Amino acid dipepetide frequency for Murine coronavirus repA59/RJHM

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.298AlaAla: 5.298 ± 0.371
2.399AlaCys: 2.399 ± 0.88
4.398AlaAsp: 4.398 ± 0.885
2.499AlaGlu: 2.499 ± 0.356
3.798AlaPhe: 3.798 ± 0.625
4.498AlaGly: 4.498 ± 0.543
1.299AlaHis: 1.299 ± 0.365
4.098AlaIle: 4.098 ± 0.701
4.098AlaLys: 4.098 ± 0.547
4.998AlaLeu: 4.998 ± 0.515
1.299AlaMet: 1.299 ± 0.418
4.198AlaAsn: 4.198 ± 0.732
2.599AlaPro: 2.599 ± 0.785
2.299AlaGln: 2.299 ± 0.807
1.799AlaArg: 1.799 ± 0.391
5.498AlaSer: 5.498 ± 0.587
3.798AlaThr: 3.798 ± 0.742
6.597AlaVal: 6.597 ± 0.626
1.0AlaTrp: 1.0 ± 0.585
2.499AlaTyr: 2.499 ± 0.469
0.0AlaXaa: 0.0 ± 0.0
Cys
2.299CysAla: 2.299 ± 0.585
1.799CysCys: 1.799 ± 0.329
1.599CysAsp: 1.599 ± 0.379
1.399CysGlu: 1.399 ± 0.22
2.299CysPhe: 2.299 ± 0.216
2.599CysGly: 2.599 ± 0.598
0.4CysHis: 0.4 ± 0.139
2.199CysIle: 2.199 ± 0.197
2.399CysLys: 2.399 ± 0.567
2.799CysLeu: 2.799 ± 0.504
0.7CysMet: 0.7 ± 0.446
2.199CysAsn: 2.199 ± 0.403
1.2CysPro: 1.2 ± 0.34
1.1CysGln: 1.1 ± 0.253
1.499CysArg: 1.499 ± 0.276
3.499CysSer: 3.499 ± 0.596
2.499CysThr: 2.499 ± 0.591
2.399CysVal: 2.399 ± 0.529
0.6CysTrp: 0.6 ± 0.208
2.099CysTyr: 2.099 ± 0.521
0.0CysXaa: 0.0 ± 0.0
Asp
3.898AspAla: 3.898 ± 0.807
1.699AspCys: 1.699 ± 0.322
3.199AspAsp: 3.199 ± 0.549
2.699AspGlu: 2.699 ± 0.372
3.299AspPhe: 3.299 ± 0.924
4.698AspGly: 4.698 ± 0.565
0.7AspHis: 0.7 ± 0.387
2.399AspIle: 2.399 ± 0.882
3.299AspLys: 3.299 ± 0.49
5.498AspLeu: 5.498 ± 1.087
1.599AspMet: 1.599 ± 0.342
2.299AspAsn: 2.299 ± 0.388
1.599AspPro: 1.599 ± 0.308
1.399AspGln: 1.399 ± 0.44
1.599AspArg: 1.599 ± 0.255
3.998AspSer: 3.998 ± 0.641
2.399AspThr: 2.399 ± 0.6
6.397AspVal: 6.397 ± 1.426
0.3AspTrp: 0.3 ± 0.148
2.399AspTyr: 2.399 ± 0.387
0.0AspXaa: 0.0 ± 0.0
Glu
4.398GluAla: 4.398 ± 0.585
1.499GluCys: 1.499 ± 0.337
2.899GluAsp: 2.899 ± 0.346
2.799GluGlu: 2.799 ± 0.512
2.499GluPhe: 2.499 ± 0.424
2.199GluGly: 2.199 ± 0.222
0.4GluHis: 0.4 ± 0.139
2.099GluIle: 2.099 ± 0.654
2.199GluLys: 2.199 ± 0.31
4.398GluLeu: 4.398 ± 0.887
0.9GluMet: 0.9 ± 0.283
1.399GluAsn: 1.399 ± 0.373
1.599GluPro: 1.599 ± 0.461
0.8GluGln: 0.8 ± 0.233
1.599GluArg: 1.599 ± 0.52
1.899GluSer: 1.899 ± 0.379
1.899GluThr: 1.899 ± 0.357
3.998GluVal: 3.998 ± 0.657
0.5GluTrp: 0.5 ± 0.255
1.799GluTyr: 1.799 ± 0.502
0.0GluXaa: 0.0 ± 0.0
Phe
3.099PheAla: 3.099 ± 0.457
1.799PheCys: 1.799 ± 0.363
3.599PheAsp: 3.599 ± 0.449
1.899PheGlu: 1.899 ± 0.241
1.699PhePhe: 1.699 ± 0.319
3.199PheGly: 3.199 ± 0.85
0.7PheHis: 0.7 ± 0.18
2.899PheIle: 2.899 ± 1.036
3.998PheLys: 3.998 ± 0.748
3.399PheLeu: 3.399 ± 0.443
1.1PheMet: 1.1 ± 0.29
3.998PheAsn: 3.998 ± 0.486
1.399PhePro: 1.399 ± 0.184
1.399PheGln: 1.399 ± 0.521
1.599PheArg: 1.599 ± 0.373
3.499PheSer: 3.499 ± 0.56
3.399PheThr: 3.399 ± 1.007
5.798PheVal: 5.798 ± 1.213
0.7PheTrp: 0.7 ± 0.387
3.299PheTyr: 3.299 ± 0.596
0.0PheXaa: 0.0 ± 0.0
Gly
3.199GlyAla: 3.199 ± 0.617
3.099GlyCys: 3.099 ± 0.635
3.399GlyAsp: 3.399 ± 0.501
1.2GlyGlu: 1.2 ± 0.305
3.798GlyPhe: 3.798 ± 0.631
3.399GlyGly: 3.399 ± 0.466
1.399GlyHis: 1.399 ± 0.401
2.499GlyIle: 2.499 ± 0.589
3.699GlyLys: 3.699 ± 0.778
5.098GlyLeu: 5.098 ± 0.538
1.299GlyMet: 1.299 ± 0.304
3.499GlyAsn: 3.499 ± 0.541
2.399GlyPro: 2.399 ± 1.425
1.799GlyGln: 1.799 ± 0.728
1.799GlyArg: 1.799 ± 0.306
5.698GlySer: 5.698 ± 0.496
4.198GlyThr: 4.198 ± 0.67
6.697GlyVal: 6.697 ± 1.072
0.7GlyTrp: 0.7 ± 0.163
3.299GlyTyr: 3.299 ± 0.377
0.0GlyXaa: 0.0 ± 0.0
His
1.299HisAla: 1.299 ± 0.571
0.4HisCys: 0.4 ± 0.164
1.1HisAsp: 1.1 ± 0.203
1.2HisGlu: 1.2 ± 0.316
1.399HisPhe: 1.399 ± 0.275
0.2HisGly: 0.2 ± 0.127
0.1HisHis: 0.1 ± 0.1
0.6HisIle: 0.6 ± 0.125
1.2HisLys: 1.2 ± 0.411
2.099HisLeu: 2.099 ± 0.704
0.4HisMet: 0.4 ± 0.214
0.9HisAsn: 0.9 ± 0.341
0.5HisPro: 0.5 ± 0.212
0.6HisGln: 0.6 ± 0.249
0.5HisArg: 0.5 ± 0.112
0.8HisSer: 0.8 ± 0.223
0.9HisThr: 0.9 ± 0.136
2.099HisVal: 2.099 ± 0.522
0.3HisTrp: 0.3 ± 0.167
0.6HisTyr: 0.6 ± 0.317
0.0HisXaa: 0.0 ± 0.0
Ile
2.299IleAla: 2.299 ± 0.336
1.499IleCys: 1.499 ± 0.402
2.399IleAsp: 2.399 ± 0.55
1.699IleGlu: 1.699 ± 0.238
1.799IlePhe: 1.799 ± 0.394
3.998IleGly: 3.998 ± 0.877
0.7IleHis: 0.7 ± 0.294
2.599IleIle: 2.599 ± 1.398
3.399IleLys: 3.399 ± 0.726
4.698IleLeu: 4.698 ± 0.701
0.8IleMet: 0.8 ± 0.345
2.499IleAsn: 2.499 ± 0.624
1.399IlePro: 1.399 ± 0.318
1.699IleGln: 1.699 ± 0.447
1.999IleArg: 1.999 ± 0.867
2.399IleSer: 2.399 ± 0.987
2.999IleThr: 2.999 ± 0.34
4.298IleVal: 4.298 ± 0.38
0.4IleTrp: 0.4 ± 0.592
1.0IleTyr: 1.0 ± 0.266
0.0IleXaa: 0.0 ± 0.0
Lys
3.998LysAla: 3.998 ± 0.757
2.099LysCys: 2.099 ± 0.488
1.999LysAsp: 1.999 ± 0.906
2.799LysGlu: 2.799 ± 0.249
3.399LysPhe: 3.399 ± 0.589
4.198LysGly: 4.198 ± 0.445
1.399LysHis: 1.399 ± 0.611
2.699LysIle: 2.699 ± 0.459
1.799LysLys: 1.799 ± 0.308
5.798LysLeu: 5.798 ± 0.803
0.9LysMet: 0.9 ± 0.19
1.699LysAsn: 1.699 ± 0.215
3.699LysPro: 3.699 ± 0.678
2.999LysGln: 2.999 ± 1.086
2.699LysArg: 2.699 ± 0.586
3.299LysSer: 3.299 ± 0.446
2.599LysThr: 2.599 ± 0.627
5.398LysVal: 5.398 ± 0.92
1.1LysTrp: 1.1 ± 0.329
2.799LysTyr: 2.799 ± 0.81
0.0LysXaa: 0.0 ± 0.0
Leu
6.397LeuAla: 6.397 ± 0.904
3.798LeuCys: 3.798 ± 0.454
4.998LeuAsp: 4.998 ± 0.442
4.198LeuGlu: 4.198 ± 0.707
5.098LeuPhe: 5.098 ± 0.676
5.198LeuGly: 5.198 ± 0.669
1.2LeuHis: 1.2 ± 0.408
2.999LeuIle: 2.999 ± 0.603
4.598LeuLys: 4.598 ± 1.145
8.197LeuLeu: 8.197 ± 1.261
1.899LeuMet: 1.899 ± 0.683
4.898LeuAsn: 4.898 ± 0.848
4.798LeuPro: 4.798 ± 0.813
4.198LeuGln: 4.198 ± 0.412
3.499LeuArg: 3.499 ± 0.328
7.097LeuSer: 7.097 ± 1.005
5.298LeuThr: 5.298 ± 0.694
7.297LeuVal: 7.297 ± 0.959
1.299LeuTrp: 1.299 ± 0.221
4.698LeuTyr: 4.698 ± 0.65
0.0LeuXaa: 0.0 ± 0.0
Met
1.799MetAla: 1.799 ± 0.585
1.0MetCys: 1.0 ± 0.27
1.0MetAsp: 1.0 ± 0.342
0.7MetGlu: 0.7 ± 0.376
1.299MetPhe: 1.299 ± 0.284
0.9MetGly: 0.9 ± 0.328
0.7MetHis: 0.7 ± 0.332
0.6MetIle: 0.6 ± 0.234
0.5MetLys: 0.5 ± 0.319
3.199MetLeu: 3.199 ± 0.455
0.6MetMet: 0.6 ± 0.208
0.9MetAsn: 0.9 ± 0.239
1.399MetPro: 1.399 ± 0.396
1.299MetGln: 1.299 ± 0.28
0.6MetArg: 0.6 ± 0.22
1.599MetSer: 1.599 ± 0.29
1.2MetThr: 1.2 ± 0.332
1.2MetVal: 1.2 ± 0.33
0.5MetTrp: 0.5 ± 0.272
1.1MetTyr: 1.1 ± 0.271
0.0MetXaa: 0.0 ± 0.0
Asn
3.798AsnAla: 3.798 ± 0.747
1.699AsnCys: 1.699 ± 0.398
1.899AsnAsp: 1.899 ± 0.507
1.999AsnGlu: 1.999 ± 0.23
2.499AsnPhe: 2.499 ± 0.47
4.098AsnGly: 4.098 ± 0.814
0.8AsnHis: 0.8 ± 0.225
1.899AsnIle: 1.899 ± 0.506
2.699AsnLys: 2.699 ± 0.645
3.798AsnLeu: 3.798 ± 0.739
1.1AsnMet: 1.1 ± 0.266
3.199AsnAsn: 3.199 ± 0.894
2.099AsnPro: 2.099 ± 0.441
1.999AsnGln: 1.999 ± 0.878
2.599AsnArg: 2.599 ± 0.634
3.599AsnSer: 3.599 ± 0.276
2.499AsnThr: 2.499 ± 0.339
5.698AsnVal: 5.698 ± 0.571
0.6AsnTrp: 0.6 ± 0.125
2.299AsnTyr: 2.299 ± 0.676
0.0AsnXaa: 0.0 ± 0.0
Pro
2.799ProAla: 2.799 ± 0.737
1.1ProCys: 1.1 ± 0.246
2.299ProAsp: 2.299 ± 0.472
1.999ProGlu: 1.999 ± 0.295
1.799ProPhe: 1.799 ± 0.396
2.299ProGly: 2.299 ± 0.606
1.299ProHis: 1.299 ± 0.53
1.599ProIle: 1.599 ± 0.389
2.499ProLys: 2.499 ± 0.938
3.499ProLeu: 3.499 ± 0.761
0.6ProMet: 0.6 ± 0.29
1.899ProAsn: 1.899 ± 0.733
1.499ProPro: 1.499 ± 0.504
1.499ProGln: 1.499 ± 0.617
1.599ProArg: 1.599 ± 0.385
2.599ProSer: 2.599 ± 0.678
3.499ProThr: 3.499 ± 0.632
3.199ProVal: 3.199 ± 0.668
0.6ProTrp: 0.6 ± 0.319
1.499ProTyr: 1.499 ± 0.276
0.0ProXaa: 0.0 ± 0.0
Gln
1.599GlnAla: 1.599 ± 0.488
1.2GlnCys: 1.2 ± 0.251
1.699GlnAsp: 1.699 ± 0.181
1.999GlnGlu: 1.999 ± 0.509
2.199GlnPhe: 2.199 ± 1.154
2.099GlnGly: 2.099 ± 0.656
0.8GlnHis: 0.8 ± 0.3
2.399GlnIle: 2.399 ± 0.675
2.299GlnLys: 2.299 ± 1.355
3.898GlnLeu: 3.898 ± 0.698
0.3GlnMet: 0.3 ± 0.148
1.499GlnAsn: 1.499 ± 0.465
1.1GlnPro: 1.1 ± 0.861
1.399GlnGln: 1.399 ± 0.654
1.0GlnArg: 1.0 ± 0.513
2.599GlnSer: 2.599 ± 0.448
2.099GlnThr: 2.099 ± 0.384
2.699GlnVal: 2.699 ± 0.696
1.1GlnTrp: 1.1 ± 0.245
1.2GlnTyr: 1.2 ± 0.214
0.0GlnXaa: 0.0 ± 0.0
Arg
3.199ArgAla: 3.199 ± 0.94
1.399ArgCys: 1.399 ± 0.307
2.299ArgAsp: 2.299 ± 0.255
1.699ArgGlu: 1.699 ± 0.24
1.699ArgPhe: 1.699 ± 0.388
2.599ArgGly: 2.599 ± 1.01
1.2ArgHis: 1.2 ± 0.446
1.0ArgIle: 1.0 ± 0.428
2.099ArgLys: 2.099 ± 0.485
4.198ArgLeu: 4.198 ± 0.563
0.9ArgMet: 0.9 ± 0.298
1.599ArgAsn: 1.599 ± 0.509
1.599ArgPro: 1.599 ± 0.788
1.1ArgGln: 1.1 ± 0.52
1.599ArgArg: 1.599 ± 0.666
3.399ArgSer: 3.399 ± 0.923
1.999ArgThr: 1.999 ± 0.483
3.499ArgVal: 3.499 ± 0.818
0.1ArgTrp: 0.1 ± 0.184
1.599ArgTyr: 1.599 ± 0.312
0.0ArgXaa: 0.0 ± 0.0
Ser
6.198SerAla: 6.198 ± 1.009
2.699SerCys: 2.699 ± 0.551
3.499SerAsp: 3.499 ± 0.403
2.999SerGlu: 2.999 ± 0.6
3.099SerPhe: 3.099 ± 0.471
4.398SerGly: 4.398 ± 1.412
1.299SerHis: 1.299 ± 0.34
3.599SerIle: 3.599 ± 0.461
3.699SerLys: 3.699 ± 0.526
7.097SerLeu: 7.097 ± 1.007
1.999SerMet: 1.999 ± 0.426
2.299SerAsn: 2.299 ± 0.426
2.099SerPro: 2.099 ± 0.429
2.099SerGln: 2.099 ± 0.41
2.999SerArg: 2.999 ± 0.922
4.998SerSer: 4.998 ± 1.139
3.399SerThr: 3.399 ± 0.455
7.797SerVal: 7.797 ± 1.01
1.0SerTrp: 1.0 ± 0.221
3.199SerTyr: 3.199 ± 0.605
0.0SerXaa: 0.0 ± 0.0
Thr
3.699ThrAla: 3.699 ± 0.763
1.899ThrCys: 1.899 ± 0.507
3.699ThrAsp: 3.699 ± 0.549
1.899ThrGlu: 1.899 ± 0.353
3.499ThrPhe: 3.499 ± 0.834
4.498ThrGly: 4.498 ± 0.693
0.9ThrHis: 0.9 ± 0.358
2.799ThrIle: 2.799 ± 1.271
2.999ThrLys: 2.999 ± 0.425
4.998ThrLeu: 4.998 ± 1.058
1.999ThrMet: 1.999 ± 0.549
2.599ThrAsn: 2.599 ± 0.521
2.499ThrPro: 2.499 ± 0.814
2.099ThrGln: 2.099 ± 0.518
2.299ThrArg: 2.299 ± 1.141
3.898ThrSer: 3.898 ± 1.043
4.098ThrThr: 4.098 ± 0.877
4.098ThrVal: 4.098 ± 0.615
0.7ThrTrp: 0.7 ± 0.279
3.199ThrTyr: 3.199 ± 0.393
0.0ThrXaa: 0.0 ± 0.0
Val
6.297ValAla: 6.297 ± 0.781
3.699ValCys: 3.699 ± 0.642
6.297ValAsp: 6.297 ± 1.129
3.898ValGlu: 3.898 ± 0.648
3.699ValPhe: 3.699 ± 0.599
3.998ValGly: 3.998 ± 0.44
0.6ValHis: 0.6 ± 0.194
3.499ValIle: 3.499 ± 0.874
6.797ValLys: 6.797 ± 1.335
8.597ValLeu: 8.597 ± 1.547
2.399ValMet: 2.399 ± 0.364
5.598ValAsn: 5.598 ± 1.084
4.398ValPro: 4.398 ± 0.469
3.499ValGln: 3.499 ± 0.827
4.298ValArg: 4.298 ± 0.48
6.198ValSer: 6.198 ± 0.622
4.898ValThr: 4.898 ± 1.233
10.196ValVal: 10.196 ± 2.272
1.0ValTrp: 1.0 ± 0.381
4.898ValTyr: 4.898 ± 1.004
0.0ValXaa: 0.0 ± 0.0
Trp
0.6TrpAla: 0.6 ± 0.206
0.4TrpCys: 0.4 ± 0.353
0.5TrpAsp: 0.5 ± 0.45
0.3TrpGlu: 0.3 ± 0.081
1.1TrpPhe: 1.1 ± 0.333
0.3TrpGly: 0.3 ± 0.098
0.3TrpHis: 0.3 ± 0.144
0.4TrpIle: 0.4 ± 0.225
0.3TrpLys: 0.3 ± 0.081
2.199TrpLeu: 2.199 ± 0.725
0.1TrpMet: 0.1 ± 0.064
1.1TrpAsn: 1.1 ± 0.424
0.5TrpPro: 0.5 ± 0.211
0.4TrpGln: 0.4 ± 0.196
0.9TrpArg: 0.9 ± 0.404
1.1TrpSer: 1.1 ± 0.183
0.8TrpThr: 0.8 ± 0.13
0.8TrpVal: 0.8 ± 0.146
0.1TrpTrp: 0.1 ± 0.162
0.8TrpTyr: 0.8 ± 0.425
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.799TyrAla: 2.799 ± 0.391
2.399TyrCys: 2.399 ± 0.691
2.599TyrAsp: 2.599 ± 0.782
1.899TyrGlu: 1.899 ± 0.294
2.499TyrPhe: 2.499 ± 0.32
2.799TyrGly: 2.799 ± 0.4
1.0TyrHis: 1.0 ± 0.533
1.699TyrIle: 1.699 ± 0.327
2.799TyrLys: 2.799 ± 0.789
3.299TyrLeu: 3.299 ± 0.514
1.1TyrMet: 1.1 ± 0.26
2.599TyrAsn: 2.599 ± 0.713
1.299TyrPro: 1.299 ± 0.443
1.499TyrGln: 1.499 ± 0.224
2.299TyrArg: 2.299 ± 0.355
2.799TyrSer: 2.799 ± 0.561
3.898TyrThr: 3.898 ± 0.906
4.598TyrVal: 4.598 ± 0.442
0.4TyrTrp: 0.4 ± 0.189
3.299TyrTyr: 3.299 ± 0.73
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (10005 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski