Amino acid dipepetide frequency for Grapevine leafroll-associated virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.424AlaAla: 7.424 ± 1.246
2.413AlaCys: 2.413 ± 0.764
3.155AlaAsp: 3.155 ± 0.678
4.269AlaGlu: 4.269 ± 1.805
4.083AlaPhe: 4.083 ± 0.785
3.712AlaGly: 3.712 ± 1.533
1.299AlaHis: 1.299 ± 0.461
3.341AlaIle: 3.341 ± 1.153
2.784AlaLys: 2.784 ± 0.678
6.682AlaLeu: 6.682 ± 0.998
1.856AlaMet: 1.856 ± 0.589
3.341AlaAsn: 3.341 ± 0.824
2.784AlaPro: 2.784 ± 0.938
1.856AlaGln: 1.856 ± 0.343
2.97AlaArg: 2.97 ± 0.731
6.31AlaSer: 6.31 ± 1.243
1.856AlaThr: 1.856 ± 1.108
7.238AlaVal: 7.238 ± 1.395
0.557AlaTrp: 0.557 ± 0.557
1.856AlaTyr: 1.856 ± 0.784
0.0AlaXaa: 0.0 ± 0.0
Cys
3.712CysAla: 3.712 ± 1.222
0.557CysCys: 0.557 ± 0.527
2.042CysAsp: 2.042 ± 0.684
1.299CysGlu: 1.299 ± 0.442
1.114CysPhe: 1.114 ± 0.482
2.97CysGly: 2.97 ± 0.601
0.557CysHis: 0.557 ± 0.258
0.742CysIle: 0.742 ± 0.455
0.742CysLys: 0.742 ± 0.387
2.413CysLeu: 2.413 ± 0.926
0.557CysMet: 0.557 ± 0.343
0.557CysAsn: 0.557 ± 0.317
0.742CysPro: 0.742 ± 0.372
0.186CysGln: 0.186 ± 0.111
1.67CysArg: 1.67 ± 0.566
3.155CysSer: 3.155 ± 0.792
1.114CysThr: 1.114 ± 0.472
1.67CysVal: 1.67 ± 0.733
0.186CysTrp: 0.186 ± 0.251
0.928CysTyr: 0.928 ± 0.369
0.0CysXaa: 0.0 ± 0.0
Asp
3.898AspAla: 3.898 ± 0.546
1.114AspCys: 1.114 ± 0.4
3.712AspAsp: 3.712 ± 1.353
3.526AspGlu: 3.526 ± 1.041
4.64AspPhe: 4.64 ± 0.765
3.526AspGly: 3.526 ± 0.929
0.928AspHis: 0.928 ± 0.325
3.341AspIle: 3.341 ± 0.801
2.784AspLys: 2.784 ± 0.771
5.568AspLeu: 5.568 ± 0.96
0.928AspMet: 0.928 ± 0.39
1.299AspAsn: 1.299 ± 0.435
1.114AspPro: 1.114 ± 0.473
0.742AspGln: 0.742 ± 0.317
3.155AspArg: 3.155 ± 0.992
6.125AspSer: 6.125 ± 0.471
1.67AspThr: 1.67 ± 0.691
6.31AspVal: 6.31 ± 1.245
0.186AspTrp: 0.186 ± 0.251
1.67AspTyr: 1.67 ± 0.65
0.0AspXaa: 0.0 ± 0.0
Glu
5.939GluAla: 5.939 ± 0.62
2.042GluCys: 2.042 ± 0.834
3.712GluAsp: 3.712 ± 1.03
3.712GluGlu: 3.712 ± 0.8
2.97GluPhe: 2.97 ± 1.06
2.042GluGly: 2.042 ± 0.658
0.186GluHis: 0.186 ± 0.294
3.898GluIle: 3.898 ± 0.843
4.083GluLys: 4.083 ± 1.111
6.496GluLeu: 6.496 ± 2.184
1.114GluMet: 1.114 ± 0.898
2.042GluAsn: 2.042 ± 0.621
1.485GluPro: 1.485 ± 0.92
0.928GluGln: 0.928 ± 0.747
3.341GluArg: 3.341 ± 0.824
4.083GluSer: 4.083 ± 1.027
2.042GluThr: 2.042 ± 0.969
5.011GluVal: 5.011 ± 0.951
0.371GluTrp: 0.371 ± 0.361
2.413GluTyr: 2.413 ± 0.633
0.0GluXaa: 0.0 ± 0.0
Phe
3.898PheAla: 3.898 ± 1.373
2.227PheCys: 2.227 ± 0.684
2.413PheAsp: 2.413 ± 0.614
4.64PheGlu: 4.64 ± 1.487
4.64PhePhe: 4.64 ± 1.471
4.64PheGly: 4.64 ± 1.338
1.299PheHis: 1.299 ± 0.58
2.97PheIle: 2.97 ± 0.776
3.526PheLys: 3.526 ± 1.122
7.424PheLeu: 7.424 ± 1.96
0.742PheMet: 0.742 ± 0.273
1.856PheAsn: 1.856 ± 0.759
1.299PhePro: 1.299 ± 0.776
0.928PheGln: 0.928 ± 0.422
2.784PheArg: 2.784 ± 0.822
8.166PheSer: 8.166 ± 1.417
3.155PheThr: 3.155 ± 0.773
3.712PheVal: 3.712 ± 0.749
0.371PheTrp: 0.371 ± 0.368
1.67PheTyr: 1.67 ± 0.486
0.0PheXaa: 0.0 ± 0.0
Gly
4.454GlyAla: 4.454 ± 0.673
1.67GlyCys: 1.67 ± 0.758
4.083GlyAsp: 4.083 ± 1.298
3.341GlyGlu: 3.341 ± 0.664
2.598GlyPhe: 2.598 ± 0.698
7.424GlyGly: 7.424 ± 1.537
0.557GlyHis: 0.557 ± 0.315
2.413GlyIle: 2.413 ± 0.93
3.341GlyLys: 3.341 ± 1.182
5.568GlyLeu: 5.568 ± 1.132
0.371GlyMet: 0.371 ± 0.394
2.227GlyAsn: 2.227 ± 0.496
1.114GlyPro: 1.114 ± 0.492
0.742GlyGln: 0.742 ± 0.556
3.155GlyArg: 3.155 ± 1.064
5.382GlySer: 5.382 ± 1.634
1.67GlyThr: 1.67 ± 1.066
5.939GlyVal: 5.939 ± 1.615
0.742GlyTrp: 0.742 ± 0.515
1.856GlyTyr: 1.856 ± 0.69
0.0GlyXaa: 0.0 ± 0.0
His
0.742HisAla: 0.742 ± 0.422
1.299HisCys: 1.299 ± 0.474
1.114HisAsp: 1.114 ± 0.53
1.114HisGlu: 1.114 ± 0.38
0.928HisPhe: 0.928 ± 0.516
0.371HisGly: 0.371 ± 0.222
0.557HisHis: 0.557 ± 0.29
1.114HisIle: 1.114 ± 0.25
1.485HisLys: 1.485 ± 0.542
1.67HisLeu: 1.67 ± 0.483
0.371HisMet: 0.371 ± 0.24
0.186HisAsn: 0.186 ± 0.111
0.557HisPro: 0.557 ± 0.332
0.371HisGln: 0.371 ± 0.24
1.299HisArg: 1.299 ± 0.472
1.299HisSer: 1.299 ± 0.416
0.557HisThr: 0.557 ± 0.317
1.114HisVal: 1.114 ± 0.53
0.0HisTrp: 0.0 ± 0.0
0.557HisTyr: 0.557 ± 0.258
0.0HisXaa: 0.0 ± 0.0
Ile
2.598IleAla: 2.598 ± 0.664
1.485IleCys: 1.485 ± 0.682
3.155IleAsp: 3.155 ± 0.783
3.526IleGlu: 3.526 ± 1.222
2.784IlePhe: 2.784 ± 1.054
2.227IleGly: 2.227 ± 1.198
0.742IleHis: 0.742 ± 0.311
2.042IleIle: 2.042 ± 0.453
3.712IleLys: 3.712 ± 0.536
3.712IleLeu: 3.712 ± 1.203
1.114IleMet: 1.114 ± 0.512
2.042IleAsn: 2.042 ± 0.299
1.299IlePro: 1.299 ± 0.841
1.299IleGln: 1.299 ± 0.349
3.155IleArg: 3.155 ± 0.917
4.269IleSer: 4.269 ± 1.375
2.784IleThr: 2.784 ± 0.778
4.083IleVal: 4.083 ± 0.892
0.371IleTrp: 0.371 ± 0.243
0.371IleTyr: 0.371 ± 0.222
0.0IleXaa: 0.0 ± 0.0
Lys
3.526LysAla: 3.526 ± 0.541
1.856LysCys: 1.856 ± 0.797
4.454LysAsp: 4.454 ± 0.66
3.341LysGlu: 3.341 ± 1.487
3.898LysPhe: 3.898 ± 0.661
3.155LysGly: 3.155 ± 0.843
1.299LysHis: 1.299 ± 0.371
2.97LysIle: 2.97 ± 0.654
4.454LysLys: 4.454 ± 0.835
6.496LysLeu: 6.496 ± 1.4
1.299LysMet: 1.299 ± 0.648
3.341LysAsn: 3.341 ± 0.927
1.114LysPro: 1.114 ± 0.473
1.485LysGln: 1.485 ± 0.561
4.083LysArg: 4.083 ± 0.672
6.867LysSer: 6.867 ± 1.148
3.341LysThr: 3.341 ± 0.541
4.269LysVal: 4.269 ± 0.892
0.0LysTrp: 0.0 ± 0.0
2.413LysTyr: 2.413 ± 1.159
0.0LysXaa: 0.0 ± 0.0
Leu
6.682LeuAla: 6.682 ± 0.895
1.485LeuCys: 1.485 ± 0.495
4.826LeuAsp: 4.826 ± 0.805
4.454LeuGlu: 4.454 ± 1.468
5.197LeuPhe: 5.197 ± 0.908
5.382LeuGly: 5.382 ± 1.304
1.114LeuHis: 1.114 ± 0.449
3.712LeuIle: 3.712 ± 1.041
6.867LeuLys: 6.867 ± 1.369
7.795LeuLeu: 7.795 ± 1.236
2.227LeuMet: 2.227 ± 0.485
5.754LeuAsn: 5.754 ± 1.012
3.898LeuPro: 3.898 ± 0.818
2.413LeuGln: 2.413 ± 0.583
7.61LeuArg: 7.61 ± 1.185
10.022LeuSer: 10.022 ± 1.434
5.754LeuThr: 5.754 ± 1.526
6.125LeuVal: 6.125 ± 1.098
0.186LeuTrp: 0.186 ± 0.251
4.64LeuTyr: 4.64 ± 1.374
0.0LeuXaa: 0.0 ± 0.0
Met
0.742MetAla: 0.742 ± 0.417
0.928MetCys: 0.928 ± 0.751
0.742MetAsp: 0.742 ± 0.288
1.114MetGlu: 1.114 ± 0.754
1.299MetPhe: 1.299 ± 0.502
0.557MetGly: 0.557 ± 0.256
0.186MetHis: 0.186 ± 0.111
0.928MetIle: 0.928 ± 0.398
1.299MetLys: 1.299 ± 0.586
1.67MetLeu: 1.67 ± 0.352
1.114MetMet: 1.114 ± 0.531
0.742MetAsn: 0.742 ± 0.668
0.371MetPro: 0.371 ± 0.366
0.928MetGln: 0.928 ± 0.554
1.67MetArg: 1.67 ± 0.703
3.155MetSer: 3.155 ± 0.635
1.299MetThr: 1.299 ± 0.474
1.485MetVal: 1.485 ± 0.496
0.0MetTrp: 0.0 ± 0.0
0.742MetTyr: 0.742 ± 0.322
0.0MetXaa: 0.0 ± 0.0
Asn
1.67AsnAla: 1.67 ± 0.617
0.742AsnCys: 0.742 ± 0.311
1.485AsnAsp: 1.485 ± 0.473
2.598AsnGlu: 2.598 ± 0.943
2.227AsnPhe: 2.227 ± 0.814
1.299AsnGly: 1.299 ± 0.466
0.928AsnHis: 0.928 ± 0.79
1.856AsnIle: 1.856 ± 1.133
2.413AsnLys: 2.413 ± 0.731
5.382AsnLeu: 5.382 ± 1.194
0.928AsnMet: 0.928 ± 0.388
1.485AsnAsn: 1.485 ± 1.003
1.485AsnPro: 1.485 ± 0.989
0.371AsnGln: 0.371 ± 0.486
2.598AsnArg: 2.598 ± 0.537
4.826AsnSer: 4.826 ± 1.137
1.67AsnThr: 1.67 ± 1.145
4.269AsnVal: 4.269 ± 1.068
0.0AsnTrp: 0.0 ± 0.0
1.856AsnTyr: 1.856 ± 0.498
0.0AsnXaa: 0.0 ± 0.0
Pro
2.227ProAla: 2.227 ± 0.739
0.557ProCys: 0.557 ± 0.332
2.227ProAsp: 2.227 ± 1.096
0.557ProGlu: 0.557 ± 0.297
2.227ProPhe: 2.227 ± 0.892
1.67ProGly: 1.67 ± 0.525
0.742ProHis: 0.742 ± 0.257
1.299ProIle: 1.299 ± 0.244
2.413ProLys: 2.413 ± 0.571
3.712ProLeu: 3.712 ± 0.485
0.371ProMet: 0.371 ± 0.266
0.928ProAsn: 0.928 ± 0.901
1.114ProPro: 1.114 ± 0.492
0.557ProGln: 0.557 ± 0.289
1.67ProArg: 1.67 ± 0.475
2.784ProSer: 2.784 ± 0.762
1.485ProThr: 1.485 ± 0.474
2.227ProVal: 2.227 ± 0.815
0.186ProTrp: 0.186 ± 0.111
0.928ProTyr: 0.928 ± 0.678
0.0ProXaa: 0.0 ± 0.0
Gln
0.371GlnAla: 0.371 ± 0.557
0.928GlnCys: 0.928 ± 0.477
0.557GlnAsp: 0.557 ± 0.256
1.67GlnGlu: 1.67 ± 0.469
0.557GlnPhe: 0.557 ± 0.43
0.742GlnGly: 0.742 ± 0.443
0.371GlnHis: 0.371 ± 0.211
1.485GlnIle: 1.485 ± 0.497
2.598GlnLys: 2.598 ± 0.547
1.67GlnLeu: 1.67 ± 0.523
0.186GlnMet: 0.186 ± 0.111
0.928GlnAsn: 0.928 ± 0.294
1.114GlnPro: 1.114 ± 0.501
0.371GlnGln: 0.371 ± 0.269
2.598GlnArg: 2.598 ± 0.609
1.485GlnSer: 1.485 ± 0.652
0.371GlnThr: 0.371 ± 0.243
2.042GlnVal: 2.042 ± 0.332
0.557GlnTrp: 0.557 ± 0.608
0.371GlnTyr: 0.371 ± 0.243
0.0GlnXaa: 0.0 ± 0.0
Arg
4.64ArgAla: 4.64 ± 1.044
1.485ArgCys: 1.485 ± 0.529
3.155ArgAsp: 3.155 ± 1.93
3.526ArgGlu: 3.526 ± 0.812
4.454ArgPhe: 4.454 ± 1.184
3.898ArgGly: 3.898 ± 1.321
0.742ArgHis: 0.742 ± 0.316
3.341ArgIle: 3.341 ± 1.283
4.269ArgLys: 4.269 ± 0.594
4.64ArgLeu: 4.64 ± 0.544
1.299ArgMet: 1.299 ± 0.677
3.155ArgAsn: 3.155 ± 0.677
1.67ArgPro: 1.67 ± 0.566
1.485ArgGln: 1.485 ± 0.818
5.754ArgArg: 5.754 ± 1.828
5.382ArgSer: 5.382 ± 1.116
3.155ArgThr: 3.155 ± 0.983
6.31ArgVal: 6.31 ± 0.962
0.186ArgTrp: 0.186 ± 0.27
2.413ArgTyr: 2.413 ± 0.384
0.0ArgXaa: 0.0 ± 0.0
Ser
6.496SerAla: 6.496 ± 1.349
2.413SerCys: 2.413 ± 0.616
3.526SerAsp: 3.526 ± 0.696
5.754SerGlu: 5.754 ± 1.284
8.352SerPhe: 8.352 ± 1.826
5.939SerGly: 5.939 ± 0.986
1.856SerHis: 1.856 ± 0.65
3.898SerIle: 3.898 ± 1.149
4.64SerLys: 4.64 ± 1.057
9.094SerLeu: 9.094 ± 0.805
1.299SerMet: 1.299 ± 0.731
5.011SerAsn: 5.011 ± 1.591
3.155SerPro: 3.155 ± 1.17
1.67SerGln: 1.67 ± 0.796
6.496SerArg: 6.496 ± 1.419
9.28SerSer: 9.28 ± 2.297
4.64SerThr: 4.64 ± 0.95
9.651SerVal: 9.651 ± 2.293
0.371SerTrp: 0.371 ± 0.211
3.341SerTyr: 3.341 ± 0.988
0.0SerXaa: 0.0 ± 0.0
Thr
1.67ThrAla: 1.67 ± 0.836
0.928ThrCys: 0.928 ± 0.459
3.155ThrAsp: 3.155 ± 0.352
1.856ThrGlu: 1.856 ± 0.936
3.712ThrPhe: 3.712 ± 1.219
2.227ThrGly: 2.227 ± 0.894
0.557ThrHis: 0.557 ± 0.258
2.042ThrIle: 2.042 ± 0.687
2.227ThrLys: 2.227 ± 0.828
4.269ThrLeu: 4.269 ± 1.276
0.928ThrMet: 0.928 ± 0.515
1.299ThrAsn: 1.299 ± 0.322
1.67ThrPro: 1.67 ± 0.47
1.114ThrGln: 1.114 ± 0.464
2.413ThrArg: 2.413 ± 1.323
4.826ThrSer: 4.826 ± 0.809
2.784ThrThr: 2.784 ± 0.656
4.269ThrVal: 4.269 ± 0.799
0.186ThrTrp: 0.186 ± 0.278
1.856ThrTyr: 1.856 ± 0.464
0.0ThrXaa: 0.0 ± 0.0
Val
6.867ValAla: 6.867 ± 1.463
2.227ValCys: 2.227 ± 0.951
5.382ValAsp: 5.382 ± 0.887
4.826ValGlu: 4.826 ± 1.068
5.568ValPhe: 5.568 ± 0.645
4.269ValGly: 4.269 ± 1.158
1.856ValHis: 1.856 ± 0.647
4.083ValIle: 4.083 ± 1.045
7.61ValLys: 7.61 ± 2.045
6.496ValLeu: 6.496 ± 1.213
2.042ValMet: 2.042 ± 0.666
2.784ValAsn: 2.784 ± 0.648
2.598ValPro: 2.598 ± 0.417
2.413ValGln: 2.413 ± 0.626
7.238ValArg: 7.238 ± 1.451
6.682ValSer: 6.682 ± 1.239
2.598ValThr: 2.598 ± 0.543
7.981ValVal: 7.981 ± 1.022
0.742ValTrp: 0.742 ± 0.311
3.341ValTyr: 3.341 ± 0.688
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.371TrpAsp: 0.371 ± 0.243
0.371TrpGlu: 0.371 ± 0.211
0.186TrpPhe: 0.186 ± 0.241
0.557TrpGly: 0.557 ± 0.433
0.0TrpHis: 0.0 ± 0.0
0.186TrpIle: 0.186 ± 0.278
0.371TrpLys: 0.371 ± 0.5
0.742TrpLeu: 0.742 ± 0.417
0.186TrpMet: 0.186 ± 0.278
0.0TrpAsn: 0.0 ± 0.0
0.186TrpPro: 0.186 ± 0.111
0.186TrpGln: 0.186 ± 0.278
0.186TrpArg: 0.186 ± 0.111
0.557TrpSer: 0.557 ± 0.451
0.0TrpThr: 0.0 ± 0.0
0.928TrpVal: 0.928 ± 0.567
0.0TrpTrp: 0.0 ± 0.0
0.186TrpTyr: 0.186 ± 0.251
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.227TyrAla: 2.227 ± 0.633
0.557TyrCys: 0.557 ± 0.324
2.97TyrAsp: 2.97 ± 0.397
2.413TyrGlu: 2.413 ± 0.39
0.928TyrPhe: 0.928 ± 0.273
2.042TyrGly: 2.042 ± 0.783
0.928TyrHis: 0.928 ± 0.351
1.114TyrIle: 1.114 ± 0.25
2.042TyrLys: 2.042 ± 1.046
4.64TyrLeu: 4.64 ± 1.025
1.856TyrMet: 1.856 ± 0.327
1.114TyrAsn: 1.114 ± 0.25
1.114TyrPro: 1.114 ± 0.482
0.928TyrGln: 0.928 ± 0.687
1.114TyrArg: 1.114 ± 0.517
2.227TyrSer: 2.227 ± 0.335
2.042TyrThr: 2.042 ± 0.614
3.155TyrVal: 3.155 ± 0.822
0.0TyrTrp: 0.0 ± 0.0
0.928TyrTyr: 0.928 ± 0.273
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (5389 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski