Amino acid dipepetide frequency for Helcococcus ovis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.86AlaAla: 2.86 ± 0.103
0.411AlaCys: 0.411 ± 0.033
2.348AlaAsp: 2.348 ± 0.07
2.892AlaGlu: 2.892 ± 0.097
2.478AlaPhe: 2.478 ± 0.075
3.175AlaGly: 3.175 ± 0.108
0.707AlaHis: 0.707 ± 0.04
5.534AlaIle: 5.534 ± 0.109
4.891AlaLys: 4.891 ± 0.119
4.657AlaLeu: 4.657 ± 0.115
1.462AlaMet: 1.462 ± 0.059
2.652AlaAsn: 2.652 ± 0.065
1.15AlaPro: 1.15 ± 0.053
1.302AlaGln: 1.302 ± 0.053
1.735AlaArg: 1.735 ± 0.065
3.139AlaSer: 3.139 ± 0.091
2.466AlaThr: 2.466 ± 0.077
3.117AlaVal: 3.117 ± 0.086
0.337AlaTrp: 0.337 ± 0.025
2.005AlaTyr: 2.005 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.304CysAla: 0.304 ± 0.026
0.042CysCys: 0.042 ± 0.009
0.403CysAsp: 0.403 ± 0.033
0.417CysGlu: 0.417 ± 0.031
0.274CysPhe: 0.274 ± 0.022
0.591CysGly: 0.591 ± 0.039
0.118CysHis: 0.118 ± 0.018
0.567CysIle: 0.567 ± 0.039
0.491CysLys: 0.491 ± 0.031
0.479CysLeu: 0.479 ± 0.033
0.14CysMet: 0.14 ± 0.017
0.282CysAsn: 0.282 ± 0.024
0.18CysPro: 0.18 ± 0.018
0.13CysGln: 0.13 ± 0.015
0.19CysArg: 0.19 ± 0.021
0.399CysSer: 0.399 ± 0.03
0.264CysThr: 0.264 ± 0.023
0.351CysVal: 0.351 ± 0.026
0.034CysTrp: 0.034 ± 0.008
0.234CysTyr: 0.234 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
2.566AspAla: 2.566 ± 0.08
0.282AspCys: 0.282 ± 0.022
2.991AspAsp: 2.991 ± 0.083
4.957AspGlu: 4.957 ± 0.135
3.281AspPhe: 3.281 ± 0.086
3.455AspGly: 3.455 ± 0.103
0.617AspHis: 0.617 ± 0.04
5.967AspIle: 5.967 ± 0.105
6.382AspLys: 6.382 ± 0.131
5.29AspLeu: 5.29 ± 0.109
1.426AspMet: 1.426 ± 0.052
3.728AspAsn: 3.728 ± 0.088
1.152AspPro: 1.152 ± 0.05
0.889AspGln: 0.889 ± 0.043
1.889AspArg: 1.889 ± 0.066
3.153AspSer: 3.153 ± 0.077
2.255AspThr: 2.255 ± 0.072
3.479AspVal: 3.479 ± 0.082
0.425AspTrp: 0.425 ± 0.025
2.884AspTyr: 2.884 ± 0.082
0.0AspXaa: 0.0 ± 0.0
Glu
3.491GluAla: 3.491 ± 0.106
0.332GluCys: 0.332 ± 0.026
4.082GluAsp: 4.082 ± 0.1
6.097GluGlu: 6.097 ± 0.149
3.327GluPhe: 3.327 ± 0.084
3.305GluGly: 3.305 ± 0.097
0.799GluHis: 0.799 ± 0.039
7.85GluIle: 7.85 ± 0.136
9.036GluLys: 9.036 ± 0.158
6.64GluLeu: 6.64 ± 0.134
1.881GluMet: 1.881 ± 0.061
6.578GluAsn: 6.578 ± 0.128
1.21GluPro: 1.21 ± 0.066
1.663GluGln: 1.663 ± 0.062
2.34GluArg: 2.34 ± 0.078
3.483GluSer: 3.483 ± 0.084
2.91GluThr: 2.91 ± 0.091
4.429GluVal: 4.429 ± 0.097
0.449GluTrp: 0.449 ± 0.036
3.505GluTyr: 3.505 ± 0.091
0.0GluXaa: 0.0 ± 0.0
Phe
2.428PheAla: 2.428 ± 0.079
0.324PheCys: 0.324 ± 0.028
3.241PheAsp: 3.241 ± 0.077
3.86PheGlu: 3.86 ± 0.087
2.209PhePhe: 2.209 ± 0.09
3.017PheGly: 3.017 ± 0.087
0.451PheHis: 0.451 ± 0.027
5.242PheIle: 5.242 ± 0.129
3.764PheLys: 3.764 ± 0.084
4.505PheLeu: 4.505 ± 0.11
1.244PheMet: 1.244 ± 0.047
3.774PheAsn: 3.774 ± 0.105
1.138PhePro: 1.138 ± 0.052
0.947PheGln: 0.947 ± 0.045
1.522PheArg: 1.522 ± 0.06
3.79PheSer: 3.79 ± 0.087
2.58PheThr: 2.58 ± 0.074
3.155PheVal: 3.155 ± 0.081
0.328PheTrp: 0.328 ± 0.024
2.207PheTyr: 2.207 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
3.343GlyAla: 3.343 ± 0.119
0.421GlyCys: 0.421 ± 0.028
2.854GlyAsp: 2.854 ± 0.09
3.742GlyGlu: 3.742 ± 0.094
3.189GlyPhe: 3.189 ± 0.085
3.696GlyGly: 3.696 ± 0.113
0.967GlyHis: 0.967 ± 0.047
6.239GlyIle: 6.239 ± 0.123
6.053GlyLys: 6.053 ± 0.116
5.362GlyLeu: 5.362 ± 0.132
1.522GlyMet: 1.522 ± 0.06
3.117GlyAsn: 3.117 ± 0.081
1.044GlyPro: 1.044 ± 0.056
1.584GlyGln: 1.584 ± 0.053
1.913GlyArg: 1.913 ± 0.067
3.269GlySer: 3.269 ± 0.076
2.924GlyThr: 2.924 ± 0.083
4.004GlyVal: 4.004 ± 0.108
0.455GlyTrp: 0.455 ± 0.037
2.93GlyTyr: 2.93 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
0.623HisAla: 0.623 ± 0.034
0.08HisCys: 0.08 ± 0.013
0.831HisAsp: 0.831 ± 0.046
0.805HisGlu: 0.805 ± 0.04
0.621HisPhe: 0.621 ± 0.035
0.891HisGly: 0.891 ± 0.048
0.276HisHis: 0.276 ± 0.03
1.216HisIle: 1.216 ± 0.057
1.046HisLys: 1.046 ± 0.048
1.21HisLeu: 1.21 ± 0.048
0.278HisMet: 0.278 ± 0.025
0.829HisAsn: 0.829 ± 0.041
0.509HisPro: 0.509 ± 0.029
0.337HisGln: 0.337 ± 0.028
0.527HisArg: 0.527 ± 0.036
0.853HisSer: 0.853 ± 0.041
0.703HisThr: 0.703 ± 0.037
0.789HisVal: 0.789 ± 0.044
0.098HisTrp: 0.098 ± 0.015
0.599HisTyr: 0.599 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.34IleAla: 5.34 ± 0.111
0.721IleCys: 0.721 ± 0.04
6.336IleAsp: 6.336 ± 0.108
7.371IleGlu: 7.371 ± 0.13
5.673IlePhe: 5.673 ± 0.146
5.699IleGly: 5.699 ± 0.132
1.2IleHis: 1.2 ± 0.051
9.869IleIle: 9.869 ± 0.204
9.679IleLys: 9.679 ± 0.147
9.837IleLeu: 9.837 ± 0.203
2.251IleMet: 2.251 ± 0.079
7.137IleAsn: 7.137 ± 0.161
3.027IlePro: 3.027 ± 0.079
2.191IleGln: 2.191 ± 0.063
2.999IleArg: 2.999 ± 0.079
7.972IleSer: 7.972 ± 0.167
4.511IleThr: 4.511 ± 0.1
6.037IleVal: 6.037 ± 0.117
0.539IleTrp: 0.539 ± 0.036
4.389IleTyr: 4.389 ± 0.103
0.0IleXaa: 0.0 ± 0.0
Lys
4.024LysAla: 4.024 ± 0.104
0.389LysCys: 0.389 ± 0.032
6.177LysAsp: 6.177 ± 0.133
8.619LysGlu: 8.619 ± 0.143
4.258LysPhe: 4.258 ± 0.088
4.541LysGly: 4.541 ± 0.103
1.232LysHis: 1.232 ± 0.053
10.161LysIle: 10.161 ± 0.14
10.125LysLys: 10.125 ± 0.175
8.945LysLeu: 8.945 ± 0.144
2.56LysMet: 2.56 ± 0.074
8.767LysAsn: 8.767 ± 0.162
2.119LysPro: 2.119 ± 0.081
2.41LysGln: 2.41 ± 0.071
2.804LysArg: 2.804 ± 0.085
6.035LysSer: 6.035 ± 0.129
4.315LysThr: 4.315 ± 0.106
5.729LysVal: 5.729 ± 0.128
0.767LysTrp: 0.767 ± 0.05
5.24LysTyr: 5.24 ± 0.107
0.0LysXaa: 0.0 ± 0.0
Leu
4.685LeuAla: 4.685 ± 0.105
0.515LeuCys: 0.515 ± 0.037
5.568LeuAsp: 5.568 ± 0.113
6.906LeuGlu: 6.906 ± 0.153
4.425LeuPhe: 4.425 ± 0.12
5.745LeuGly: 5.745 ± 0.119
1.16LeuHis: 1.16 ± 0.048
9.006LeuIle: 9.006 ± 0.177
8.609LeuLys: 8.609 ± 0.142
8.549LeuLeu: 8.549 ± 0.151
2.169LeuMet: 2.169 ± 0.069
6.652LeuAsn: 6.652 ± 0.129
2.584LeuPro: 2.584 ± 0.068
2.111LeuGln: 2.111 ± 0.056
3.089LeuArg: 3.089 ± 0.075
7.061LeuSer: 7.061 ± 0.14
4.236LeuThr: 4.236 ± 0.093
5.476LeuVal: 5.476 ± 0.113
0.453LeuTrp: 0.453 ± 0.035
3.453LeuTyr: 3.453 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
1.498MetAla: 1.498 ± 0.059
0.138MetCys: 0.138 ± 0.018
1.33MetAsp: 1.33 ± 0.054
1.566MetGlu: 1.566 ± 0.059
1.058MetPhe: 1.058 ± 0.045
1.564MetGly: 1.564 ± 0.069
0.332MetHis: 0.332 ± 0.027
2.546MetIle: 2.546 ± 0.073
2.664MetLys: 2.664 ± 0.075
2.037MetLeu: 2.037 ± 0.062
0.705MetMet: 0.705 ± 0.038
1.618MetAsn: 1.618 ± 0.055
0.723MetPro: 0.723 ± 0.04
0.597MetGln: 0.597 ± 0.036
0.847MetArg: 0.847 ± 0.044
1.502MetSer: 1.502 ± 0.057
1.228MetThr: 1.228 ± 0.045
1.35MetVal: 1.35 ± 0.057
0.146MetTrp: 0.146 ± 0.018
0.871MetTyr: 0.871 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
2.946AsnAla: 2.946 ± 0.088
0.415AsnCys: 0.415 ± 0.03
3.664AsnAsp: 3.664 ± 0.093
4.725AsnGlu: 4.725 ± 0.118
3.347AsnPhe: 3.347 ± 0.096
4.048AsnGly: 4.048 ± 0.115
0.961AsnHis: 0.961 ± 0.042
8.046AsnIle: 8.046 ± 0.165
7.373AsnLys: 7.373 ± 0.137
6.682AsnLeu: 6.682 ± 0.145
1.526AsnMet: 1.526 ± 0.05
4.933AsnAsn: 4.933 ± 0.133
2.249AsnPro: 2.249 ± 0.072
1.883AsnGln: 1.883 ± 0.056
2.207AsnArg: 2.207 ± 0.07
4.509AsnSer: 4.509 ± 0.129
3.081AsnThr: 3.081 ± 0.073
3.702AsnVal: 3.702 ± 0.087
0.531AsnTrp: 0.531 ± 0.036
3.187AsnTyr: 3.187 ± 0.101
0.0AsnXaa: 0.0 ± 0.0
Pro
1.258ProAla: 1.258 ± 0.052
0.154ProCys: 0.154 ± 0.016
1.32ProAsp: 1.32 ± 0.054
2.027ProGlu: 2.027 ± 0.082
1.376ProPhe: 1.376 ± 0.054
1.468ProGly: 1.468 ± 0.062
0.437ProHis: 0.437 ± 0.031
2.428ProIle: 2.428 ± 0.071
2.279ProLys: 2.279 ± 0.071
2.049ProLeu: 2.049 ± 0.067
0.643ProMet: 0.643 ± 0.039
1.663ProAsn: 1.663 ± 0.059
0.461ProPro: 0.461 ± 0.066
0.713ProGln: 0.713 ± 0.037
0.635ProArg: 0.635 ± 0.039
1.604ProSer: 1.604 ± 0.054
1.358ProThr: 1.358 ± 0.054
1.837ProVal: 1.837 ± 0.079
0.232ProTrp: 0.232 ± 0.023
1.186ProTyr: 1.186 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.238GlnAla: 1.238 ± 0.054
0.074GlnCys: 0.074 ± 0.011
1.134GlnAsp: 1.134 ± 0.05
1.823GlnGlu: 1.823 ± 0.059
1.046GlnPhe: 1.046 ± 0.053
1.42GlnGly: 1.42 ± 0.048
0.298GlnHis: 0.298 ± 0.026
2.58GlnIle: 2.58 ± 0.072
2.438GlnLys: 2.438 ± 0.072
2.161GlnLeu: 2.161 ± 0.068
0.679GlnMet: 0.679 ± 0.041
1.847GlnAsn: 1.847 ± 0.06
0.553GlnPro: 0.553 ± 0.037
0.619GlnGln: 0.619 ± 0.042
0.939GlnArg: 0.939 ± 0.043
1.314GlnSer: 1.314 ± 0.057
1.13GlnThr: 1.13 ± 0.051
1.346GlnVal: 1.346 ± 0.054
0.192GlnTrp: 0.192 ± 0.019
1.104GlnTyr: 1.104 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
1.646ArgAla: 1.646 ± 0.062
0.19ArgCys: 0.19 ± 0.022
1.871ArgAsp: 1.871 ± 0.073
2.61ArgGlu: 2.61 ± 0.073
1.512ArgPhe: 1.512 ± 0.054
1.867ArgGly: 1.867 ± 0.065
0.407ArgHis: 0.407 ± 0.029
2.94ArgIle: 2.94 ± 0.076
3.403ArgLys: 3.403 ± 0.074
2.999ArgLeu: 2.999 ± 0.07
0.847ArgMet: 0.847 ± 0.044
2.185ArgAsn: 2.185 ± 0.073
0.881ArgPro: 0.881 ± 0.042
0.971ArgGln: 0.971 ± 0.044
1.274ArgArg: 1.274 ± 0.058
1.528ArgSer: 1.528 ± 0.046
1.348ArgThr: 1.348 ± 0.051
1.979ArgVal: 1.979 ± 0.076
0.204ArgTrp: 0.204 ± 0.023
1.586ArgTyr: 1.586 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
2.87SerAla: 2.87 ± 0.075
0.353SerCys: 0.353 ± 0.03
3.688SerAsp: 3.688 ± 0.091
4.315SerGlu: 4.315 ± 0.104
3.363SerPhe: 3.363 ± 0.092
4.094SerGly: 4.094 ± 0.094
0.889SerHis: 0.889 ± 0.04
6.954SerIle: 6.954 ± 0.155
6.558SerLys: 6.558 ± 0.147
5.841SerLeu: 5.841 ± 0.113
1.492SerMet: 1.492 ± 0.051
4.192SerAsn: 4.192 ± 0.09
1.464SerPro: 1.464 ± 0.051
1.65SerGln: 1.65 ± 0.061
2.257SerArg: 2.257 ± 0.075
4.174SerSer: 4.174 ± 0.092
3.061SerThr: 3.061 ± 0.075
3.9SerVal: 3.9 ± 0.086
0.511SerTrp: 0.511 ± 0.036
2.738SerTyr: 2.738 ± 0.083
0.0SerXaa: 0.0 ± 0.0
Thr
2.358ThrAla: 2.358 ± 0.07
0.254ThrCys: 0.254 ± 0.026
2.352ThrAsp: 2.352 ± 0.072
2.64ThrGlu: 2.64 ± 0.072
2.313ThrPhe: 2.313 ± 0.068
3.275ThrGly: 3.275 ± 0.096
0.787ThrHis: 0.787 ± 0.036
4.659ThrIle: 4.659 ± 0.118
4.17ThrLys: 4.17 ± 0.1
4.427ThrLeu: 4.427 ± 0.093
0.975ThrMet: 0.975 ± 0.043
2.872ThrAsn: 2.872 ± 0.072
1.638ThrPro: 1.638 ± 0.063
1.254ThrGln: 1.254 ± 0.054
1.504ThrArg: 1.504 ± 0.057
3.087ThrSer: 3.087 ± 0.08
2.392ThrThr: 2.392 ± 0.085
3.025ThrVal: 3.025 ± 0.091
0.312ThrTrp: 0.312 ± 0.025
1.707ThrTyr: 1.707 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
3.375ValAla: 3.375 ± 0.097
0.431ValCys: 0.431 ± 0.03
3.652ValAsp: 3.652 ± 0.098
4.567ValGlu: 4.567 ± 0.112
3.141ValPhe: 3.141 ± 0.078
3.786ValGly: 3.786 ± 0.104
0.715ValHis: 0.715 ± 0.044
5.783ValIle: 5.783 ± 0.132
5.524ValLys: 5.524 ± 0.121
5.883ValLeu: 5.883 ± 0.131
1.346ValMet: 1.346 ± 0.047
3.704ValAsn: 3.704 ± 0.091
1.719ValPro: 1.719 ± 0.079
1.286ValGln: 1.286 ± 0.054
1.791ValArg: 1.791 ± 0.073
4.26ValSer: 4.26 ± 0.092
2.816ValThr: 2.816 ± 0.071
4.076ValVal: 4.076 ± 0.115
0.345ValTrp: 0.345 ± 0.027
2.454ValTyr: 2.454 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.371TrpAla: 0.371 ± 0.031
0.046TrpCys: 0.046 ± 0.012
0.423TrpAsp: 0.423 ± 0.031
0.425TrpGlu: 0.425 ± 0.041
0.32TrpPhe: 0.32 ± 0.03
0.425TrpGly: 0.425 ± 0.03
0.136TrpHis: 0.136 ± 0.017
0.715TrpIle: 0.715 ± 0.046
0.585TrpLys: 0.585 ± 0.038
0.529TrpLeu: 0.529 ± 0.032
0.172TrpMet: 0.172 ± 0.02
0.445TrpAsn: 0.445 ± 0.029
0.13TrpPro: 0.13 ± 0.018
0.216TrpGln: 0.216 ± 0.023
0.21TrpArg: 0.21 ± 0.02
0.361TrpSer: 0.361 ± 0.03
0.333TrpThr: 0.333 ± 0.022
0.335TrpVal: 0.335 ± 0.028
0.052TrpTrp: 0.052 ± 0.01
0.475TrpTyr: 0.475 ± 0.052
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.097TyrAla: 2.097 ± 0.063
0.318TyrCys: 0.318 ± 0.027
2.8TyrAsp: 2.8 ± 0.085
3.043TyrGlu: 3.043 ± 0.083
2.516TyrPhe: 2.516 ± 0.068
2.564TyrGly: 2.564 ± 0.07
0.633TyrHis: 0.633 ± 0.033
4.477TyrIle: 4.477 ± 0.118
4.148TyrLys: 4.148 ± 0.098
4.369TyrLeu: 4.369 ± 0.117
1.002TyrMet: 1.002 ± 0.047
3.039TyrAsn: 3.039 ± 0.084
1.196TyrPro: 1.196 ± 0.053
1.184TyrGln: 1.184 ± 0.054
1.574TyrArg: 1.574 ± 0.063
2.87TyrSer: 2.87 ± 0.086
2.089TyrThr: 2.089 ± 0.071
2.538TyrVal: 2.538 ± 0.074
0.296TyrTrp: 0.296 ± 0.022
2.271TyrTyr: 2.271 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1566 proteins (500755 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski