Amino acid dipepetide frequency for Pasteurella bettyae CCUG 2042

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.931AlaAla: 5.931 ± 0.127
0.936AlaCys: 0.936 ± 0.042
4.195AlaAsp: 4.195 ± 0.077
5.726AlaGlu: 5.726 ± 0.102
3.409AlaPhe: 3.409 ± 0.092
5.229AlaGly: 5.229 ± 0.121
1.422AlaHis: 1.422 ± 0.045
6.251AlaIle: 6.251 ± 0.117
5.696AlaLys: 5.696 ± 0.117
9.255AlaLeu: 9.255 ± 0.142
2.336AlaMet: 2.336 ± 0.069
3.631AlaAsn: 3.631 ± 0.085
2.402AlaPro: 2.402 ± 0.066
3.683AlaGln: 3.683 ± 0.071
3.284AlaArg: 3.284 ± 0.079
4.249AlaSer: 4.249 ± 0.092
4.205AlaThr: 4.205 ± 0.081
5.637AlaVal: 5.637 ± 0.095
0.793AlaTrp: 0.793 ± 0.035
2.432AlaTyr: 2.432 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.759CysAla: 0.759 ± 0.037
0.153CysCys: 0.153 ± 0.017
0.583CysAsp: 0.583 ± 0.03
0.615CysGlu: 0.615 ± 0.031
0.478CysPhe: 0.478 ± 0.029
1.008CysGly: 1.008 ± 0.046
0.31CysHis: 0.31 ± 0.027
0.682CysIle: 0.682 ± 0.035
0.481CysLys: 0.481 ± 0.027
1.062CysLeu: 1.062 ± 0.045
0.171CysMet: 0.171 ± 0.016
0.373CysAsn: 0.373 ± 0.023
0.489CysPro: 0.489 ± 0.033
0.46CysGln: 0.46 ± 0.027
0.415CysArg: 0.415 ± 0.027
0.741CysSer: 0.741 ± 0.036
0.51CysThr: 0.51 ± 0.029
0.646CysVal: 0.646 ± 0.031
0.121CysTrp: 0.121 ± 0.013
0.394CysTyr: 0.394 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.562AspAla: 3.562 ± 0.085
0.52AspCys: 0.52 ± 0.03
2.495AspAsp: 2.495 ± 0.074
3.763AspGlu: 3.763 ± 0.092
2.527AspPhe: 2.527 ± 0.062
3.271AspGly: 3.271 ± 0.103
0.943AspHis: 0.943 ± 0.041
3.979AspIle: 3.979 ± 0.072
3.725AspLys: 3.725 ± 0.079
5.015AspLeu: 5.015 ± 0.084
1.221AspMet: 1.221 ± 0.044
2.672AspAsn: 2.672 ± 0.078
1.963AspPro: 1.963 ± 0.05
1.713AspGln: 1.713 ± 0.054
1.974AspArg: 1.974 ± 0.059
2.581AspSer: 2.581 ± 0.057
2.336AspThr: 2.336 ± 0.07
3.428AspVal: 3.428 ± 0.078
0.747AspTrp: 0.747 ± 0.033
2.109AspTyr: 2.109 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
4.43GluAla: 4.43 ± 0.091
0.454GluCys: 0.454 ± 0.025
2.756GluAsp: 2.756 ± 0.076
3.841GluGlu: 3.841 ± 0.096
2.443GluPhe: 2.443 ± 0.059
3.214GluGly: 3.214 ± 0.073
1.5GluHis: 1.5 ± 0.054
4.884GluIle: 4.884 ± 0.094
5.217GluLys: 5.217 ± 0.105
6.606GluLeu: 6.606 ± 0.124
1.72GluMet: 1.72 ± 0.048
3.851GluAsn: 3.851 ± 0.087
1.836GluPro: 1.836 ± 0.058
4.12GluGln: 4.12 ± 0.095
3.107GluArg: 3.107 ± 0.087
3.106GluSer: 3.106 ± 0.075
3.107GluThr: 3.107 ± 0.067
3.988GluVal: 3.988 ± 0.086
0.783GluTrp: 0.783 ± 0.035
1.999GluTyr: 1.999 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.565PheAla: 3.565 ± 0.088
0.556PheCys: 0.556 ± 0.032
2.653PheAsp: 2.653 ± 0.077
2.542PheGlu: 2.542 ± 0.068
1.933PhePhe: 1.933 ± 0.07
3.34PheGly: 3.34 ± 0.088
0.841PheHis: 0.841 ± 0.034
3.491PheIle: 3.491 ± 0.094
2.374PheLys: 2.374 ± 0.069
3.896PheLeu: 3.896 ± 0.096
1.095PheMet: 1.095 ± 0.041
2.456PheAsn: 2.456 ± 0.06
1.428PhePro: 1.428 ± 0.05
1.366PheGln: 1.366 ± 0.051
1.494PheArg: 1.494 ± 0.046
3.293PheSer: 3.293 ± 0.081
2.45PheThr: 2.45 ± 0.054
2.816PheVal: 2.816 ± 0.078
0.516PheTrp: 0.516 ± 0.032
1.56PheTyr: 1.56 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.958GlyAla: 4.958 ± 0.105
0.85GlyCys: 0.85 ± 0.045
3.115GlyAsp: 3.115 ± 0.079
4.019GlyGlu: 4.019 ± 0.092
3.133GlyPhe: 3.133 ± 0.078
4.555GlyGly: 4.555 ± 0.113
1.336GlyHis: 1.336 ± 0.055
5.394GlyIle: 5.394 ± 0.119
4.923GlyLys: 4.923 ± 0.099
6.888GlyLeu: 6.888 ± 0.129
1.921GlyMet: 1.921 ± 0.055
2.851GlyAsn: 2.851 ± 0.087
1.291GlyPro: 1.291 ± 0.046
2.392GlyGln: 2.392 ± 0.057
2.815GlyArg: 2.815 ± 0.062
3.779GlySer: 3.779 ± 0.107
3.373GlyThr: 3.373 ± 0.082
4.779GlyVal: 4.779 ± 0.11
0.835GlyTrp: 0.835 ± 0.032
2.594GlyTyr: 2.594 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.371HisAla: 1.371 ± 0.046
0.346HisCys: 0.346 ± 0.022
0.912HisAsp: 0.912 ± 0.046
1.024HisGlu: 1.024 ± 0.04
1.15HisPhe: 1.15 ± 0.044
1.356HisGly: 1.356 ± 0.043
0.714HisHis: 0.714 ± 0.045
1.606HisIle: 1.606 ± 0.051
1.218HisLys: 1.218 ± 0.045
2.341HisLeu: 2.341 ± 0.062
0.42HisMet: 0.42 ± 0.023
1.026HisAsn: 1.026 ± 0.04
1.029HisPro: 1.029 ± 0.045
1.18HisGln: 1.18 ± 0.047
0.967HisArg: 0.967 ± 0.038
1.383HisSer: 1.383 ± 0.049
0.951HisThr: 0.951 ± 0.039
1.008HisVal: 1.008 ± 0.044
0.3HisTrp: 0.3 ± 0.022
0.885HisTyr: 0.885 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.879IleAla: 6.879 ± 0.126
0.874IleCys: 0.874 ± 0.037
4.084IleAsp: 4.084 ± 0.077
4.944IleGlu: 4.944 ± 0.1
3.145IlePhe: 3.145 ± 0.085
5.139IleGly: 5.139 ± 0.101
1.45IleHis: 1.45 ± 0.045
5.189IleIle: 5.189 ± 0.113
4.414IleLys: 4.414 ± 0.085
6.905IleLeu: 6.905 ± 0.134
1.522IleMet: 1.522 ± 0.05
3.736IleAsn: 3.736 ± 0.08
2.947IlePro: 2.947 ± 0.079
2.821IleGln: 2.821 ± 0.073
2.996IleArg: 2.996 ± 0.066
5.09IleSer: 5.09 ± 0.092
4.061IleThr: 4.061 ± 0.086
4.546IleVal: 4.546 ± 0.08
0.675IleTrp: 0.675 ± 0.033
2.268IleTyr: 2.268 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
5.439LysAla: 5.439 ± 0.117
0.46LysCys: 0.46 ± 0.031
3.361LysAsp: 3.361 ± 0.089
3.946LysGlu: 3.946 ± 0.095
2.229LysPhe: 2.229 ± 0.064
4.12LysGly: 4.12 ± 0.097
1.293LysHis: 1.293 ± 0.047
4.474LysIle: 4.474 ± 0.093
3.968LysLys: 3.968 ± 0.09
6.408LysLeu: 6.408 ± 0.098
1.894LysMet: 1.894 ± 0.055
3.551LysAsn: 3.551 ± 0.09
2.443LysPro: 2.443 ± 0.065
3.544LysGln: 3.544 ± 0.087
2.879LysArg: 2.879 ± 0.073
3.569LysSer: 3.569 ± 0.078
3.637LysThr: 3.637 ± 0.086
4.283LysVal: 4.283 ± 0.1
0.625LysTrp: 0.625 ± 0.026
1.87LysTyr: 1.87 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
9.184LeuAla: 9.184 ± 0.127
1.086LeuCys: 1.086 ± 0.042
5.481LeuAsp: 5.481 ± 0.089
5.963LeuGlu: 5.963 ± 0.104
4.619LeuPhe: 4.619 ± 0.113
7.132LeuGly: 7.132 ± 0.133
1.987LeuHis: 1.987 ± 0.052
7.245LeuIle: 7.245 ± 0.129
6.188LeuLys: 6.188 ± 0.116
10.619LeuLeu: 10.619 ± 0.183
2.504LeuMet: 2.504 ± 0.056
5.093LeuAsn: 5.093 ± 0.098
4.447LeuPro: 4.447 ± 0.089
4.207LeuGln: 4.207 ± 0.085
4.399LeuArg: 4.399 ± 0.084
7.497LeuSer: 7.497 ± 0.122
6.147LeuThr: 6.147 ± 0.106
6.423LeuVal: 6.423 ± 0.12
1.038LeuTrp: 1.038 ± 0.038
2.735LeuTyr: 2.735 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.33MetAla: 2.33 ± 0.059
0.204MetCys: 0.204 ± 0.016
1.048MetAsp: 1.048 ± 0.038
1.297MetGlu: 1.297 ± 0.045
0.961MetPhe: 0.961 ± 0.042
1.6MetGly: 1.6 ± 0.06
0.433MetHis: 0.433 ± 0.025
1.717MetIle: 1.717 ± 0.058
1.777MetLys: 1.777 ± 0.05
2.69MetLeu: 2.69 ± 0.077
0.694MetMet: 0.694 ± 0.035
1.233MetAsn: 1.233 ± 0.047
1.119MetPro: 1.119 ± 0.042
1.27MetGln: 1.27 ± 0.049
1.035MetArg: 1.035 ± 0.041
1.626MetSer: 1.626 ± 0.048
1.615MetThr: 1.615 ± 0.05
1.498MetVal: 1.498 ± 0.049
0.189MetTrp: 0.189 ± 0.019
0.526MetTyr: 0.526 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.769AsnAla: 3.769 ± 0.087
0.487AsnCys: 0.487 ± 0.027
2.227AsnAsp: 2.227 ± 0.062
2.879AsnGlu: 2.879 ± 0.07
1.879AsnPhe: 1.879 ± 0.051
3.251AsnGly: 3.251 ± 0.094
1.077AsnHis: 1.077 ± 0.039
3.841AsnIle: 3.841 ± 0.085
3.203AsnLys: 3.203 ± 0.078
5.135AsnLeu: 5.135 ± 0.104
1.195AsnMet: 1.195 ± 0.044
2.599AsnAsn: 2.599 ± 0.077
2.33AsnPro: 2.33 ± 0.066
2.581AsnGln: 2.581 ± 0.076
2.079AsnArg: 2.079 ± 0.057
2.788AsnSer: 2.788 ± 0.067
2.506AsnThr: 2.506 ± 0.08
3.155AsnVal: 3.155 ± 0.088
0.639AsnTrp: 0.639 ± 0.033
1.822AsnTyr: 1.822 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.684ProAla: 2.684 ± 0.067
0.327ProCys: 0.327 ± 0.024
1.806ProAsp: 1.806 ± 0.059
3.014ProGlu: 3.014 ± 0.068
1.77ProPhe: 1.77 ± 0.053
1.599ProGly: 1.599 ± 0.057
0.934ProHis: 0.934 ± 0.043
2.822ProIle: 2.822 ± 0.075
2.227ProLys: 2.227 ± 0.06
3.538ProLeu: 3.538 ± 0.083
0.982ProMet: 0.982 ± 0.041
2.047ProAsn: 2.047 ± 0.06
0.972ProPro: 0.972 ± 0.042
1.674ProGln: 1.674 ± 0.058
1.315ProArg: 1.315 ± 0.048
2.109ProSer: 2.109 ± 0.055
2.26ProThr: 2.26 ± 0.056
2.651ProVal: 2.651 ± 0.069
0.372ProTrp: 0.372 ± 0.022
1.282ProTyr: 1.282 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
4.103GlnAla: 4.103 ± 0.09
0.397GlnCys: 0.397 ± 0.025
2.088GlnAsp: 2.088 ± 0.058
2.585GlnGlu: 2.585 ± 0.07
2.077GlnPhe: 2.077 ± 0.06
2.905GlnGly: 2.905 ± 0.075
1.126GlnHis: 1.126 ± 0.043
3.281GlnIle: 3.281 ± 0.083
2.888GlnLys: 2.888 ± 0.071
5.13GlnLeu: 5.13 ± 0.115
0.97GlnMet: 0.97 ± 0.043
2.245GlnAsn: 2.245 ± 0.055
1.692GlnPro: 1.692 ± 0.051
3.217GlnGln: 3.217 ± 0.099
2.196GlnArg: 2.196 ± 0.072
2.536GlnSer: 2.536 ± 0.065
2.293GlnThr: 2.293 ± 0.061
2.923GlnVal: 2.923 ± 0.064
0.61GlnTrp: 0.61 ± 0.033
1.612GlnTyr: 1.612 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
2.951ArgAla: 2.951 ± 0.06
0.445ArgCys: 0.445 ± 0.027
2.194ArgAsp: 2.194 ± 0.063
2.764ArgGlu: 2.764 ± 0.077
2.047ArgPhe: 2.047 ± 0.066
2.467ArgGly: 2.467 ± 0.062
1.017ArgHis: 1.017 ± 0.044
3.106ArgIle: 3.106 ± 0.054
2.597ArgLys: 2.597 ± 0.065
4.639ArgLeu: 4.639 ± 0.097
1.068ArgMet: 1.068 ± 0.043
2.007ArgAsn: 2.007 ± 0.051
1.501ArgPro: 1.501 ± 0.048
2.142ArgGln: 2.142 ± 0.07
2.088ArgArg: 2.088 ± 0.07
2.35ArgSer: 2.35 ± 0.059
2.146ArgThr: 2.146 ± 0.061
2.656ArgVal: 2.656 ± 0.061
0.52ArgTrp: 0.52 ± 0.033
1.777ArgTyr: 1.777 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.118SerAla: 5.118 ± 0.095
0.558SerCys: 0.558 ± 0.033
2.953SerAsp: 2.953 ± 0.067
3.776SerGlu: 3.776 ± 0.091
2.83SerPhe: 2.83 ± 0.077
4.378SerGly: 4.378 ± 0.09
1.413SerHis: 1.413 ± 0.046
4.276SerIle: 4.276 ± 0.091
3.371SerLys: 3.371 ± 0.085
6.375SerLeu: 6.375 ± 0.118
1.417SerMet: 1.417 ± 0.049
2.666SerAsn: 2.666 ± 0.077
2.11SerPro: 2.11 ± 0.06
2.87SerGln: 2.87 ± 0.075
2.41SerArg: 2.41 ± 0.063
3.802SerSer: 3.802 ± 0.101
3.13SerThr: 3.13 ± 0.077
3.992SerVal: 3.992 ± 0.075
0.714SerTrp: 0.714 ± 0.034
1.995SerTyr: 1.995 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
4.844ThrAla: 4.844 ± 0.084
0.487ThrCys: 0.487 ± 0.032
2.846ThrAsp: 2.846 ± 0.075
3.574ThrGlu: 3.574 ± 0.078
2.217ThrPhe: 2.217 ± 0.051
3.838ThrGly: 3.838 ± 0.088
1.116ThrHis: 1.116 ± 0.035
3.608ThrIle: 3.608 ± 0.079
2.971ThrLys: 2.971 ± 0.068
5.771ThrLeu: 5.771 ± 0.1
1.134ThrMet: 1.134 ± 0.047
2.31ThrAsn: 2.31 ± 0.071
2.356ThrPro: 2.356 ± 0.053
2.422ThrGln: 2.422 ± 0.058
2.037ThrArg: 2.037 ± 0.063
3.005ThrSer: 3.005 ± 0.078
3.055ThrThr: 3.055 ± 0.085
3.592ThrVal: 3.592 ± 0.083
0.579ThrTrp: 0.579 ± 0.031
1.668ThrTyr: 1.668 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.511ValAla: 5.511 ± 0.106
0.709ValCys: 0.709 ± 0.033
3.506ValAsp: 3.506 ± 0.08
4.456ValGlu: 4.456 ± 0.091
2.531ValPhe: 2.531 ± 0.066
4.522ValGly: 4.522 ± 0.095
1.126ValHis: 1.126 ± 0.04
4.991ValIle: 4.991 ± 0.093
4.37ValLys: 4.37 ± 0.085
6.453ValLeu: 6.453 ± 0.111
1.705ValMet: 1.705 ± 0.061
3.187ValAsn: 3.187 ± 0.083
2.383ValPro: 2.383 ± 0.068
2.329ValGln: 2.329 ± 0.061
2.765ValArg: 2.765 ± 0.08
4.067ValSer: 4.067 ± 0.086
3.608ValThr: 3.608 ± 0.089
4.618ValVal: 4.618 ± 0.093
0.592ValTrp: 0.592 ± 0.029
1.831ValTyr: 1.831 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.76TrpAla: 0.76 ± 0.035
0.154TrpCys: 0.154 ± 0.015
0.528TrpAsp: 0.528 ± 0.03
0.565TrpGlu: 0.565 ± 0.028
0.558TrpPhe: 0.558 ± 0.029
0.681TrpGly: 0.681 ± 0.037
0.267TrpHis: 0.267 ± 0.019
0.804TrpIle: 0.804 ± 0.036
0.708TrpLys: 0.708 ± 0.028
1.579TrpLeu: 1.579 ± 0.046
0.237TrpMet: 0.237 ± 0.019
0.561TrpAsn: 0.561 ± 0.028
0.187TrpPro: 0.187 ± 0.017
0.879TrpGln: 0.879 ± 0.035
0.538TrpArg: 0.538 ± 0.027
0.561TrpSer: 0.561 ± 0.026
0.46TrpThr: 0.46 ± 0.03
0.709TrpVal: 0.709 ± 0.034
0.142TrpTrp: 0.142 ± 0.016
0.357TrpTyr: 0.357 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.552TyrAla: 2.552 ± 0.069
0.447TyrCys: 0.447 ± 0.023
1.713TyrAsp: 1.713 ± 0.063
1.669TyrGlu: 1.669 ± 0.057
1.731TyrPhe: 1.731 ± 0.052
2.2TyrGly: 2.2 ± 0.051
0.88TyrHis: 0.88 ± 0.034
2.043TyrIle: 2.043 ± 0.065
1.675TyrLys: 1.675 ± 0.051
3.691TyrLeu: 3.691 ± 0.086
0.655TyrMet: 0.655 ± 0.029
1.348TyrAsn: 1.348 ± 0.048
1.461TyrPro: 1.461 ± 0.051
2.007TyrGln: 2.007 ± 0.066
1.689TyrArg: 1.689 ± 0.049
2.023TyrSer: 2.023 ± 0.061
1.576TyrThr: 1.576 ± 0.05
1.912TyrVal: 1.912 ± 0.057
0.445TyrTrp: 0.445 ± 0.027
1.167TyrTyr: 1.167 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2177 proteins (666811 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski