Amino acid dipepetide frequency for Lishizhenia tianjinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.251AlaAla: 4.251 ± 0.102	0.763AlaCys: 0.763 ± 0.027	3.439AlaAsp: 3.439 ± 0.063	4.135AlaGlu: 4.135 ± 0.093	3.466AlaPhe: 3.466 ± 0.064	4.366AlaGly: 4.366 ± 0.083	1.245AlaHis: 1.245 ± 0.036	4.644AlaIle: 4.644 ± 0.07	4.477AlaLys: 4.477 ± 0.096	6.812AlaLeu: 6.812 ± 0.096	1.633AlaMet: 1.633 ± 0.042	3.656AlaAsn: 3.656 ± 0.067	2.237AlaPro: 2.237 ± 0.065	3.102AlaGln: 3.102 ± 0.07	2.047AlaArg: 2.047 ± 0.051	4.213AlaSer: 4.213 ± 0.091	3.825AlaThr: 3.825 ± 0.149	4.035AlaVal: 4.035 ± 0.068	0.731AlaTrp: 0.731 ± 0.029	2.818AlaTyr: 2.818 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.643CysAla: 0.643 ± 0.028	0.12CysCys: 0.12 ± 0.012	0.605CysAsp: 0.605 ± 0.03	0.535CysGlu: 0.535 ± 0.03	0.51CysPhe: 0.51 ± 0.028	0.784CysGly: 0.784 ± 0.04	0.169CysHis: 0.169 ± 0.015	0.686CysIle: 0.686 ± 0.026	0.579CysLys: 0.579 ± 0.025	0.786CysLeu: 0.786 ± 0.027	0.183CysMet: 0.183 ± 0.015	0.536CysAsn: 0.536 ± 0.027	0.422CysPro: 0.422 ± 0.034	0.227CysGln: 0.227 ± 0.017	0.246CysArg: 0.246 ± 0.014	0.804CysSer: 0.804 ± 0.039	0.619CysThr: 0.619 ± 0.062	0.571CysVal: 0.571 ± 0.023	0.089CysTrp: 0.089 ± 0.009	0.353CysTyr: 0.353 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.81AspAla: 3.81 ± 0.087	0.505AspCys: 0.505 ± 0.026	2.638AspAsp: 2.638 ± 0.058	3.866AspGlu: 3.866 ± 0.073	3.567AspPhe: 3.567 ± 0.068	3.645AspGly: 3.645 ± 0.065	0.958AspHis: 0.958 ± 0.029	3.896AspIle: 3.896 ± 0.061	3.676AspLys: 3.676 ± 0.083	5.633AspLeu: 5.633 ± 0.078	1.169AspMet: 1.169 ± 0.035	2.837AspAsn: 2.837 ± 0.06	1.786AspPro: 1.786 ± 0.047	1.732AspGln: 1.732 ± 0.042	1.776AspArg: 1.776 ± 0.046	3.473AspSer: 3.473 ± 0.082	3.339AspThr: 3.339 ± 0.075	3.695AspVal: 3.695 ± 0.063	0.658AspTrp: 0.658 ± 0.028	2.754AspTyr: 2.754 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.618GluAla: 4.618 ± 0.114	0.431GluCys: 0.431 ± 0.021	3.805GluAsp: 3.805 ± 0.068	5.908GluGlu: 5.908 ± 0.117	3.052GluPhe: 3.052 ± 0.051	4.234GluGly: 4.234 ± 0.076	1.327GluHis: 1.327 ± 0.036	5.544GluIle: 5.544 ± 0.078	5.576GluLys: 5.576 ± 0.105	6.75GluLeu: 6.75 ± 0.096	1.796GluMet: 1.796 ± 0.05	4.523GluAsn: 4.523 ± 0.08	1.454GluPro: 1.454 ± 0.044	2.554GluGln: 2.554 ± 0.059	2.578GluArg: 2.578 ± 0.056	3.029GluSer: 3.029 ± 0.052	3.035GluThr: 3.035 ± 0.056	4.857GluVal: 4.857 ± 0.082	0.662GluTrp: 0.662 ± 0.025	2.587GluTyr: 2.587 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.997PheAla: 2.997 ± 0.059	0.519PheCys: 0.519 ± 0.026	3.158PheAsp: 3.158 ± 0.061	3.471PheGlu: 3.471 ± 0.06	2.596PhePhe: 2.596 ± 0.072	3.632PheGly: 3.632 ± 0.067	0.962PheHis: 0.962 ± 0.03	3.726PheIle: 3.726 ± 0.07	3.336PheLys: 3.336 ± 0.066	4.679PheLeu: 4.679 ± 0.091	1.136PheMet: 1.136 ± 0.027	3.188PheAsn: 3.188 ± 0.068	1.721PhePro: 1.721 ± 0.044	1.811PheGln: 1.811 ± 0.042	1.566PheArg: 1.566 ± 0.048	3.764PheSer: 3.764 ± 0.061	3.43PheThr: 3.43 ± 0.06	3.258PheVal: 3.258 ± 0.064	0.558PheTrp: 0.558 ± 0.022	2.34PheTyr: 2.34 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.458GlyAla: 4.458 ± 0.085	0.833GlyCys: 0.833 ± 0.061	3.607GlyAsp: 3.607 ± 0.063	4.177GlyGlu: 4.177 ± 0.063	3.247GlyPhe: 3.247 ± 0.061	4.713GlyGly: 4.713 ± 0.12	1.122GlyHis: 1.122 ± 0.037	4.967GlyIle: 4.967 ± 0.082	4.55GlyLys: 4.55 ± 0.083	5.868GlyLeu: 5.868 ± 0.082	1.661GlyMet: 1.661 ± 0.046	3.847GlyAsn: 3.847 ± 0.087	1.436GlyPro: 1.436 ± 0.035	2.162GlyGln: 2.162 ± 0.05	2.158GlyArg: 2.158 ± 0.048	4.146GlySer: 4.146 ± 0.082	4.11GlyThr: 4.11 ± 0.118	4.845GlyVal: 4.845 ± 0.077	0.729GlyTrp: 0.729 ± 0.026	2.782GlyTyr: 2.782 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.188HisAla: 1.188 ± 0.032	0.218HisCys: 0.218 ± 0.013	0.888HisAsp: 0.888 ± 0.032	1.071HisGlu: 1.071 ± 0.031	1.217HisPhe: 1.217 ± 0.034	1.142HisGly: 1.142 ± 0.035	0.547HisHis: 0.547 ± 0.025	1.361HisIle: 1.361 ± 0.039	1.138HisLys: 1.138 ± 0.036	2.022HisLeu: 2.022 ± 0.049	0.355HisMet: 0.355 ± 0.021	0.98HisAsn: 0.98 ± 0.029	1.03HisPro: 1.03 ± 0.029	0.832HisGln: 0.832 ± 0.031	0.698HisArg: 0.698 ± 0.028	1.007HisSer: 1.007 ± 0.029	0.981HisThr: 0.981 ± 0.03	1.109HisVal: 1.109 ± 0.033	0.235HisTrp: 0.235 ± 0.014	0.979HisTyr: 0.979 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.344IleAla: 5.344 ± 0.081	0.721IleCys: 0.721 ± 0.028	4.573IleAsp: 4.573 ± 0.065	4.934IleGlu: 4.934 ± 0.081	3.295IlePhe: 3.295 ± 0.068	4.451IleGly: 4.451 ± 0.07	1.435IleHis: 1.435 ± 0.04	4.773IleIle: 4.773 ± 0.077	4.461IleLys: 4.461 ± 0.089	6.442IleLeu: 6.442 ± 0.101	1.278IleMet: 1.278 ± 0.037	4.138IleAsn: 4.138 ± 0.066	2.822IlePro: 2.822 ± 0.053	2.682IleGln: 2.682 ± 0.052	2.354IleArg: 2.354 ± 0.053	5.065IleSer: 5.065 ± 0.075	4.43IleThr: 4.43 ± 0.093	4.358IleVal: 4.358 ± 0.076	0.643IleTrp: 0.643 ± 0.025	2.918IleTyr: 2.918 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.844LysAla: 4.844 ± 0.095	0.413LysCys: 0.413 ± 0.023	4.209LysAsp: 4.209 ± 0.075	6.064LysGlu: 6.064 ± 0.113	2.773LysPhe: 2.773 ± 0.05	4.292LysGly: 4.292 ± 0.083	1.448LysHis: 1.448 ± 0.044	4.918LysIle: 4.918 ± 0.083	5.581LysLys: 5.581 ± 0.116	6.058LysLeu: 6.058 ± 0.097	1.966LysMet: 1.966 ± 0.048	4.032LysAsn: 4.032 ± 0.076	1.868LysPro: 1.868 ± 0.057	2.429LysGln: 2.429 ± 0.051	2.802LysArg: 2.802 ± 0.055	3.955LysSer: 3.955 ± 0.078	3.574LysThr: 3.574 ± 0.057	4.643LysVal: 4.643 ± 0.078	0.682LysTrp: 0.682 ± 0.028	2.8LysTyr: 2.8 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.028LeuAla: 6.028 ± 0.093	0.866LeuCys: 0.866 ± 0.033	5.158LeuAsp: 5.158 ± 0.07	6.545LeuGlu: 6.545 ± 0.081	4.867LeuPhe: 4.867 ± 0.088	6.215LeuGly: 6.215 ± 0.088	1.832LeuHis: 1.832 ± 0.049	6.536LeuIle: 6.536 ± 0.092	7.179LeuLys: 7.179 ± 0.126	9.214LeuLeu: 9.214 ± 0.134	2.219LeuMet: 2.219 ± 0.059	5.986LeuAsn: 5.986 ± 0.085	3.714LeuPro: 3.714 ± 0.059	3.315LeuGln: 3.315 ± 0.058	3.269LeuArg: 3.269 ± 0.056	7.037LeuSer: 7.037 ± 0.086	5.528LeuThr: 5.528 ± 0.078	5.629LeuVal: 5.629 ± 0.088	0.884LeuTrp: 0.884 ± 0.033	3.408LeuTyr: 3.408 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.632MetAla: 1.632 ± 0.042	0.158MetCys: 0.158 ± 0.012	1.396MetAsp: 1.396 ± 0.041	1.618MetGlu: 1.618 ± 0.043	0.92MetPhe: 0.92 ± 0.028	1.5MetGly: 1.5 ± 0.045	0.497MetHis: 0.497 ± 0.024	1.48MetIle: 1.48 ± 0.039	2.157MetLys: 2.157 ± 0.049	1.969MetLeu: 1.969 ± 0.047	0.672MetMet: 0.672 ± 0.026	1.44MetAsn: 1.44 ± 0.033	0.758MetPro: 0.758 ± 0.031	0.852MetGln: 0.852 ± 0.031	0.98MetArg: 0.98 ± 0.029	1.365MetSer: 1.365 ± 0.038	1.117MetThr: 1.117 ± 0.036	1.342MetVal: 1.342 ± 0.036	0.171MetTrp: 0.171 ± 0.013	0.847MetTyr: 0.847 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	4.047AsnAla: 4.047 ± 0.076	0.647AsnCys: 0.647 ± 0.047	2.936AsnAsp: 2.936 ± 0.053	3.469AsnGlu: 3.469 ± 0.062	3.292AsnPhe: 3.292 ± 0.067	4.235AsnGly: 4.235 ± 0.096	1.038AsnHis: 1.038 ± 0.035	4.189AsnIle: 4.189 ± 0.071	3.747AsnLys: 3.747 ± 0.074	5.584AsnLeu: 5.584 ± 0.076	1.245AsnMet: 1.245 ± 0.034	3.639AsnAsn: 3.639 ± 0.075	2.675AsnPro: 2.675 ± 0.055	2.347AsnGln: 2.347 ± 0.055	1.908AsnArg: 1.908 ± 0.041	3.502AsnSer: 3.502 ± 0.074	3.797AsnThr: 3.797 ± 0.092	3.564AsnVal: 3.564 ± 0.074	0.805AsnTrp: 0.805 ± 0.029	3.182AsnTyr: 3.182 ± 0.074	0.0AsnXaa: 0.0 ± 0.0
Pro	2.174ProAla: 2.174 ± 0.054	0.271ProCys: 0.271 ± 0.015	1.839ProAsp: 1.839 ± 0.048	2.707ProGlu: 2.707 ± 0.053	1.806ProPhe: 1.806 ± 0.042	2.083ProGly: 2.083 ± 0.063	0.672ProHis: 0.672 ± 0.025	2.256ProIle: 2.256 ± 0.046	2.127ProLys: 2.127 ± 0.044	3.017ProLeu: 3.017 ± 0.061	0.715ProMet: 0.715 ± 0.025	2.357ProAsn: 2.357 ± 0.058	0.811ProPro: 0.811 ± 0.031	1.28ProGln: 1.28 ± 0.036	0.901ProArg: 0.901 ± 0.036	2.388ProSer: 2.388 ± 0.059	2.123ProThr: 2.123 ± 0.062	2.414ProVal: 2.414 ± 0.059	0.333ProTrp: 0.333 ± 0.02	1.506ProTyr: 1.506 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.323GlnAla: 2.323 ± 0.051	0.234GlnCys: 0.234 ± 0.014	1.916GlnAsp: 1.916 ± 0.045	2.836GlnGlu: 2.836 ± 0.061	1.76GlnPhe: 1.76 ± 0.04	2.175GlnGly: 2.175 ± 0.044	0.765GlnHis: 0.765 ± 0.031	2.593GlnIle: 2.593 ± 0.048	2.726GlnLys: 2.726 ± 0.058	3.605GlnLeu: 3.605 ± 0.067	0.903GlnMet: 0.903 ± 0.031	2.404GlnAsn: 2.404 ± 0.061	1.179GlnPro: 1.179 ± 0.052	1.575GlnGln: 1.575 ± 0.046	1.546GlnArg: 1.546 ± 0.044	2.045GlnSer: 2.045 ± 0.047	2.012GlnThr: 2.012 ± 0.055	2.253GlnVal: 2.253 ± 0.054	0.42GlnTrp: 0.42 ± 0.02	1.432GlnTyr: 1.432 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.04ArgAla: 2.04 ± 0.045	0.228ArgCys: 0.228 ± 0.015	1.7ArgAsp: 1.7 ± 0.043	2.276ArgGlu: 2.276 ± 0.058	1.804ArgPhe: 1.804 ± 0.044	1.804ArgGly: 1.804 ± 0.049	0.566ArgHis: 0.566 ± 0.023	2.862ArgIle: 2.862 ± 0.054	2.89ArgLys: 2.89 ± 0.061	3.305ArgLeu: 3.305 ± 0.061	1.001ArgMet: 1.001 ± 0.037	1.957ArgAsn: 1.957 ± 0.049	1.015ArgPro: 1.015 ± 0.04	1.069ArgGln: 1.069 ± 0.032	1.361ArgArg: 1.361 ± 0.039	1.914ArgSer: 1.914 ± 0.053	1.821ArgThr: 1.821 ± 0.045	2.287ArgVal: 2.287 ± 0.051	0.362ArgTrp: 0.362 ± 0.015	1.528ArgTyr: 1.528 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.997SerAla: 3.997 ± 0.074	0.798SerCys: 0.798 ± 0.032	3.075SerAsp: 3.075 ± 0.055	3.584SerGlu: 3.584 ± 0.065	4.208SerPhe: 4.208 ± 0.071	4.359SerGly: 4.359 ± 0.085	0.977SerHis: 0.977 ± 0.033	4.945SerIle: 4.945 ± 0.08	4.149SerLys: 4.149 ± 0.077	6.35SerLeu: 6.35 ± 0.08	1.335SerMet: 1.335 ± 0.039	3.701SerAsn: 3.701 ± 0.077	2.297SerPro: 2.297 ± 0.051	1.956SerGln: 1.956 ± 0.046	1.852SerArg: 1.852 ± 0.046	4.648SerSer: 4.648 ± 0.088	4.3SerThr: 4.3 ± 0.086	3.969SerVal: 3.969 ± 0.078	0.729SerTrp: 0.729 ± 0.037	2.917SerTyr: 2.917 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	4.055ThrAla: 4.055 ± 0.135	0.563ThrCys: 0.563 ± 0.053	3.267ThrAsp: 3.267 ± 0.087	3.397ThrGlu: 3.397 ± 0.059	2.826ThrPhe: 2.826 ± 0.062	4.203ThrGly: 4.203 ± 0.109	1.097ThrHis: 1.097 ± 0.034	3.965ThrIle: 3.965 ± 0.087	3.153ThrLys: 3.153 ± 0.059	6.039ThrLeu: 6.039 ± 0.103	0.966ThrMet: 0.966 ± 0.028	3.222ThrAsn: 3.222 ± 0.078	2.768ThrPro: 2.768 ± 0.08	2.328ThrGln: 2.328 ± 0.056	1.621ThrArg: 1.621 ± 0.046	4.017ThrSer: 4.017 ± 0.087	3.823ThrThr: 3.823 ± 0.122	4.087ThrVal: 4.087 ± 0.125	0.733ThrTrp: 0.733 ± 0.039	2.78ThrTyr: 2.78 ± 0.088	0.0ThrXaa: 0.0 ± 0.0
Val	4.124ValAla: 4.124 ± 0.071	0.643ValCys: 0.643 ± 0.027	3.971ValAsp: 3.971 ± 0.073	4.697ValGlu: 4.697 ± 0.076	3.398ValPhe: 3.398 ± 0.06	4.057ValGly: 4.057 ± 0.077	1.179ValHis: 1.179 ± 0.035	4.402ValIle: 4.402 ± 0.073	4.287ValLys: 4.287 ± 0.073	6.307ValLeu: 6.307 ± 0.087	1.442ValMet: 1.442 ± 0.039	4.09ValAsn: 4.09 ± 0.07	1.916ValPro: 1.916 ± 0.041	2.257ValGln: 2.257 ± 0.057	2.054ValArg: 2.054 ± 0.046	4.106ValSer: 4.106 ± 0.067	3.458ValThr: 3.458 ± 0.133	4.498ValVal: 4.498 ± 0.086	0.658ValTrp: 0.658 ± 0.026	2.905ValTyr: 2.905 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.578TrpAla: 0.578 ± 0.024	0.117TrpCys: 0.117 ± 0.012	0.655TrpAsp: 0.655 ± 0.026	0.68TrpGlu: 0.68 ± 0.023	0.521TrpPhe: 0.521 ± 0.023	0.709TrpGly: 0.709 ± 0.028	0.197TrpHis: 0.197 ± 0.014	0.73TrpIle: 0.73 ± 0.026	0.805TrpLys: 0.805 ± 0.03	0.89TrpLeu: 0.89 ± 0.029	0.355TrpMet: 0.355 ± 0.019	0.702TrpAsn: 0.702 ± 0.042	0.239TrpPro: 0.239 ± 0.016	0.403TrpGln: 0.403 ± 0.019	0.419TrpArg: 0.419 ± 0.021	0.769TrpSer: 0.769 ± 0.029	0.63TrpThr: 0.63 ± 0.028	0.694TrpVal: 0.694 ± 0.025	0.141TrpTrp: 0.141 ± 0.013	0.487TrpTyr: 0.487 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.747TyrAla: 2.747 ± 0.048	0.418TyrCys: 0.418 ± 0.02	2.579TyrAsp: 2.579 ± 0.051	2.349TyrGlu: 2.349 ± 0.044	2.72TyrPhe: 2.72 ± 0.057	2.817TyrGly: 2.817 ± 0.054	0.966TyrHis: 0.966 ± 0.036	2.643TyrIle: 2.643 ± 0.054	2.758TyrLys: 2.758 ± 0.056	4.098TyrLeu: 4.098 ± 0.073	0.842TyrMet: 0.842 ± 0.025	2.615TyrAsn: 2.615 ± 0.061	1.632TyrPro: 1.632 ± 0.041	1.789TyrGln: 1.789 ± 0.045	1.653TyrArg: 1.653 ± 0.045	2.903TyrSer: 2.903 ± 0.073	2.956TyrThr: 2.956 ± 0.099	2.344TyrVal: 2.344 ± 0.047	0.494TyrTrp: 0.494 ± 0.022	2.201TyrTyr: 2.201 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3112 proteins (1077000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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