Amino acid dipepetide frequency for Phyllobacterium leguminum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.147AlaAla: 15.147 ± 0.167	0.864AlaCys: 0.864 ± 0.03	6.484AlaAsp: 6.484 ± 0.081	7.249AlaGlu: 7.249 ± 0.098	4.568AlaPhe: 4.568 ± 0.064	10.211AlaGly: 10.211 ± 0.121	2.101AlaHis: 2.101 ± 0.046	6.932AlaIle: 6.932 ± 0.095	4.765AlaLys: 4.765 ± 0.083	12.334AlaLeu: 12.334 ± 0.132	3.44AlaMet: 3.44 ± 0.056	3.189AlaAsn: 3.189 ± 0.063	5.085AlaPro: 5.085 ± 0.076	3.709AlaGln: 3.709 ± 0.061	7.773AlaArg: 7.773 ± 0.095	6.323AlaSer: 6.323 ± 0.086	5.823AlaThr: 5.823 ± 0.094	8.262AlaVal: 8.262 ± 0.096	1.35AlaTrp: 1.35 ± 0.039	2.716AlaTyr: 2.716 ± 0.061	0.001AlaXaa: 0.001 ± 0.001
Cys	0.764CysAla: 0.764 ± 0.024	0.087CysCys: 0.087 ± 0.009	0.476CysAsp: 0.476 ± 0.02	0.383CysGlu: 0.383 ± 0.017	0.306CysPhe: 0.306 ± 0.016	0.795CysGly: 0.795 ± 0.028	0.214CysHis: 0.214 ± 0.015	0.385CysIle: 0.385 ± 0.019	0.194CysLys: 0.194 ± 0.014	0.7CysLeu: 0.7 ± 0.027	0.137CysMet: 0.137 ± 0.012	0.182CysAsn: 0.182 ± 0.012	0.399CysPro: 0.399 ± 0.018	0.208CysGln: 0.208 ± 0.013	0.527CysArg: 0.527 ± 0.024	0.415CysSer: 0.415 ± 0.02	0.362CysThr: 0.362 ± 0.018	0.518CysVal: 0.518 ± 0.025	0.09CysTrp: 0.09 ± 0.009	0.164CysTyr: 0.164 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.353AspAla: 6.353 ± 0.083	0.415AspCys: 0.415 ± 0.018	3.009AspAsp: 3.009 ± 0.067	3.585AspGlu: 3.585 ± 0.065	2.39AspPhe: 2.39 ± 0.058	5.216AspGly: 5.216 ± 0.077	1.199AspHis: 1.199 ± 0.038	3.765AspIle: 3.765 ± 0.062	2.142AspLys: 2.142 ± 0.045	5.416AspLeu: 5.416 ± 0.063	1.42AspMet: 1.42 ± 0.038	1.56AspAsn: 1.56 ± 0.039	3.178AspPro: 3.178 ± 0.063	1.519AspGln: 1.519 ± 0.035	3.88AspArg: 3.88 ± 0.066	2.114AspSer: 2.114 ± 0.046	2.594AspThr: 2.594 ± 0.053	3.864AspVal: 3.864 ± 0.052	0.929AspTrp: 0.929 ± 0.032	1.584AspTyr: 1.584 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.612GluAla: 7.612 ± 0.103	0.334GluCys: 0.334 ± 0.018	2.727GluAsp: 2.727 ± 0.056	3.534GluGlu: 3.534 ± 0.068	1.845GluPhe: 1.845 ± 0.044	4.351GluGly: 4.351 ± 0.072	1.198GluHis: 1.198 ± 0.038	3.837GluIle: 3.837 ± 0.072	3.127GluLys: 3.127 ± 0.061	5.16GluLeu: 5.16 ± 0.068	1.751GluMet: 1.751 ± 0.044	2.017GluAsn: 2.017 ± 0.045	2.699GluPro: 2.699 ± 0.051	1.979GluGln: 1.979 ± 0.044	4.932GluArg: 4.932 ± 0.079	2.291GluSer: 2.291 ± 0.045	3.759GluThr: 3.759 ± 0.063	3.488GluVal: 3.488 ± 0.058	0.693GluTrp: 0.693 ± 0.022	1.136GluTyr: 1.136 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.489PheAla: 4.489 ± 0.069	0.379PheCys: 0.379 ± 0.02	2.67PheAsp: 2.67 ± 0.051	2.173PheGlu: 2.173 ± 0.042	1.614PhePhe: 1.614 ± 0.048	3.673PheGly: 3.673 ± 0.067	0.796PheHis: 0.796 ± 0.029	2.108PheIle: 2.108 ± 0.043	1.143PheLys: 1.143 ± 0.034	3.646PheLeu: 3.646 ± 0.054	0.889PheMet: 0.889 ± 0.031	1.305PheAsn: 1.305 ± 0.042	1.626PhePro: 1.626 ± 0.036	1.097PheGln: 1.097 ± 0.034	2.321PheArg: 2.321 ± 0.048	2.556PheSer: 2.556 ± 0.048	2.181PheThr: 2.181 ± 0.049	2.774PheVal: 2.774 ± 0.055	0.529PheTrp: 0.529 ± 0.027	1.025PheTyr: 1.025 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.669GlyAla: 8.669 ± 0.117	0.72GlyCys: 0.72 ± 0.03	4.537GlyAsp: 4.537 ± 0.084	5.051GlyGlu: 5.051 ± 0.072	3.675GlyPhe: 3.675 ± 0.056	7.372GlyGly: 7.372 ± 0.171	1.793GlyHis: 1.793 ± 0.048	5.213GlyIle: 5.213 ± 0.075	4.132GlyLys: 4.132 ± 0.075	8.396GlyLeu: 8.396 ± 0.1	2.292GlyMet: 2.292 ± 0.043	2.712GlyAsn: 2.712 ± 0.061	3.136GlyPro: 3.136 ± 0.063	2.824GlyGln: 2.824 ± 0.055	5.613GlyArg: 5.613 ± 0.078	4.815GlySer: 4.815 ± 0.076	4.717GlyThr: 4.717 ± 0.094	5.744GlyVal: 5.744 ± 0.078	1.296GlyTrp: 1.296 ± 0.036	2.38GlyTyr: 2.38 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.107HisAla: 2.107 ± 0.047	0.195HisCys: 0.195 ± 0.014	1.16HisAsp: 1.16 ± 0.041	1.111HisGlu: 1.111 ± 0.033	0.87HisPhe: 0.87 ± 0.029	1.847HisGly: 1.847 ± 0.044	0.549HisHis: 0.549 ± 0.028	1.117HisIle: 1.117 ± 0.033	0.563HisLys: 0.563 ± 0.024	2.081HisLeu: 2.081 ± 0.045	0.504HisMet: 0.504 ± 0.022	0.478HisAsn: 0.478 ± 0.019	1.26HisPro: 1.26 ± 0.034	0.568HisGln: 0.568 ± 0.024	1.335HisArg: 1.335 ± 0.034	0.916HisSer: 0.916 ± 0.029	0.861HisThr: 0.861 ± 0.032	1.448HisVal: 1.448 ± 0.035	0.286HisTrp: 0.286 ± 0.016	0.577HisTyr: 0.577 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	8.018IleAla: 8.018 ± 0.101	0.494IleCys: 0.494 ± 0.021	3.968IleAsp: 3.968 ± 0.069	3.948IleGlu: 3.948 ± 0.066	2.126IlePhe: 2.126 ± 0.047	5.419IleGly: 5.419 ± 0.07	1.066IleHis: 1.066 ± 0.032	3.127IleIle: 3.127 ± 0.062	1.77IleLys: 1.77 ± 0.054	5.068IleLeu: 5.068 ± 0.072	1.21IleMet: 1.21 ± 0.039	1.728IleAsn: 1.728 ± 0.042	2.597IlePro: 2.597 ± 0.048	1.32IleGln: 1.32 ± 0.037	3.612IleArg: 3.612 ± 0.064	3.404IleSer: 3.404 ± 0.058	2.954IleThr: 2.954 ± 0.056	4.625IleVal: 4.625 ± 0.072	0.651IleTrp: 0.651 ± 0.026	1.322IleTyr: 1.322 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.925LysAla: 4.925 ± 0.086	0.175LysCys: 0.175 ± 0.013	1.957LysAsp: 1.957 ± 0.043	2.08LysGlu: 2.08 ± 0.05	1.084LysPhe: 1.084 ± 0.037	3.165LysGly: 3.165 ± 0.059	0.716LysHis: 0.716 ± 0.027	2.178LysIle: 2.178 ± 0.055	1.858LysLys: 1.858 ± 0.051	3.921LysLeu: 3.921 ± 0.062	0.986LysMet: 0.986 ± 0.033	1.297LysAsn: 1.297 ± 0.04	2.626LysPro: 2.626 ± 0.063	1.268LysGln: 1.268 ± 0.037	2.868LysArg: 2.868 ± 0.061	2.308LysSer: 2.308 ± 0.046	2.462LysThr: 2.462 ± 0.05	2.613LysVal: 2.613 ± 0.062	0.409LysTrp: 0.409 ± 0.019	0.744LysTyr: 0.744 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.556LeuAla: 12.556 ± 0.151	0.8LeuCys: 0.8 ± 0.029	5.861LeuAsp: 5.861 ± 0.076	5.237LeuGlu: 5.237 ± 0.084	3.807LeuPhe: 3.807 ± 0.069	8.023LeuGly: 8.023 ± 0.102	1.805LeuHis: 1.805 ± 0.045	5.589LeuIle: 5.589 ± 0.087	4.179LeuLys: 4.179 ± 0.071	8.829LeuLeu: 8.829 ± 0.144	2.342LeuMet: 2.342 ± 0.049	2.75LeuAsn: 2.75 ± 0.049	5.322LeuPro: 5.322 ± 0.072	2.67LeuGln: 2.67 ± 0.051	6.002LeuArg: 6.002 ± 0.089	6.387LeuSer: 6.387 ± 0.083	5.599LeuThr: 5.599 ± 0.085	6.87LeuVal: 6.87 ± 0.101	1.07LeuTrp: 1.07 ± 0.036	2.189LeuTyr: 2.189 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.131MetAla: 3.131 ± 0.051	0.134MetCys: 0.134 ± 0.012	1.139MetAsp: 1.139 ± 0.029	1.306MetGlu: 1.306 ± 0.038	0.713MetPhe: 0.713 ± 0.028	1.881MetGly: 1.881 ± 0.043	0.437MetHis: 0.437 ± 0.021	1.475MetIle: 1.475 ± 0.037	1.203MetLys: 1.203 ± 0.036	2.549MetLeu: 2.549 ± 0.055	0.695MetMet: 0.695 ± 0.027	0.896MetAsn: 0.896 ± 0.028	1.551MetPro: 1.551 ± 0.038	0.866MetGln: 0.866 ± 0.025	1.891MetArg: 1.891 ± 0.04	1.656MetSer: 1.656 ± 0.042	1.811MetThr: 1.811 ± 0.042	1.692MetVal: 1.692 ± 0.043	0.209MetTrp: 0.209 ± 0.014	0.3MetTyr: 0.3 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.469AsnAla: 3.469 ± 0.058	0.229AsnCys: 0.229 ± 0.016	1.702AsnAsp: 1.702 ± 0.052	1.483AsnGlu: 1.483 ± 0.034	1.137AsnPhe: 1.137 ± 0.033	2.906AsnGly: 2.906 ± 0.061	0.558AsnHis: 0.558 ± 0.023	1.672AsnIle: 1.672 ± 0.045	0.926AsnLys: 0.926 ± 0.031	2.724AsnLeu: 2.724 ± 0.047	0.722AsnMet: 0.722 ± 0.026	0.925AsnAsn: 0.925 ± 0.033	2.082AsnPro: 2.082 ± 0.039	0.861AsnGln: 0.861 ± 0.031	2.027AsnArg: 2.027 ± 0.047	1.509AsnSer: 1.509 ± 0.044	1.43AsnThr: 1.43 ± 0.039	2.091AsnVal: 2.091 ± 0.047	0.494AsnTrp: 0.494 ± 0.021	0.777AsnTyr: 0.777 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.921ProAla: 5.921 ± 0.1	0.275ProCys: 0.275 ± 0.017	3.601ProAsp: 3.601 ± 0.058	3.588ProGlu: 3.588 ± 0.063	2.035ProPhe: 2.035 ± 0.042	4.267ProGly: 4.267 ± 0.066	1.058ProHis: 1.058 ± 0.03	2.422ProIle: 2.422 ± 0.054	1.862ProLys: 1.862 ± 0.048	4.677ProLeu: 4.677 ± 0.073	1.163ProMet: 1.163 ± 0.034	1.372ProAsn: 1.372 ± 0.041	2.287ProPro: 2.287 ± 0.059	1.759ProGln: 1.759 ± 0.043	2.707ProArg: 2.707 ± 0.058	2.799ProSer: 2.799 ± 0.058	2.329ProThr: 2.329 ± 0.052	4.325ProVal: 4.325 ± 0.073	0.65ProTrp: 0.65 ± 0.025	1.278ProTyr: 1.278 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.801GlnAla: 3.801 ± 0.065	0.169GlnCys: 0.169 ± 0.012	1.329GlnAsp: 1.329 ± 0.035	1.623GlnGlu: 1.623 ± 0.042	1.117GlnPhe: 1.117 ± 0.036	2.302GlnGly: 2.302 ± 0.049	0.584GlnHis: 0.584 ± 0.024	1.945GlnIle: 1.945 ± 0.044	1.357GlnLys: 1.357 ± 0.04	2.79GlnLeu: 2.79 ± 0.052	0.947GlnMet: 0.947 ± 0.032	1.008GlnAsn: 1.008 ± 0.032	1.749GlnPro: 1.749 ± 0.048	1.124GlnGln: 1.124 ± 0.033	2.227GlnArg: 2.227 ± 0.042	1.851GlnSer: 1.851 ± 0.04	1.69GlnThr: 1.69 ± 0.038	2.126GlnVal: 2.126 ± 0.044	0.398GlnTrp: 0.398 ± 0.022	0.691GlnTyr: 0.691 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.926ArgAla: 6.926 ± 0.102	0.392ArgCys: 0.392 ± 0.021	3.747ArgAsp: 3.747 ± 0.068	4.279ArgGlu: 4.279 ± 0.066	2.951ArgPhe: 2.951 ± 0.057	4.455ArgGly: 4.455 ± 0.079	1.598ArgHis: 1.598 ± 0.043	4.328ArgIle: 4.328 ± 0.066	2.686ArgLys: 2.686 ± 0.055	7.201ArgLeu: 7.201 ± 0.099	1.854ArgMet: 1.854 ± 0.042	2.034ArgAsn: 2.034 ± 0.039	3.185ArgPro: 3.185 ± 0.066	2.516ArgGln: 2.516 ± 0.046	5.133ArgArg: 5.133 ± 0.089	3.532ArgSer: 3.532 ± 0.06	3.117ArgThr: 3.117 ± 0.057	4.263ArgVal: 4.263 ± 0.069	0.877ArgTrp: 0.877 ± 0.033	1.758ArgTyr: 1.758 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.156SerAla: 6.156 ± 0.074	0.363SerCys: 0.363 ± 0.017	3.081SerAsp: 3.081 ± 0.057	2.892SerGlu: 2.892 ± 0.055	2.453SerPhe: 2.453 ± 0.052	5.729SerGly: 5.729 ± 0.08	1.07SerHis: 1.07 ± 0.035	3.129SerIle: 3.129 ± 0.05	1.844SerLys: 1.844 ± 0.044	5.663SerLeu: 5.663 ± 0.082	1.32SerMet: 1.32 ± 0.035	1.556SerAsn: 1.556 ± 0.04	2.898SerPro: 2.898 ± 0.051	1.724SerGln: 1.724 ± 0.04	3.527SerArg: 3.527 ± 0.067	3.133SerSer: 3.133 ± 0.062	2.733SerThr: 2.733 ± 0.054	4.069SerVal: 4.069 ± 0.063	0.718SerTrp: 0.718 ± 0.026	1.414SerTyr: 1.414 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.141ThrAla: 6.141 ± 0.106	0.382ThrCys: 0.382 ± 0.022	2.781ThrAsp: 2.781 ± 0.053	2.641ThrGlu: 2.641 ± 0.047	2.011ThrPhe: 2.011 ± 0.052	5.334ThrGly: 5.334 ± 0.092	1.045ThrHis: 1.045 ± 0.032	3.296ThrIle: 3.296 ± 0.052	1.734ThrLys: 1.734 ± 0.044	5.752ThrLeu: 5.752 ± 0.089	1.238ThrMet: 1.238 ± 0.041	1.451ThrAsn: 1.451 ± 0.041	3.259ThrPro: 3.259 ± 0.065	1.531ThrGln: 1.531 ± 0.04	3.139ThrArg: 3.139 ± 0.053	2.862ThrSer: 2.862 ± 0.051	2.749ThrThr: 2.749 ± 0.061	4.5ThrVal: 4.5 ± 0.091	0.629ThrTrp: 0.629 ± 0.024	1.302ThrTyr: 1.302 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	8.426ValAla: 8.426 ± 0.098	0.517ValCys: 0.517 ± 0.021	3.806ValAsp: 3.806 ± 0.062	4.463ValGlu: 4.463 ± 0.067	2.776ValPhe: 2.776 ± 0.045	5.084ValGly: 5.084 ± 0.079	1.273ValHis: 1.273 ± 0.041	4.167ValIle: 4.167 ± 0.068	2.77ValLys: 2.77 ± 0.058	6.999ValLeu: 6.999 ± 0.101	1.772ValMet: 1.772 ± 0.04	2.079ValAsn: 2.079 ± 0.05	3.544ValPro: 3.544 ± 0.055	1.921ValGln: 1.921 ± 0.046	4.459ValArg: 4.459 ± 0.064	4.527ValSer: 4.527 ± 0.059	4.659ValThr: 4.659 ± 0.096	5.019ValVal: 5.019 ± 0.087	0.865ValTrp: 0.865 ± 0.029	1.572ValTyr: 1.572 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.118TrpAla: 1.118 ± 0.039	0.13TrpCys: 0.13 ± 0.013	0.576TrpAsp: 0.576 ± 0.024	0.572TrpGlu: 0.572 ± 0.021	0.497TrpPhe: 0.497 ± 0.024	0.889TrpGly: 0.889 ± 0.03	0.292TrpHis: 0.292 ± 0.019	0.639TrpIle: 0.639 ± 0.022	0.586TrpLys: 0.586 ± 0.023	1.569TrpLeu: 1.569 ± 0.041	0.357TrpMet: 0.357 ± 0.019	0.485TrpAsn: 0.485 ± 0.021	0.653TrpPro: 0.653 ± 0.026	0.566TrpGln: 0.566 ± 0.023	1.057TrpArg: 1.057 ± 0.031	0.754TrpSer: 0.754 ± 0.025	0.74TrpThr: 0.74 ± 0.028	0.756TrpVal: 0.756 ± 0.027	0.221TrpTrp: 0.221 ± 0.015	0.305TrpTyr: 0.305 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.598TyrAla: 2.598 ± 0.051	0.251TyrCys: 0.251 ± 0.015	1.519TyrAsp: 1.519 ± 0.041	1.272TyrGlu: 1.272 ± 0.037	1.019TyrPhe: 1.019 ± 0.035	2.171TyrGly: 2.171 ± 0.052	0.481TyrHis: 0.481 ± 0.023	1.105TyrIle: 1.105 ± 0.036	0.801TyrLys: 0.801 ± 0.028	2.411TyrLeu: 2.411 ± 0.051	0.494TyrMet: 0.494 ± 0.022	0.699TyrAsn: 0.699 ± 0.024	1.236TyrPro: 1.236 ± 0.038	0.8TyrGln: 0.8 ± 0.025	1.802TyrArg: 1.802 ± 0.042	1.321TyrSer: 1.321 ± 0.045	1.207TyrThr: 1.207 ± 0.033	1.653TyrVal: 1.653 ± 0.047	0.397TyrTrp: 0.397 ± 0.021	0.644TyrTyr: 0.644 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.006

Statistics based on 3580 proteins (1086818 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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