Amino acid dipepetide frequency for Adlercreutzia caecicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.112AlaAla: 17.112 ± 0.322
2.039AlaCys: 2.039 ± 0.108
6.96AlaAsp: 6.96 ± 0.243
7.583AlaGlu: 7.583 ± 0.152
4.298AlaPhe: 4.298 ± 0.127
9.48AlaGly: 9.48 ± 0.153
1.86AlaHis: 1.86 ± 0.07
5.571AlaIle: 5.571 ± 0.169
4.361AlaLys: 4.361 ± 0.103
12.245AlaLeu: 12.245 ± 0.363
3.173AlaMet: 3.173 ± 0.1
3.302AlaAsn: 3.302 ± 0.223
5.566AlaPro: 5.566 ± 0.124
4.884AlaGln: 4.884 ± 0.102
6.195AlaArg: 6.195 ± 0.185
6.408AlaSer: 6.408 ± 0.107
5.809AlaThr: 5.809 ± 0.264
9.274AlaVal: 9.274 ± 0.232
1.236AlaTrp: 1.236 ± 0.044
3.019AlaTyr: 3.019 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
1.769CysAla: 1.769 ± 0.086
0.324CysCys: 0.324 ± 0.027
0.89CysAsp: 0.89 ± 0.046
0.937CysGlu: 0.937 ± 0.056
0.55CysPhe: 0.55 ± 0.04
1.743CysGly: 1.743 ± 0.081
0.37CysHis: 0.37 ± 0.032
0.812CysIle: 0.812 ± 0.053
0.513CysLys: 0.513 ± 0.033
1.371CysLeu: 1.371 ± 0.077
0.425CysMet: 0.425 ± 0.036
0.437CysAsn: 0.437 ± 0.035
1.018CysPro: 1.018 ± 0.068
0.5CysGln: 0.5 ± 0.035
0.845CysArg: 0.845 ± 0.062
0.819CysSer: 0.819 ± 0.051
0.85CysThr: 0.85 ± 0.049
1.324CysVal: 1.324 ± 0.076
0.183CysTrp: 0.183 ± 0.02
0.418CysTyr: 0.418 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
6.965AspAla: 6.965 ± 0.212
0.732AspCys: 0.732 ± 0.039
3.286AspAsp: 3.286 ± 0.148
4.766AspGlu: 4.766 ± 0.13
2.373AspPhe: 2.373 ± 0.05
5.883AspGly: 5.883 ± 0.402
0.863AspHis: 0.863 ± 0.044
2.867AspIle: 2.867 ± 0.07
1.947AspLys: 1.947 ± 0.076
4.634AspLeu: 4.634 ± 0.083
1.377AspMet: 1.377 ± 0.043
1.682AspAsn: 1.682 ± 0.102
2.986AspPro: 2.986 ± 0.112
1.61AspGln: 1.61 ± 0.049
2.565AspArg: 2.565 ± 0.062
2.862AspSer: 2.862 ± 0.101
2.551AspThr: 2.551 ± 0.136
4.384AspVal: 4.384 ± 0.114
0.712AspTrp: 0.712 ± 0.049
2.011AspTyr: 2.011 ± 0.133
0.0AspXaa: 0.0 ± 0.0
Glu
8.88GluAla: 8.88 ± 0.145
0.768GluCys: 0.768 ± 0.047
3.508GluAsp: 3.508 ± 0.103
5.544GluGlu: 5.544 ± 0.127
2.052GluPhe: 2.052 ± 0.072
6.286GluGly: 6.286 ± 0.133
1.032GluHis: 1.032 ± 0.05
2.82GluIle: 2.82 ± 0.087
3.115GluLys: 3.115 ± 0.086
5.332GluLeu: 5.332 ± 0.143
1.943GluMet: 1.943 ± 0.08
2.341GluAsn: 2.341 ± 0.106
2.534GluPro: 2.534 ± 0.075
2.403GluGln: 2.403 ± 0.078
3.919GluArg: 3.919 ± 0.117
3.0GluSer: 3.0 ± 0.069
3.308GluThr: 3.308 ± 0.087
5.133GluVal: 5.133 ± 0.112
0.698GluTrp: 0.698 ± 0.035
1.67GluTyr: 1.67 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
4.439PheAla: 4.439 ± 0.137
0.79PheCys: 0.79 ± 0.059
2.633PheAsp: 2.633 ± 0.071
2.347PheGlu: 2.347 ± 0.067
1.629PhePhe: 1.629 ± 0.084
3.591PheGly: 3.591 ± 0.082
0.543PheHis: 0.543 ± 0.026
1.703PheIle: 1.703 ± 0.08
1.215PheLys: 1.215 ± 0.039
3.283PheLeu: 3.283 ± 0.133
1.035PheMet: 1.035 ± 0.055
1.207PheAsn: 1.207 ± 0.046
1.629PhePro: 1.629 ± 0.066
1.095PheGln: 1.095 ± 0.042
1.637PheArg: 1.637 ± 0.047
2.608PheSer: 2.608 ± 0.084
2.084PheThr: 2.084 ± 0.064
2.968PheVal: 2.968 ± 0.068
0.534PheTrp: 0.534 ± 0.033
1.124PheTyr: 1.124 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
9.571GlyAla: 9.571 ± 0.157
1.653GlyCys: 1.653 ± 0.091
4.371GlyAsp: 4.371 ± 0.182
5.192GlyGlu: 5.192 ± 0.109
3.574GlyPhe: 3.574 ± 0.083
6.403GlyGly: 6.403 ± 0.136
1.366GlyHis: 1.366 ± 0.05
4.391GlyIle: 4.391 ± 0.121
3.683GlyLys: 3.683 ± 0.08
7.554GlyLeu: 7.554 ± 0.178
2.309GlyMet: 2.309 ± 0.064
3.183GlyAsn: 3.183 ± 0.255
2.756GlyPro: 2.756 ± 0.113
3.084GlyGln: 3.084 ± 0.078
4.786GlyArg: 4.786 ± 0.161
4.839GlySer: 4.839 ± 0.157
4.905GlyThr: 4.905 ± 0.31
6.347GlyVal: 6.347 ± 0.091
1.195GlyTrp: 1.195 ± 0.055
2.624GlyTyr: 2.624 ± 0.16
0.0GlyXaa: 0.0 ± 0.0
His
1.536HisAla: 1.536 ± 0.056
0.373HisCys: 0.373 ± 0.025
0.932HisAsp: 0.932 ± 0.035
1.006HisGlu: 1.006 ± 0.041
0.645HisPhe: 0.645 ± 0.028
1.438HisGly: 1.438 ± 0.056
0.396HisHis: 0.396 ± 0.025
0.819HisIle: 0.819 ± 0.037
0.479HisLys: 0.479 ± 0.028
1.552HisLeu: 1.552 ± 0.053
0.391HisMet: 0.391 ± 0.024
0.526HisAsn: 0.526 ± 0.028
1.038HisPro: 1.038 ± 0.051
0.591HisGln: 0.591 ± 0.028
1.06HisArg: 1.06 ± 0.064
0.987HisSer: 0.987 ± 0.034
0.889HisThr: 0.889 ± 0.042
1.186HisVal: 1.186 ± 0.041
0.227HisTrp: 0.227 ± 0.019
0.559HisTyr: 0.559 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.768IleAla: 5.768 ± 0.161
0.848IleCys: 0.848 ± 0.049
3.174IleAsp: 3.174 ± 0.063
3.193IleGlu: 3.193 ± 0.119
1.459IlePhe: 1.459 ± 0.065
3.837IleGly: 3.837 ± 0.153
0.675IleHis: 0.675 ± 0.034
2.31IleIle: 2.31 ± 0.101
1.496IleLys: 1.496 ± 0.057
3.604IleLeu: 3.604 ± 0.14
1.227IleMet: 1.227 ± 0.062
1.548IleAsn: 1.548 ± 0.046
2.367IlePro: 2.367 ± 0.065
1.276IleGln: 1.276 ± 0.042
2.162IleArg: 2.162 ± 0.067
2.971IleSer: 2.971 ± 0.074
2.971IleThr: 2.971 ± 0.086
3.89IleVal: 3.89 ± 0.118
0.489IleTrp: 0.489 ± 0.027
1.285IleTyr: 1.285 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.3LysAla: 4.3 ± 0.102
0.518LysCys: 0.518 ± 0.04
1.943LysAsp: 1.943 ± 0.076
2.525LysGlu: 2.525 ± 0.067
0.967LysPhe: 0.967 ± 0.042
3.179LysGly: 3.179 ± 0.08
0.6LysHis: 0.6 ± 0.03
1.638LysIle: 1.638 ± 0.046
2.093LysLys: 2.093 ± 0.076
3.172LysLeu: 3.172 ± 0.071
1.035LysMet: 1.035 ± 0.042
1.32LysAsn: 1.32 ± 0.059
1.854LysPro: 1.854 ± 0.069
1.234LysGln: 1.234 ± 0.045
2.418LysArg: 2.418 ± 0.097
1.924LysSer: 1.924 ± 0.059
2.207LysThr: 2.207 ± 0.068
2.938LysVal: 2.938 ± 0.073
0.404LysTrp: 0.404 ± 0.023
0.97LysTyr: 0.97 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
11.783LeuAla: 11.783 ± 0.296
1.545LeuCys: 1.545 ± 0.082
5.09LeuAsp: 5.09 ± 0.077
5.851LeuGlu: 5.851 ± 0.159
3.699LeuPhe: 3.699 ± 0.136
7.426LeuGly: 7.426 ± 0.194
1.349LeuHis: 1.349 ± 0.06
3.734LeuIle: 3.734 ± 0.145
3.391LeuLys: 3.391 ± 0.08
9.043LeuLeu: 9.043 ± 0.279
2.596LeuMet: 2.596 ± 0.098
2.486LeuAsn: 2.486 ± 0.094
4.712LeuPro: 4.712 ± 0.088
2.875LeuGln: 2.875 ± 0.086
5.305LeuArg: 5.305 ± 0.133
5.714LeuSer: 5.714 ± 0.142
4.763LeuThr: 4.763 ± 0.094
7.721LeuVal: 7.721 ± 0.204
1.027LeuTrp: 1.027 ± 0.04
2.492LeuTyr: 2.492 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
3.517MetAla: 3.517 ± 0.121
0.292MetCys: 0.292 ± 0.023
1.513MetAsp: 1.513 ± 0.053
1.789MetGlu: 1.789 ± 0.07
0.813MetPhe: 0.813 ± 0.04
2.35MetGly: 2.35 ± 0.087
0.449MetHis: 0.449 ± 0.026
1.015MetIle: 1.015 ± 0.053
1.13MetLys: 1.13 ± 0.052
2.229MetLeu: 2.229 ± 0.089
0.672MetMet: 0.672 ± 0.043
0.932MetAsn: 0.932 ± 0.031
1.356MetPro: 1.356 ± 0.052
0.822MetGln: 0.822 ± 0.039
1.538MetArg: 1.538 ± 0.059
1.397MetSer: 1.397 ± 0.049
1.599MetThr: 1.599 ± 0.047
2.114MetVal: 2.114 ± 0.058
0.257MetTrp: 0.257 ± 0.02
0.556MetTyr: 0.556 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.204AsnAla: 3.204 ± 0.151
0.504AsnCys: 0.504 ± 0.038
1.658AsnAsp: 1.658 ± 0.137
1.735AsnGlu: 1.735 ± 0.069
1.104AsnPhe: 1.104 ± 0.059
2.856AsnGly: 2.856 ± 0.242
0.6AsnHis: 0.6 ± 0.041
1.464AsnIle: 1.464 ± 0.047
0.992AsnLys: 0.992 ± 0.051
2.872AsnLeu: 2.872 ± 0.078
0.809AsnMet: 0.809 ± 0.031
1.12AsnAsn: 1.12 ± 0.156
2.508AsnPro: 2.508 ± 0.106
1.08AsnGln: 1.08 ± 0.089
1.82AsnArg: 1.82 ± 0.058
1.763AsnSer: 1.763 ± 0.129
1.609AsnThr: 1.609 ± 0.191
2.287AsnVal: 2.287 ± 0.106
0.41AsnTrp: 0.41 ± 0.041
1.083AsnTyr: 1.083 ± 0.124
0.0AsnXaa: 0.0 ± 0.0
Pro
5.848ProAla: 5.848 ± 0.101
0.598ProCys: 0.598 ± 0.041
3.05ProAsp: 3.05 ± 0.082
3.938ProGlu: 3.938 ± 0.097
2.024ProPhe: 2.024 ± 0.072
3.609ProGly: 3.609 ± 0.07
0.855ProHis: 0.855 ± 0.047
1.911ProIle: 1.911 ± 0.068
1.699ProLys: 1.699 ± 0.061
4.494ProLeu: 4.494 ± 0.114
1.018ProMet: 1.018 ± 0.045
1.336ProAsn: 1.336 ± 0.066
1.443ProPro: 1.443 ± 0.066
1.96ProGln: 1.96 ± 0.053
2.326ProArg: 2.326 ± 0.073
2.74ProSer: 2.74 ± 0.072
2.504ProThr: 2.504 ± 0.088
4.102ProVal: 4.102 ± 0.085
0.627ProTrp: 0.627 ± 0.035
1.516ProTyr: 1.516 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
3.98GlnAla: 3.98 ± 0.093
0.491GlnCys: 0.491 ± 0.037
1.484GlnAsp: 1.484 ± 0.066
2.289GlnGlu: 2.289 ± 0.067
1.307GlnPhe: 1.307 ± 0.05
2.489GlnGly: 2.489 ± 0.064
0.537GlnHis: 0.537 ± 0.029
1.471GlnIle: 1.471 ± 0.047
1.486GlnLys: 1.486 ± 0.047
4.312GlnLeu: 4.312 ± 0.112
1.057GlnMet: 1.057 ± 0.042
1.056GlnAsn: 1.056 ± 0.066
1.757GlnPro: 1.757 ± 0.062
1.818GlnGln: 1.818 ± 0.069
2.366GlnArg: 2.366 ± 0.084
1.565GlnSer: 1.565 ± 0.045
1.592GlnThr: 1.592 ± 0.056
2.675GlnVal: 2.675 ± 0.07
0.6GlnTrp: 0.6 ± 0.047
0.806GlnTyr: 0.806 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
5.637ArgAla: 5.637 ± 0.181
0.897ArgCys: 0.897 ± 0.059
2.928ArgAsp: 2.928 ± 0.08
3.922ArgGlu: 3.922 ± 0.135
2.332ArgPhe: 2.332 ± 0.08
3.705ArgGly: 3.705 ± 0.094
1.165ArgHis: 1.165 ± 0.048
3.148ArgIle: 3.148 ± 0.096
2.196ArgLys: 2.196 ± 0.081
5.203ArgLeu: 5.203 ± 0.143
1.702ArgMet: 1.702 ± 0.06
1.654ArgAsn: 1.654 ± 0.047
2.493ArgPro: 2.493 ± 0.082
2.326ArgGln: 2.326 ± 0.08
3.97ArgArg: 3.97 ± 0.179
2.883ArgSer: 2.883 ± 0.093
2.907ArgThr: 2.907 ± 0.077
3.773ArgVal: 3.773 ± 0.08
0.623ArgTrp: 0.623 ± 0.031
1.808ArgTyr: 1.808 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
6.311SerAla: 6.311 ± 0.128
0.871SerCys: 0.871 ± 0.055
3.143SerAsp: 3.143 ± 0.109
2.926SerGlu: 2.926 ± 0.074
2.489SerPhe: 2.489 ± 0.067
5.084SerGly: 5.084 ± 0.122
1.011SerHis: 1.011 ± 0.038
2.761SerIle: 2.761 ± 0.071
1.782SerLys: 1.782 ± 0.053
5.072SerLeu: 5.072 ± 0.117
1.442SerMet: 1.442 ± 0.045
1.698SerAsn: 1.698 ± 0.106
2.717SerPro: 2.717 ± 0.069
2.043SerGln: 2.043 ± 0.065
3.132SerArg: 3.132 ± 0.1
3.562SerSer: 3.562 ± 0.106
2.849SerThr: 2.849 ± 0.125
4.282SerVal: 4.282 ± 0.085
0.758SerTrp: 0.758 ± 0.036
1.821SerTyr: 1.821 ± 0.082
0.0SerXaa: 0.0 ± 0.0
Thr
6.044ThrAla: 6.044 ± 0.172
0.786ThrCys: 0.786 ± 0.053
3.106ThrAsp: 3.106 ± 0.238
2.974ThrGlu: 2.974 ± 0.088
1.965ThrPhe: 1.965 ± 0.059
4.932ThrGly: 4.932 ± 0.236
0.918ThrHis: 0.918 ± 0.037
2.589ThrIle: 2.589 ± 0.075
1.651ThrLys: 1.651 ± 0.065
4.856ThrLeu: 4.856 ± 0.124
1.208ThrMet: 1.208 ± 0.05
1.58ThrAsn: 1.58 ± 0.165
2.946ThrPro: 2.946 ± 0.079
1.509ThrGln: 1.509 ± 0.08
2.473ThrArg: 2.473 ± 0.065
2.806ThrSer: 2.806 ± 0.122
3.028ThrThr: 3.028 ± 0.276
5.075ThrVal: 5.075 ± 0.215
0.667ThrTrp: 0.667 ± 0.049
1.719ThrTyr: 1.719 ± 0.142
0.0ThrXaa: 0.0 ± 0.0
Val
9.875ValAla: 9.875 ± 0.183
1.377ValCys: 1.377 ± 0.077
4.561ValAsp: 4.561 ± 0.13
5.122ValGlu: 5.122 ± 0.091
3.099ValPhe: 3.099 ± 0.105
5.862ValGly: 5.862 ± 0.115
1.224ValHis: 1.224 ± 0.04
3.793ValIle: 3.793 ± 0.093
2.701ValLys: 2.701 ± 0.072
7.601ValLeu: 7.601 ± 0.167
1.907ValMet: 1.907 ± 0.07
2.49ValAsn: 2.49 ± 0.095
4.12ValPro: 4.12 ± 0.087
2.383ValGln: 2.383 ± 0.061
4.293ValArg: 4.293 ± 0.098
4.717ValSer: 4.717 ± 0.087
4.37ValThr: 4.37 ± 0.182
7.18ValVal: 7.18 ± 0.158
0.899ValTrp: 0.899 ± 0.044
2.126ValTyr: 2.126 ± 0.079
0.0ValXaa: 0.0 ± 0.0
Trp
1.133TrpAla: 1.133 ± 0.039
0.232TrpCys: 0.232 ± 0.023
0.746TrpAsp: 0.746 ± 0.043
0.842TrpGlu: 0.842 ± 0.04
0.463TrpPhe: 0.463 ± 0.029
1.037TrpGly: 1.037 ± 0.047
0.251TrpHis: 0.251 ± 0.02
0.53TrpIle: 0.53 ± 0.03
0.427TrpLys: 0.427 ± 0.028
1.263TrpLeu: 1.263 ± 0.051
0.376TrpMet: 0.376 ± 0.027
0.553TrpAsn: 0.553 ± 0.073
0.472TrpPro: 0.472 ± 0.032
0.561TrpGln: 0.561 ± 0.03
0.659TrpArg: 0.659 ± 0.031
0.54TrpSer: 0.54 ± 0.028
0.534TrpThr: 0.534 ± 0.045
0.913TrpVal: 0.913 ± 0.053
0.203TrpTrp: 0.203 ± 0.019
0.363TrpTyr: 0.363 ± 0.048
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.703TyrAla: 2.703 ± 0.064
0.459TyrCys: 0.459 ± 0.028
2.077TyrAsp: 2.077 ± 0.153
1.808TyrGlu: 1.808 ± 0.074
1.253TyrPhe: 1.253 ± 0.056
2.599TyrGly: 2.599 ± 0.093
0.566TyrHis: 0.566 ± 0.032
1.207TyrIle: 1.207 ± 0.041
0.884TyrLys: 0.884 ± 0.071
2.909TyrLeu: 2.909 ± 0.08
0.636TyrMet: 0.636 ± 0.031
1.027TyrAsn: 1.027 ± 0.154
1.326TyrPro: 1.326 ± 0.045
1.08TyrGln: 1.08 ± 0.058
1.804TyrArg: 1.804 ± 0.067
1.648TyrSer: 1.648 ± 0.082
1.503TyrThr: 1.503 ± 0.132
2.13TyrVal: 2.13 ± 0.11
0.353TyrTrp: 0.353 ± 0.027
1.083TyrTyr: 1.083 ± 0.094
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1821 proteins (688622 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski