Amino acid dipepetide frequency for Smittium mucronatum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.213AlaAla: 3.213 ± 0.053
0.59AlaCys: 0.59 ± 0.017
2.562AlaAsp: 2.562 ± 0.03
2.781AlaGlu: 2.781 ± 0.036
2.081AlaPhe: 2.081 ± 0.029
2.565AlaGly: 2.565 ± 0.037
0.918AlaHis: 0.918 ± 0.019
3.589AlaIle: 3.589 ± 0.039
3.283AlaLys: 3.283 ± 0.042
4.512AlaLeu: 4.512 ± 0.048
1.017AlaMet: 1.017 ± 0.02
2.798AlaAsn: 2.798 ± 0.031
2.336AlaPro: 2.336 ± 0.037
1.808AlaGln: 1.808 ± 0.026
2.029AlaArg: 2.029 ± 0.029
4.997AlaSer: 4.997 ± 0.042
2.611AlaThr: 2.611 ± 0.037
2.809AlaVal: 2.809 ± 0.04
0.376AlaTrp: 0.376 ± 0.012
1.497AlaTyr: 1.497 ± 0.027
0.0AlaXaa: 0.0 ± 0.0
Cys
0.522CysAla: 0.522 ± 0.014
0.235CysCys: 0.235 ± 0.013
0.674CysAsp: 0.674 ± 0.014
0.568CysGlu: 0.568 ± 0.015
0.609CysPhe: 0.609 ± 0.014
0.765CysGly: 0.765 ± 0.022
0.253CysHis: 0.253 ± 0.011
0.818CysIle: 0.818 ± 0.016
0.687CysLys: 0.687 ± 0.015
1.159CysLeu: 1.159 ± 0.025
0.237CysMet: 0.237 ± 0.008
0.662CysAsn: 0.662 ± 0.019
0.593CysPro: 0.593 ± 0.016
0.379CysGln: 0.379 ± 0.014
0.523CysArg: 0.523 ± 0.013
1.18CysSer: 1.18 ± 0.023
0.572CysThr: 0.572 ± 0.014
0.657CysVal: 0.657 ± 0.014
0.117CysTrp: 0.117 ± 0.006
0.426CysTyr: 0.426 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
2.38AspAla: 2.38 ± 0.027
0.677AspCys: 0.677 ± 0.016
3.317AspAsp: 3.317 ± 0.046
3.503AspGlu: 3.503 ± 0.047
3.406AspPhe: 3.406 ± 0.036
2.823AspGly: 2.823 ± 0.031
1.105AspHis: 1.105 ± 0.021
4.289AspIle: 4.289 ± 0.036
3.295AspLys: 3.295 ± 0.031
5.905AspLeu: 5.905 ± 0.049
1.08AspMet: 1.08 ± 0.019
3.052AspAsn: 3.052 ± 0.036
3.071AspPro: 3.071 ± 0.033
2.161AspGln: 2.161 ± 0.028
2.169AspArg: 2.169 ± 0.025
7.536AspSer: 7.536 ± 0.072
2.785AspThr: 2.785 ± 0.033
3.029AspVal: 3.029 ± 0.039
0.514AspTrp: 0.514 ± 0.013
2.24AspTyr: 2.24 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
2.899GluAla: 2.899 ± 0.04
0.611GluCys: 0.611 ± 0.016
3.338GluAsp: 3.338 ± 0.038
3.622GluGlu: 3.622 ± 0.048
2.786GluPhe: 2.786 ± 0.035
2.182GluGly: 2.182 ± 0.033
0.909GluHis: 0.909 ± 0.018
4.748GluIle: 4.748 ± 0.051
4.898GluLys: 4.898 ± 0.049
5.399GluLeu: 5.399 ± 0.048
1.31GluMet: 1.31 ± 0.02
4.797GluAsn: 4.797 ± 0.052
2.146GluPro: 2.146 ± 0.028
1.72GluGln: 1.72 ± 0.028
2.266GluArg: 2.266 ± 0.037
6.09GluSer: 6.09 ± 0.057
3.22GluThr: 3.22 ± 0.043
2.633GluVal: 2.633 ± 0.033
0.497GluTrp: 0.497 ± 0.013
2.228GluTyr: 2.228 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
2.08PheAla: 2.08 ± 0.029
0.657PheCys: 0.657 ± 0.016
3.12PheAsp: 3.12 ± 0.035
2.815PheGlu: 2.815 ± 0.032
2.326PhePhe: 2.326 ± 0.036
2.965PheGly: 2.965 ± 0.033
0.872PheHis: 0.872 ± 0.015
3.0PheIle: 3.0 ± 0.032
3.06PheLys: 3.06 ± 0.036
4.101PheLeu: 4.101 ± 0.039
0.954PheMet: 0.954 ± 0.017
3.121PheAsn: 3.121 ± 0.033
2.127PhePro: 2.127 ± 0.026
1.475PheGln: 1.475 ± 0.024
1.785PheArg: 1.785 ± 0.024
5.546PheSer: 5.546 ± 0.052
2.128PheThr: 2.128 ± 0.026
2.581PheVal: 2.581 ± 0.032
0.42PheTrp: 0.42 ± 0.011
1.724PheTyr: 1.724 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
2.612GlyAla: 2.612 ± 0.04
0.691GlyCys: 0.691 ± 0.016
2.687GlyAsp: 2.687 ± 0.032
2.463GlyGlu: 2.463 ± 0.034
2.713GlyPhe: 2.713 ± 0.03
3.152GlyGly: 3.152 ± 0.049
1.026GlyHis: 1.026 ± 0.023
3.879GlyIle: 3.879 ± 0.037
3.265GlyLys: 3.265 ± 0.034
4.629GlyLeu: 4.629 ± 0.043
1.085GlyMet: 1.085 ± 0.021
3.142GlyAsn: 3.142 ± 0.044
1.894GlyPro: 1.894 ± 0.027
1.465GlyGln: 1.465 ± 0.025
2.131GlyArg: 2.131 ± 0.031
5.471GlySer: 5.471 ± 0.046
2.535GlyThr: 2.535 ± 0.032
2.961GlyVal: 2.961 ± 0.043
0.501GlyTrp: 0.501 ± 0.013
2.093GlyTyr: 2.093 ± 0.03
0.0GlyXaa: 0.0 ± 0.0
His
0.756HisAla: 0.756 ± 0.016
0.223HisCys: 0.223 ± 0.009
0.932HisAsp: 0.932 ± 0.018
0.998HisGlu: 0.998 ± 0.019
0.898HisPhe: 0.898 ± 0.018
0.981HisGly: 0.981 ± 0.02
0.523HisHis: 0.523 ± 0.018
1.327HisIle: 1.327 ± 0.02
1.249HisLys: 1.249 ± 0.02
1.815HisLeu: 1.815 ± 0.027
0.365HisMet: 0.365 ± 0.013
1.211HisAsn: 1.211 ± 0.02
1.153HisPro: 1.153 ± 0.022
0.81HisGln: 0.81 ± 0.018
0.874HisArg: 0.874 ± 0.019
2.134HisSer: 2.134 ± 0.03
0.894HisThr: 0.894 ± 0.017
0.915HisVal: 0.915 ± 0.018
0.162HisTrp: 0.162 ± 0.006
0.641HisTyr: 0.641 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
3.209IleAla: 3.209 ± 0.036
0.921IleCys: 0.921 ± 0.02
4.525IleAsp: 4.525 ± 0.039
4.333IleGlu: 4.333 ± 0.047
3.218IlePhe: 3.218 ± 0.034
3.462IleGly: 3.462 ± 0.037
1.374IleHis: 1.374 ± 0.022
4.5IleIle: 4.5 ± 0.052
5.117IleLys: 5.117 ± 0.053
6.169IleLeu: 6.169 ± 0.053
1.287IleMet: 1.287 ± 0.023
4.831IleAsn: 4.831 ± 0.041
4.025IlePro: 4.025 ± 0.04
2.509IleGln: 2.509 ± 0.034
2.76IleArg: 2.76 ± 0.031
8.818IleSer: 8.818 ± 0.065
3.262IleThr: 3.262 ± 0.037
3.647IleVal: 3.647 ± 0.038
0.545IleTrp: 0.545 ± 0.015
2.376IleTyr: 2.376 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.24LysAla: 3.24 ± 0.039
0.703LysCys: 0.703 ± 0.018
4.007LysAsp: 4.007 ± 0.042
3.8LysGlu: 3.8 ± 0.038
2.975LysPhe: 2.975 ± 0.033
2.666LysGly: 2.666 ± 0.029
1.221LysHis: 1.221 ± 0.02
5.585LysIle: 5.585 ± 0.057
6.869LysLys: 6.869 ± 0.069
6.187LysLeu: 6.187 ± 0.056
1.416LysMet: 1.416 ± 0.023
5.914LysAsn: 5.914 ± 0.054
3.209LysPro: 3.209 ± 0.042
2.044LysGln: 2.044 ± 0.028
3.324LysArg: 3.324 ± 0.039
7.987LysSer: 7.987 ± 0.081
4.011LysThr: 4.011 ± 0.036
3.504LysVal: 3.504 ± 0.038
0.534LysTrp: 0.534 ± 0.014
2.648LysTyr: 2.648 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
4.973LeuAla: 4.973 ± 0.046
1.092LeuCys: 1.092 ± 0.02
5.753LeuAsp: 5.753 ± 0.05
5.866LeuGlu: 5.866 ± 0.058
4.088LeuPhe: 4.088 ± 0.048
4.705LeuGly: 4.705 ± 0.046
1.561LeuHis: 1.561 ± 0.023
5.912LeuIle: 5.912 ± 0.055
6.607LeuLys: 6.607 ± 0.059
8.068LeuLeu: 8.068 ± 0.069
1.661LeuMet: 1.661 ± 0.024
6.087LeuAsn: 6.087 ± 0.06
4.125LeuPro: 4.125 ± 0.038
3.007LeuGln: 3.007 ± 0.038
3.433LeuArg: 3.433 ± 0.033
9.691LeuSer: 9.691 ± 0.064
4.214LeuThr: 4.214 ± 0.043
5.361LeuVal: 5.361 ± 0.049
0.687LeuTrp: 0.687 ± 0.017
2.847LeuTyr: 2.847 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
1.197MetAla: 1.197 ± 0.021
0.237MetCys: 0.237 ± 0.008
1.276MetAsp: 1.276 ± 0.023
1.267MetGlu: 1.267 ± 0.021
0.902MetPhe: 0.902 ± 0.018
1.121MetGly: 1.121 ± 0.018
0.342MetHis: 0.342 ± 0.011
1.241MetIle: 1.241 ± 0.019
1.248MetLys: 1.248 ± 0.02
1.591MetLeu: 1.591 ± 0.024
0.413MetMet: 0.413 ± 0.012
1.217MetAsn: 1.217 ± 0.018
0.767MetPro: 0.767 ± 0.015
0.624MetGln: 0.624 ± 0.015
0.797MetArg: 0.797 ± 0.016
1.805MetSer: 1.805 ± 0.025
0.942MetThr: 0.942 ± 0.017
1.207MetVal: 1.207 ± 0.021
0.154MetTrp: 0.154 ± 0.006
0.699MetTyr: 0.699 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.65AsnAla: 2.65 ± 0.033
0.748AsnCys: 0.748 ± 0.02
3.765AsnAsp: 3.765 ± 0.041
3.684AsnGlu: 3.684 ± 0.042
3.207AsnPhe: 3.207 ± 0.038
3.423AsnGly: 3.423 ± 0.044
1.469AsnHis: 1.469 ± 0.026
4.843AsnIle: 4.843 ± 0.048
4.487AsnLys: 4.487 ± 0.05
6.166AsnLeu: 6.166 ± 0.056
1.264AsnMet: 1.264 ± 0.021
4.994AsnAsn: 4.994 ± 0.061
3.955AsnPro: 3.955 ± 0.045
2.739AsnGln: 2.739 ± 0.04
2.664AsnArg: 2.664 ± 0.037
9.158AsnSer: 9.158 ± 0.097
3.464AsnThr: 3.464 ± 0.037
3.205AsnVal: 3.205 ± 0.031
0.503AsnTrp: 0.503 ± 0.012
2.452AsnTyr: 2.452 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
2.277ProAla: 2.277 ± 0.037
0.37ProCys: 0.37 ± 0.014
2.635ProAsp: 2.635 ± 0.03
3.3ProGlu: 3.3 ± 0.037
1.952ProPhe: 1.952 ± 0.03
2.192ProGly: 2.192 ± 0.028
0.903ProHis: 0.903 ± 0.019
3.653ProIle: 3.653 ± 0.037
3.748ProLys: 3.748 ± 0.045
3.996ProLeu: 3.996 ± 0.035
0.728ProMet: 0.728 ± 0.019
3.561ProAsn: 3.561 ± 0.04
2.869ProPro: 2.869 ± 0.051
1.948ProGln: 1.948 ± 0.032
1.762ProArg: 1.762 ± 0.03
5.715ProSer: 5.715 ± 0.066
2.904ProThr: 2.904 ± 0.04
2.762ProVal: 2.762 ± 0.032
0.305ProTrp: 0.305 ± 0.011
1.414ProTyr: 1.414 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
1.712GlnAla: 1.712 ± 0.026
0.321GlnCys: 0.321 ± 0.01
1.886GlnAsp: 1.886 ± 0.026
1.959GlnGlu: 1.959 ± 0.029
1.519GlnPhe: 1.519 ± 0.025
1.433GlnGly: 1.433 ± 0.028
0.609GlnHis: 0.609 ± 0.015
2.767GlnIle: 2.767 ± 0.033
2.723GlnLys: 2.723 ± 0.029
3.132GlnLeu: 3.132 ± 0.04
0.769GlnMet: 0.769 ± 0.017
3.011GlnAsn: 3.011 ± 0.047
1.548GlnPro: 1.548 ± 0.027
1.57GlnGln: 1.57 ± 0.057
1.417GlnArg: 1.417 ± 0.023
3.462GlnSer: 3.462 ± 0.045
2.026GlnThr: 2.026 ± 0.029
1.851GlnVal: 1.851 ± 0.025
0.261GlnTrp: 0.261 ± 0.008
1.18GlnTyr: 1.18 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
2.072ArgAla: 2.072 ± 0.03
0.482ArgCys: 0.482 ± 0.012
2.326ArgAsp: 2.326 ± 0.033
2.088ArgGlu: 2.088 ± 0.028
1.996ArgPhe: 1.996 ± 0.025
1.977ArgGly: 1.977 ± 0.032
0.781ArgHis: 0.781 ± 0.019
3.056ArgIle: 3.056 ± 0.034
3.166ArgLys: 3.166 ± 0.038
3.746ArgLeu: 3.746 ± 0.039
0.875ArgMet: 0.875 ± 0.018
2.756ArgAsn: 2.756 ± 0.032
1.815ArgPro: 1.815 ± 0.033
1.345ArgGln: 1.345 ± 0.023
2.175ArgArg: 2.175 ± 0.034
3.983ArgSer: 3.983 ± 0.045
1.934ArgThr: 1.934 ± 0.027
2.222ArgVal: 2.222 ± 0.027
0.386ArgTrp: 0.386 ± 0.012
1.416ArgTyr: 1.416 ± 0.022
0.0ArgXaa: 0.0 ± 0.0
Ser
5.239SerAla: 5.239 ± 0.055
1.119SerCys: 1.119 ± 0.019
6.799SerAsp: 6.799 ± 0.07
6.787SerGlu: 6.787 ± 0.058
5.102SerPhe: 5.102 ± 0.044
5.737SerGly: 5.737 ± 0.055
2.187SerHis: 2.187 ± 0.029
7.927SerIle: 7.927 ± 0.065
8.637SerLys: 8.637 ± 0.073
9.913SerLeu: 9.913 ± 0.071
1.867SerMet: 1.867 ± 0.024
8.453SerAsn: 8.453 ± 0.086
5.433SerPro: 5.433 ± 0.059
4.391SerGln: 4.391 ± 0.057
4.49SerArg: 4.49 ± 0.045
14.789SerSer: 14.789 ± 0.135
6.348SerThr: 6.348 ± 0.082
5.663SerVal: 5.663 ± 0.049
0.757SerTrp: 0.757 ± 0.019
3.208SerTyr: 3.208 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
2.578ThrAla: 2.578 ± 0.034
0.592ThrCys: 0.592 ± 0.016
2.825ThrAsp: 2.825 ± 0.033
2.998ThrGlu: 2.998 ± 0.034
2.37ThrPhe: 2.37 ± 0.03
2.871ThrGly: 2.871 ± 0.037
0.984ThrHis: 0.984 ± 0.018
3.589ThrIle: 3.589 ± 0.037
3.465ThrLys: 3.465 ± 0.036
4.438ThrLeu: 4.438 ± 0.038
0.839ThrMet: 0.839 ± 0.018
3.335ThrAsn: 3.335 ± 0.038
3.123ThrPro: 3.123 ± 0.037
1.863ThrGln: 1.863 ± 0.031
2.065ThrArg: 2.065 ± 0.026
5.933ThrSer: 5.933 ± 0.079
3.178ThrThr: 3.178 ± 0.092
2.863ThrVal: 2.863 ± 0.042
0.39ThrTrp: 0.39 ± 0.01
1.405ThrTyr: 1.405 ± 0.023
0.0ThrXaa: 0.0 ± 0.0
Val
2.938ValAla: 2.938 ± 0.04
0.768ValCys: 0.768 ± 0.018
3.376ValAsp: 3.376 ± 0.04
3.198ValGlu: 3.198 ± 0.046
2.57ValPhe: 2.57 ± 0.035
2.954ValGly: 2.954 ± 0.037
1.032ValHis: 1.032 ± 0.019
3.351ValIle: 3.351 ± 0.036
3.27ValLys: 3.27 ± 0.036
4.847ValLeu: 4.847 ± 0.042
1.018ValMet: 1.018 ± 0.018
3.047ValAsn: 3.047 ± 0.036
2.823ValPro: 2.823 ± 0.032
1.766ValGln: 1.766 ± 0.024
2.019ValArg: 2.019 ± 0.03
5.952ValSer: 5.952 ± 0.049
2.598ValThr: 2.598 ± 0.045
3.351ValVal: 3.351 ± 0.054
0.503ValTrp: 0.503 ± 0.016
1.962ValTyr: 1.962 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
0.441TrpAla: 0.441 ± 0.013
0.125TrpCys: 0.125 ± 0.007
0.571TrpAsp: 0.571 ± 0.016
0.476TrpGlu: 0.476 ± 0.012
0.392TrpPhe: 0.392 ± 0.01
0.419TrpGly: 0.419 ± 0.013
0.128TrpHis: 0.128 ± 0.006
0.601TrpIle: 0.601 ± 0.014
0.564TrpLys: 0.564 ± 0.015
0.701TrpLeu: 0.701 ± 0.017
0.195TrpMet: 0.195 ± 0.008
0.519TrpAsn: 0.519 ± 0.014
0.269TrpPro: 0.269 ± 0.009
0.213TrpGln: 0.213 ± 0.008
0.406TrpArg: 0.406 ± 0.012
0.743TrpSer: 0.743 ± 0.017
0.386TrpThr: 0.386 ± 0.011
0.477TrpVal: 0.477 ± 0.012
0.119TrpTrp: 0.119 ± 0.006
0.302TrpTyr: 0.302 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.384TyrAla: 1.384 ± 0.025
0.475TyrCys: 0.475 ± 0.014
1.964TyrAsp: 1.964 ± 0.024
1.794TyrGlu: 1.794 ± 0.029
1.744TyrPhe: 1.744 ± 0.025
2.001TyrGly: 2.001 ± 0.032
0.661TyrHis: 0.661 ± 0.015
2.213TyrIle: 2.213 ± 0.028
2.208TyrLys: 2.208 ± 0.027
3.262TyrLeu: 3.262 ± 0.032
0.665TyrMet: 0.665 ± 0.015
2.333TyrAsn: 2.333 ± 0.033
1.716TyrPro: 1.716 ± 0.026
1.32TyrGln: 1.32 ± 0.022
1.508TyrArg: 1.508 ± 0.025
3.857TyrSer: 3.857 ± 0.04
1.689TyrThr: 1.689 ± 0.027
1.647TyrVal: 1.647 ± 0.025
0.316TyrTrp: 0.316 ± 0.01
1.369TyrTyr: 1.369 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.069XaaXaa: 0.069 ± 0.035
Statistics based on 7962 proteins (3195901 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski