Amino acid dipepetide frequency for Pontibaca methylaminivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.688AlaAla: 18.688 ± 0.239	1.061AlaCys: 1.061 ± 0.041	7.077AlaAsp: 7.077 ± 0.098	8.909AlaGlu: 8.909 ± 0.128	3.919AlaPhe: 3.919 ± 0.078	12.551AlaGly: 12.551 ± 0.149	2.436AlaHis: 2.436 ± 0.057	5.736AlaIle: 5.736 ± 0.097	2.367AlaLys: 2.367 ± 0.065	15.094AlaLeu: 15.094 ± 0.181	3.849AlaMet: 3.849 ± 0.072	2.322AlaAsn: 2.322 ± 0.06	6.828AlaPro: 6.828 ± 0.127	4.242AlaGln: 4.242 ± 0.08	11.558AlaArg: 11.558 ± 0.144	5.148AlaSer: 5.148 ± 0.082	5.519AlaThr: 5.519 ± 0.09	8.31AlaVal: 8.31 ± 0.121	1.413AlaTrp: 1.413 ± 0.046	2.219AlaTyr: 2.219 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.104CysAla: 1.104 ± 0.037	0.111CysCys: 0.111 ± 0.014	0.604CysAsp: 0.604 ± 0.029	0.441CysGlu: 0.441 ± 0.025	0.299CysPhe: 0.299 ± 0.019	0.875CysGly: 0.875 ± 0.038	0.265CysHis: 0.265 ± 0.02	0.382CysIle: 0.382 ± 0.02	0.158CysLys: 0.158 ± 0.016	0.801CysLeu: 0.801 ± 0.032	0.174CysMet: 0.174 ± 0.016	0.194CysAsn: 0.194 ± 0.018	0.555CysPro: 0.555 ± 0.03	0.173CysGln: 0.173 ± 0.016	0.657CysArg: 0.657 ± 0.032	0.494CysSer: 0.494 ± 0.026	0.433CysThr: 0.433 ± 0.028	0.525CysVal: 0.525 ± 0.027	0.134CysTrp: 0.134 ± 0.015	0.208CysTyr: 0.208 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.303AspAla: 7.303 ± 0.108	0.547AspCys: 0.547 ± 0.03	3.538AspAsp: 3.538 ± 0.085	3.848AspGlu: 3.848 ± 0.082	2.335AspPhe: 2.335 ± 0.058	5.316AspGly: 5.316 ± 0.094	1.53AspHis: 1.53 ± 0.047	3.019AspIle: 3.019 ± 0.064	1.259AspLys: 1.259 ± 0.047	6.723AspLeu: 6.723 ± 0.1	1.602AspMet: 1.602 ± 0.043	1.216AspAsn: 1.216 ± 0.042	3.975AspPro: 3.975 ± 0.08	1.653AspGln: 1.653 ± 0.048	4.745AspArg: 4.745 ± 0.086	2.587AspSer: 2.587 ± 0.064	2.653AspThr: 2.653 ± 0.072	3.784AspVal: 3.784 ± 0.084	1.178AspTrp: 1.178 ± 0.04	1.495AspTyr: 1.495 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.287GluAla: 8.287 ± 0.129	0.355GluCys: 0.355 ± 0.021	3.403GluAsp: 3.403 ± 0.07	3.389GluGlu: 3.389 ± 0.08	1.725GluPhe: 1.725 ± 0.046	5.095GluGly: 5.095 ± 0.081	1.271GluHis: 1.271 ± 0.041	3.722GluIle: 3.722 ± 0.085	1.816GluLys: 1.816 ± 0.062	5.376GluLeu: 5.376 ± 0.089	1.639GluMet: 1.639 ± 0.051	1.681GluAsn: 1.681 ± 0.049	2.949GluPro: 2.949 ± 0.075	2.212GluGln: 2.212 ± 0.062	5.63GluArg: 5.63 ± 0.099	3.054GluSer: 3.054 ± 0.065	3.823GluThr: 3.823 ± 0.074	4.193GluVal: 4.193 ± 0.071	0.808GluTrp: 0.808 ± 0.035	1.118GluTyr: 1.118 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.324PheAla: 4.324 ± 0.075	0.367PheCys: 0.367 ± 0.021	2.684PheAsp: 2.684 ± 0.063	2.051PheGlu: 2.051 ± 0.049	1.299PhePhe: 1.299 ± 0.048	3.542PheGly: 3.542 ± 0.079	0.815PheHis: 0.815 ± 0.036	1.519PheIle: 1.519 ± 0.049	0.619PheLys: 0.619 ± 0.03	3.422PheLeu: 3.422 ± 0.079	0.811PheMet: 0.811 ± 0.031	0.873PheAsn: 0.873 ± 0.034	1.528PhePro: 1.528 ± 0.048	0.845PheGln: 0.845 ± 0.031	2.417PheArg: 2.417 ± 0.056	2.019PheSer: 2.019 ± 0.059	1.92PheThr: 1.92 ± 0.052	2.424PheVal: 2.424 ± 0.061	0.549PheTrp: 0.549 ± 0.028	0.863PheTyr: 0.863 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	11.073GlyAla: 11.073 ± 0.139	0.87GlyCys: 0.87 ± 0.034	4.967GlyAsp: 4.967 ± 0.097	5.449GlyGlu: 5.449 ± 0.093	3.631GlyPhe: 3.631 ± 0.061	7.927GlyGly: 7.927 ± 0.131	2.101GlyHis: 2.101 ± 0.057	4.683GlyIle: 4.683 ± 0.079	2.581GlyLys: 2.581 ± 0.065	9.311GlyLeu: 9.311 ± 0.122	2.498GlyMet: 2.498 ± 0.063	2.051GlyAsn: 2.051 ± 0.056	4.041GlyPro: 4.041 ± 0.078	3.011GlyGln: 3.011 ± 0.062	7.382GlyArg: 7.382 ± 0.113	4.331GlySer: 4.331 ± 0.072	4.59GlyThr: 4.59 ± 0.083	6.063GlyVal: 6.063 ± 0.101	1.612GlyTrp: 1.612 ± 0.055	2.149GlyTyr: 2.149 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.596HisAla: 2.596 ± 0.061	0.228HisCys: 0.228 ± 0.016	1.477HisAsp: 1.477 ± 0.045	1.203HisGlu: 1.203 ± 0.044	0.784HisPhe: 0.784 ± 0.032	2.106HisGly: 2.106 ± 0.054	0.597HisHis: 0.597 ± 0.033	0.881HisIle: 0.881 ± 0.03	0.396HisLys: 0.396 ± 0.025	2.208HisLeu: 2.208 ± 0.058	0.545HisMet: 0.545 ± 0.026	0.429HisAsn: 0.429 ± 0.025	1.495HisPro: 1.495 ± 0.049	0.533HisGln: 0.533 ± 0.027	1.688HisArg: 1.688 ± 0.046	0.914HisSer: 0.914 ± 0.038	0.704HisThr: 0.704 ± 0.033	1.738HisVal: 1.738 ± 0.042	0.346HisTrp: 0.346 ± 0.02	0.592HisTyr: 0.592 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.233IleAla: 7.233 ± 0.095	0.583IleCys: 0.583 ± 0.025	3.341IleAsp: 3.341 ± 0.073	3.629IleGlu: 3.629 ± 0.071	1.552IlePhe: 1.552 ± 0.046	4.841IleGly: 4.841 ± 0.089	1.019IleHis: 1.019 ± 0.039	2.195IleIle: 2.195 ± 0.058	1.006IleLys: 1.006 ± 0.039	4.654IleLeu: 4.654 ± 0.088	1.067IleMet: 1.067 ± 0.039	1.198IleAsn: 1.198 ± 0.043	2.284IlePro: 2.284 ± 0.049	0.955IleGln: 0.955 ± 0.039	4.014IleArg: 4.014 ± 0.078	2.814IleSer: 2.814 ± 0.059	2.879IleThr: 2.879 ± 0.08	3.253IleVal: 3.253 ± 0.072	0.705IleTrp: 0.705 ± 0.029	1.031IleTyr: 1.031 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	2.876LysAla: 2.876 ± 0.068	0.154LysCys: 0.154 ± 0.014	1.297LysAsp: 1.297 ± 0.046	1.157LysGlu: 1.157 ± 0.044	0.658LysPhe: 0.658 ± 0.028	2.181LysGly: 2.181 ± 0.065	0.455LysHis: 0.455 ± 0.022	1.178LysIle: 1.178 ± 0.048	0.82LysLys: 0.82 ± 0.04	2.203LysLeu: 2.203 ± 0.059	0.587LysMet: 0.587 ± 0.031	0.521LysAsn: 0.521 ± 0.03	1.417LysPro: 1.417 ± 0.04	0.703LysGln: 0.703 ± 0.03	1.86LysArg: 1.86 ± 0.052	1.347LysSer: 1.347 ± 0.043	1.399LysThr: 1.399 ± 0.049	1.628LysVal: 1.628 ± 0.049	0.316LysTrp: 0.316 ± 0.02	0.486LysTyr: 0.486 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.847LeuAla: 14.847 ± 0.194	0.963LeuCys: 0.963 ± 0.036	6.448LeuAsp: 6.448 ± 0.111	5.466LeuGlu: 5.466 ± 0.085	3.518LeuPhe: 3.518 ± 0.086	8.826LeuGly: 8.826 ± 0.125	2.103LeuHis: 2.103 ± 0.06	4.978LeuIle: 4.978 ± 0.09	2.392LeuLys: 2.392 ± 0.073	10.037LeuLeu: 10.037 ± 0.141	2.552LeuMet: 2.552 ± 0.058	2.257LeuAsn: 2.257 ± 0.062	6.015LeuPro: 6.015 ± 0.092	2.548LeuGln: 2.548 ± 0.051	9.03LeuArg: 9.03 ± 0.132	6.058LeuSer: 6.058 ± 0.099	5.146LeuThr: 5.146 ± 0.081	7.45LeuVal: 7.45 ± 0.117	1.329LeuTrp: 1.329 ± 0.045	1.863LeuTyr: 1.863 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.335MetAla: 3.335 ± 0.07	0.145MetCys: 0.145 ± 0.013	1.271MetAsp: 1.271 ± 0.043	1.352MetGlu: 1.352 ± 0.042	0.8MetPhe: 0.8 ± 0.036	2.084MetGly: 2.084 ± 0.06	0.376MetHis: 0.376 ± 0.024	1.53MetIle: 1.53 ± 0.043	0.913MetLys: 0.913 ± 0.033	2.712MetLeu: 2.712 ± 0.056	0.708MetMet: 0.708 ± 0.034	0.851MetAsn: 0.851 ± 0.032	1.507MetPro: 1.507 ± 0.046	0.963MetGln: 0.963 ± 0.032	2.112MetArg: 2.112 ± 0.047	1.7MetSer: 1.7 ± 0.051	1.875MetThr: 1.875 ± 0.052	1.821MetVal: 1.821 ± 0.057	0.204MetTrp: 0.204 ± 0.016	0.26MetTyr: 0.26 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.771AsnAla: 2.771 ± 0.057	0.223AsnCys: 0.223 ± 0.018	1.395AsnAsp: 1.395 ± 0.045	1.109AsnGlu: 1.109 ± 0.036	0.797AsnPhe: 0.797 ± 0.032	2.042AsnGly: 2.042 ± 0.058	0.488AsnHis: 0.488 ± 0.023	1.165AsnIle: 1.165 ± 0.034	0.48AsnLys: 0.48 ± 0.022	2.293AsnLeu: 2.293 ± 0.052	0.64AsnMet: 0.64 ± 0.029	0.488AsnAsn: 0.488 ± 0.027	1.744AsnPro: 1.744 ± 0.042	0.574AsnGln: 0.574 ± 0.025	1.926AsnArg: 1.926 ± 0.05	1.043AsnSer: 1.043 ± 0.036	1.086AsnThr: 1.086 ± 0.041	1.592AsnVal: 1.592 ± 0.048	0.407AsnTrp: 0.407 ± 0.028	0.553AsnTyr: 0.553 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.047ProAla: 7.047 ± 0.111	0.424ProCys: 0.424 ± 0.026	4.247ProAsp: 4.247 ± 0.09	4.87ProGlu: 4.87 ± 0.102	1.917ProPhe: 1.917 ± 0.043	5.53ProGly: 5.53 ± 0.102	1.128ProHis: 1.128 ± 0.039	1.99ProIle: 1.99 ± 0.055	1.057ProLys: 1.057 ± 0.044	5.309ProLeu: 5.309 ± 0.086	1.297ProMet: 1.297 ± 0.04	1.038ProAsn: 1.038 ± 0.034	2.853ProPro: 2.853 ± 0.079	1.597ProGln: 1.597 ± 0.046	3.742ProArg: 3.742 ± 0.069	2.154ProSer: 2.154 ± 0.057	1.93ProThr: 1.93 ± 0.055	4.407ProVal: 4.407 ± 0.081	0.68ProTrp: 0.68 ± 0.033	1.058ProTyr: 1.058 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.916GlnAla: 3.916 ± 0.067	0.158GlnCys: 0.158 ± 0.014	1.548GlnAsp: 1.548 ± 0.047	1.692GlnGlu: 1.692 ± 0.052	0.996GlnPhe: 0.996 ± 0.034	2.453GlnGly: 2.453 ± 0.056	0.575GlnHis: 0.575 ± 0.026	1.825GlnIle: 1.825 ± 0.052	0.837GlnLys: 0.837 ± 0.034	2.554GlnLeu: 2.554 ± 0.063	0.945GlnMet: 0.945 ± 0.036	0.749GlnAsn: 0.749 ± 0.034	1.6GlnPro: 1.6 ± 0.048	1.075GlnGln: 1.075 ± 0.038	2.325GlnArg: 2.325 ± 0.055	1.546GlnSer: 1.546 ± 0.042	1.404GlnThr: 1.404 ± 0.038	2.143GlnVal: 2.143 ± 0.054	0.379GlnTrp: 0.379 ± 0.023	0.532GlnTyr: 0.532 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	10.125ArgAla: 10.125 ± 0.13	0.513ArgCys: 0.513 ± 0.026	5.317ArgAsp: 5.317 ± 0.084	5.213ArgGlu: 5.213 ± 0.083	3.037ArgPhe: 3.037 ± 0.06	6.026ArgGly: 6.026 ± 0.1	2.074ArgHis: 2.074 ± 0.052	4.916ArgIle: 4.916 ± 0.091	2.206ArgLys: 2.206 ± 0.054	9.202ArgLeu: 9.202 ± 0.139	2.322ArgMet: 2.322 ± 0.053	2.046ArgAsn: 2.046 ± 0.049	4.408ArgPro: 4.408 ± 0.091	2.521ArgGln: 2.521 ± 0.058	7.388ArgArg: 7.388 ± 0.131	3.771ArgSer: 3.771 ± 0.078	3.09ArgThr: 3.09 ± 0.07	5.09ArgVal: 5.09 ± 0.081	1.089ArgTrp: 1.089 ± 0.035	1.656ArgTyr: 1.656 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.979SerAla: 5.979 ± 0.087	0.451SerCys: 0.451 ± 0.027	3.216SerAsp: 3.216 ± 0.066	2.903SerGlu: 2.903 ± 0.069	2.082SerPhe: 2.082 ± 0.054	5.816SerGly: 5.816 ± 0.092	1.101SerHis: 1.101 ± 0.041	2.21SerIle: 2.21 ± 0.056	1.005SerLys: 1.005 ± 0.036	4.649SerLeu: 4.649 ± 0.081	1.245SerMet: 1.245 ± 0.036	1.143SerAsn: 1.143 ± 0.043	2.6SerPro: 2.6 ± 0.059	1.255SerGln: 1.255 ± 0.043	3.826SerArg: 3.826 ± 0.077	2.326SerSer: 2.326 ± 0.069	2.297SerThr: 2.297 ± 0.047	3.254SerVal: 3.254 ± 0.067	0.628SerTrp: 0.628 ± 0.031	1.208SerTyr: 1.208 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.875ThrAla: 5.875 ± 0.09	0.477ThrCys: 0.477 ± 0.026	2.759ThrAsp: 2.759 ± 0.07	2.657ThrGlu: 2.657 ± 0.064	1.556ThrPhe: 1.556 ± 0.049	5.258ThrGly: 5.258 ± 0.096	0.993ThrHis: 0.993 ± 0.035	2.61ThrIle: 2.61 ± 0.072	0.877ThrLys: 0.877 ± 0.037	5.637ThrLeu: 5.637 ± 0.083	1.246ThrMet: 1.246 ± 0.04	1.052ThrAsn: 1.052 ± 0.042	3.123ThrPro: 3.123 ± 0.065	1.232ThrGln: 1.232 ± 0.04	3.933ThrArg: 3.933 ± 0.067	2.24ThrSer: 2.24 ± 0.061	2.531ThrThr: 2.531 ± 0.069	3.624ThrVal: 3.624 ± 0.071	0.579ThrTrp: 0.579 ± 0.024	0.994ThrTyr: 0.994 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.346ValAla: 8.346 ± 0.125	0.574ValCys: 0.574 ± 0.028	3.599ValAsp: 3.599 ± 0.078	4.311ValGlu: 4.311 ± 0.085	2.632ValPhe: 2.632 ± 0.068	4.81ValGly: 4.81 ± 0.087	1.341ValHis: 1.341 ± 0.052	4.156ValIle: 4.156 ± 0.075	1.621ValLys: 1.621 ± 0.047	7.746ValLeu: 7.746 ± 0.12	1.996ValMet: 1.996 ± 0.057	1.812ValAsn: 1.812 ± 0.053	3.635ValPro: 3.635 ± 0.074	2.0ValGln: 2.0 ± 0.049	4.697ValArg: 4.697 ± 0.075	3.741ValSer: 3.741 ± 0.073	4.404ValThr: 4.404 ± 0.106	5.369ValVal: 5.369 ± 0.092	0.857ValTrp: 0.857 ± 0.034	1.267ValTyr: 1.267 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.309TrpAla: 1.309 ± 0.044	0.144TrpCys: 0.144 ± 0.015	0.695TrpAsp: 0.695 ± 0.028	0.681TrpGlu: 0.681 ± 0.03	0.568TrpPhe: 0.568 ± 0.027	1.011TrpGly: 1.011 ± 0.038	0.341TrpHis: 0.341 ± 0.021	0.732TrpIle: 0.732 ± 0.029	0.383TrpLys: 0.383 ± 0.022	1.753TrpLeu: 1.753 ± 0.06	0.358TrpMet: 0.358 ± 0.019	0.385TrpAsn: 0.385 ± 0.023	0.763TrpPro: 0.763 ± 0.034	0.591TrpGln: 0.591 ± 0.026	1.282TrpArg: 1.282 ± 0.039	0.819TrpSer: 0.819 ± 0.036	0.654TrpThr: 0.654 ± 0.035	0.803TrpVal: 0.803 ± 0.032	0.206TrpTrp: 0.206 ± 0.017	0.265TrpTyr: 0.265 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.213TyrAla: 2.213 ± 0.059	0.237TyrCys: 0.237 ± 0.021	1.422TyrAsp: 1.422 ± 0.053	1.216TyrGlu: 1.216 ± 0.043	0.787TyrPhe: 0.787 ± 0.03	2.031TyrGly: 2.031 ± 0.052	0.453TyrHis: 0.453 ± 0.021	0.826TyrIle: 0.826 ± 0.034	0.452TyrLys: 0.452 ± 0.025	2.143TyrLeu: 2.143 ± 0.047	0.434TyrMet: 0.434 ± 0.024	0.512TyrAsn: 0.512 ± 0.025	0.955TyrPro: 0.955 ± 0.034	0.569TyrGln: 0.569 ± 0.028	1.797TyrArg: 1.797 ± 0.058	1.089TyrSer: 1.089 ± 0.042	0.914TyrThr: 0.914 ± 0.04	1.445TyrVal: 1.445 ± 0.045	0.323TyrTrp: 0.323 ± 0.021	0.525TyrTyr: 0.525 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2497 proteins (785412 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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