Amino acid dipepetide frequency for Oceanobacillus profundus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.926AlaAla: 5.926 ± 0.089	0.589AlaCys: 0.589 ± 0.02	3.638AlaAsp: 3.638 ± 0.091	4.811AlaGlu: 4.811 ± 0.075	3.483AlaPhe: 3.483 ± 0.056	5.258AlaGly: 5.258 ± 0.076	1.187AlaHis: 1.187 ± 0.032	6.423AlaIle: 6.423 ± 0.084	4.512AlaLys: 4.512 ± 0.067	7.185AlaLeu: 7.185 ± 0.095	2.04AlaMet: 2.04 ± 0.041	2.988AlaAsn: 2.988 ± 0.048	2.061AlaPro: 2.061 ± 0.04	2.057AlaGln: 2.057 ± 0.04	2.487AlaArg: 2.487 ± 0.044	4.157AlaSer: 4.157 ± 0.059	3.84AlaThr: 3.84 ± 0.059	5.301AlaVal: 5.301 ± 0.071	0.666AlaTrp: 0.666 ± 0.026	2.488AlaTyr: 2.488 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.389CysAla: 0.389 ± 0.019	0.073CysCys: 0.073 ± 0.008	0.343CysAsp: 0.343 ± 0.016	0.397CysGlu: 0.397 ± 0.02	0.281CysPhe: 0.281 ± 0.015	0.602CysGly: 0.602 ± 0.022	0.174CysHis: 0.174 ± 0.013	0.509CysIle: 0.509 ± 0.02	0.36CysLys: 0.36 ± 0.015	0.56CysLeu: 0.56 ± 0.025	0.167CysMet: 0.167 ± 0.011	0.308CysAsn: 0.308 ± 0.016	0.3CysPro: 0.3 ± 0.017	0.21CysGln: 0.21 ± 0.013	0.239CysArg: 0.239 ± 0.013	0.448CysSer: 0.448 ± 0.017	0.366CysThr: 0.366 ± 0.016	0.382CysVal: 0.382 ± 0.018	0.057CysTrp: 0.057 ± 0.006	0.24CysTyr: 0.24 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.628AspAla: 3.628 ± 0.085	0.312AspCys: 0.312 ± 0.018	2.696AspAsp: 2.696 ± 0.053	4.668AspGlu: 4.668 ± 0.072	2.47AspPhe: 2.47 ± 0.046	3.501AspGly: 3.501 ± 0.061	1.077AspHis: 1.077 ± 0.028	4.437AspIle: 4.437 ± 0.061	3.274AspLys: 3.274 ± 0.054	5.048AspLeu: 5.048 ± 0.059	1.466AspMet: 1.466 ± 0.028	2.195AspAsn: 2.195 ± 0.043	2.063AspPro: 2.063 ± 0.046	1.936AspGln: 1.936 ± 0.039	2.206AspArg: 2.206 ± 0.047	2.805AspSer: 2.805 ± 0.088	2.723AspThr: 2.723 ± 0.052	3.797AspVal: 3.797 ± 0.056	0.633AspTrp: 0.633 ± 0.024	2.367AspTyr: 2.367 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.593GluAla: 5.593 ± 0.077	0.325GluCys: 0.325 ± 0.017	4.047GluAsp: 4.047 ± 0.062	7.04GluGlu: 7.04 ± 0.099	2.56GluPhe: 2.56 ± 0.051	4.271GluGly: 4.271 ± 0.062	1.489GluHis: 1.489 ± 0.036	5.923GluIle: 5.923 ± 0.071	6.26GluLys: 6.26 ± 0.075	7.162GluLeu: 7.162 ± 0.076	2.393GluMet: 2.393 ± 0.046	4.067GluAsn: 4.067 ± 0.06	1.977GluPro: 1.977 ± 0.038	3.554GluGln: 3.554 ± 0.054	3.425GluArg: 3.425 ± 0.048	3.843GluSer: 3.843 ± 0.059	3.998GluThr: 3.998 ± 0.062	5.337GluVal: 5.337 ± 0.073	0.819GluTrp: 0.819 ± 0.028	2.186GluTyr: 2.186 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.01PheAla: 3.01 ± 0.049	0.315PheCys: 0.315 ± 0.016	2.422PheAsp: 2.422 ± 0.049	2.875PheGlu: 2.875 ± 0.048	2.304PhePhe: 2.304 ± 0.05	3.323PheGly: 3.323 ± 0.068	1.036PheHis: 1.036 ± 0.027	4.141PheIle: 4.141 ± 0.074	2.34PheLys: 2.34 ± 0.046	4.301PheLeu: 4.301 ± 0.068	1.238PheMet: 1.238 ± 0.03	2.076PheAsn: 2.076 ± 0.041	1.629PhePro: 1.629 ± 0.035	1.656PheGln: 1.656 ± 0.037	1.495PheArg: 1.495 ± 0.037	3.164PheSer: 3.164 ± 0.056	2.703PheThr: 2.703 ± 0.046	3.091PheVal: 3.091 ± 0.06	0.442PheTrp: 0.442 ± 0.018	1.756PheTyr: 1.756 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	4.745GlyAla: 4.745 ± 0.078	0.545GlyCys: 0.545 ± 0.023	3.295GlyAsp: 3.295 ± 0.049	4.632GlyGlu: 4.632 ± 0.07	3.429GlyPhe: 3.429 ± 0.062	4.721GlyGly: 4.721 ± 0.086	1.3GlyHis: 1.3 ± 0.033	6.293GlyIle: 6.293 ± 0.08	4.665GlyLys: 4.665 ± 0.066	6.403GlyLeu: 6.403 ± 0.087	2.189GlyMet: 2.189 ± 0.048	3.007GlyAsn: 3.007 ± 0.053	1.657GlyPro: 1.657 ± 0.042	2.035GlyGln: 2.035 ± 0.041	2.486GlyArg: 2.486 ± 0.043	4.055GlySer: 4.055 ± 0.06	3.998GlyThr: 3.998 ± 0.057	4.939GlyVal: 4.939 ± 0.069	0.815GlyTrp: 0.815 ± 0.027	2.824GlyTyr: 2.824 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.435HisAla: 1.435 ± 0.03	0.174HisCys: 0.174 ± 0.011	1.071HisAsp: 1.071 ± 0.029	1.425HisGlu: 1.425 ± 0.031	1.037HisPhe: 1.037 ± 0.028	1.404HisGly: 1.404 ± 0.033	0.649HisHis: 0.649 ± 0.033	1.566HisIle: 1.566 ± 0.031	0.989HisLys: 0.989 ± 0.026	2.059HisLeu: 2.059 ± 0.039	0.528HisMet: 0.528 ± 0.019	0.816HisAsn: 0.816 ± 0.025	1.087HisPro: 1.087 ± 0.028	0.84HisGln: 0.84 ± 0.026	0.812HisArg: 0.812 ± 0.024	1.102HisSer: 1.102 ± 0.03	1.049HisThr: 1.049 ± 0.03	1.435HisVal: 1.435 ± 0.034	0.213HisTrp: 0.213 ± 0.013	0.895HisTyr: 0.895 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.687IleAla: 6.687 ± 0.085	0.604IleCys: 0.604 ± 0.022	4.691IleAsp: 4.691 ± 0.063	5.917IleGlu: 5.917 ± 0.074	3.465IlePhe: 3.465 ± 0.059	6.29IleGly: 6.29 ± 0.079	1.767IleHis: 1.767 ± 0.035	6.757IleIle: 6.757 ± 0.102	4.639IleLys: 4.639 ± 0.059	7.483IleLeu: 7.483 ± 0.1	1.938IleMet: 1.938 ± 0.042	3.578IleAsn: 3.578 ± 0.053	3.581IlePro: 3.581 ± 0.051	3.116IleGln: 3.116 ± 0.047	3.143IleArg: 3.143 ± 0.048	5.205IleSer: 5.205 ± 0.072	4.686IleThr: 4.686 ± 0.067	5.794IleVal: 5.794 ± 0.078	0.692IleTrp: 0.692 ± 0.024	2.582IleTyr: 2.582 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.489LysAla: 4.489 ± 0.063	0.3LysCys: 0.3 ± 0.015	3.728LysAsp: 3.728 ± 0.056	6.451LysGlu: 6.451 ± 0.093	1.806LysPhe: 1.806 ± 0.036	4.009LysGly: 4.009 ± 0.06	1.479LysHis: 1.479 ± 0.03	4.452LysIle: 4.452 ± 0.063	5.283LysLys: 5.283 ± 0.078	5.791LysLeu: 5.791 ± 0.073	1.985LysMet: 1.985 ± 0.046	3.275LysAsn: 3.275 ± 0.043	1.994LysPro: 1.994 ± 0.046	3.314LysGln: 3.314 ± 0.056	3.162LysArg: 3.162 ± 0.051	3.49LysSer: 3.49 ± 0.054	3.352LysThr: 3.352 ± 0.052	4.235LysVal: 4.235 ± 0.058	0.709LysTrp: 0.709 ± 0.022	2.075LysTyr: 2.075 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	7.025LeuAla: 7.025 ± 0.088	0.571LeuCys: 0.571 ± 0.022	5.014LeuAsp: 5.014 ± 0.067	6.802LeuGlu: 6.802 ± 0.075	4.794LeuPhe: 4.794 ± 0.076	6.266LeuGly: 6.266 ± 0.095	1.894LeuHis: 1.894 ± 0.037	7.533LeuIle: 7.533 ± 0.093	6.053LeuLys: 6.053 ± 0.073	9.707LeuLeu: 9.707 ± 0.124	2.467LeuMet: 2.467 ± 0.053	4.459LeuAsn: 4.459 ± 0.061	3.821LeuPro: 3.821 ± 0.059	3.547LeuGln: 3.547 ± 0.052	3.463LeuArg: 3.463 ± 0.049	6.412LeuSer: 6.412 ± 0.066	5.582LeuThr: 5.582 ± 0.074	5.967LeuVal: 5.967 ± 0.078	0.772LeuTrp: 0.772 ± 0.027	3.054LeuTyr: 3.054 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.928MetAla: 1.928 ± 0.043	0.119MetCys: 0.119 ± 0.011	1.614MetAsp: 1.614 ± 0.037	2.189MetGlu: 2.189 ± 0.042	1.083MetPhe: 1.083 ± 0.03	1.775MetGly: 1.775 ± 0.042	0.517MetHis: 0.517 ± 0.022	2.204MetIle: 2.204 ± 0.045	2.417MetLys: 2.417 ± 0.034	2.575MetLeu: 2.575 ± 0.049	0.84MetMet: 0.84 ± 0.031	1.63MetAsn: 1.63 ± 0.033	0.958MetPro: 0.958 ± 0.03	1.015MetGln: 1.015 ± 0.03	1.114MetArg: 1.114 ± 0.029	1.604MetSer: 1.604 ± 0.034	1.584MetThr: 1.584 ± 0.036	1.779MetVal: 1.779 ± 0.038	0.195MetTrp: 0.195 ± 0.012	0.808MetTyr: 0.808 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.02AsnAla: 3.02 ± 0.056	0.314AsnCys: 0.314 ± 0.014	2.504AsnAsp: 2.504 ± 0.048	3.772AsnGlu: 3.772 ± 0.061	1.774AsnPhe: 1.774 ± 0.042	3.399AsnGly: 3.399 ± 0.063	1.133AsnHis: 1.133 ± 0.029	3.588AsnIle: 3.588 ± 0.06	3.152AsnLys: 3.152 ± 0.052	3.961AsnLeu: 3.961 ± 0.059	1.329AsnMet: 1.329 ± 0.031	2.364AsnAsn: 2.364 ± 0.051	2.222AsnPro: 2.222 ± 0.043	2.126AsnGln: 2.126 ± 0.042	2.217AsnArg: 2.217 ± 0.045	2.482AsnSer: 2.482 ± 0.047	2.441AsnThr: 2.441 ± 0.043	3.031AsnVal: 3.031 ± 0.042	0.583AsnTrp: 0.583 ± 0.023	1.827AsnTyr: 1.827 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.362ProAla: 2.362 ± 0.047	0.184ProCys: 0.184 ± 0.012	2.063ProAsp: 2.063 ± 0.04	2.956ProGlu: 2.956 ± 0.05	1.928ProPhe: 1.928 ± 0.042	2.37ProGly: 2.37 ± 0.046	0.708ProHis: 0.708 ± 0.022	3.098ProIle: 3.098 ± 0.053	2.016ProLys: 2.016 ± 0.039	3.242ProLeu: 3.242 ± 0.054	0.869ProMet: 0.869 ± 0.024	1.763ProAsn: 1.763 ± 0.04	0.954ProPro: 0.954 ± 0.027	0.94ProGln: 0.94 ± 0.03	1.058ProArg: 1.058 ± 0.03	2.197ProSer: 2.197 ± 0.043	1.98ProThr: 1.98 ± 0.04	2.749ProVal: 2.749 ± 0.053	0.371ProTrp: 0.371 ± 0.016	1.381ProTyr: 1.381 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.884GlnAla: 2.884 ± 0.055	0.19GlnCys: 0.19 ± 0.012	1.821GlnAsp: 1.821 ± 0.044	2.969GlnGlu: 2.969 ± 0.05	1.605GlnPhe: 1.605 ± 0.038	2.183GlnGly: 2.183 ± 0.042	0.809GlnHis: 0.809 ± 0.024	2.783GlnIle: 2.783 ± 0.046	2.475GlnLys: 2.475 ± 0.046	4.117GlnLeu: 4.117 ± 0.062	1.072GlnMet: 1.072 ± 0.027	1.646GlnAsn: 1.646 ± 0.038	1.124GlnPro: 1.124 ± 0.031	1.829GlnGln: 1.829 ± 0.052	1.446GlnArg: 1.446 ± 0.037	2.131GlnSer: 2.131 ± 0.045	2.096GlnThr: 2.096 ± 0.039	2.474GlnVal: 2.474 ± 0.037	0.391GlnTrp: 0.391 ± 0.019	1.207GlnTyr: 1.207 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.349ArgAla: 2.349 ± 0.042	0.235ArgCys: 0.235 ± 0.014	2.03ArgAsp: 2.03 ± 0.042	3.114ArgGlu: 3.114 ± 0.049	1.891ArgPhe: 1.891 ± 0.041	2.242ArgGly: 2.242 ± 0.04	0.691ArgHis: 0.691 ± 0.021	3.28ArgIle: 3.28 ± 0.051	3.094ArgLys: 3.094 ± 0.053	3.743ArgLeu: 3.743 ± 0.059	1.231ArgMet: 1.231 ± 0.031	2.094ArgAsn: 2.094 ± 0.038	1.124ArgPro: 1.124 ± 0.031	1.375ArgGln: 1.375 ± 0.034	1.725ArgArg: 1.725 ± 0.043	2.176ArgSer: 2.176 ± 0.04	2.107ArgThr: 2.107 ± 0.039	2.523ArgVal: 2.523 ± 0.049	0.394ArgTrp: 0.394 ± 0.018	1.488ArgTyr: 1.488 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	3.728SerAla: 3.728 ± 0.056	0.345SerCys: 0.345 ± 0.015	3.091SerAsp: 3.091 ± 0.102	4.068SerGlu: 4.068 ± 0.06	3.129SerPhe: 3.129 ± 0.056	4.455SerGly: 4.455 ± 0.061	1.199SerHis: 1.199 ± 0.028	5.266SerIle: 5.266 ± 0.069	3.567SerLys: 3.567 ± 0.058	5.837SerLeu: 5.837 ± 0.08	1.691SerMet: 1.691 ± 0.038	2.86SerAsn: 2.86 ± 0.058	2.057SerPro: 2.057 ± 0.04	1.931SerGln: 1.931 ± 0.04	2.162SerArg: 2.162 ± 0.041	3.795SerSer: 3.795 ± 0.059	3.205SerThr: 3.205 ± 0.06	3.97SerVal: 3.97 ± 0.051	0.646SerTrp: 0.646 ± 0.022	2.34SerTyr: 2.34 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.14ThrAla: 4.14 ± 0.068	0.331ThrCys: 0.331 ± 0.016	2.956ThrAsp: 2.956 ± 0.053	3.895ThrGlu: 3.895 ± 0.06	2.701ThrPhe: 2.701 ± 0.049	4.231ThrGly: 4.231 ± 0.059	1.074ThrHis: 1.074 ± 0.03	5.043ThrIle: 5.043 ± 0.069	3.337ThrLys: 3.337 ± 0.054	5.013ThrLeu: 5.013 ± 0.063	1.352ThrMet: 1.352 ± 0.033	2.703ThrAsn: 2.703 ± 0.041	2.306ThrPro: 2.306 ± 0.041	1.453ThrGln: 1.453 ± 0.032	1.776ThrArg: 1.776 ± 0.04	3.303ThrSer: 3.303 ± 0.066	3.17ThrThr: 3.17 ± 0.055	4.093ThrVal: 4.093 ± 0.06	0.557ThrTrp: 0.557 ± 0.022	2.038ThrTyr: 2.038 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.98ValAla: 4.98 ± 0.059	0.502ValCys: 0.502 ± 0.02	3.742ValAsp: 3.742 ± 0.062	4.955ValGlu: 4.955 ± 0.063	3.113ValPhe: 3.113 ± 0.052	4.62ValGly: 4.62 ± 0.062	1.31ValHis: 1.31 ± 0.034	5.886ValIle: 5.886 ± 0.06	4.235ValLys: 4.235 ± 0.057	6.537ValLeu: 6.537 ± 0.076	1.861ValMet: 1.861 ± 0.039	3.23ValAsn: 3.23 ± 0.052	2.574ValPro: 2.574 ± 0.043	2.356ValGln: 2.356 ± 0.039	2.485ValArg: 2.485 ± 0.042	4.341ValSer: 4.341 ± 0.062	4.081ValThr: 4.081 ± 0.06	4.85ValVal: 4.85 ± 0.07	0.607ValTrp: 0.607 ± 0.023	2.303ValTyr: 2.303 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.583TrpAla: 0.583 ± 0.022	0.077TrpCys: 0.077 ± 0.009	0.561TrpAsp: 0.561 ± 0.026	0.705TrpGlu: 0.705 ± 0.025	0.542TrpPhe: 0.542 ± 0.025	0.665TrpGly: 0.665 ± 0.023	0.188TrpHis: 0.188 ± 0.011	0.858TrpIle: 0.858 ± 0.024	0.698TrpLys: 0.698 ± 0.022	1.036TrpLeu: 1.036 ± 0.034	0.347TrpMet: 0.347 ± 0.017	0.57TrpAsn: 0.57 ± 0.023	0.259TrpPro: 0.259 ± 0.015	0.344TrpGln: 0.344 ± 0.018	0.382TrpArg: 0.382 ± 0.017	0.583TrpSer: 0.583 ± 0.021	0.558TrpThr: 0.558 ± 0.022	0.643TrpVal: 0.643 ± 0.024	0.142TrpTrp: 0.142 ± 0.012	0.383TrpTyr: 0.383 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.197TyrAla: 2.197 ± 0.036	0.3TyrCys: 0.3 ± 0.016	1.975TyrAsp: 1.975 ± 0.044	2.631TyrGlu: 2.631 ± 0.049	1.926TyrPhe: 1.926 ± 0.042	2.449TyrGly: 2.449 ± 0.047	0.905TyrHis: 0.905 ± 0.028	2.574TyrIle: 2.574 ± 0.042	2.013TyrLys: 2.013 ± 0.041	3.442TyrLeu: 3.442 ± 0.054	0.944TyrMet: 0.944 ± 0.027	1.61TyrAsn: 1.61 ± 0.036	1.438TyrPro: 1.438 ± 0.032	1.617TyrGln: 1.617 ± 0.036	1.622TyrArg: 1.622 ± 0.041	2.048TyrSer: 2.048 ± 0.039	1.951TyrThr: 1.951 ± 0.04	2.18TyrVal: 2.18 ± 0.044	0.42TyrTrp: 0.42 ± 0.017	1.513TyrTyr: 1.513 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4512 proteins (1318155 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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