Amino acid dipepetide frequency for Genlisea aurea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.639AlaAla: 8.639 ± 0.053
1.274AlaCys: 1.274 ± 0.015
3.602AlaAsp: 3.602 ± 0.026
4.776AlaGlu: 4.776 ± 0.036
3.052AlaPhe: 3.052 ± 0.024
4.845AlaGly: 4.845 ± 0.036
1.358AlaHis: 1.358 ± 0.016
3.939AlaIle: 3.939 ± 0.028
3.848AlaLys: 3.848 ± 0.032
7.189AlaLeu: 7.189 ± 0.045
1.833AlaMet: 1.833 ± 0.017
2.352AlaAsn: 2.352 ± 0.019
2.88AlaPro: 2.88 ± 0.025
1.94AlaGln: 1.94 ± 0.02
3.818AlaArg: 3.818 ± 0.028
6.163AlaSer: 6.163 ± 0.035
3.55AlaThr: 3.55 ± 0.026
6.129AlaVal: 6.129 ± 0.034
0.798AlaTrp: 0.798 ± 0.012
2.003AlaTyr: 2.003 ± 0.021
0.0AlaXaa: 0.0 ± 0.0
Cys
1.05CysAla: 1.05 ± 0.014
0.548CysCys: 0.548 ± 0.011
0.905CysAsp: 0.905 ± 0.014
0.884CysGlu: 0.884 ± 0.012
0.903CysPhe: 0.903 ± 0.013
1.481CysGly: 1.481 ± 0.02
0.429CysHis: 0.429 ± 0.008
0.981CysIle: 0.981 ± 0.012
0.94CysLys: 0.94 ± 0.015
1.802CysLeu: 1.802 ± 0.019
0.345CysMet: 0.345 ± 0.008
0.724CysAsn: 0.724 ± 0.012
0.891CysPro: 0.891 ± 0.014
0.479CysGln: 0.479 ± 0.01
1.311CysArg: 1.311 ± 0.017
1.803CysSer: 1.803 ± 0.02
0.76CysThr: 0.76 ± 0.013
1.109CysVal: 1.109 ± 0.014
0.233CysTrp: 0.233 ± 0.008
0.548CysTyr: 0.548 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
4.04AspAla: 4.04 ± 0.025
0.954AspCys: 0.954 ± 0.013
4.224AspAsp: 4.224 ± 0.043
4.397AspGlu: 4.397 ± 0.033
2.518AspPhe: 2.518 ± 0.021
4.296AspGly: 4.296 ± 0.029
1.261AspHis: 1.261 ± 0.017
2.827AspIle: 2.827 ± 0.023
2.391AspLys: 2.391 ± 0.024
5.203AspLeu: 5.203 ± 0.03
1.186AspMet: 1.186 ± 0.017
1.684AspAsn: 1.684 ± 0.02
2.823AspPro: 2.823 ± 0.024
1.518AspGln: 1.518 ± 0.018
2.891AspArg: 2.891 ± 0.026
4.433AspSer: 4.433 ± 0.031
1.943AspThr: 1.943 ± 0.019
3.916AspVal: 3.916 ± 0.026
0.746AspTrp: 0.746 ± 0.011
1.585AspTyr: 1.585 ± 0.019
0.0AspXaa: 0.0 ± 0.0
Glu
5.251GluAla: 5.251 ± 0.038
0.889GluCys: 0.889 ± 0.014
3.779GluAsp: 3.779 ± 0.029
6.467GluGlu: 6.467 ± 0.054
2.565GluPhe: 2.565 ± 0.021
3.65GluGly: 3.65 ± 0.024
1.154GluHis: 1.154 ± 0.016
3.947GluIle: 3.947 ± 0.03
4.694GluLys: 4.694 ± 0.037
5.967GluLeu: 5.967 ± 0.04
1.886GluMet: 1.886 ± 0.021
2.923GluAsn: 2.923 ± 0.027
2.011GluPro: 2.011 ± 0.018
1.901GluGln: 1.901 ± 0.02
3.603GluArg: 3.603 ± 0.032
4.757GluSer: 4.757 ± 0.033
3.155GluThr: 3.155 ± 0.026
4.017GluVal: 4.017 ± 0.031
0.782GluTrp: 0.782 ± 0.011
1.699GluTyr: 1.699 ± 0.015
0.0GluXaa: 0.0 ± 0.0
Phe
2.783PheAla: 2.783 ± 0.023
0.916PheCys: 0.916 ± 0.015
2.58PheAsp: 2.58 ± 0.02
2.366PheGlu: 2.366 ± 0.022
2.215PhePhe: 2.215 ± 0.023
3.151PheGly: 3.151 ± 0.026
1.134PheHis: 1.134 ± 0.014
2.126PheIle: 2.126 ± 0.02
1.903PheLys: 1.903 ± 0.018
4.531PheLeu: 4.531 ± 0.028
0.892PheMet: 0.892 ± 0.012
1.62PheAsn: 1.62 ± 0.018
2.134PhePro: 2.134 ± 0.021
1.45PheGln: 1.45 ± 0.015
2.642PheArg: 2.642 ± 0.022
4.164PheSer: 4.164 ± 0.029
1.967PheThr: 1.967 ± 0.019
3.015PheVal: 3.015 ± 0.023
0.586PheTrp: 0.586 ± 0.011
1.337PheTyr: 1.337 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
4.281GlyAla: 4.281 ± 0.028
1.317GlyCys: 1.317 ± 0.014
3.813GlyAsp: 3.813 ± 0.026
3.955GlyGlu: 3.955 ± 0.023
3.439GlyPhe: 3.439 ± 0.027
6.53GlyGly: 6.53 ± 0.065
1.487GlyHis: 1.487 ± 0.018
4.052GlyIle: 4.052 ± 0.03
4.047GlyLys: 4.047 ± 0.03
6.036GlyLeu: 6.036 ± 0.034
1.51GlyMet: 1.51 ± 0.017
3.029GlyAsn: 3.029 ± 0.025
2.347GlyPro: 2.347 ± 0.025
1.835GlyGln: 1.835 ± 0.018
4.219GlyArg: 4.219 ± 0.033
6.002GlySer: 6.002 ± 0.033
3.169GlyThr: 3.169 ± 0.03
4.57GlyVal: 4.57 ± 0.03
0.968GlyTrp: 0.968 ± 0.013
2.153GlyTyr: 2.153 ± 0.021
0.0GlyXaa: 0.0 ± 0.0
His
1.414HisAla: 1.414 ± 0.016
0.509HisCys: 0.509 ± 0.011
1.143HisAsp: 1.143 ± 0.015
1.243HisGlu: 1.243 ± 0.014
1.064HisPhe: 1.064 ± 0.015
1.775HisGly: 1.775 ± 0.018
1.027HisHis: 1.027 ± 0.021
1.111HisIle: 1.111 ± 0.013
0.987HisLys: 0.987 ± 0.014
2.369HisLeu: 2.369 ± 0.023
0.458HisMet: 0.458 ± 0.009
0.769HisAsn: 0.769 ± 0.012
1.352HisPro: 1.352 ± 0.015
0.895HisGln: 0.895 ± 0.014
1.592HisArg: 1.592 ± 0.019
1.845HisSer: 1.845 ± 0.019
0.867HisThr: 0.867 ± 0.013
1.526HisVal: 1.526 ± 0.018
0.314HisTrp: 0.314 ± 0.008
0.713HisTyr: 0.713 ± 0.011
0.0HisXaa: 0.0 ± 0.0
Ile
3.764IleAla: 3.764 ± 0.027
1.083IleCys: 1.083 ± 0.016
2.981IleAsp: 2.981 ± 0.024
3.092IleGlu: 3.092 ± 0.023
2.394IlePhe: 2.394 ± 0.023
3.573IleGly: 3.573 ± 0.028
1.37IleHis: 1.37 ± 0.015
2.657IleIle: 2.657 ± 0.027
2.62IleLys: 2.62 ± 0.027
5.488IleLeu: 5.488 ± 0.034
1.01IleMet: 1.01 ± 0.011
1.944IleAsn: 1.944 ± 0.022
2.993IlePro: 2.993 ± 0.026
1.85IleGln: 1.85 ± 0.02
3.152IleArg: 3.152 ± 0.024
4.921IleSer: 4.921 ± 0.033
2.398IleThr: 2.398 ± 0.02
3.563IleVal: 3.563 ± 0.027
0.732IleTrp: 0.732 ± 0.013
1.555IleTyr: 1.555 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
3.906LysAla: 3.906 ± 0.031
0.908LysCys: 0.908 ± 0.015
2.863LysAsp: 2.863 ± 0.026
3.918LysGlu: 3.918 ± 0.033
2.106LysPhe: 2.106 ± 0.019
3.246LysGly: 3.246 ± 0.025
1.257LysHis: 1.257 ± 0.015
3.144LysIle: 3.144 ± 0.027
4.563LysLys: 4.563 ± 0.038
5.757LysLeu: 5.757 ± 0.034
1.389LysMet: 1.389 ± 0.016
2.452LysAsn: 2.452 ± 0.02
2.518LysPro: 2.518 ± 0.023
2.047LysGln: 2.047 ± 0.022
3.633LysArg: 3.633 ± 0.027
4.411LysSer: 4.411 ± 0.029
2.701LysThr: 2.701 ± 0.026
3.405LysVal: 3.405 ± 0.026
0.805LysTrp: 0.805 ± 0.012
1.606LysTyr: 1.606 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
6.749LeuAla: 6.749 ± 0.038
1.834LeuCys: 1.834 ± 0.022
5.089LeuAsp: 5.089 ± 0.031
6.089LeuGlu: 6.089 ± 0.048
4.0LeuPhe: 4.0 ± 0.029
5.836LeuGly: 5.836 ± 0.032
2.511LeuHis: 2.511 ± 0.021
4.892LeuIle: 4.892 ± 0.036
5.952LeuLys: 5.952 ± 0.037
10.268LeuLeu: 10.268 ± 0.055
2.081LeuMet: 2.081 ± 0.019
3.827LeuAsn: 3.827 ± 0.027
5.0LeuPro: 5.0 ± 0.033
4.0LeuGln: 4.0 ± 0.033
6.174LeuArg: 6.174 ± 0.031
8.366LeuSer: 8.366 ± 0.046
4.176LeuThr: 4.176 ± 0.03
6.401LeuVal: 6.401 ± 0.038
1.187LeuTrp: 1.187 ± 0.015
2.605LeuTyr: 2.605 ± 0.021
0.0LeuXaa: 0.0 ± 0.0
Met
2.018MetAla: 2.018 ± 0.021
0.308MetCys: 0.308 ± 0.007
1.329MetAsp: 1.329 ± 0.014
1.834MetGlu: 1.834 ± 0.019
0.746MetPhe: 0.746 ± 0.012
1.479MetGly: 1.479 ± 0.019
0.453MetHis: 0.453 ± 0.009
1.259MetIle: 1.259 ± 0.017
1.608MetLys: 1.608 ± 0.017
2.03MetLeu: 2.03 ± 0.019
0.66MetMet: 0.66 ± 0.012
0.99MetAsn: 0.99 ± 0.014
0.94MetPro: 0.94 ± 0.013
0.789MetGln: 0.789 ± 0.013
1.263MetArg: 1.263 ± 0.015
1.551MetSer: 1.551 ± 0.017
0.943MetThr: 0.943 ± 0.013
1.516MetVal: 1.516 ± 0.018
0.255MetTrp: 0.255 ± 0.007
0.574MetTyr: 0.574 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
2.808AsnAla: 2.808 ± 0.024
0.731AsnCys: 0.731 ± 0.013
1.977AsnAsp: 1.977 ± 0.02
2.302AsnGlu: 2.302 ± 0.024
1.776AsnPhe: 1.776 ± 0.018
3.102AsnGly: 3.102 ± 0.027
0.961AsnHis: 0.961 ± 0.013
1.991AsnIle: 1.991 ± 0.022
1.912AsnLys: 1.912 ± 0.018
4.081AsnLeu: 4.081 ± 0.034
0.834AsnMet: 0.834 ± 0.013
1.744AsnAsn: 1.744 ± 0.024
2.266AsnPro: 2.266 ± 0.022
1.362AsnGln: 1.362 ± 0.015
2.257AsnArg: 2.257 ± 0.018
3.443AsnSer: 3.443 ± 0.029
1.613AsnThr: 1.613 ± 0.018
2.714AsnVal: 2.714 ± 0.022
0.531AsnTrp: 0.531 ± 0.01
1.19AsnTyr: 1.19 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
3.276ProAla: 3.276 ± 0.026
0.733ProCys: 0.733 ± 0.013
2.726ProAsp: 2.726 ± 0.023
3.342ProGlu: 3.342 ± 0.026
2.043ProPhe: 2.043 ± 0.021
2.898ProGly: 2.898 ± 0.023
1.053ProHis: 1.053 ± 0.015
2.212ProIle: 2.212 ± 0.023
2.332ProLys: 2.332 ± 0.023
4.217ProLeu: 4.217 ± 0.03
0.853ProMet: 0.853 ± 0.014
1.968ProAsn: 1.968 ± 0.021
4.186ProPro: 4.186 ± 0.056
1.563ProGln: 1.563 ± 0.02
2.578ProArg: 2.578 ± 0.024
4.681ProSer: 4.681 ± 0.035
2.339ProThr: 2.339 ± 0.021
3.178ProVal: 3.178 ± 0.024
0.66ProTrp: 0.66 ± 0.01
1.341ProTyr: 1.341 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
2.173GlnAla: 2.173 ± 0.022
0.512GlnCys: 0.512 ± 0.011
1.408GlnAsp: 1.408 ± 0.015
2.025GlnGlu: 2.025 ± 0.023
1.298GlnPhe: 1.298 ± 0.016
1.868GlnGly: 1.868 ± 0.019
0.806GlnHis: 0.806 ± 0.012
1.95GlnIle: 1.95 ± 0.019
2.066GlnLys: 2.066 ± 0.02
3.306GlnLeu: 3.306 ± 0.029
0.861GlnMet: 0.861 ± 0.014
1.431GlnAsn: 1.431 ± 0.017
1.511GlnPro: 1.511 ± 0.018
1.901GlnGln: 1.901 ± 0.034
2.138GlnArg: 2.138 ± 0.025
2.401GlnSer: 2.401 ± 0.025
1.405GlnThr: 1.405 ± 0.015
2.187GlnVal: 2.187 ± 0.018
0.428GlnTrp: 0.428 ± 0.008
0.868GlnTyr: 0.868 ± 0.014
0.0GlnXaa: 0.0 ± 0.0
Arg
3.879ArgAla: 3.879 ± 0.029
1.107ArgCys: 1.107 ± 0.016
3.115ArgAsp: 3.115 ± 0.027
3.701ArgGlu: 3.701 ± 0.028
2.607ArgPhe: 2.607 ± 0.024
3.756ArgGly: 3.756 ± 0.033
1.387ArgHis: 1.387 ± 0.015
3.515ArgIle: 3.515 ± 0.028
4.088ArgLys: 4.088 ± 0.025
5.548ArgLeu: 5.548 ± 0.034
1.426ArgMet: 1.426 ± 0.016
2.815ArgAsn: 2.815 ± 0.02
2.514ArgPro: 2.514 ± 0.021
1.834ArgGln: 1.834 ± 0.018
5.242ArgArg: 5.242 ± 0.044
4.867ArgSer: 4.867 ± 0.034
2.567ArgThr: 2.567 ± 0.019
3.672ArgVal: 3.672 ± 0.027
0.852ArgTrp: 0.852 ± 0.015
1.699ArgTyr: 1.699 ± 0.018
0.0ArgXaa: 0.0 ± 0.0
Ser
5.932SerAla: 5.932 ± 0.039
1.606SerCys: 1.606 ± 0.018
4.677SerAsp: 4.677 ± 0.032
4.993SerGlu: 4.993 ± 0.035
3.874SerPhe: 3.874 ± 0.027
6.369SerGly: 6.369 ± 0.03
1.881SerHis: 1.881 ± 0.019
4.394SerIle: 4.394 ± 0.031
4.43SerLys: 4.43 ± 0.033
8.261SerLeu: 8.261 ± 0.043
1.841SerMet: 1.841 ± 0.018
3.307SerAsn: 3.307 ± 0.029
4.422SerPro: 4.422 ± 0.045
2.568SerGln: 2.568 ± 0.025
5.001SerArg: 5.001 ± 0.035
10.767SerSer: 10.767 ± 0.063
4.012SerThr: 4.012 ± 0.031
5.64SerVal: 5.64 ± 0.037
1.234SerTrp: 1.234 ± 0.015
2.263SerTyr: 2.263 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
3.803ThrAla: 3.803 ± 0.029
0.843ThrCys: 0.843 ± 0.014
2.21ThrAsp: 2.21 ± 0.021
2.604ThrGlu: 2.604 ± 0.024
1.946ThrPhe: 1.946 ± 0.02
3.351ThrGly: 3.351 ± 0.027
0.908ThrHis: 0.908 ± 0.013
2.384ThrIle: 2.384 ± 0.02
2.23ThrLys: 2.23 ± 0.018
4.373ThrLeu: 4.373 ± 0.031
0.98ThrMet: 0.98 ± 0.014
1.609ThrAsn: 1.609 ± 0.017
2.425ThrPro: 2.425 ± 0.022
1.238ThrGln: 1.238 ± 0.014
2.417ThrArg: 2.417 ± 0.019
3.875ThrSer: 3.875 ± 0.029
2.641ThrThr: 2.641 ± 0.024
3.485ThrVal: 3.485 ± 0.024
0.636ThrTrp: 0.636 ± 0.01
1.341ThrTyr: 1.341 ± 0.018
0.0ThrXaa: 0.0 ± 0.0
Val
5.393ValAla: 5.393 ± 0.033
1.188ValCys: 1.188 ± 0.016
4.029ValAsp: 4.029 ± 0.028
4.651ValGlu: 4.651 ± 0.033
3.033ValPhe: 3.033 ± 0.024
4.468ValGly: 4.468 ± 0.031
1.535ValHis: 1.535 ± 0.017
3.534ValIle: 3.534 ± 0.03
3.787ValLys: 3.787 ± 0.027
6.543ValLeu: 6.543 ± 0.037
1.535ValMet: 1.535 ± 0.016
2.48ValAsn: 2.48 ± 0.022
3.184ValPro: 3.184 ± 0.024
2.075ValGln: 2.075 ± 0.021
3.519ValArg: 3.519 ± 0.027
5.729ValSer: 5.729 ± 0.037
3.164ValThr: 3.164 ± 0.027
5.602ValVal: 5.602 ± 0.038
0.835ValTrp: 0.835 ± 0.014
2.049ValTyr: 2.049 ± 0.022
0.0ValXaa: 0.0 ± 0.0
Trp
0.815TrpAla: 0.815 ± 0.011
0.242TrpCys: 0.242 ± 0.007
0.759TrpAsp: 0.759 ± 0.013
0.81TrpGlu: 0.81 ± 0.012
0.579TrpPhe: 0.579 ± 0.011
0.803TrpGly: 0.803 ± 0.012
0.305TrpHis: 0.305 ± 0.008
0.804TrpIle: 0.804 ± 0.012
0.919TrpLys: 0.919 ± 0.013
1.263TrpLeu: 1.263 ± 0.018
0.343TrpMet: 0.343 ± 0.008
0.734TrpAsn: 0.734 ± 0.012
0.521TrpPro: 0.521 ± 0.009
0.416TrpGln: 0.416 ± 0.009
0.944TrpArg: 0.944 ± 0.013
1.004TrpSer: 1.004 ± 0.015
0.632TrpThr: 0.632 ± 0.01
0.733TrpVal: 0.733 ± 0.012
0.267TrpTrp: 0.267 ± 0.007
0.366TrpTyr: 0.366 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.015TyrAla: 2.015 ± 0.018
0.624TyrCys: 0.624 ± 0.011
1.626TyrAsp: 1.626 ± 0.017
1.65TyrGlu: 1.65 ± 0.017
1.355TyrPhe: 1.355 ± 0.017
2.284TyrGly: 2.284 ± 0.024
0.695TyrHis: 0.695 ± 0.012
1.419TyrIle: 1.419 ± 0.017
1.317TyrLys: 1.317 ± 0.015
2.806TyrLeu: 2.806 ± 0.025
0.619TyrMet: 0.619 ± 0.011
1.193TyrAsn: 1.193 ± 0.016
1.262TyrPro: 1.262 ± 0.018
0.88TyrGln: 0.88 ± 0.012
1.797TyrArg: 1.797 ± 0.019
2.289TyrSer: 2.289 ± 0.024
1.298TyrThr: 1.298 ± 0.017
1.957TyrVal: 1.957 ± 0.019
0.411TyrTrp: 0.411 ± 0.008
0.977TyrTyr: 0.977 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17675 proteins (5688215 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski