Amino acid dipepetide frequency for Podoviridae sp. ctbj_2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.674AlaAla: 8.674 ± 1.37
0.734AlaCys: 0.734 ± 0.227
4.27AlaAsp: 4.27 ± 0.528
5.738AlaGlu: 5.738 ± 0.751
3.737AlaPhe: 3.737 ± 0.488
6.406AlaGly: 6.406 ± 0.626
1.401AlaHis: 1.401 ± 0.256
4.537AlaIle: 4.537 ± 0.509
5.004AlaLys: 5.004 ± 0.721
5.471AlaLeu: 5.471 ± 0.563
2.068AlaMet: 2.068 ± 0.356
4.604AlaAsn: 4.604 ± 0.624
3.336AlaPro: 3.336 ± 0.552
4.137AlaGln: 4.137 ± 0.743
4.804AlaArg: 4.804 ± 0.626
5.405AlaSer: 5.405 ± 0.761
4.604AlaThr: 4.604 ± 0.617
5.805AlaVal: 5.805 ± 0.661
1.068AlaTrp: 1.068 ± 0.252
3.27AlaTyr: 3.27 ± 0.427
0.0AlaXaa: 0.0 ± 0.0
Cys
0.4CysAla: 0.4 ± 0.213
0.334CysCys: 0.334 ± 0.135
0.4CysAsp: 0.4 ± 0.205
0.467CysGlu: 0.467 ± 0.224
0.467CysPhe: 0.467 ± 0.17
0.534CysGly: 0.534 ± 0.261
0.534CysHis: 0.534 ± 0.284
1.201CysIle: 1.201 ± 0.369
0.601CysLys: 0.601 ± 0.247
1.268CysLeu: 1.268 ± 0.406
0.334CysMet: 0.334 ± 0.144
0.667CysAsn: 0.667 ± 0.251
0.467CysPro: 0.467 ± 0.181
0.4CysGln: 0.4 ± 0.192
0.667CysArg: 0.667 ± 0.238
0.801CysSer: 0.801 ± 0.299
0.2CysThr: 0.2 ± 0.118
0.801CysVal: 0.801 ± 0.244
0.067CysTrp: 0.067 ± 0.072
0.601CysTyr: 0.601 ± 0.224
0.0CysXaa: 0.0 ± 0.0
Asp
4.537AspAla: 4.537 ± 0.486
0.467AspCys: 0.467 ± 0.2
3.403AspAsp: 3.403 ± 0.517
4.804AspGlu: 4.804 ± 0.594
2.869AspPhe: 2.869 ± 0.505
4.537AspGly: 4.537 ± 0.546
1.334AspHis: 1.334 ± 0.346
3.069AspIle: 3.069 ± 0.482
4.137AspLys: 4.137 ± 0.475
4.204AspLeu: 4.204 ± 0.534
1.868AspMet: 1.868 ± 0.484
2.802AspAsn: 2.802 ± 0.484
2.402AspPro: 2.402 ± 0.397
1.268AspGln: 1.268 ± 0.28
2.869AspArg: 2.869 ± 0.502
3.27AspSer: 3.27 ± 0.538
2.936AspThr: 2.936 ± 0.367
4.07AspVal: 4.07 ± 0.516
1.201AspTrp: 1.201 ± 0.335
2.002AspTyr: 2.002 ± 0.325
0.0AspXaa: 0.0 ± 0.0
Glu
6.072GluAla: 6.072 ± 0.786
0.734GluCys: 0.734 ± 0.338
4.471GluAsp: 4.471 ± 0.584
4.204GluGlu: 4.204 ± 0.553
3.003GluPhe: 3.003 ± 0.426
4.671GluGly: 4.671 ± 0.621
1.401GluHis: 1.401 ± 0.309
3.67GluIle: 3.67 ± 0.458
4.003GluLys: 4.003 ± 0.592
4.938GluLeu: 4.938 ± 0.575
2.135GluMet: 2.135 ± 0.4
3.536GluAsn: 3.536 ± 0.438
1.201GluPro: 1.201 ± 0.311
3.403GluGln: 3.403 ± 0.479
4.204GluArg: 4.204 ± 0.616
3.27GluSer: 3.27 ± 0.441
3.203GluThr: 3.203 ± 0.426
3.87GluVal: 3.87 ± 0.481
1.134GluTrp: 1.134 ± 0.262
3.003GluTyr: 3.003 ± 0.486
0.0GluXaa: 0.0 ± 0.0
Phe
2.335PheAla: 2.335 ± 0.414
0.867PheCys: 0.867 ± 0.284
2.536PheAsp: 2.536 ± 0.461
2.402PheGlu: 2.402 ± 0.438
1.735PhePhe: 1.735 ± 0.501
3.403PheGly: 3.403 ± 0.45
0.534PheHis: 0.534 ± 0.167
2.669PheIle: 2.669 ± 0.433
2.602PheLys: 2.602 ± 0.452
3.003PheLeu: 3.003 ± 0.443
1.001PheMet: 1.001 ± 0.274
1.668PheAsn: 1.668 ± 0.305
1.001PhePro: 1.001 ± 0.262
1.268PheGln: 1.268 ± 0.282
2.335PheArg: 2.335 ± 0.353
3.67PheSer: 3.67 ± 0.64
2.669PheThr: 2.669 ± 0.398
1.935PheVal: 1.935 ± 0.406
0.534PheTrp: 0.534 ± 0.144
1.668PheTyr: 1.668 ± 0.408
0.0PheXaa: 0.0 ± 0.0
Gly
4.671GlyAla: 4.671 ± 0.552
0.867GlyCys: 0.867 ± 0.327
5.004GlyAsp: 5.004 ± 0.539
4.804GlyGlu: 4.804 ± 0.516
3.87GlyPhe: 3.87 ± 0.474
5.138GlyGly: 5.138 ± 0.565
1.334GlyHis: 1.334 ± 0.283
3.47GlyIle: 3.47 ± 0.494
4.337GlyLys: 4.337 ± 0.637
5.271GlyLeu: 5.271 ± 0.432
2.736GlyMet: 2.736 ± 0.489
3.937GlyAsn: 3.937 ± 0.512
1.268GlyPro: 1.268 ± 0.213
1.535GlyGln: 1.535 ± 0.389
4.337GlyArg: 4.337 ± 0.48
5.338GlySer: 5.338 ± 0.608
5.071GlyThr: 5.071 ± 0.792
6.005GlyVal: 6.005 ± 0.812
1.868GlyTrp: 1.868 ± 0.262
2.936GlyTyr: 2.936 ± 0.414
0.0GlyXaa: 0.0 ± 0.0
His
1.201HisAla: 1.201 ± 0.293
0.534HisCys: 0.534 ± 0.251
0.867HisAsp: 0.867 ± 0.266
1.134HisGlu: 1.134 ± 0.302
0.734HisPhe: 0.734 ± 0.247
1.068HisGly: 1.068 ± 0.237
0.734HisHis: 0.734 ± 0.269
1.401HisIle: 1.401 ± 0.342
1.468HisLys: 1.468 ± 0.356
1.401HisLeu: 1.401 ± 0.377
0.667HisMet: 0.667 ± 0.176
1.201HisAsn: 1.201 ± 0.392
0.734HisPro: 0.734 ± 0.304
1.268HisGln: 1.268 ± 0.36
1.668HisArg: 1.668 ± 0.338
1.068HisSer: 1.068 ± 0.266
1.001HisThr: 1.001 ± 0.272
0.734HisVal: 0.734 ± 0.24
0.534HisTrp: 0.534 ± 0.22
0.934HisTyr: 0.934 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
4.404IleAla: 4.404 ± 0.575
0.867IleCys: 0.867 ± 0.247
3.937IleAsp: 3.937 ± 0.485
3.003IleGlu: 3.003 ± 0.474
1.468IlePhe: 1.468 ± 0.231
3.603IleGly: 3.603 ± 0.472
0.867IleHis: 0.867 ± 0.284
2.402IleIle: 2.402 ± 0.348
3.603IleLys: 3.603 ± 0.56
3.737IleLeu: 3.737 ± 0.545
1.601IleMet: 1.601 ± 0.398
2.536IleAsn: 2.536 ± 0.386
3.47IlePro: 3.47 ± 0.52
2.536IleGln: 2.536 ± 0.359
2.802IleArg: 2.802 ± 0.39
3.203IleSer: 3.203 ± 0.324
3.603IleThr: 3.603 ± 0.577
3.336IleVal: 3.336 ± 0.585
0.534IleTrp: 0.534 ± 0.155
1.535IleTyr: 1.535 ± 0.331
0.0IleXaa: 0.0 ± 0.0
Lys
5.471LysAla: 5.471 ± 0.812
0.467LysCys: 0.467 ± 0.199
4.137LysAsp: 4.137 ± 0.636
5.071LysGlu: 5.071 ± 0.82
1.735LysPhe: 1.735 ± 0.384
4.871LysGly: 4.871 ± 0.715
0.934LysHis: 0.934 ± 0.247
2.869LysIle: 2.869 ± 0.512
4.204LysLys: 4.204 ± 0.619
5.138LysLeu: 5.138 ± 0.614
1.735LysMet: 1.735 ± 0.398
3.203LysAsn: 3.203 ± 0.448
2.802LysPro: 2.802 ± 0.399
2.736LysGln: 2.736 ± 0.482
3.536LysArg: 3.536 ± 0.379
3.336LysSer: 3.336 ± 0.537
2.602LysThr: 2.602 ± 0.502
3.403LysVal: 3.403 ± 0.488
1.334LysTrp: 1.334 ± 0.316
2.602LysTyr: 2.602 ± 0.385
0.0LysXaa: 0.0 ± 0.0
Leu
6.939LeuAla: 6.939 ± 0.805
1.068LeuCys: 1.068 ± 0.358
4.137LeuAsp: 4.137 ± 0.655
5.605LeuGlu: 5.605 ± 0.719
3.069LeuPhe: 3.069 ± 0.485
5.205LeuGly: 5.205 ± 0.609
1.401LeuHis: 1.401 ± 0.333
3.803LeuIle: 3.803 ± 0.606
4.537LeuLys: 4.537 ± 0.533
6.472LeuLeu: 6.472 ± 0.805
1.935LeuMet: 1.935 ± 0.336
3.737LeuAsn: 3.737 ± 0.388
4.137LeuPro: 4.137 ± 0.551
3.136LeuGln: 3.136 ± 0.478
4.07LeuArg: 4.07 ± 0.544
5.471LeuSer: 5.471 ± 0.628
5.338LeuThr: 5.338 ± 0.549
4.471LeuVal: 4.471 ± 0.584
0.734LeuTrp: 0.734 ± 0.199
2.335LeuTyr: 2.335 ± 0.445
0.0LeuXaa: 0.0 ± 0.0
Met
2.869MetAla: 2.869 ± 0.575
0.334MetCys: 0.334 ± 0.159
1.601MetAsp: 1.601 ± 0.384
2.002MetGlu: 2.002 ± 0.394
1.201MetPhe: 1.201 ± 0.353
1.935MetGly: 1.935 ± 0.353
0.534MetHis: 0.534 ± 0.175
1.468MetIle: 1.468 ± 0.28
2.002MetLys: 2.002 ± 0.361
1.868MetLeu: 1.868 ± 0.38
1.001MetMet: 1.001 ± 0.28
1.601MetAsn: 1.601 ± 0.328
1.468MetPro: 1.468 ± 0.219
1.601MetGln: 1.601 ± 0.365
1.601MetArg: 1.601 ± 0.308
1.868MetSer: 1.868 ± 0.314
1.535MetThr: 1.535 ± 0.298
1.868MetVal: 1.868 ± 0.32
0.267MetTrp: 0.267 ± 0.133
1.134MetTyr: 1.134 ± 0.214
0.0MetXaa: 0.0 ± 0.0
Asn
4.337AsnAla: 4.337 ± 0.428
0.334AsnCys: 0.334 ± 0.192
2.469AsnAsp: 2.469 ± 0.295
2.402AsnGlu: 2.402 ± 0.36
1.868AsnPhe: 1.868 ± 0.459
4.27AsnGly: 4.27 ± 0.471
1.068AsnHis: 1.068 ± 0.297
2.536AsnIle: 2.536 ± 0.332
3.87AsnLys: 3.87 ± 0.586
4.604AsnLeu: 4.604 ± 0.521
1.401AsnMet: 1.401 ± 0.279
3.003AsnAsn: 3.003 ± 0.454
3.203AsnPro: 3.203 ± 0.434
2.469AsnGln: 2.469 ± 0.343
3.27AsnArg: 3.27 ± 0.387
3.203AsnSer: 3.203 ± 0.464
3.67AsnThr: 3.67 ± 0.476
3.069AsnVal: 3.069 ± 0.356
0.601AsnTrp: 0.601 ± 0.226
1.668AsnTyr: 1.668 ± 0.418
0.0AsnXaa: 0.0 ± 0.0
Pro
3.069ProAla: 3.069 ± 0.627
0.4ProCys: 0.4 ± 0.209
2.402ProAsp: 2.402 ± 0.392
4.003ProGlu: 4.003 ± 0.603
1.468ProPhe: 1.468 ± 0.283
2.402ProGly: 2.402 ± 0.359
0.934ProHis: 0.934 ± 0.203
2.536ProIle: 2.536 ± 0.505
2.669ProLys: 2.669 ± 0.392
2.736ProLeu: 2.736 ± 0.5
0.734ProMet: 0.734 ± 0.183
2.135ProAsn: 2.135 ± 0.371
1.068ProPro: 1.068 ± 0.251
1.802ProGln: 1.802 ± 0.327
1.001ProArg: 1.001 ± 0.225
2.335ProSer: 2.335 ± 0.485
2.068ProThr: 2.068 ± 0.365
3.336ProVal: 3.336 ± 0.446
0.534ProTrp: 0.534 ± 0.182
1.201ProTyr: 1.201 ± 0.319
0.0ProXaa: 0.0 ± 0.0
Gln
4.27GlnAla: 4.27 ± 0.753
0.267GlnCys: 0.267 ± 0.135
1.401GlnAsp: 1.401 ± 0.337
4.07GlnGlu: 4.07 ± 0.581
1.268GlnPhe: 1.268 ± 0.295
2.736GlnGly: 2.736 ± 0.374
0.601GlnHis: 0.601 ± 0.234
2.135GlnIle: 2.135 ± 0.425
2.202GlnLys: 2.202 ± 0.454
4.537GlnLeu: 4.537 ± 0.376
1.668GlnMet: 1.668 ± 0.245
2.002GlnAsn: 2.002 ± 0.388
1.401GlnPro: 1.401 ± 0.358
1.935GlnGln: 1.935 ± 0.416
2.536GlnArg: 2.536 ± 0.558
1.735GlnSer: 1.735 ± 0.42
1.668GlnThr: 1.668 ± 0.389
2.802GlnVal: 2.802 ± 0.401
0.601GlnTrp: 0.601 ± 0.208
1.802GlnTyr: 1.802 ± 0.314
0.0GlnXaa: 0.0 ± 0.0
Arg
5.938ArgAla: 5.938 ± 0.695
0.4ArgCys: 0.4 ± 0.179
3.536ArgAsp: 3.536 ± 0.584
3.47ArgGlu: 3.47 ± 0.511
1.735ArgPhe: 1.735 ± 0.33
3.803ArgGly: 3.803 ± 0.577
1.201ArgHis: 1.201 ± 0.315
3.47ArgIle: 3.47 ± 0.548
3.403ArgLys: 3.403 ± 0.656
4.003ArgLeu: 4.003 ± 0.491
2.335ArgMet: 2.335 ± 0.338
3.403ArgAsn: 3.403 ± 0.435
1.935ArgPro: 1.935 ± 0.367
2.402ArgGln: 2.402 ± 0.4
3.336ArgArg: 3.336 ± 0.487
2.402ArgSer: 2.402 ± 0.381
3.737ArgThr: 3.737 ± 0.512
3.136ArgVal: 3.136 ± 0.462
0.801ArgTrp: 0.801 ± 0.283
2.068ArgTyr: 2.068 ± 0.443
0.0ArgXaa: 0.0 ± 0.0
Ser
5.071SerAla: 5.071 ± 0.569
0.934SerCys: 0.934 ± 0.229
2.602SerAsp: 2.602 ± 0.363
3.336SerGlu: 3.336 ± 0.42
2.869SerPhe: 2.869 ± 0.543
5.205SerGly: 5.205 ± 0.785
1.668SerHis: 1.668 ± 0.438
3.403SerIle: 3.403 ± 0.458
3.136SerLys: 3.136 ± 0.479
5.271SerLeu: 5.271 ± 0.581
1.868SerMet: 1.868 ± 0.358
3.67SerAsn: 3.67 ± 0.558
2.202SerPro: 2.202 ± 0.36
3.203SerGln: 3.203 ± 0.512
3.603SerArg: 3.603 ± 0.635
3.403SerSer: 3.403 ± 0.564
2.869SerThr: 2.869 ± 0.404
3.87SerVal: 3.87 ± 0.554
0.734SerTrp: 0.734 ± 0.202
1.401SerTyr: 1.401 ± 0.292
0.0SerXaa: 0.0 ± 0.0
Thr
5.004ThrAla: 5.004 ± 0.618
0.267ThrCys: 0.267 ± 0.134
3.069ThrAsp: 3.069 ± 0.507
2.936ThrGlu: 2.936 ± 0.478
2.002ThrPhe: 2.002 ± 0.368
5.405ThrGly: 5.405 ± 0.83
1.068ThrHis: 1.068 ± 0.272
3.336ThrIle: 3.336 ± 0.512
3.403ThrLys: 3.403 ± 0.55
4.204ThrLeu: 4.204 ± 0.511
1.134ThrMet: 1.134 ± 0.258
3.069ThrAsn: 3.069 ± 0.379
2.602ThrPro: 2.602 ± 0.356
2.469ThrGln: 2.469 ± 0.45
2.536ThrArg: 2.536 ± 0.345
4.204ThrSer: 4.204 ± 0.54
3.87ThrThr: 3.87 ± 0.453
4.07ThrVal: 4.07 ± 0.654
0.667ThrTrp: 0.667 ± 0.161
1.401ThrTyr: 1.401 ± 0.325
0.0ThrXaa: 0.0 ± 0.0
Val
6.005ValAla: 6.005 ± 0.679
0.801ValCys: 0.801 ± 0.233
4.471ValAsp: 4.471 ± 0.641
3.47ValGlu: 3.47 ± 0.434
2.802ValPhe: 2.802 ± 0.429
4.804ValGly: 4.804 ± 0.525
1.802ValHis: 1.802 ± 0.391
2.602ValIle: 2.602 ± 0.468
3.336ValLys: 3.336 ± 0.503
4.27ValLeu: 4.27 ± 0.562
2.002ValMet: 2.002 ± 0.355
3.87ValAsn: 3.87 ± 0.523
2.135ValPro: 2.135 ± 0.442
2.536ValGln: 2.536 ± 0.498
4.137ValArg: 4.137 ± 0.589
3.47ValSer: 3.47 ± 0.46
3.803ValThr: 3.803 ± 0.724
4.871ValVal: 4.871 ± 0.64
1.134ValTrp: 1.134 ± 0.323
2.536ValTyr: 2.536 ± 0.427
0.0ValXaa: 0.0 ± 0.0
Trp
0.734TrpAla: 0.734 ± 0.259
0.067TrpCys: 0.067 ± 0.05
0.867TrpAsp: 0.867 ± 0.224
1.268TrpGlu: 1.268 ± 0.322
0.334TrpPhe: 0.334 ± 0.146
0.801TrpGly: 0.801 ± 0.194
0.534TrpHis: 0.534 ± 0.175
0.534TrpIle: 0.534 ± 0.174
1.802TrpLys: 1.802 ± 0.309
1.735TrpLeu: 1.735 ± 0.388
0.4TrpMet: 0.4 ± 0.167
0.667TrpAsn: 0.667 ± 0.205
0.4TrpPro: 0.4 ± 0.164
0.334TrpGln: 0.334 ± 0.136
1.134TrpArg: 1.134 ± 0.248
0.934TrpSer: 0.934 ± 0.204
0.801TrpThr: 0.801 ± 0.213
0.867TrpVal: 0.867 ± 0.236
0.067TrpTrp: 0.067 ± 0.077
0.4TrpTyr: 0.4 ± 0.155
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.069TyrAla: 3.069 ± 0.425
0.467TyrCys: 0.467 ± 0.214
2.469TyrAsp: 2.469 ± 0.367
1.935TyrGlu: 1.935 ± 0.428
1.601TyrPhe: 1.601 ± 0.418
3.003TyrGly: 3.003 ± 0.601
0.467TyrHis: 0.467 ± 0.21
1.935TyrIle: 1.935 ± 0.328
1.868TyrLys: 1.868 ± 0.451
3.47TyrLeu: 3.47 ± 0.629
1.068TyrMet: 1.068 ± 0.276
2.002TyrAsn: 2.002 ± 0.412
1.601TyrPro: 1.601 ± 0.31
1.201TyrGln: 1.201 ± 0.273
2.068TyrArg: 2.068 ± 0.371
1.935TyrSer: 1.935 ± 0.384
1.468TyrThr: 1.468 ± 0.261
2.602TyrVal: 2.602 ± 0.423
0.267TyrTrp: 0.267 ± 0.126
1.601TyrTyr: 1.601 ± 0.334
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (14988 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski