Amino acid dipepetide frequency for Pseudoalteromonas rubra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.429AlaAla: 8.429 ± 0.113
1.128AlaCys: 1.128 ± 0.032
4.963AlaAsp: 4.963 ± 0.054
5.474AlaGlu: 5.474 ± 0.083
3.651AlaPhe: 3.651 ± 0.055
6.132AlaGly: 6.132 ± 0.08
2.182AlaHis: 2.182 ± 0.038
5.54AlaIle: 5.54 ± 0.07
4.662AlaLys: 4.662 ± 0.065
11.518AlaLeu: 11.518 ± 0.131
2.582AlaMet: 2.582 ± 0.052
3.622AlaAsn: 3.622 ± 0.057
3.433AlaPro: 3.433 ± 0.063
6.005AlaGln: 6.005 ± 0.084
4.251AlaArg: 4.251 ± 0.062
5.718AlaSer: 5.718 ± 0.075
4.759AlaThr: 4.759 ± 0.076
5.928AlaVal: 5.928 ± 0.084
0.967AlaTrp: 0.967 ± 0.027
2.752AlaTyr: 2.752 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.908CysAla: 0.908 ± 0.032
0.166CysCys: 0.166 ± 0.011
0.698CysAsp: 0.698 ± 0.025
0.665CysGlu: 0.665 ± 0.025
0.456CysPhe: 0.456 ± 0.018
0.837CysGly: 0.837 ± 0.028
0.325CysHis: 0.325 ± 0.014
0.575CysIle: 0.575 ± 0.02
0.452CysLys: 0.452 ± 0.018
1.007CysLeu: 1.007 ± 0.028
0.226CysMet: 0.226 ± 0.013
0.372CysAsn: 0.372 ± 0.018
0.458CysPro: 0.458 ± 0.02
0.6CysGln: 0.6 ± 0.02
0.478CysArg: 0.478 ± 0.017
0.675CysSer: 0.675 ± 0.019
0.512CysThr: 0.512 ± 0.022
0.692CysVal: 0.692 ± 0.021
0.131CysTrp: 0.131 ± 0.009
0.381CysTyr: 0.381 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.966AspAla: 4.966 ± 0.07
0.529AspCys: 0.529 ± 0.02
3.173AspAsp: 3.173 ± 0.061
3.939AspGlu: 3.939 ± 0.06
2.46AspPhe: 2.46 ± 0.045
3.972AspGly: 3.972 ± 0.077
1.142AspHis: 1.142 ± 0.03
3.786AspIle: 3.786 ± 0.06
3.369AspLys: 3.369 ± 0.046
5.173AspLeu: 5.173 ± 0.06
1.446AspMet: 1.446 ± 0.034
2.634AspAsn: 2.634 ± 0.051
2.246AspPro: 2.246 ± 0.044
2.032AspGln: 2.032 ± 0.041
1.955AspArg: 1.955 ± 0.039
3.441AspSer: 3.441 ± 0.053
3.131AspThr: 3.131 ± 0.063
3.818AspVal: 3.818 ± 0.052
0.87AspTrp: 0.87 ± 0.025
2.236AspTyr: 2.236 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
5.338GluAla: 5.338 ± 0.075
0.462GluCys: 0.462 ± 0.018
2.725GluAsp: 2.725 ± 0.051
3.228GluGlu: 3.228 ± 0.069
2.525GluPhe: 2.525 ± 0.05
3.248GluGly: 3.248 ± 0.047
1.823GluHis: 1.823 ± 0.04
3.51GluIle: 3.51 ± 0.057
3.047GluLys: 3.047 ± 0.059
7.381GluLeu: 7.381 ± 0.084
1.376GluMet: 1.376 ± 0.034
2.218GluAsn: 2.218 ± 0.041
2.086GluPro: 2.086 ± 0.036
5.255GluGln: 5.255 ± 0.08
3.313GluArg: 3.313 ± 0.053
3.235GluSer: 3.235 ± 0.043
2.739GluThr: 2.739 ± 0.047
4.242GluVal: 4.242 ± 0.066
0.573GluTrp: 0.573 ± 0.02
1.787GluTyr: 1.787 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
4.077PheAla: 4.077 ± 0.062
0.49PheCys: 0.49 ± 0.016
3.029PheAsp: 3.029 ± 0.043
2.711PheGlu: 2.711 ± 0.046
1.63PhePhe: 1.63 ± 0.039
2.944PheGly: 2.944 ± 0.047
0.808PheHis: 0.808 ± 0.025
2.555PheIle: 2.555 ± 0.045
2.044PheLys: 2.044 ± 0.04
3.029PheLeu: 3.029 ± 0.054
0.945PheMet: 0.945 ± 0.026
2.064PheAsn: 2.064 ± 0.04
1.26PhePro: 1.26 ± 0.031
1.096PheGln: 1.096 ± 0.025
1.496PheArg: 1.496 ± 0.031
3.382PheSer: 3.382 ± 0.046
2.348PheThr: 2.348 ± 0.045
2.848PheVal: 2.848 ± 0.048
0.494PheTrp: 0.494 ± 0.02
1.448PheTyr: 1.448 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
5.565GlyAla: 5.565 ± 0.067
0.877GlyCys: 0.877 ± 0.023
3.697GlyAsp: 3.697 ± 0.063
4.364GlyGlu: 4.364 ± 0.056
3.172GlyPhe: 3.172 ± 0.048
4.492GlyGly: 4.492 ± 0.076
1.616GlyHis: 1.616 ± 0.037
3.966GlyIle: 3.966 ± 0.054
3.686GlyLys: 3.686 ± 0.051
6.763GlyLeu: 6.763 ± 0.071
1.702GlyMet: 1.702 ± 0.036
2.604GlyAsn: 2.604 ± 0.061
1.734GlyPro: 1.734 ± 0.035
3.236GlyGln: 3.236 ± 0.052
2.972GlyArg: 2.972 ± 0.045
4.016GlySer: 4.016 ± 0.067
3.481GlyThr: 3.481 ± 0.07
4.951GlyVal: 4.951 ± 0.062
0.896GlyTrp: 0.896 ± 0.027
2.573GlyTyr: 2.573 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.891HisAla: 1.891 ± 0.039
0.382HisCys: 0.382 ± 0.015
1.228HisAsp: 1.228 ± 0.029
1.212HisGlu: 1.212 ± 0.029
1.226HisPhe: 1.226 ± 0.029
1.6HisGly: 1.6 ± 0.037
0.798HisHis: 0.798 ± 0.026
1.52HisIle: 1.52 ± 0.034
1.079HisLys: 1.079 ± 0.029
2.408HisLeu: 2.408 ± 0.041
0.492HisMet: 0.492 ± 0.017
1.044HisAsn: 1.044 ± 0.028
1.182HisPro: 1.182 ± 0.03
1.421HisGln: 1.421 ± 0.039
1.051HisArg: 1.051 ± 0.023
1.722HisSer: 1.722 ± 0.034
1.325HisThr: 1.325 ± 0.03
1.287HisVal: 1.287 ± 0.035
0.413HisTrp: 0.413 ± 0.017
1.044HisTyr: 1.044 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.125IleAla: 6.125 ± 0.071
0.663IleCys: 0.663 ± 0.023
3.83IleAsp: 3.83 ± 0.052
4.268IleGlu: 4.268 ± 0.054
1.849IlePhe: 1.849 ± 0.039
3.85IleGly: 3.85 ± 0.055
1.13IleHis: 1.13 ± 0.025
2.628IleIle: 2.628 ± 0.054
2.999IleLys: 2.999 ± 0.043
4.615IleLeu: 4.615 ± 0.062
1.143IleMet: 1.143 ± 0.028
2.685IleAsn: 2.685 ± 0.042
2.161IlePro: 2.161 ± 0.043
2.029IleGln: 2.029 ± 0.032
2.636IleArg: 2.636 ± 0.04
4.143IleSer: 4.143 ± 0.06
3.343IleThr: 3.343 ± 0.051
3.53IleVal: 3.53 ± 0.05
0.612IleTrp: 0.612 ± 0.022
1.633IleTyr: 1.633 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.743LysAla: 4.743 ± 0.061
0.301LysCys: 0.301 ± 0.014
2.522LysAsp: 2.522 ± 0.045
2.78LysGlu: 2.78 ± 0.053
1.407LysPhe: 1.407 ± 0.03
2.941LysGly: 2.941 ± 0.046
1.27LysHis: 1.27 ± 0.033
2.414LysIle: 2.414 ± 0.045
2.47LysLys: 2.47 ± 0.05
5.269LysLeu: 5.269 ± 0.06
1.095LysMet: 1.095 ± 0.026
1.822LysAsn: 1.822 ± 0.033
2.219LysPro: 2.219 ± 0.043
2.994LysGln: 2.994 ± 0.045
2.689LysArg: 2.689 ± 0.048
2.919LysSer: 2.919 ± 0.05
2.745LysThr: 2.745 ± 0.039
3.6LysVal: 3.6 ± 0.055
0.481LysTrp: 0.481 ± 0.018
1.358LysTyr: 1.358 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
10.987LeuAla: 10.987 ± 0.134
1.317LeuCys: 1.317 ± 0.031
6.212LeuAsp: 6.212 ± 0.069
5.965LeuGlu: 5.965 ± 0.063
4.205LeuPhe: 4.205 ± 0.06
6.819LeuGly: 6.819 ± 0.07
2.289LeuHis: 2.289 ± 0.047
5.623LeuIle: 5.623 ± 0.072
5.333LeuLys: 5.333 ± 0.063
11.239LeuLeu: 11.239 ± 0.142
2.46LeuMet: 2.46 ± 0.045
4.869LeuAsn: 4.869 ± 0.059
4.874LeuPro: 4.874 ± 0.065
4.348LeuGln: 4.348 ± 0.066
4.544LeuArg: 4.544 ± 0.061
9.027LeuSer: 9.027 ± 0.085
6.46LeuThr: 6.46 ± 0.069
6.926LeuVal: 6.926 ± 0.073
1.08LeuTrp: 1.08 ± 0.027
2.953LeuTyr: 2.953 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.453MetAla: 2.453 ± 0.046
0.19MetCys: 0.19 ± 0.012
1.113MetAsp: 1.113 ± 0.028
1.051MetGlu: 1.051 ± 0.022
0.736MetPhe: 0.736 ± 0.026
1.414MetGly: 1.414 ± 0.033
0.514MetHis: 0.514 ± 0.02
1.189MetIle: 1.189 ± 0.032
1.157MetLys: 1.157 ± 0.029
2.764MetLeu: 2.764 ± 0.043
0.659MetMet: 0.659 ± 0.024
0.874MetAsn: 0.874 ± 0.025
1.13MetPro: 1.13 ± 0.031
1.279MetGln: 1.279 ± 0.033
1.13MetArg: 1.13 ± 0.029
1.814MetSer: 1.814 ± 0.037
1.492MetThr: 1.492 ± 0.035
1.512MetVal: 1.512 ± 0.035
0.223MetTrp: 0.223 ± 0.012
0.519MetTyr: 0.519 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.666AsnAla: 3.666 ± 0.062
0.4AsnCys: 0.4 ± 0.016
2.21AsnAsp: 2.21 ± 0.056
2.36AsnGlu: 2.36 ± 0.044
1.438AsnPhe: 1.438 ± 0.03
2.958AsnGly: 2.958 ± 0.055
0.944AsnHis: 0.944 ± 0.024
2.321AsnIle: 2.321 ± 0.039
2.053AsnLys: 2.053 ± 0.039
3.895AsnLeu: 3.895 ± 0.057
0.925AsnMet: 0.925 ± 0.026
1.891AsnAsn: 1.891 ± 0.041
1.982AsnPro: 1.982 ± 0.036
2.119AsnGln: 2.119 ± 0.043
2.013AsnArg: 2.013 ± 0.038
2.458AsnSer: 2.458 ± 0.046
2.529AsnThr: 2.529 ± 0.049
2.403AsnVal: 2.403 ± 0.056
0.645AsnTrp: 0.645 ± 0.02
1.427AsnTyr: 1.427 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
3.617ProAla: 3.617 ± 0.054
0.327ProCys: 0.327 ± 0.015
2.742ProAsp: 2.742 ± 0.041
3.026ProGlu: 3.026 ± 0.045
1.719ProPhe: 1.719 ± 0.034
2.768ProGly: 2.768 ± 0.043
0.934ProHis: 0.934 ± 0.023
2.068ProIle: 2.068 ± 0.038
1.775ProLys: 1.775 ± 0.044
4.163ProLeu: 4.163 ± 0.056
0.881ProMet: 0.881 ± 0.023
1.506ProAsn: 1.506 ± 0.036
1.139ProPro: 1.139 ± 0.031
2.08ProGln: 2.08 ± 0.042
1.361ProArg: 1.361 ± 0.026
2.319ProSer: 2.319 ± 0.043
1.898ProThr: 1.898 ± 0.044
3.261ProVal: 3.261 ± 0.047
0.496ProTrp: 0.496 ± 0.019
1.33ProTyr: 1.33 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
5.775GlnAla: 5.775 ± 0.085
0.499GlnCys: 0.499 ± 0.02
2.47GlnAsp: 2.47 ± 0.038
2.329GlnGlu: 2.329 ± 0.043
2.087GlnPhe: 2.087 ± 0.034
3.765GlnGly: 3.765 ± 0.053
1.503GlnHis: 1.503 ± 0.038
2.719GlnIle: 2.719 ± 0.038
1.95GlnLys: 1.95 ± 0.04
6.532GlnLeu: 6.532 ± 0.095
1.048GlnMet: 1.048 ± 0.029
1.688GlnAsn: 1.688 ± 0.031
2.1GlnPro: 2.1 ± 0.044
4.182GlnGln: 4.182 ± 0.085
2.591GlnArg: 2.591 ± 0.055
3.624GlnSer: 3.624 ± 0.054
2.707GlnThr: 2.707 ± 0.046
3.941GlnVal: 3.941 ± 0.057
0.737GlnTrp: 0.737 ± 0.026
1.602GlnTyr: 1.602 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
4.02ArgAla: 4.02 ± 0.064
0.452ArgCys: 0.452 ± 0.02
2.509ArgAsp: 2.509 ± 0.042
2.719ArgGlu: 2.719 ± 0.05
2.434ArgPhe: 2.434 ± 0.041
2.583ArgGly: 2.583 ± 0.038
1.298ArgHis: 1.298 ± 0.031
2.685ArgIle: 2.685 ± 0.042
1.996ArgLys: 1.996 ± 0.039
5.281ArgLeu: 5.281 ± 0.073
1.013ArgMet: 1.013 ± 0.025
1.786ArgAsn: 1.786 ± 0.036
1.634ArgPro: 1.634 ± 0.031
2.373ArgGln: 2.373 ± 0.049
2.194ArgArg: 2.194 ± 0.044
2.603ArgSer: 2.603 ± 0.045
2.221ArgThr: 2.221 ± 0.039
3.213ArgVal: 3.213 ± 0.042
0.629ArgTrp: 0.629 ± 0.021
1.89ArgTyr: 1.89 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.396SerAla: 6.396 ± 0.074
0.632SerCys: 0.632 ± 0.021
4.011SerAsp: 4.011 ± 0.054
4.359SerGlu: 4.359 ± 0.054
2.708SerPhe: 2.708 ± 0.046
5.259SerGly: 5.259 ± 0.062
1.693SerHis: 1.693 ± 0.039
3.426SerIle: 3.426 ± 0.047
2.978SerLys: 2.978 ± 0.047
6.845SerLeu: 6.845 ± 0.074
1.477SerMet: 1.477 ± 0.032
2.64SerAsn: 2.64 ± 0.051
2.383SerPro: 2.383 ± 0.042
3.367SerGln: 3.367 ± 0.05
2.868SerArg: 2.868 ± 0.041
4.137SerSer: 4.137 ± 0.069
3.214SerThr: 3.214 ± 0.047
4.809SerVal: 4.809 ± 0.063
0.896SerTrp: 0.896 ± 0.024
2.229SerTyr: 2.229 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.706ThrAla: 4.706 ± 0.071
0.478ThrCys: 0.478 ± 0.019
2.9ThrAsp: 2.9 ± 0.061
3.085ThrGlu: 3.085 ± 0.046
2.045ThrPhe: 2.045 ± 0.041
3.866ThrGly: 3.866 ± 0.062
1.36ThrHis: 1.36 ± 0.031
2.94ThrIle: 2.94 ± 0.052
1.985ThrLys: 1.985 ± 0.039
7.263ThrLeu: 7.263 ± 0.084
1.061ThrMet: 1.061 ± 0.027
1.813ThrAsn: 1.813 ± 0.036
2.945ThrPro: 2.945 ± 0.054
3.246ThrGln: 3.246 ± 0.052
2.412ThrArg: 2.412 ± 0.048
3.303ThrSer: 3.303 ± 0.054
2.879ThrThr: 2.879 ± 0.047
3.799ThrVal: 3.799 ± 0.08
0.617ThrTrp: 0.617 ± 0.022
1.579ThrTyr: 1.579 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
6.679ValAla: 6.679 ± 0.074
0.773ValCys: 0.773 ± 0.024
3.926ValAsp: 3.926 ± 0.054
4.376ValGlu: 4.376 ± 0.06
2.877ValPhe: 2.877 ± 0.052
4.1ValGly: 4.1 ± 0.059
1.332ValHis: 1.332 ± 0.03
4.212ValIle: 4.212 ± 0.058
3.323ValLys: 3.323 ± 0.048
7.001ValLeu: 7.001 ± 0.081
1.769ValMet: 1.769 ± 0.038
2.904ValAsn: 2.904 ± 0.057
2.57ValPro: 2.57 ± 0.047
2.599ValGln: 2.599 ± 0.046
2.973ValArg: 2.973 ± 0.041
5.044ValSer: 5.044 ± 0.07
4.321ValThr: 4.321 ± 0.083
5.03ValVal: 5.03 ± 0.074
0.731ValTrp: 0.731 ± 0.02
2.071ValTyr: 2.071 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.797TrpAla: 0.797 ± 0.021
0.136TrpCys: 0.136 ± 0.009
0.549TrpAsp: 0.549 ± 0.022
0.519TrpGlu: 0.519 ± 0.019
0.573TrpPhe: 0.573 ± 0.02
0.704TrpGly: 0.704 ± 0.021
0.462TrpHis: 0.462 ± 0.018
0.523TrpIle: 0.523 ± 0.019
0.349TrpLys: 0.349 ± 0.015
1.763TrpLeu: 1.763 ± 0.043
0.289TrpMet: 0.289 ± 0.014
0.374TrpAsn: 0.374 ± 0.019
0.488TrpPro: 0.488 ± 0.02
1.323TrpGln: 1.323 ± 0.037
0.722TrpArg: 0.722 ± 0.021
0.705TrpSer: 0.705 ± 0.024
0.474TrpThr: 0.474 ± 0.018
0.784TrpVal: 0.784 ± 0.025
0.185TrpTrp: 0.185 ± 0.011
0.417TrpTyr: 0.417 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.556TyrAla: 2.556 ± 0.044
0.412TyrCys: 0.412 ± 0.019
1.81TyrAsp: 1.81 ± 0.048
1.682TyrGlu: 1.682 ± 0.029
1.501TyrPhe: 1.501 ± 0.037
2.111TyrGly: 2.111 ± 0.04
0.902TyrHis: 0.902 ± 0.024
1.674TyrIle: 1.674 ± 0.036
1.329TyrLys: 1.329 ± 0.035
3.622TyrLeu: 3.622 ± 0.06
0.626TyrMet: 0.626 ± 0.019
1.228TyrAsn: 1.228 ± 0.029
1.388TyrPro: 1.388 ± 0.029
2.262TyrGln: 2.262 ± 0.043
1.885TyrArg: 1.885 ± 0.038
2.043TyrSer: 2.043 ± 0.04
1.703TyrThr: 1.703 ± 0.038
2.037TyrVal: 2.037 ± 0.037
0.458TyrTrp: 0.458 ± 0.016
1.2TyrTyr: 1.2 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4390 proteins (1545420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski