Amino acid dipepetide frequency for Aliterella atlantica CENA595

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.861AlaAla: 8.861 ± 0.105	0.937AlaCys: 0.937 ± 0.029	4.434AlaAsp: 4.434 ± 0.063	5.537AlaGlu: 5.537 ± 0.074	3.073AlaPhe: 3.073 ± 0.044	5.987AlaGly: 5.987 ± 0.082	1.323AlaHis: 1.323 ± 0.035	7.958AlaIle: 7.958 ± 0.095	4.383AlaLys: 4.383 ± 0.07	9.368AlaLeu: 9.368 ± 0.092	1.809AlaMet: 1.809 ± 0.047	3.772AlaAsn: 3.772 ± 0.064	3.373AlaPro: 3.373 ± 0.06	4.983AlaGln: 4.983 ± 0.073	3.997AlaArg: 3.997 ± 0.062	5.291AlaSer: 5.291 ± 0.067	5.309AlaThr: 5.309 ± 0.075	6.051AlaVal: 6.051 ± 0.082	1.112AlaTrp: 1.112 ± 0.034	2.596AlaTyr: 2.596 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.71CysAla: 0.71 ± 0.026	0.167CysCys: 0.167 ± 0.012	0.666CysAsp: 0.666 ± 0.024	0.483CysGlu: 0.483 ± 0.02	0.42CysPhe: 0.42 ± 0.018	0.824CysGly: 0.824 ± 0.027	0.292CysHis: 0.292 ± 0.015	0.593CysIle: 0.593 ± 0.022	0.359CysLys: 0.359 ± 0.018	1.114CysLeu: 1.114 ± 0.028	0.15CysMet: 0.15 ± 0.011	0.422CysAsn: 0.422 ± 0.02	0.566CysPro: 0.566 ± 0.02	0.618CysGln: 0.618 ± 0.02	0.519CysArg: 0.519 ± 0.019	0.63CysSer: 0.63 ± 0.021	0.529CysThr: 0.529 ± 0.019	0.574CysVal: 0.574 ± 0.023	0.17CysTrp: 0.17 ± 0.011	0.369CysTyr: 0.369 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.002AspAla: 4.002 ± 0.062	0.542AspCys: 0.542 ± 0.022	2.234AspAsp: 2.234 ± 0.055	3.032AspGlu: 3.032 ± 0.05	2.252AspPhe: 2.252 ± 0.044	3.258AspGly: 3.258 ± 0.057	0.478AspHis: 0.478 ± 0.02	3.357AspIle: 3.357 ± 0.053	2.342AspLys: 2.342 ± 0.044	5.65AspLeu: 5.65 ± 0.078	0.808AspMet: 0.808 ± 0.025	2.008AspAsn: 2.008 ± 0.04	2.369AspPro: 2.369 ± 0.05	1.102AspGln: 1.102 ± 0.034	4.583AspArg: 4.583 ± 0.063	2.894AspSer: 2.894 ± 0.043	2.543AspThr: 2.543 ± 0.044	3.214AspVal: 3.214 ± 0.052	0.94AspTrp: 0.94 ± 0.028	1.797AspTyr: 1.797 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.421GluAla: 5.421 ± 0.075	0.468GluCys: 0.468 ± 0.019	2.644GluAsp: 2.644 ± 0.043	3.592GluGlu: 3.592 ± 0.061	2.346GluPhe: 2.346 ± 0.045	2.95GluGly: 2.95 ± 0.058	0.974GluHis: 0.974 ± 0.026	4.461GluIle: 4.461 ± 0.059	2.927GluLys: 2.927 ± 0.056	6.876GluLeu: 6.876 ± 0.085	1.292GluMet: 1.292 ± 0.026	2.327GluAsn: 2.327 ± 0.043	2.478GluPro: 2.478 ± 0.049	4.026GluGln: 4.026 ± 0.068	3.707GluArg: 3.707 ± 0.061	3.086GluSer: 3.086 ± 0.045	3.259GluThr: 3.259 ± 0.048	4.362GluVal: 4.362 ± 0.057	0.71GluTrp: 0.71 ± 0.025	1.82GluTyr: 1.82 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.521PheAla: 3.521 ± 0.058	0.507PheCys: 0.507 ± 0.02	2.181PheAsp: 2.181 ± 0.043	2.061PheGlu: 2.061 ± 0.038	1.526PhePhe: 1.526 ± 0.04	2.88PheGly: 2.88 ± 0.055	0.755PheHis: 0.755 ± 0.026	2.265PheIle: 2.265 ± 0.043	1.519PheLys: 1.519 ± 0.036	3.804PheLeu: 3.804 ± 0.058	0.663PheMet: 0.663 ± 0.02	1.638PheAsn: 1.638 ± 0.036	1.708PhePro: 1.708 ± 0.039	1.63PheGln: 1.63 ± 0.029	1.805PheArg: 1.805 ± 0.041	2.735PheSer: 2.735 ± 0.05	2.207PheThr: 2.207 ± 0.043	2.478PheVal: 2.478 ± 0.048	0.691PheTrp: 0.691 ± 0.025	1.299PheTyr: 1.299 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.339GlyAla: 5.339 ± 0.077	0.808GlyCys: 0.808 ± 0.031	3.481GlyAsp: 3.481 ± 0.053	3.893GlyGlu: 3.893 ± 0.056	2.88GlyPhe: 2.88 ± 0.052	4.713GlyGly: 4.713 ± 0.086	1.141GlyHis: 1.141 ± 0.036	5.076GlyIle: 5.076 ± 0.064	4.026GlyLys: 4.026 ± 0.057	6.934GlyLeu: 6.934 ± 0.085	1.525GlyMet: 1.525 ± 0.037	2.694GlyAsn: 2.694 ± 0.052	1.323GlyPro: 1.323 ± 0.035	2.916GlyGln: 2.916 ± 0.053	3.319GlyArg: 3.319 ± 0.057	4.09GlySer: 4.09 ± 0.058	3.708GlyThr: 3.708 ± 0.077	4.923GlyVal: 4.923 ± 0.07	1.167GlyTrp: 1.167 ± 0.034	2.367GlyTyr: 2.367 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.078HisAla: 1.078 ± 0.031	0.26HisCys: 0.26 ± 0.013	0.717HisAsp: 0.717 ± 0.025	0.824HisGlu: 0.824 ± 0.024	0.732HisPhe: 0.732 ± 0.024	1.067HisGly: 1.067 ± 0.029	0.573HisHis: 0.573 ± 0.028	1.124HisIle: 1.124 ± 0.029	0.711HisLys: 0.711 ± 0.022	2.175HisLeu: 2.175 ± 0.043	0.235HisMet: 0.235 ± 0.014	0.745HisAsn: 0.745 ± 0.023	1.271HisPro: 1.271 ± 0.035	1.133HisGln: 1.133 ± 0.031	1.067HisArg: 1.067 ± 0.03	1.134HisSer: 1.134 ± 0.033	0.909HisThr: 0.909 ± 0.03	0.796HisVal: 0.796 ± 0.026	0.31HisTrp: 0.31 ± 0.016	0.649HisTyr: 0.649 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	8.373IleAla: 8.373 ± 0.088	0.782IleCys: 0.782 ± 0.03	3.772IleAsp: 3.772 ± 0.062	4.33IleGlu: 4.33 ± 0.055	2.415IlePhe: 2.415 ± 0.052	4.749IleGly: 4.749 ± 0.076	1.089IleHis: 1.089 ± 0.029	3.42IleIle: 3.42 ± 0.063	2.724IleLys: 2.724 ± 0.051	6.253IleLeu: 6.253 ± 0.083	0.877IleMet: 0.877 ± 0.027	2.721IleAsn: 2.721 ± 0.053	3.37IlePro: 3.37 ± 0.051	2.679IleGln: 2.679 ± 0.051	3.0IleArg: 3.0 ± 0.054	4.349IleSer: 4.349 ± 0.056	3.383IleThr: 3.383 ± 0.054	4.733IleVal: 4.733 ± 0.064	0.838IleTrp: 0.838 ± 0.027	1.978IleTyr: 1.978 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.127LysAla: 4.127 ± 0.06	0.323LysCys: 0.323 ± 0.016	2.074LysAsp: 2.074 ± 0.042	2.651LysGlu: 2.651 ± 0.044	1.678LysPhe: 1.678 ± 0.033	2.459LysGly: 2.459 ± 0.045	0.803LysHis: 0.803 ± 0.024	3.051LysIle: 3.051 ± 0.052	1.943LysLys: 1.943 ± 0.046	5.334LysLeu: 5.334 ± 0.071	0.948LysMet: 0.948 ± 0.027	1.819LysAsn: 1.819 ± 0.039	2.414LysPro: 2.414 ± 0.045	3.002LysGln: 3.002 ± 0.053	2.333LysArg: 2.333 ± 0.041	2.846LysSer: 2.846 ± 0.05	2.648LysThr: 2.648 ± 0.047	3.314LysVal: 3.314 ± 0.054	0.494LysTrp: 0.494 ± 0.022	1.389LysTyr: 1.389 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	10.563LeuAla: 10.563 ± 0.108	1.002LeuCys: 1.002 ± 0.028	5.355LeuAsp: 5.355 ± 0.067	7.056LeuGlu: 7.056 ± 0.082	3.752LeuPhe: 3.752 ± 0.062	7.598LeuGly: 7.598 ± 0.078	1.946LeuHis: 1.946 ± 0.043	6.523LeuIle: 6.523 ± 0.082	5.157LeuLys: 5.157 ± 0.066	11.598LeuLeu: 11.598 ± 0.134	2.035LeuMet: 2.035 ± 0.038	4.282LeuAsn: 4.282 ± 0.059	5.888LeuPro: 5.888 ± 0.069	6.049LeuGln: 6.049 ± 0.074	5.475LeuArg: 5.475 ± 0.063	7.229LeuSer: 7.229 ± 0.075	6.195LeuThr: 6.195 ± 0.068	7.533LeuVal: 7.533 ± 0.08	1.411LeuTrp: 1.411 ± 0.04	2.749LeuTyr: 2.749 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.711MetAla: 1.711 ± 0.033	0.116MetCys: 0.116 ± 0.009	0.781MetAsp: 0.781 ± 0.025	0.955MetGlu: 0.955 ± 0.027	0.571MetPhe: 0.571 ± 0.022	1.343MetGly: 1.343 ± 0.034	0.368MetHis: 0.368 ± 0.015	0.802MetIle: 0.802 ± 0.03	0.858MetLys: 0.858 ± 0.025	2.021MetLeu: 2.021 ± 0.039	0.444MetMet: 0.444 ± 0.02	0.859MetAsn: 0.859 ± 0.025	1.045MetPro: 1.045 ± 0.03	1.219MetGln: 1.219 ± 0.028	1.077MetArg: 1.077 ± 0.03	1.43MetSer: 1.43 ± 0.032	1.274MetThr: 1.274 ± 0.032	1.232MetVal: 1.232 ± 0.031	0.181MetTrp: 0.181 ± 0.011	0.384MetTyr: 0.384 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.215AsnAla: 3.215 ± 0.063	0.507AsnCys: 0.507 ± 0.019	1.621AsnAsp: 1.621 ± 0.037	1.809AsnGlu: 1.809 ± 0.039	1.724AsnPhe: 1.724 ± 0.04	2.502AsnGly: 2.502 ± 0.05	0.711AsnHis: 0.711 ± 0.027	2.709AsnIle: 2.709 ± 0.054	1.662AsnLys: 1.662 ± 0.037	5.242AsnLeu: 5.242 ± 0.076	0.647AsnMet: 0.647 ± 0.021	1.958AsnAsn: 1.958 ± 0.045	2.671AsnPro: 2.671 ± 0.048	2.324AsnGln: 2.324 ± 0.042	2.396AsnArg: 2.396 ± 0.044	2.944AsnSer: 2.944 ± 0.051	2.252AsnThr: 2.252 ± 0.044	2.383AsnVal: 2.383 ± 0.048	0.704AsnTrp: 0.704 ± 0.029	1.491AsnTyr: 1.491 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.64ProAla: 3.64 ± 0.064	0.361ProCys: 0.361 ± 0.019	2.796ProAsp: 2.796 ± 0.05	3.486ProGlu: 3.486 ± 0.06	1.675ProPhe: 1.675 ± 0.035	3.071ProGly: 3.071 ± 0.054	0.931ProHis: 0.931 ± 0.025	3.133ProIle: 3.133 ± 0.053	2.094ProLys: 2.094 ± 0.041	4.719ProLeu: 4.719 ± 0.064	0.785ProMet: 0.785 ± 0.023	2.252ProAsn: 2.252 ± 0.049	2.299ProPro: 2.299 ± 0.066	2.89ProGln: 2.89 ± 0.053	1.829ProArg: 1.829 ± 0.037	2.863ProSer: 2.863 ± 0.05	2.968ProThr: 2.968 ± 0.063	3.389ProVal: 3.389 ± 0.06	0.604ProTrp: 0.604 ± 0.023	1.373ProTyr: 1.373 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.37GlnAla: 5.37 ± 0.088	0.363GlnCys: 0.363 ± 0.018	2.156GlnAsp: 2.156 ± 0.038	3.434GlnGlu: 3.434 ± 0.054	1.788GlnPhe: 1.788 ± 0.038	3.157GlnGly: 3.157 ± 0.046	0.921GlnHis: 0.921 ± 0.028	3.812GlnIle: 3.812 ± 0.06	2.735GlnLys: 2.735 ± 0.055	6.328GlnLeu: 6.328 ± 0.082	1.187GlnMet: 1.187 ± 0.029	2.133GlnAsn: 2.133 ± 0.046	2.697GlnPro: 2.697 ± 0.048	3.907GlnGln: 3.907 ± 0.077	2.902GlnArg: 2.902 ± 0.051	2.947GlnSer: 2.947 ± 0.049	2.98GlnThr: 2.98 ± 0.051	4.112GlnVal: 4.112 ± 0.065	0.702GlnTrp: 0.702 ± 0.024	1.3GlnTyr: 1.3 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.896ArgAla: 3.896 ± 0.061	0.541ArgCys: 0.541 ± 0.023	2.668ArgAsp: 2.668 ± 0.047	3.058ArgGlu: 3.058 ± 0.048	2.152ArgPhe: 2.152 ± 0.042	3.05ArgGly: 3.05 ± 0.05	1.05ArgHis: 1.05 ± 0.029	3.327ArgIle: 3.327 ± 0.052	2.146ArgLys: 2.146 ± 0.042	6.248ArgLeu: 6.248 ± 0.082	1.042ArgMet: 1.042 ± 0.025	2.131ArgAsn: 2.131 ± 0.038	2.1ArgPro: 2.1 ± 0.043	3.577ArgGln: 3.577 ± 0.065	3.255ArgArg: 3.255 ± 0.063	3.749ArgSer: 3.749 ± 0.056	2.721ArgThr: 2.721 ± 0.046	3.66ArgVal: 3.66 ± 0.055	0.848ArgTrp: 0.848 ± 0.029	2.015ArgTyr: 2.015 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.154SerAla: 5.154 ± 0.059	0.675SerCys: 0.675 ± 0.025	3.368SerAsp: 3.368 ± 0.052	3.326SerGlu: 3.326 ± 0.052	2.368SerPhe: 2.368 ± 0.048	4.428SerGly: 4.428 ± 0.069	1.229SerHis: 1.229 ± 0.032	3.727SerIle: 3.727 ± 0.061	2.667SerLys: 2.667 ± 0.052	6.985SerLeu: 6.985 ± 0.074	1.199SerMet: 1.199 ± 0.025	2.681SerAsn: 2.681 ± 0.054	3.474SerPro: 3.474 ± 0.064	3.622SerGln: 3.622 ± 0.058	3.279SerArg: 3.279 ± 0.051	4.487SerSer: 4.487 ± 0.08	3.494SerThr: 3.494 ± 0.056	4.078SerVal: 4.078 ± 0.059	0.944SerTrp: 0.944 ± 0.031	1.879SerTyr: 1.879 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.157ThrAla: 5.157 ± 0.078	0.526ThrCys: 0.526 ± 0.023	2.677ThrAsp: 2.677 ± 0.045	2.965ThrGlu: 2.965 ± 0.052	2.066ThrPhe: 2.066 ± 0.044	4.322ThrGly: 4.322 ± 0.067	0.948ThrHis: 0.948 ± 0.029	3.835ThrIle: 3.835 ± 0.059	2.344ThrLys: 2.344 ± 0.039	6.197ThrLeu: 6.197 ± 0.069	0.836ThrMet: 0.836 ± 0.025	2.359ThrAsn: 2.359 ± 0.048	3.292ThrPro: 3.292 ± 0.062	2.812ThrGln: 2.812 ± 0.048	2.42ThrArg: 2.42 ± 0.04	3.394ThrSer: 3.394 ± 0.052	3.396ThrThr: 3.396 ± 0.055	3.947ThrVal: 3.947 ± 0.063	0.682ThrTrp: 0.682 ± 0.023	1.72ThrTyr: 1.72 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.694ValAla: 6.694 ± 0.074	0.714ValCys: 0.714 ± 0.023	3.635ValAsp: 3.635 ± 0.052	4.754ValGlu: 4.754 ± 0.068	2.523ValPhe: 2.523 ± 0.049	4.972ValGly: 4.972 ± 0.08	0.993ValHis: 0.993 ± 0.03	4.059ValIle: 4.059 ± 0.067	3.279ValLys: 3.279 ± 0.054	6.91ValLeu: 6.91 ± 0.077	1.425ValMet: 1.425 ± 0.035	2.833ValAsn: 2.833 ± 0.053	3.112ValPro: 3.112 ± 0.057	3.053ValGln: 3.053 ± 0.043	3.444ValArg: 3.444 ± 0.053	4.275ValSer: 4.275 ± 0.054	3.948ValThr: 3.948 ± 0.06	5.357ValVal: 5.357 ± 0.094	0.879ValTrp: 0.879 ± 0.029	1.862ValTyr: 1.862 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.012TrpAla: 1.012 ± 0.03	0.144TrpCys: 0.144 ± 0.012	0.65TrpAsp: 0.65 ± 0.029	0.792TrpGlu: 0.792 ± 0.024	0.601TrpPhe: 0.601 ± 0.025	0.952TrpGly: 0.952 ± 0.03	0.367TrpHis: 0.367 ± 0.02	0.816TrpIle: 0.816 ± 0.024	0.492TrpLys: 0.492 ± 0.021	2.032TrpLeu: 2.032 ± 0.049	0.317TrpMet: 0.317 ± 0.016	0.591TrpAsn: 0.591 ± 0.022	0.121TrpPro: 0.121 ± 0.011	1.414TrpGln: 1.414 ± 0.038	0.879TrpArg: 0.879 ± 0.029	0.805TrpSer: 0.805 ± 0.028	0.635TrpThr: 0.635 ± 0.022	0.911TrpVal: 0.911 ± 0.032	0.272TrpTrp: 0.272 ± 0.016	0.421TrpTyr: 0.421 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.309TyrAla: 2.309 ± 0.042	0.427TyrCys: 0.427 ± 0.019	1.495TyrAsp: 1.495 ± 0.034	1.69TyrGlu: 1.69 ± 0.04	1.329TyrPhe: 1.329 ± 0.032	2.041TyrGly: 2.041 ± 0.045	0.62TyrHis: 0.62 ± 0.025	1.785TyrIle: 1.785 ± 0.037	1.282TyrLys: 1.282 ± 0.035	3.612TyrLeu: 3.612 ± 0.057	0.448TyrMet: 0.448 ± 0.02	1.244TyrAsn: 1.244 ± 0.03	1.589TyrPro: 1.589 ± 0.031	1.976TyrGln: 1.976 ± 0.04	1.95TyrArg: 1.95 ± 0.038	1.889TyrSer: 1.889 ± 0.042	1.535TyrThr: 1.535 ± 0.035	1.675TyrVal: 1.675 ± 0.038	0.564TyrTrp: 0.564 ± 0.02	1.122TyrTyr: 1.122 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4366 proteins (1296007 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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