Amino acid dipepetide frequency for Cyclovirus Equ1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
0.0AlaAsp: 0.0 ± 0.0
1.859AlaGlu: 1.859 ± 1.183
1.859AlaPhe: 1.859 ± 1.197
1.859AlaGly: 1.859 ± 1.197
1.859AlaHis: 1.859 ± 1.197
3.717AlaIle: 3.717 ± 0.013
3.717AlaLys: 3.717 ± 2.367
3.717AlaLeu: 3.717 ± 2.367
0.0AlaMet: 0.0 ± 0.0
7.435AlaAsn: 7.435 ± 4.786
0.0AlaPro: 0.0 ± 0.0
1.859AlaGln: 1.859 ± 1.183
0.0AlaArg: 0.0 ± 0.0
3.717AlaSer: 3.717 ± 0.013
1.859AlaThr: 1.859 ± 1.197
9.294AlaVal: 9.294 ± 5.983
0.0AlaTrp: 0.0 ± 0.0
3.717AlaTyr: 3.717 ± 2.393
0.0AlaXaa: 0.0 ± 0.0
Cys
1.859CysAla: 1.859 ± 1.183
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
3.717CysGlu: 3.717 ± 2.367
1.859CysPhe: 1.859 ± 1.183
1.859CysGly: 1.859 ± 1.183
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.859CysLys: 1.859 ± 1.183
1.859CysLeu: 1.859 ± 1.183
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.859CysPro: 1.859 ± 1.183
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
1.859CysThr: 1.859 ± 1.183
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.859AspAla: 1.859 ± 1.197
0.0AspCys: 0.0 ± 0.0
1.859AspAsp: 1.859 ± 1.183
5.576AspGlu: 5.576 ± 1.17
3.717AspPhe: 3.717 ± 0.013
1.859AspGly: 1.859 ± 1.183
0.0AspHis: 0.0 ± 0.0
3.717AspIle: 3.717 ± 2.367
1.859AspLys: 1.859 ± 1.197
0.0AspLeu: 0.0 ± 0.0
3.717AspMet: 3.717 ± 2.393
0.0AspAsn: 0.0 ± 0.0
1.859AspPro: 1.859 ± 1.197
0.0AspGln: 0.0 ± 0.0
1.859AspArg: 1.859 ± 1.183
0.0AspSer: 0.0 ± 0.0
0.0AspThr: 0.0 ± 0.0
1.859AspVal: 1.859 ± 1.197
1.859AspTrp: 1.859 ± 1.183
3.717AspTyr: 3.717 ± 2.367
0.0AspXaa: 0.0 ± 0.0
Glu
3.717GluAla: 3.717 ± 0.013
0.0GluCys: 0.0 ± 0.0
1.859GluAsp: 1.859 ± 1.183
3.717GluGlu: 3.717 ± 0.013
0.0GluPhe: 0.0 ± 0.0
0.0GluGly: 0.0 ± 0.0
0.0GluHis: 0.0 ± 0.0
3.717GluIle: 3.717 ± 0.013
0.0GluLys: 0.0 ± 0.0
7.435GluLeu: 7.435 ± 2.353
0.0GluMet: 0.0 ± 0.0
3.717GluAsn: 3.717 ± 2.393
5.576GluPro: 5.576 ± 1.17
3.717GluGln: 3.717 ± 0.013
3.717GluArg: 3.717 ± 2.367
3.717GluSer: 3.717 ± 0.013
5.576GluThr: 5.576 ± 3.55
3.717GluVal: 3.717 ± 2.367
1.859GluTrp: 1.859 ± 1.183
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
5.576PheAla: 5.576 ± 1.21
0.0PheCys: 0.0 ± 0.0
1.859PheAsp: 1.859 ± 1.183
0.0PheGlu: 0.0 ± 0.0
0.0PhePhe: 0.0 ± 0.0
3.717PheGly: 3.717 ± 0.013
0.0PheHis: 0.0 ± 0.0
3.717PheIle: 3.717 ± 0.013
5.576PheLys: 5.576 ± 1.21
1.859PheLeu: 1.859 ± 1.183
0.0PheMet: 0.0 ± 0.0
7.435PheAsn: 7.435 ± 0.027
0.0PhePro: 0.0 ± 0.0
0.0PheGln: 0.0 ± 0.0
3.717PheArg: 3.717 ± 2.393
1.859PheSer: 1.859 ± 1.197
7.435PheThr: 7.435 ± 0.027
1.859PheVal: 1.859 ± 1.183
0.0PheTrp: 0.0 ± 0.0
1.859PheTyr: 1.859 ± 1.183
0.0PheXaa: 0.0 ± 0.0
Gly
1.859GlyAla: 1.859 ± 1.197
0.0GlyCys: 0.0 ± 0.0
3.717GlyAsp: 3.717 ± 0.013
5.576GlyGlu: 5.576 ± 1.17
1.859GlyPhe: 1.859 ± 1.197
3.717GlyGly: 3.717 ± 0.013
0.0GlyHis: 0.0 ± 0.0
1.859GlyIle: 1.859 ± 1.183
9.294GlyLys: 9.294 ± 5.917
3.717GlyLeu: 3.717 ± 0.013
0.0GlyMet: 0.0 ± 0.0
1.859GlyAsn: 1.859 ± 1.197
0.0GlyPro: 0.0 ± 0.0
1.859GlyGln: 1.859 ± 1.183
0.0GlyArg: 0.0 ± 0.0
3.717GlySer: 3.717 ± 2.367
11.152GlyThr: 11.152 ± 2.34
1.859GlyVal: 1.859 ± 1.197
3.717GlyTrp: 3.717 ± 2.367
7.435GlyTyr: 7.435 ± 2.353
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
1.859HisHis: 1.859 ± 1.183
1.859HisIle: 1.859 ± 1.183
1.859HisLys: 1.859 ± 1.197
1.859HisLeu: 1.859 ± 1.183
0.0HisMet: 0.0 ± 0.0
1.859HisAsn: 1.859 ± 1.197
1.859HisPro: 1.859 ± 1.197
1.859HisGln: 1.859 ± 1.197
3.717HisArg: 3.717 ± 2.367
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.859HisTyr: 1.859 ± 1.197
0.0HisXaa: 0.0 ± 0.0
Ile
3.717IleAla: 3.717 ± 0.013
1.859IleCys: 1.859 ± 1.183
3.717IleAsp: 3.717 ± 0.013
3.717IleGlu: 3.717 ± 0.013
1.859IlePhe: 1.859 ± 1.183
3.717IleGly: 3.717 ± 2.367
0.0IleHis: 0.0 ± 0.0
3.717IleIle: 3.717 ± 0.013
1.859IleLys: 1.859 ± 1.183
1.859IleLeu: 1.859 ± 1.183
0.0IleMet: 0.0 ± 0.0
1.859IleAsn: 1.859 ± 1.197
1.859IlePro: 1.859 ± 1.197
0.0IleGln: 0.0 ± 0.0
3.717IleArg: 3.717 ± 2.393
3.717IleSer: 3.717 ± 0.013
7.435IleThr: 7.435 ± 2.353
7.435IleVal: 7.435 ± 0.027
0.0IleTrp: 0.0 ± 0.0
5.576IleTyr: 5.576 ± 1.21
0.0IleXaa: 0.0 ± 0.0
Lys
3.717LysAla: 3.717 ± 2.393
1.859LysCys: 1.859 ± 1.183
0.0LysAsp: 0.0 ± 0.0
5.576LysGlu: 5.576 ± 3.55
5.576LysPhe: 5.576 ± 1.17
7.435LysGly: 7.435 ± 2.353
1.859LysHis: 1.859 ± 1.183
7.435LysIle: 7.435 ± 4.786
3.717LysLys: 3.717 ± 2.367
1.859LysLeu: 1.859 ± 1.183
1.859LysMet: 1.859 ± 0.923
0.0LysAsn: 0.0 ± 0.0
5.576LysPro: 5.576 ± 1.17
3.717LysGln: 3.717 ± 2.393
3.717LysArg: 3.717 ± 0.013
7.435LysSer: 7.435 ± 4.733
3.717LysThr: 3.717 ± 2.367
3.717LysVal: 3.717 ± 2.393
1.859LysTrp: 1.859 ± 1.183
5.576LysTyr: 5.576 ± 1.17
0.0LysXaa: 0.0 ± 0.0
Leu
1.859LeuAla: 1.859 ± 1.183
1.859LeuCys: 1.859 ± 1.183
0.0LeuAsp: 0.0 ± 0.0
1.859LeuGlu: 1.859 ± 1.183
3.717LeuPhe: 3.717 ± 2.367
5.576LeuGly: 5.576 ± 1.21
0.0LeuHis: 0.0 ± 0.0
1.859LeuIle: 1.859 ± 1.197
3.717LeuLys: 3.717 ± 2.367
1.859LeuLeu: 1.859 ± 1.183
0.0LeuMet: 0.0 ± 0.0
7.435LeuAsn: 7.435 ± 0.027
5.576LeuPro: 5.576 ± 1.21
3.717LeuGln: 3.717 ± 2.367
9.294LeuArg: 9.294 ± 1.157
0.0LeuSer: 0.0 ± 0.0
0.0LeuThr: 0.0 ± 0.0
3.717LeuVal: 3.717 ± 2.393
0.0LeuTrp: 0.0 ± 0.0
3.717LeuTyr: 3.717 ± 0.013
0.0LeuXaa: 0.0 ± 0.0
Met
3.717MetAla: 3.717 ± 0.013
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
1.859MetPhe: 1.859 ± 1.197
0.0MetGly: 0.0 ± 0.0
1.859MetHis: 1.859 ± 1.197
0.0MetIle: 0.0 ± 0.0
3.717MetLys: 3.717 ± 0.013
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.927
1.859MetAsn: 1.859 ± 1.197
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.859MetArg: 1.859 ± 1.197
3.717MetSer: 3.717 ± 2.393
1.859MetThr: 1.859 ± 1.197
3.717MetVal: 3.717 ± 0.013
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.717AsnAla: 3.717 ± 2.393
0.0AsnCys: 0.0 ± 0.0
3.717AsnAsp: 3.717 ± 2.393
5.576AsnGlu: 5.576 ± 1.17
1.859AsnPhe: 1.859 ± 1.197
1.859AsnGly: 1.859 ± 1.183
0.0AsnHis: 0.0 ± 0.0
0.0AsnIle: 0.0 ± 0.0
3.717AsnLys: 3.717 ± 0.013
1.859AsnLeu: 1.859 ± 1.197
0.0AsnMet: 0.0 ± 0.0
7.435AsnAsn: 7.435 ± 2.407
1.859AsnPro: 1.859 ± 1.197
1.859AsnGln: 1.859 ± 1.197
3.717AsnArg: 3.717 ± 0.013
1.859AsnSer: 1.859 ± 1.197
5.576AsnThr: 5.576 ± 3.59
3.717AsnVal: 3.717 ± 2.367
1.859AsnTrp: 1.859 ± 1.197
7.435AsnTyr: 7.435 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
1.859ProAla: 1.859 ± 1.183
0.0ProCys: 0.0 ± 0.0
1.859ProAsp: 1.859 ± 1.197
3.717ProGlu: 3.717 ± 0.013
0.0ProPhe: 0.0 ± 0.0
0.0ProGly: 0.0 ± 0.0
1.859ProHis: 1.859 ± 1.183
0.0ProIle: 0.0 ± 0.0
3.717ProLys: 3.717 ± 0.013
1.859ProLeu: 1.859 ± 1.183
3.717ProMet: 3.717 ± 0.013
1.859ProAsn: 1.859 ± 1.183
0.0ProPro: 0.0 ± 0.0
5.576ProGln: 5.576 ± 1.21
7.435ProArg: 7.435 ± 2.407
3.717ProSer: 3.717 ± 2.393
3.717ProThr: 3.717 ± 2.367
5.576ProVal: 5.576 ± 1.21
1.859ProTrp: 1.859 ± 1.197
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
1.859GlnGlu: 1.859 ± 1.197
1.859GlnPhe: 1.859 ± 1.183
3.717GlnGly: 3.717 ± 0.013
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
3.717GlnLys: 3.717 ± 0.013
7.435GlnLeu: 7.435 ± 4.786
1.859GlnMet: 1.859 ± 1.197
3.717GlnAsn: 3.717 ± 0.013
1.859GlnPro: 1.859 ± 1.183
3.717GlnGln: 3.717 ± 2.367
5.576GlnArg: 5.576 ± 1.21
0.0GlnSer: 0.0 ± 0.0
1.859GlnThr: 1.859 ± 1.183
1.859GlnVal: 1.859 ± 1.197
0.0GlnTrp: 0.0 ± 0.0
1.859GlnTyr: 1.859 ± 1.197
0.0GlnXaa: 0.0 ± 0.0
Arg
1.859ArgAla: 1.859 ± 1.197
1.859ArgCys: 1.859 ± 1.183
1.859ArgAsp: 1.859 ± 1.183
0.0ArgGlu: 0.0 ± 0.0
5.576ArgPhe: 5.576 ± 1.17
5.576ArgGly: 5.576 ± 3.55
1.859ArgHis: 1.859 ± 1.183
7.435ArgIle: 7.435 ± 0.027
7.435ArgLys: 7.435 ± 0.027
3.717ArgLeu: 3.717 ± 2.393
3.717ArgMet: 3.717 ± 2.393
0.0ArgAsn: 0.0 ± 0.0
3.717ArgPro: 3.717 ± 2.393
5.576ArgGln: 5.576 ± 3.59
13.011ArgArg: 13.011 ± 5.996
0.0ArgSer: 0.0 ± 0.0
5.576ArgThr: 5.576 ± 1.21
1.859ArgVal: 1.859 ± 1.183
0.0ArgTrp: 0.0 ± 0.0
7.435ArgTyr: 7.435 ± 2.407
0.0ArgXaa: 0.0 ± 0.0
Ser
1.859SerAla: 1.859 ± 1.183
0.0SerCys: 0.0 ± 0.0
0.0SerAsp: 0.0 ± 0.0
1.859SerGlu: 1.859 ± 1.197
0.0SerPhe: 0.0 ± 0.0
3.717SerGly: 3.717 ± 2.367
1.859SerHis: 1.859 ± 1.183
0.0SerIle: 0.0 ± 0.0
1.859SerLys: 1.859 ± 1.197
0.0SerLeu: 0.0 ± 0.0
0.0SerMet: 0.0 ± 0.0
3.717SerAsn: 3.717 ± 0.013
1.859SerPro: 1.859 ± 1.183
1.859SerGln: 1.859 ± 1.197
3.717SerArg: 3.717 ± 0.013
7.435SerSer: 7.435 ± 4.786
14.87SerThr: 14.87 ± 2.433
1.859SerVal: 1.859 ± 1.183
1.859SerTrp: 1.859 ± 1.197
3.717SerTyr: 3.717 ± 2.393
0.0SerXaa: 0.0 ± 0.0
Thr
1.859ThrAla: 1.859 ± 1.197
0.0ThrCys: 0.0 ± 0.0
5.576ThrAsp: 5.576 ± 1.21
3.717ThrGlu: 3.717 ± 2.367
5.576ThrPhe: 5.576 ± 1.17
11.152ThrGly: 11.152 ± 2.34
0.0ThrHis: 0.0 ± 0.0
5.576ThrIle: 5.576 ± 1.17
9.294ThrLys: 9.294 ± 1.223
13.011ThrLeu: 13.011 ± 3.523
0.0ThrMet: 0.0 ± 0.0
3.717ThrAsn: 3.717 ± 0.013
5.576ThrPro: 5.576 ± 1.17
1.859ThrGln: 1.859 ± 1.197
5.576ThrArg: 5.576 ± 1.21
1.859ThrSer: 1.859 ± 1.183
3.717ThrThr: 3.717 ± 0.013
0.0ThrVal: 0.0 ± 0.0
0.0ThrTrp: 0.0 ± 0.0
7.435ThrTyr: 7.435 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
5.576ValAla: 5.576 ± 3.59
3.717ValCys: 3.717 ± 2.367
1.859ValAsp: 1.859 ± 1.197
0.0ValGlu: 0.0 ± 0.0
3.717ValPhe: 3.717 ± 2.393
3.717ValGly: 3.717 ± 0.013
3.717ValHis: 3.717 ± 2.393
5.576ValIle: 5.576 ± 1.17
3.717ValLys: 3.717 ± 2.367
1.859ValLeu: 1.859 ± 1.197
3.717ValMet: 3.717 ± 2.393
1.859ValAsn: 1.859 ± 1.197
7.435ValPro: 7.435 ± 2.407
0.0ValGln: 0.0 ± 0.0
1.859ValArg: 1.859 ± 1.183
1.859ValSer: 1.859 ± 1.197
5.576ValThr: 5.576 ± 1.21
3.717ValVal: 3.717 ± 0.013
0.0ValTrp: 0.0 ± 0.0
1.859ValTyr: 1.859 ± 1.183
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
1.859TrpCys: 1.859 ± 1.183
1.859TrpAsp: 1.859 ± 1.183
0.0TrpGlu: 0.0 ± 0.0
1.859TrpPhe: 1.859 ± 1.197
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
3.717TrpIle: 3.717 ± 0.013
1.859TrpLys: 1.859 ± 1.183
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.859TrpSer: 1.859 ± 1.197
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
1.859TrpTrp: 1.859 ± 1.183
1.859TrpTyr: 1.859 ± 1.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.859TyrAla: 1.859 ± 1.197
3.717TyrCys: 3.717 ± 2.367
5.576TyrAsp: 5.576 ± 3.55
3.717TyrGlu: 3.717 ± 0.013
3.717TyrPhe: 3.717 ± 2.393
3.717TyrGly: 3.717 ± 0.013
1.859TyrHis: 1.859 ± 1.197
3.717TyrIle: 3.717 ± 2.367
3.717TyrLys: 3.717 ± 0.013
0.0TyrLeu: 0.0 ± 0.0
5.576TyrMet: 5.576 ± 1.21
1.859TyrAsn: 1.859 ± 1.183
1.859TyrPro: 1.859 ± 1.183
3.717TyrGln: 3.717 ± 0.013
5.576TyrArg: 5.576 ± 3.59
5.576TyrSer: 5.576 ± 1.21
3.717TyrThr: 3.717 ± 2.367
5.576TyrVal: 5.576 ± 3.59
0.0TyrTrp: 0.0 ± 0.0
1.859TyrTyr: 1.859 ± 1.183
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (539 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski