Amino acid dipepetide frequency for Macaca fascicularis papillomavirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.302AlaAla: 4.302 ± 1.459
1.173AlaCys: 1.173 ± 0.774
3.129AlaAsp: 3.129 ± 0.736
3.911AlaGlu: 3.911 ± 0.917
4.302AlaPhe: 4.302 ± 1.283
2.738AlaGly: 2.738 ± 1.32
0.0AlaHis: 0.0 ± 0.0
1.955AlaIle: 1.955 ± 0.691
3.911AlaLys: 3.911 ± 1.476
2.346AlaLeu: 2.346 ± 0.831
0.782AlaMet: 0.782 ± 0.38
1.173AlaAsn: 1.173 ± 0.613
4.693AlaPro: 4.693 ± 1.572
2.346AlaGln: 2.346 ± 1.136
6.257AlaArg: 6.257 ± 1.183
3.911AlaSer: 3.911 ± 1.417
6.648AlaThr: 6.648 ± 1.867
3.52AlaVal: 3.52 ± 1.114
0.782AlaTrp: 0.782 ± 0.614
2.738AlaTyr: 2.738 ± 1.22
0.0AlaXaa: 0.0 ± 0.0
Cys
1.564CysAla: 1.564 ± 1.011
0.782CysCys: 0.782 ± 0.539
0.0CysAsp: 0.0 ± 0.0
0.782CysGlu: 0.782 ± 0.38
1.173CysPhe: 1.173 ± 0.714
0.782CysGly: 0.782 ± 1.231
0.391CysHis: 0.391 ± 0.538
0.391CysIle: 0.391 ± 0.317
1.564CysLys: 1.564 ± 0.557
1.173CysLeu: 1.173 ± 1.032
0.0CysMet: 0.0 ± 0.0
0.782CysAsn: 0.782 ± 0.862
1.955CysPro: 1.955 ± 0.746
0.0CysGln: 0.0 ± 0.0
1.955CysArg: 1.955 ± 1.178
1.955CysSer: 1.955 ± 1.193
0.782CysThr: 0.782 ± 0.447
0.782CysVal: 0.782 ± 0.447
1.173CysTrp: 1.173 ± 0.542
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.693AspAla: 4.693 ± 0.974
0.782AspCys: 0.782 ± 0.614
2.738AspAsp: 2.738 ± 1.785
2.346AspGlu: 2.346 ± 0.862
1.955AspPhe: 1.955 ± 1.016
4.693AspGly: 4.693 ± 1.277
1.173AspHis: 1.173 ± 0.861
4.302AspIle: 4.302 ± 0.771
1.173AspLys: 1.173 ± 0.621
7.822AspLeu: 7.822 ± 2.043
1.564AspMet: 1.564 ± 0.674
1.955AspAsn: 1.955 ± 0.626
7.822AspPro: 7.822 ± 3.921
3.129AspGln: 3.129 ± 1.219
2.738AspArg: 2.738 ± 0.707
5.866AspSer: 5.866 ± 1.498
3.911AspThr: 3.911 ± 1.158
4.302AspVal: 4.302 ± 1.284
1.564AspTrp: 1.564 ± 0.939
1.173AspTyr: 1.173 ± 0.612
0.0AspXaa: 0.0 ± 0.0
Glu
2.346GluAla: 2.346 ± 0.71
2.346GluCys: 2.346 ± 1.461
4.302GluAsp: 4.302 ± 1.303
5.475GluGlu: 5.475 ± 2.969
1.173GluPhe: 1.173 ± 0.542
3.911GluGly: 3.911 ± 1.286
1.564GluHis: 1.564 ± 0.269
3.129GluIle: 3.129 ± 1.277
2.738GluLys: 2.738 ± 1.304
4.693GluLeu: 4.693 ± 1.591
0.782GluMet: 0.782 ± 0.536
4.302GluAsn: 4.302 ± 0.701
5.475GluPro: 5.475 ± 1.948
3.52GluGln: 3.52 ± 0.862
3.129GluArg: 3.129 ± 1.328
1.564GluSer: 1.564 ± 0.774
3.129GluThr: 3.129 ± 1.431
7.039GluVal: 7.039 ± 1.176
0.0GluTrp: 0.0 ± 0.0
1.173GluTyr: 1.173 ± 0.673
0.0GluXaa: 0.0 ± 0.0
Phe
1.564PheAla: 1.564 ± 0.808
0.391PheCys: 0.391 ± 0.538
2.738PheAsp: 2.738 ± 1.09
3.52PheGlu: 3.52 ± 1.534
1.173PhePhe: 1.173 ± 0.39
2.346PheGly: 2.346 ± 0.428
1.173PheHis: 1.173 ± 0.612
1.173PheIle: 1.173 ± 0.613
1.955PheLys: 1.955 ± 0.942
4.302PheLeu: 4.302 ± 0.862
0.391PheMet: 0.391 ± 0.574
2.346PheAsn: 2.346 ± 1.258
1.955PhePro: 1.955 ± 0.81
1.955PheGln: 1.955 ± 0.536
2.346PheArg: 2.346 ± 1.042
3.129PheSer: 3.129 ± 0.928
0.782PheThr: 0.782 ± 0.365
3.52PheVal: 3.52 ± 1.015
1.564PheTrp: 1.564 ± 0.759
1.955PheTyr: 1.955 ± 0.707
0.0PheXaa: 0.0 ± 0.0
Gly
3.911GlyAla: 3.911 ± 1.313
1.955GlyCys: 1.955 ± 0.536
7.431GlyAsp: 7.431 ± 1.255
3.911GlyGlu: 3.911 ± 0.885
1.173GlyPhe: 1.173 ± 0.952
8.604GlyGly: 8.604 ± 2.812
1.564GlyHis: 1.564 ± 0.9
2.738GlyIle: 2.738 ± 1.451
2.346GlyLys: 2.346 ± 0.843
3.911GlyLeu: 3.911 ± 1.121
0.782GlyMet: 0.782 ± 0.754
3.129GlyAsn: 3.129 ± 1.032
3.129GlyPro: 3.129 ± 1.015
3.911GlyGln: 3.911 ± 1.954
6.257GlyArg: 6.257 ± 1.654
5.084GlySer: 5.084 ± 1.219
3.911GlyThr: 3.911 ± 0.921
5.866GlyVal: 5.866 ± 1.251
0.391GlyTrp: 0.391 ± 0.538
2.346GlyTyr: 2.346 ± 0.972
0.0GlyXaa: 0.0 ± 0.0
His
0.782HisAla: 0.782 ± 0.404
1.173HisCys: 1.173 ± 0.79
0.391HisAsp: 0.391 ± 0.377
0.782HisGlu: 0.782 ± 0.614
0.782HisPhe: 0.782 ± 0.387
0.391HisGly: 0.391 ± 0.336
0.391HisHis: 0.391 ± 0.307
0.391HisIle: 0.391 ± 0.377
1.564HisLys: 1.564 ± 0.605
1.564HisLeu: 1.564 ± 0.817
0.391HisMet: 0.391 ± 0.317
0.782HisAsn: 0.782 ± 0.427
2.346HisPro: 2.346 ± 0.699
0.782HisGln: 0.782 ± 0.54
1.955HisArg: 1.955 ± 0.735
1.173HisSer: 1.173 ± 0.561
0.782HisThr: 0.782 ± 0.483
0.391HisVal: 0.391 ± 0.616
0.782HisTrp: 0.782 ± 0.404
1.564HisTyr: 1.564 ± 0.657
0.0HisXaa: 0.0 ± 0.0
Ile
3.129IleAla: 3.129 ± 1.017
0.782IleCys: 0.782 ± 0.586
2.738IleAsp: 2.738 ± 1.12
2.738IleGlu: 2.738 ± 0.503
1.955IlePhe: 1.955 ± 0.448
3.52IleGly: 3.52 ± 1.112
0.782IleHis: 0.782 ± 0.38
3.129IleIle: 3.129 ± 0.596
0.782IleLys: 0.782 ± 0.722
2.738IleLeu: 2.738 ± 0.827
1.173IleMet: 1.173 ± 0.637
1.173IleAsn: 1.173 ± 0.629
1.564IlePro: 1.564 ± 0.456
0.782IleGln: 0.782 ± 0.38
4.302IleArg: 4.302 ± 1.643
3.129IleSer: 3.129 ± 1.053
2.346IleThr: 2.346 ± 0.688
1.955IleVal: 1.955 ± 0.776
0.782IleTrp: 0.782 ± 0.614
2.346IleTyr: 2.346 ± 0.746
0.0IleXaa: 0.0 ± 0.0
Lys
1.955LysAla: 1.955 ± 0.527
1.173LysCys: 1.173 ± 0.612
3.129LysAsp: 3.129 ± 1.28
3.52LysGlu: 3.52 ± 1.423
1.955LysPhe: 1.955 ± 1.185
1.955LysGly: 1.955 ± 0.766
0.782LysHis: 0.782 ± 0.447
0.782LysIle: 0.782 ± 0.38
1.173LysLys: 1.173 ± 0.522
3.129LysLeu: 3.129 ± 1.062
0.391LysMet: 0.391 ± 0.317
1.173LysAsn: 1.173 ± 0.923
0.782LysPro: 0.782 ± 0.483
1.564LysGln: 1.564 ± 0.605
5.084LysArg: 5.084 ± 1.132
3.129LysSer: 3.129 ± 1.741
1.955LysThr: 1.955 ± 0.952
3.52LysVal: 3.52 ± 1.336
0.391LysTrp: 0.391 ± 0.424
2.346LysTyr: 2.346 ± 0.556
0.0LysXaa: 0.0 ± 0.0
Leu
3.911LeuAla: 3.911 ± 1.3
1.173LeuCys: 1.173 ± 0.835
7.039LeuAsp: 7.039 ± 1.829
6.257LeuGlu: 6.257 ± 1.924
4.693LeuPhe: 4.693 ± 1.068
6.648LeuGly: 6.648 ± 1.765
3.129LeuHis: 3.129 ± 1.021
2.346LeuIle: 2.346 ± 1.092
5.866LeuLys: 5.866 ± 1.388
11.341LeuLeu: 11.341 ± 1.531
1.955LeuMet: 1.955 ± 0.691
2.738LeuAsn: 2.738 ± 0.895
3.911LeuPro: 3.911 ± 1.356
5.475LeuGln: 5.475 ± 1.301
3.129LeuArg: 3.129 ± 1.134
9.386LeuSer: 9.386 ± 1.442
3.129LeuThr: 3.129 ± 1.053
3.52LeuVal: 3.52 ± 1.202
1.564LeuTrp: 1.564 ± 1.062
1.955LeuTyr: 1.955 ± 0.8
0.0LeuXaa: 0.0 ± 0.0
Met
1.173MetAla: 1.173 ± 0.561
0.0MetCys: 0.0 ± 0.0
0.391MetAsp: 0.391 ± 0.377
1.173MetGlu: 1.173 ± 0.714
0.391MetPhe: 0.391 ± 0.317
1.173MetGly: 1.173 ± 0.668
0.0MetHis: 0.0 ± 0.0
0.391MetIle: 0.391 ± 0.616
0.0MetLys: 0.0 ± 0.0
2.346MetLeu: 2.346 ± 1.093
0.0MetMet: 0.0 ± 0.0
0.782MetAsn: 0.782 ± 0.635
0.0MetPro: 0.0 ± 0.0
0.391MetGln: 0.391 ± 0.424
0.391MetArg: 0.391 ± 0.307
2.738MetSer: 2.738 ± 1.158
0.782MetThr: 0.782 ± 0.365
2.346MetVal: 2.346 ± 0.96
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.955AsnAla: 1.955 ± 0.441
1.173AsnCys: 1.173 ± 1.032
1.955AsnAsp: 1.955 ± 0.632
1.564AsnGlu: 1.564 ± 0.793
1.173AsnPhe: 1.173 ± 0.542
1.955AsnGly: 1.955 ± 0.738
0.391AsnHis: 0.391 ± 0.307
3.52AsnIle: 3.52 ± 1.146
1.955AsnLys: 1.955 ± 0.441
1.564AsnLeu: 1.564 ± 0.542
0.0AsnMet: 0.0 ± 0.0
1.564AsnAsn: 1.564 ± 0.9
2.738AsnPro: 2.738 ± 1.197
1.564AsnGln: 1.564 ± 0.9
2.738AsnArg: 2.738 ± 1.429
4.693AsnSer: 4.693 ± 2.181
3.129AsnThr: 3.129 ± 0.942
1.564AsnVal: 1.564 ± 0.557
0.391AsnTrp: 0.391 ± 0.317
1.173AsnTyr: 1.173 ± 0.688
0.0AsnXaa: 0.0 ± 0.0
Pro
5.475ProAla: 5.475 ± 0.808
1.564ProCys: 1.564 ± 1.089
7.431ProAsp: 7.431 ± 3.298
6.648ProGlu: 6.648 ± 1.892
1.173ProPhe: 1.173 ± 0.6
3.911ProGly: 3.911 ± 1.057
0.782ProHis: 0.782 ± 0.54
1.173ProIle: 1.173 ± 0.77
1.955ProLys: 1.955 ± 0.845
5.866ProLeu: 5.866 ± 1.733
0.0ProMet: 0.0 ± 0.0
2.346ProAsn: 2.346 ± 0.957
7.822ProPro: 7.822 ± 2.941
5.084ProGln: 5.084 ± 1.853
2.346ProArg: 2.346 ± 0.779
3.52ProSer: 3.52 ± 1.49
5.084ProThr: 5.084 ± 1.675
5.475ProVal: 5.475 ± 1.357
0.0ProTrp: 0.0 ± 0.0
1.173ProTyr: 1.173 ± 0.621
0.0ProXaa: 0.0 ± 0.0
Gln
0.782GlnAla: 0.782 ± 0.38
0.391GlnCys: 0.391 ± 0.377
3.129GlnAsp: 3.129 ± 0.954
3.129GlnGlu: 3.129 ± 1.197
3.52GlnPhe: 3.52 ± 0.853
3.911GlnGly: 3.911 ± 1.247
1.564GlnHis: 1.564 ± 0.908
1.564GlnIle: 1.564 ± 0.584
1.564GlnLys: 1.564 ± 0.74
5.475GlnLeu: 5.475 ± 1.434
1.173GlnMet: 1.173 ± 0.456
1.564GlnAsn: 1.564 ± 0.892
3.911GlnPro: 3.911 ± 1.607
3.52GlnGln: 3.52 ± 0.9
3.911GlnArg: 3.911 ± 1.059
2.738GlnSer: 2.738 ± 0.798
2.738GlnThr: 2.738 ± 1.206
4.693GlnVal: 4.693 ± 1.36
0.391GlnTrp: 0.391 ± 0.307
2.738GlnTyr: 2.738 ± 1.247
0.0GlnXaa: 0.0 ± 0.0
Arg
6.257ArgAla: 6.257 ± 1.313
0.782ArgCys: 0.782 ± 0.586
5.084ArgAsp: 5.084 ± 1.867
3.52ArgGlu: 3.52 ± 1.476
3.911ArgPhe: 3.911 ± 0.887
7.822ArgGly: 7.822 ± 1.68
1.955ArgHis: 1.955 ± 0.65
2.346ArgIle: 2.346 ± 0.462
2.738ArgLys: 2.738 ± 0.574
8.995ArgLeu: 8.995 ± 1.363
0.782ArgMet: 0.782 ± 0.754
1.955ArgAsn: 1.955 ± 0.746
3.129ArgPro: 3.129 ± 1.243
3.911ArgGln: 3.911 ± 0.805
4.302ArgArg: 4.302 ± 0.81
6.257ArgSer: 6.257 ± 3.825
4.693ArgThr: 4.693 ± 1.053
1.955ArgVal: 1.955 ± 0.678
0.391ArgTrp: 0.391 ± 0.424
1.955ArgTyr: 1.955 ± 0.8
0.0ArgXaa: 0.0 ± 0.0
Ser
4.302SerAla: 4.302 ± 1.289
1.564SerCys: 1.564 ± 0.687
4.302SerAsp: 4.302 ± 1.593
2.346SerGlu: 2.346 ± 0.775
2.738SerPhe: 2.738 ± 1.199
5.866SerGly: 5.866 ± 1.346
1.173SerHis: 1.173 ± 0.366
4.302SerIle: 4.302 ± 1.059
1.564SerLys: 1.564 ± 0.793
6.648SerLeu: 6.648 ± 1.28
1.564SerMet: 1.564 ± 1.228
2.738SerAsn: 2.738 ± 1.158
5.084SerPro: 5.084 ± 1.399
3.52SerGln: 3.52 ± 1.134
7.431SerArg: 7.431 ± 4.057
3.911SerSer: 3.911 ± 0.773
6.648SerThr: 6.648 ± 1.258
4.693SerVal: 4.693 ± 1.23
2.346SerTrp: 2.346 ± 1.537
2.738SerTyr: 2.738 ± 0.502
0.0SerXaa: 0.0 ± 0.0
Thr
4.302ThrAla: 4.302 ± 1.527
0.782ThrCys: 0.782 ± 0.365
3.52ThrAsp: 3.52 ± 1.323
2.738ThrGlu: 2.738 ± 0.774
3.52ThrPhe: 3.52 ± 1.061
4.302ThrGly: 4.302 ± 0.995
0.391ThrHis: 0.391 ± 0.377
3.911ThrIle: 3.911 ± 1.473
1.955ThrLys: 1.955 ± 0.971
3.52ThrLeu: 3.52 ± 0.613
2.346ThrMet: 2.346 ± 1.116
1.955ThrAsn: 1.955 ± 0.678
5.084ThrPro: 5.084 ± 1.944
2.738ThrGln: 2.738 ± 1.568
6.648ThrArg: 6.648 ± 1.751
5.866ThrSer: 5.866 ± 1.727
3.52ThrThr: 3.52 ± 1.338
3.129ThrVal: 3.129 ± 1.537
0.391ThrTrp: 0.391 ± 0.377
0.391ThrTyr: 0.391 ± 0.307
0.0ThrXaa: 0.0 ± 0.0
Val
4.302ValAla: 4.302 ± 1.471
0.0ValCys: 0.0 ± 0.0
4.302ValAsp: 4.302 ± 0.979
5.084ValGlu: 5.084 ± 0.953
0.782ValPhe: 0.782 ± 0.671
4.302ValGly: 4.302 ± 0.815
1.173ValHis: 1.173 ± 0.561
1.955ValIle: 1.955 ± 0.448
2.346ValLys: 2.346 ± 1.111
5.866ValLeu: 5.866 ± 2.576
0.0ValMet: 0.0 ± 0.0
1.955ValAsn: 1.955 ± 0.891
5.475ValPro: 5.475 ± 0.626
5.084ValGln: 5.084 ± 0.816
5.475ValArg: 5.475 ± 1.688
4.302ValSer: 4.302 ± 1.665
5.084ValThr: 5.084 ± 1.979
3.129ValVal: 3.129 ± 1.456
0.391ValTrp: 0.391 ± 0.317
2.346ValTyr: 2.346 ± 0.795
0.0ValXaa: 0.0 ± 0.0
Trp
1.173TrpAla: 1.173 ± 0.613
0.0TrpCys: 0.0 ± 0.0
0.391TrpAsp: 0.391 ± 0.317
0.782TrpGlu: 0.782 ± 0.54
0.391TrpPhe: 0.391 ± 0.307
0.391TrpGly: 0.391 ± 0.307
0.0TrpHis: 0.0 ± 0.0
0.782TrpIle: 0.782 ± 0.614
1.173TrpLys: 1.173 ± 1.032
2.346TrpLeu: 2.346 ± 0.96
0.0TrpMet: 0.0 ± 0.0
0.782TrpAsn: 0.782 ± 1.076
0.0TrpPro: 0.0 ± 0.0
1.955TrpGln: 1.955 ± 1.097
0.0TrpArg: 0.0 ± 0.0
1.564TrpSer: 1.564 ± 1.125
0.391TrpThr: 0.391 ± 0.307
1.173TrpVal: 1.173 ± 0.412
0.0TrpTrp: 0.0 ± 0.0
0.782TrpTyr: 0.782 ± 0.483
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.738TyrAla: 2.738 ± 0.893
0.0TyrCys: 0.0 ± 0.0
1.564TyrAsp: 1.564 ± 0.584
1.564TyrGlu: 1.564 ± 1.281
2.346TyrPhe: 2.346 ± 0.93
3.129TyrGly: 3.129 ± 1.05
0.782TyrHis: 0.782 ± 0.427
1.564TyrIle: 1.564 ± 0.557
1.564TyrLys: 1.564 ± 0.925
3.52TyrLeu: 3.52 ± 1.157
0.0TyrMet: 0.0 ± 0.0
1.564TyrAsn: 1.564 ± 0.605
1.955TyrPro: 1.955 ± 0.757
1.173TyrGln: 1.173 ± 0.896
2.346TyrArg: 2.346 ± 0.499
1.564TyrSer: 1.564 ± 0.584
1.955TyrThr: 1.955 ± 0.976
0.782TyrVal: 0.782 ± 0.447
0.782TyrTrp: 0.782 ± 0.491
1.173TyrTyr: 1.173 ± 0.373
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2558 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski