: 0.544 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.912AsnAla: 3.912 ± 0.076
0.224AsnCys: 0.224 ± 0.02
2.402AsnAsp: 2.402 ± 0.061
1.996AsnGlu: 1.996 ± 0.061
1.196AsnPhe: 1.196 ± 0.048
3.117AsnGly: 3.117 ± 0.075
0.822AsnHis: 0.822 ± 0.035
2.003AsnIle: 2.003 ± 0.05
1.321AsnLys: 1.321 ± 0.046
3.098AsnLeu: 3.098 ± 0.071
0.891AsnMet: 0.891 ± 0.039
1.472AsnAsn: 1.472 ± 0.059
2.409AsnPro: 2.409 ± 0.067
1.428AsnGln: 1.428 ± 0.051
2.083AsnArg: 2.083 ± 0.052
2.436AsnSer: 2.436 ± 0.07
2.288AsnThr: 2.288 ± 0.064
2.751AsnVal: 2.751 ± 0.066
0.451AsnTrp: 0.451 ± 0.029
1.017AsnTyr: 1.017 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
3.661ProAla: 3.661 ± 0.078
0.353ProCys: 0.353 ± 0.025
2.942ProAsp: 2.942 ± 0.073
2.948ProGlu: 2.948 ± 0.068
1.63ProPhe: 1.63 ± 0.05
2.92ProGly: 2.92 ± 0.066
1.088ProHis: 1.088 ± 0.036
2.434ProIle: 2.434 ± 0.056
1.816ProLys: 1.816 ± 0.056
3.679ProLeu: 3.679 ± 0.079
0.98ProMet: 0.98 ± 0.041
1.593ProAsn: 1.593 ± 0.05
1.076ProPro: 1.076 ± 0.044
2.089ProGln: 2.089 ± 0.062
2.059ProArg: 2.059 ± 0.053
3.393ProSer: 3.393 ± 0.088
2.794ProThr: 2.794 ± 0.071
3.296ProVal: 3.296 ± 0.074
0.659ProTrp: 0.659 ± 0.029
1.376ProTyr: 1.376 ± 0.049
0.001ProXaa: 0.001 ± 0.001
Gln
4.048GlnAla: 4.048 ± 0.086
0.299GlnCys: 0.299 ± 0.02
1.861GlnAsp: 1.861 ± 0.058
2.092GlnGlu: 2.092 ± 0.063
1.216GlnPhe: 1.216 ± 0.045
2.932GlnGly: 2.932 ± 0.076
1.19GlnHis: 1.19 ± 0.042
2.357GlnIle: 2.357 ± 0.052
1.4GlnLys: 1.4 ± 0.052
3.669GlnLeu: 3.669 ± 0.074
0.974GlnMet: 0.974 ± 0.041
1.341GlnAsn: 1.341 ± 0.054
1.689GlnPro: 1.689 ± 0.078
2.143GlnGln: 2.143 ± 0.074
2.609GlnArg: 2.609 ± 0.059
3.059GlnSer: 3.059 ± 0.073
2.405GlnThr: 2.405 ± 0.06
2.562GlnVal: 2.562 ± 0.065
0.646GlnTrp: 0.646 ± 0.032
1.301GlnTyr: 1.301 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
4.295ArgAla: 4.295 ± 0.083
0.507ArgCys: 0.507 ± 0.032
3.067ArgAsp: 3.067 ± 0.078
3.21ArgGlu: 3.21 ± 0.073
2.133ArgPhe: 2.133 ± 0.059
3.292ArgGly: 3.292 ± 0.08
1.655ArgHis: 1.655 ± 0.047
3.779ArgIle: 3.779 ± 0.073
2.693ArgLys: 2.693 ± 0.068
5.055ArgLeu: 5.055 ± 0.095
1.743ArgMet: 1.743 ± 0.05
2.264ArgAsn: 2.264 ± 0.064
2.012ArgPro: 2.012 ± 0.058
2.384ArgGln: 2.384 ± 0.064
3.92ArgArg: 3.92 ± 0.118
3.775ArgSer: 3.775 ± 0.087
3.084ArgThr: 3.084 ± 0.066
3.711ArgVal: 3.711 ± 0.085
0.786ArgTrp: 0.786 ± 0.034
1.739ArgTyr: 1.739 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
7.046SerAla: 7.046 ± 0.115
0.597SerCys: 0.597 ± 0.036
4.709SerAsp: 4.709 ± 0.111
3.728SerGlu: 3.728 ± 0.08
2.767SerPhe: 2.767 ± 0.071
6.288SerGly: 6.288 ± 0.168
1.8SerHis: 1.8 ± 0.051
4.595SerIle: 4.595 ± 0.091
2.929SerLys: 2.929 ± 0.073
6.493SerLeu: 6.493 ± 0.096
2.16SerMet: 2.16 ± 0.06
2.859SerAsn: 2.859 ± 0.075
2.794SerPro: 2.794 ± 0.07
3.292SerGln: 3.292 ± 0.079
3.971SerArg: 3.971 ± 0.078
6.584SerSer: 6.584 ± 0.18
4.92SerThr: 4.92 ± 0.115
5.256SerVal: 5.256 ± 0.095
1.059SerTrp: 1.059 ± 0.039
1.935SerTyr: 1.935 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
5.972ThrAla: 5.972 ± 0.113
0.493ThrCys: 0.493 ± 0.03
3.292ThrAsp: 3.292 ± 0.086
2.653ThrGlu: 2.653 ± 0.071
2.181ThrPhe: 2.181 ± 0.066
4.897ThrGly: 4.897 ± 0.119
1.417ThrHis: 1.417 ± 0.042
4.027ThrIle: 4.027 ± 0.089
2.443ThrLys: 2.443 ± 0.071
5.773ThrLeu: 5.773 ± 0.103
1.385ThrMet: 1.385 ± 0.043
2.27ThrAsn: 2.27 ± 0.069
3.064ThrPro: 3.064 ± 0.07
2.434ThrGln: 2.434 ± 0.066
3.013ThrArg: 3.013 ± 0.071
4.535ThrSer: 4.535 ± 0.11
4.075ThrThr: 4.075 ± 0.091
5.169ThrVal: 5.169 ± 0.098
0.83ThrTrp: 0.83 ± 0.038
1.616ThrTyr: 1.616 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
7.221ValAla: 7.221 ± 0.118
0.782ValCys: 0.782 ± 0.036
4.591ValAsp: 4.591 ± 0.093
3.99ValGlu: 3.99 ± 0.089
2.723ValPhe: 2.723 ± 0.068
5.088ValGly: 5.088 ± 0.109
1.595ValHis: 1.595 ± 0.051
4.636ValIle: 4.636 ± 0.101
2.96ValLys: 2.96 ± 0.086
7.031ValLeu: 7.031 ± 0.135
1.84ValMet: 1.84 ± 0.061
2.827ValAsn: 2.827 ± 0.067
3.299ValPro: 3.299 ± 0.064
2.483ValGln: 2.483 ± 0.063
3.601ValArg: 3.601 ± 0.081
5.869ValSer: 5.869 ± 0.108
4.743ValThr: 4.743 ± 0.11
5.79ValVal: 5.79 ± 0.12
0.864ValTrp: 0.864 ± 0.035
1.68ValTyr: 1.68 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
1.049TrpAla: 1.049 ± 0.037
0.128TrpCys: 0.128 ± 0.015
0.715TrpAsp: 0.715 ± 0.037
0.551TrpGlu: 0.551 ± 0.026
0.57TrpPhe: 0.57 ± 0.029
0.93TrpGly: 0.93 ± 0.04
0.298TrpHis: 0.298 ± 0.021
0.887TrpIle: 0.887 ± 0.038
0.651TrpLys: 0.651 ± 0.033
1.395TrpLeu: 1.395 ± 0.048
0.386TrpMet: 0.386 ± 0.025
0.668TrpAsn: 0.668 ± 0.034
0.424TrpPro: 0.424 ± 0.026
0.645TrpGln: 0.645 ± 0.032
0.792TrpArg: 0.792 ± 0.033
0.881TrpSer: 0.881 ± 0.036
0.702TrpThr: 0.702 ± 0.034
0.817TrpVal: 0.817 ± 0.034
0.271TrpTrp: 0.271 ± 0.023
0.386TrpTyr: 0.386 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.785TyrAla: 2.785 ± 0.062
0.263TyrCys: 0.263 ± 0.019
1.645TyrAsp: 1.645 ± 0.053
1.534TyrGlu: 1.534 ± 0.049
1.098TyrPhe: 1.098 ± 0.043
2.3TyrGly: 2.3 ± 0.052
0.496TyrHis: 0.496 ± 0.022
1.37TyrIle: 1.37 ± 0.049
0.928TyrLys: 0.928 ± 0.042
2.372TyrLeu: 2.372 ± 0.054
0.59TyrMet: 0.59 ± 0.029
0.903TyrAsn: 0.903 ± 0.037
1.243TyrPro: 1.243 ± 0.041
1.151TyrGln: 1.151 ± 0.041
1.636TyrArg: 1.636 ± 0.05
1.841TyrSer: 1.841 ± 0.052
1.45TyrThr: 1.45 ± 0.06
2.005TyrVal: 2.005 ± 0.063
0.387TyrTrp: 0.387 ± 0.022
0.79TyrTyr: 0.79 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1995 proteins (702279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski