Amino acid dipepetide frequency for Skermania sp. ID1734

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.062AlaAla: 20.062 ± 0.167	1.047AlaCys: 1.047 ± 0.027	8.279AlaAsp: 8.279 ± 0.087	7.966AlaGlu: 7.966 ± 0.076	3.426AlaPhe: 3.426 ± 0.051	11.2AlaGly: 11.2 ± 0.093	2.674AlaHis: 2.674 ± 0.042	5.548AlaIle: 5.548 ± 0.062	3.273AlaLys: 3.273 ± 0.047	12.867AlaLeu: 12.867 ± 0.103	2.768AlaMet: 2.768 ± 0.046	2.751AlaAsn: 2.751 ± 0.044	5.913AlaPro: 5.913 ± 0.074	4.253AlaGln: 4.253 ± 0.048	8.902AlaArg: 8.902 ± 0.094	6.184AlaSer: 6.184 ± 0.073	7.413AlaThr: 7.413 ± 0.082	11.501AlaVal: 11.501 ± 0.12	1.621AlaTrp: 1.621 ± 0.039	2.381AlaTyr: 2.381 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.128CysAla: 1.128 ± 0.027	0.112CysCys: 0.112 ± 0.009	0.501CysAsp: 0.501 ± 0.017	0.405CysGlu: 0.405 ± 0.015	0.254CysPhe: 0.254 ± 0.013	0.989CysGly: 0.989 ± 0.025	0.205CysHis: 0.205 ± 0.014	0.298CysIle: 0.298 ± 0.013	0.147CysLys: 0.147 ± 0.011	0.713CysLeu: 0.713 ± 0.023	0.128CysMet: 0.128 ± 0.009	0.182CysAsn: 0.182 ± 0.013	0.493CysPro: 0.493 ± 0.018	0.213CysGln: 0.213 ± 0.011	0.637CysArg: 0.637 ± 0.022	0.503CysSer: 0.503 ± 0.02	0.508CysThr: 0.508 ± 0.019	0.65CysVal: 0.65 ± 0.02	0.144CysTrp: 0.144 ± 0.009	0.178CysTyr: 0.178 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.653AspAla: 7.653 ± 0.076	0.488AspCys: 0.488 ± 0.018	3.683AspAsp: 3.683 ± 0.053	3.896AspGlu: 3.896 ± 0.053	1.742AspPhe: 1.742 ± 0.029	5.565AspGly: 5.565 ± 0.065	1.414AspHis: 1.414 ± 0.03	2.572AspIle: 2.572 ± 0.046	1.38AspLys: 1.38 ± 0.035	6.163AspLeu: 6.163 ± 0.072	0.982AspMet: 0.982 ± 0.028	1.342AspAsn: 1.342 ± 0.031	4.29AspPro: 4.29 ± 0.051	1.761AspGln: 1.761 ± 0.038	4.71AspArg: 4.71 ± 0.061	3.016AspSer: 3.016 ± 0.042	3.14AspThr: 3.14 ± 0.046	5.316AspVal: 5.316 ± 0.073	1.013AspTrp: 1.013 ± 0.028	1.395AspTyr: 1.395 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.846GluAla: 5.846 ± 0.08	0.406GluCys: 0.406 ± 0.013	2.281GluAsp: 2.281 ± 0.035	2.455GluGlu: 2.455 ± 0.046	1.85GluPhe: 1.85 ± 0.034	3.114GluGly: 3.114 ± 0.046	1.604GluHis: 1.604 ± 0.036	2.785GluIle: 2.785 ± 0.041	1.343GluLys: 1.343 ± 0.033	6.926GluLeu: 6.926 ± 0.088	1.042GluMet: 1.042 ± 0.027	1.211GluAsn: 1.211 ± 0.028	3.035GluPro: 3.035 ± 0.05	2.394GluGln: 2.394 ± 0.045	4.8GluArg: 4.8 ± 0.059	2.971GluSer: 2.971 ± 0.047	2.745GluThr: 2.745 ± 0.046	4.44GluVal: 4.44 ± 0.057	0.764GluTrp: 0.764 ± 0.021	1.149GluTyr: 1.149 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.171PheAla: 4.171 ± 0.054	0.296PheCys: 0.296 ± 0.014	2.406PheAsp: 2.406 ± 0.049	1.622PheGlu: 1.622 ± 0.045	0.952PhePhe: 0.952 ± 0.029	3.407PheGly: 3.407 ± 0.057	0.687PheHis: 0.687 ± 0.021	1.117PheIle: 1.117 ± 0.029	0.536PheLys: 0.536 ± 0.021	2.614PheLeu: 2.614 ± 0.046	0.467PheMet: 0.467 ± 0.021	0.704PheAsn: 0.704 ± 0.023	1.376PhePro: 1.376 ± 0.036	0.724PheGln: 0.724 ± 0.024	1.793PheArg: 1.793 ± 0.035	1.671PheSer: 1.671 ± 0.039	1.951PheThr: 1.951 ± 0.038	2.595PheVal: 2.595 ± 0.043	0.414PheTrp: 0.414 ± 0.02	0.687PheTyr: 0.687 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.69GlyAla: 9.69 ± 0.088	0.844GlyCys: 0.844 ± 0.025	4.736GlyAsp: 4.736 ± 0.063	4.374GlyGlu: 4.374 ± 0.057	3.045GlyPhe: 3.045 ± 0.051	7.316GlyGly: 7.316 ± 0.101	2.05GlyHis: 2.05 ± 0.042	4.273GlyIle: 4.273 ± 0.058	2.55GlyLys: 2.55 ± 0.042	8.427GlyLeu: 8.427 ± 0.091	2.064GlyMet: 2.064 ± 0.034	2.005GlyAsn: 2.005 ± 0.036	4.296GlyPro: 4.296 ± 0.057	2.693GlyGln: 2.693 ± 0.046	6.165GlyArg: 6.165 ± 0.066	5.185GlySer: 5.185 ± 0.058	5.087GlyThr: 5.087 ± 0.066	7.17GlyVal: 7.17 ± 0.066	1.577GlyTrp: 1.577 ± 0.035	2.323GlyTyr: 2.323 ± 0.041	0.001GlyXaa: 0.001 ± 0.001
His	2.667HisAla: 2.667 ± 0.042	0.219HisCys: 0.219 ± 0.011	1.395HisAsp: 1.395 ± 0.034	1.092HisGlu: 1.092 ± 0.025	0.657HisPhe: 0.657 ± 0.021	2.192HisGly: 2.192 ± 0.043	0.702HisHis: 0.702 ± 0.023	0.907HisIle: 0.907 ± 0.024	0.411HisLys: 0.411 ± 0.018	2.164HisLeu: 2.164 ± 0.044	0.386HisMet: 0.386 ± 0.019	0.587HisAsn: 0.587 ± 0.02	1.705HisPro: 1.705 ± 0.035	0.695HisGln: 0.695 ± 0.02	1.938HisArg: 1.938 ± 0.043	1.229HisSer: 1.229 ± 0.027	1.213HisThr: 1.213 ± 0.029	1.706HisVal: 1.706 ± 0.031	0.37HisTrp: 0.37 ± 0.017	0.55HisTyr: 0.55 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.525IleAla: 6.525 ± 0.073	0.382IleCys: 0.382 ± 0.017	3.686IleAsp: 3.686 ± 0.054	2.843IleGlu: 2.843 ± 0.044	1.134IlePhe: 1.134 ± 0.029	4.63IleGly: 4.63 ± 0.063	0.8IleHis: 0.8 ± 0.022	1.614IleIle: 1.614 ± 0.037	0.91IleLys: 0.91 ± 0.024	3.289IleLeu: 3.289 ± 0.051	0.633IleMet: 0.633 ± 0.021	1.129IleAsn: 1.129 ± 0.028	2.398IlePro: 2.398 ± 0.043	0.929IleGln: 0.929 ± 0.022	2.821IleArg: 2.821 ± 0.039	2.487IleSer: 2.487 ± 0.035	2.759IleThr: 2.759 ± 0.043	3.955IleVal: 3.955 ± 0.062	0.468IleTrp: 0.468 ± 0.018	0.853IleTyr: 0.853 ± 0.025	0.001IleXaa: 0.001 ± 0.001
Lys	2.81LysAla: 2.81 ± 0.059	0.132LysCys: 0.132 ± 0.009	1.147LysAsp: 1.147 ± 0.028	1.03LysGlu: 1.03 ± 0.027	0.685LysPhe: 0.685 ± 0.019	1.592LysGly: 1.592 ± 0.038	0.538LysHis: 0.538 ± 0.02	1.151LysIle: 1.151 ± 0.028	0.737LysLys: 0.737 ± 0.023	2.443LysLeu: 2.443 ± 0.042	0.5LysMet: 0.5 ± 0.017	0.542LysAsn: 0.542 ± 0.021	1.47LysPro: 1.47 ± 0.032	0.886LysGln: 0.886 ± 0.027	1.763LysArg: 1.763 ± 0.036	1.297LysSer: 1.297 ± 0.028	1.442LysThr: 1.442 ± 0.033	2.042LysVal: 2.042 ± 0.038	0.335LysTrp: 0.335 ± 0.016	0.53LysTyr: 0.53 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.324LeuAla: 14.324 ± 0.118	0.846LeuCys: 0.846 ± 0.02	6.915LeuAsp: 6.915 ± 0.085	4.686LeuGlu: 4.686 ± 0.06	2.719LeuPhe: 2.719 ± 0.043	8.655LeuGly: 8.655 ± 0.083	2.176LeuHis: 2.176 ± 0.039	4.238LeuIle: 4.238 ± 0.057	1.692LeuLys: 1.692 ± 0.032	9.81LeuLeu: 9.81 ± 0.118	1.649LeuMet: 1.649 ± 0.036	2.125LeuAsn: 2.125 ± 0.043	5.776LeuPro: 5.776 ± 0.062	2.731LeuGln: 2.731 ± 0.047	8.008LeuArg: 8.008 ± 0.083	5.547LeuSer: 5.547 ± 0.056	6.224LeuThr: 6.224 ± 0.054	8.406LeuVal: 8.406 ± 0.079	1.152LeuTrp: 1.152 ± 0.03	1.703LeuTyr: 1.703 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.404MetAla: 2.404 ± 0.044	0.191MetCys: 0.191 ± 0.011	0.843MetAsp: 0.843 ± 0.026	0.672MetGlu: 0.672 ± 0.021	0.615MetPhe: 0.615 ± 0.021	1.363MetGly: 1.363 ± 0.031	0.484MetHis: 0.484 ± 0.017	0.872MetIle: 0.872 ± 0.028	0.435MetLys: 0.435 ± 0.017	2.081MetLeu: 2.081 ± 0.04	0.38MetMet: 0.38 ± 0.016	0.527MetAsn: 0.527 ± 0.02	1.209MetPro: 1.209 ± 0.029	0.614MetGln: 0.614 ± 0.017	1.581MetArg: 1.581 ± 0.034	1.515MetSer: 1.515 ± 0.032	1.684MetThr: 1.684 ± 0.036	1.604MetVal: 1.604 ± 0.033	0.27MetTrp: 0.27 ± 0.013	0.332MetTyr: 0.332 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.808AsnAla: 2.808 ± 0.047	0.199AsnCys: 0.199 ± 0.012	1.271AsnAsp: 1.271 ± 0.031	1.035AsnGlu: 1.035 ± 0.029	0.717AsnPhe: 0.717 ± 0.021	2.272AsnGly: 2.272 ± 0.045	0.476AsnHis: 0.476 ± 0.016	1.003AsnIle: 1.003 ± 0.026	0.558AsnLys: 0.558 ± 0.021	2.173AsnLeu: 2.173 ± 0.042	0.42AsnMet: 0.42 ± 0.017	0.605AsnAsn: 0.605 ± 0.023	1.769AsnPro: 1.769 ± 0.04	0.675AsnGln: 0.675 ± 0.023	1.658AsnArg: 1.658 ± 0.032	1.282AsnSer: 1.282 ± 0.031	1.352AsnThr: 1.352 ± 0.034	1.868AsnVal: 1.868 ± 0.031	0.384AsnTrp: 0.384 ± 0.015	0.593AsnTyr: 0.593 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.041ProAla: 7.041 ± 0.076	0.333ProCys: 0.333 ± 0.016	4.165ProAsp: 4.165 ± 0.058	3.523ProGlu: 3.523 ± 0.045	1.591ProPhe: 1.591 ± 0.036	5.181ProGly: 5.181 ± 0.065	1.233ProHis: 1.233 ± 0.031	2.357ProIle: 2.357 ± 0.04	1.41ProLys: 1.41 ± 0.033	4.844ProLeu: 4.844 ± 0.06	1.115ProMet: 1.115 ± 0.03	1.47ProAsn: 1.47 ± 0.036	3.184ProPro: 3.184 ± 0.057	1.863ProGln: 1.863 ± 0.037	3.484ProArg: 3.484 ± 0.051	2.945ProSer: 2.945 ± 0.048	3.498ProThr: 3.498 ± 0.057	5.074ProVal: 5.074 ± 0.064	0.798ProTrp: 0.798 ± 0.022	1.146ProTyr: 1.146 ± 0.029	0.001ProXaa: 0.001 ± 0.001
Gln	3.698GlnAla: 3.698 ± 0.051	0.244GlnCys: 0.244 ± 0.012	1.175GlnAsp: 1.175 ± 0.027	1.181GlnGlu: 1.181 ± 0.024	1.002GlnPhe: 1.002 ± 0.024	1.888GlnGly: 1.888 ± 0.039	0.835GlnHis: 0.835 ± 0.021	1.537GlnIle: 1.537 ± 0.032	0.657GlnLys: 0.657 ± 0.024	3.916GlnLeu: 3.916 ± 0.059	0.685GlnMet: 0.685 ± 0.019	0.646GlnAsn: 0.646 ± 0.021	2.004GlnPro: 2.004 ± 0.039	1.504GlnGln: 1.504 ± 0.043	3.072GlnArg: 3.072 ± 0.049	1.639GlnSer: 1.639 ± 0.032	1.616GlnThr: 1.616 ± 0.029	2.65GlnVal: 2.65 ± 0.048	0.589GlnTrp: 0.589 ± 0.02	0.66GlnTyr: 0.66 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.632ArgAla: 8.632 ± 0.082	0.61ArgCys: 0.61 ± 0.021	4.271ArgAsp: 4.271 ± 0.057	4.231ArgGlu: 4.231 ± 0.062	2.499ArgPhe: 2.499 ± 0.039	5.213ArgGly: 5.213 ± 0.071	1.831ArgHis: 1.831 ± 0.035	3.72ArgIle: 3.72 ± 0.048	1.934ArgLys: 1.934 ± 0.035	7.606ArgLeu: 7.606 ± 0.093	1.837ArgMet: 1.837 ± 0.032	1.846ArgAsn: 1.846 ± 0.034	3.974ArgPro: 3.974 ± 0.057	2.438ArgGln: 2.438 ± 0.046	6.802ArgArg: 6.802 ± 0.089	4.264ArgSer: 4.264 ± 0.053	4.236ArgThr: 4.236 ± 0.054	5.701ArgVal: 5.701 ± 0.071	1.366ArgTrp: 1.366 ± 0.03	1.833ArgTyr: 1.833 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.128SerAla: 7.128 ± 0.077	0.416SerCys: 0.416 ± 0.017	3.366SerAsp: 3.366 ± 0.052	2.721SerGlu: 2.721 ± 0.043	1.705SerPhe: 1.705 ± 0.031	5.583SerGly: 5.583 ± 0.068	1.096SerHis: 1.096 ± 0.028	2.369SerIle: 2.369 ± 0.041	1.324SerLys: 1.324 ± 0.034	4.771SerLeu: 4.771 ± 0.057	1.356SerMet: 1.356 ± 0.029	1.279SerAsn: 1.279 ± 0.032	3.08SerPro: 3.08 ± 0.043	1.605SerGln: 1.605 ± 0.04	3.741SerArg: 3.741 ± 0.056	3.148SerSer: 3.148 ± 0.055	3.377SerThr: 3.377 ± 0.048	4.687SerVal: 4.687 ± 0.054	0.923SerTrp: 0.923 ± 0.021	1.26SerTyr: 1.26 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.917ThrAla: 7.917 ± 0.084	0.449ThrCys: 0.449 ± 0.02	3.817ThrAsp: 3.817 ± 0.054	3.18ThrGlu: 3.18 ± 0.054	1.775ThrPhe: 1.775 ± 0.039	5.709ThrGly: 5.709 ± 0.06	1.175ThrHis: 1.175 ± 0.034	2.595ThrIle: 2.595 ± 0.04	1.382ThrLys: 1.382 ± 0.03	5.397ThrLeu: 5.397 ± 0.06	1.139ThrMet: 1.139 ± 0.028	1.3ThrAsn: 1.3 ± 0.032	3.614ThrPro: 3.614 ± 0.061	1.493ThrGln: 1.493 ± 0.033	3.582ThrArg: 3.582 ± 0.052	3.2ThrSer: 3.2 ± 0.056	3.723ThrThr: 3.723 ± 0.066	5.742ThrVal: 5.742 ± 0.066	0.807ThrTrp: 0.807 ± 0.025	1.222ThrTyr: 1.222 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.524ValAla: 11.524 ± 0.128	0.783ValCys: 0.783 ± 0.025	5.538ValAsp: 5.538 ± 0.062	4.548ValGlu: 4.548 ± 0.058	2.552ValPhe: 2.552 ± 0.043	6.958ValGly: 6.958 ± 0.079	1.97ValHis: 1.97 ± 0.039	3.93ValIle: 3.93 ± 0.056	1.677ValLys: 1.677 ± 0.033	9.075ValLeu: 9.075 ± 0.085	1.509ValMet: 1.509 ± 0.032	1.96ValAsn: 1.96 ± 0.04	4.676ValPro: 4.676 ± 0.068	2.382ValGln: 2.382 ± 0.04	6.22ValArg: 6.22 ± 0.071	4.762ValSer: 4.762 ± 0.062	5.245ValThr: 5.245 ± 0.06	8.401ValVal: 8.401 ± 0.084	1.024ValTrp: 1.024 ± 0.025	1.528ValTyr: 1.528 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.495TrpAla: 1.495 ± 0.036	0.16TrpCys: 0.16 ± 0.011	0.754TrpAsp: 0.754 ± 0.021	0.642TrpGlu: 0.642 ± 0.019	0.516TrpPhe: 0.516 ± 0.02	0.984TrpGly: 0.984 ± 0.025	0.384TrpHis: 0.384 ± 0.016	0.7TrpIle: 0.7 ± 0.024	0.347TrpLys: 0.347 ± 0.015	1.749TrpLeu: 1.749 ± 0.033	0.313TrpMet: 0.313 ± 0.015	0.429TrpAsn: 0.429 ± 0.019	0.782TrpPro: 0.782 ± 0.02	0.64TrpGln: 0.64 ± 0.02	1.301TrpArg: 1.301 ± 0.027	0.935TrpSer: 0.935 ± 0.027	0.879TrpThr: 0.879 ± 0.026	1.078TrpVal: 1.078 ± 0.026	0.337TrpTrp: 0.337 ± 0.017	0.307TrpTyr: 0.307 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.505TyrAla: 2.505 ± 0.051	0.23TyrCys: 0.23 ± 0.012	1.292TyrAsp: 1.292 ± 0.03	1.059TyrGlu: 1.059 ± 0.029	0.755TyrPhe: 0.755 ± 0.024	2.06TyrGly: 2.06 ± 0.036	0.452TyrHis: 0.452 ± 0.019	0.659TyrIle: 0.659 ± 0.019	0.373TyrLys: 0.373 ± 0.016	2.354TyrLeu: 2.354 ± 0.04	0.3TyrMet: 0.3 ± 0.015	0.48TyrAsn: 0.48 ± 0.02	1.213TyrPro: 1.213 ± 0.03	0.706TyrGln: 0.706 ± 0.021	1.863TyrArg: 1.863 ± 0.037	1.156TyrSer: 1.156 ± 0.031	1.123TyrThr: 1.123 ± 0.029	1.673TyrVal: 1.673 ± 0.037	0.378TyrTrp: 0.378 ± 0.017	0.481TyrTyr: 0.481 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4709 proteins (1532270 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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