Amino acid dipepetide frequency for Neisseria sp. oral taxon 020 str. F0370

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.311AlaAla: 21.311 ± 0.297
1.51AlaCys: 1.51 ± 0.055
7.793AlaAsp: 7.793 ± 0.122
8.068AlaGlu: 8.068 ± 0.15
4.683AlaPhe: 4.683 ± 0.1
9.24AlaGly: 9.24 ± 0.147
2.16AlaHis: 2.16 ± 0.069
3.674AlaIle: 3.674 ± 0.091
5.151AlaLys: 5.151 ± 0.093
12.111AlaLeu: 12.111 ± 0.172
2.525AlaMet: 2.525 ± 0.065
3.114AlaAsn: 3.114 ± 0.071
4.508AlaPro: 4.508 ± 0.103
5.327AlaGln: 5.327 ± 0.101
6.223AlaArg: 6.223 ± 0.109
4.586AlaSer: 4.586 ± 0.093
3.719AlaThr: 3.719 ± 0.09
10.151AlaVal: 10.151 ± 0.159
1.363AlaTrp: 1.363 ± 0.051
2.906AlaTyr: 2.906 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
1.268CysAla: 1.268 ± 0.047
0.236CysCys: 0.236 ± 0.02
0.467CysAsp: 0.467 ± 0.028
0.511CysGlu: 0.511 ± 0.031
0.542CysPhe: 0.542 ± 0.03
1.395CysGly: 1.395 ± 0.051
0.271CysHis: 0.271 ± 0.018
0.466CysIle: 0.466 ± 0.024
0.342CysLys: 0.342 ± 0.024
1.066CysLeu: 1.066 ± 0.043
0.197CysMet: 0.197 ± 0.017
0.307CysAsn: 0.307 ± 0.02
0.591CysPro: 0.591 ± 0.03
0.368CysGln: 0.368 ± 0.025
0.944CysArg: 0.944 ± 0.035
0.547CysSer: 0.547 ± 0.03
0.522CysThr: 0.522 ± 0.026
0.653CysVal: 0.653 ± 0.034
0.115CysTrp: 0.115 ± 0.012
0.291CysTyr: 0.291 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
5.726AspAla: 5.726 ± 0.1
0.544AspCys: 0.544 ± 0.027
2.649AspAsp: 2.649 ± 0.068
3.449AspGlu: 3.449 ± 0.079
2.507AspPhe: 2.507 ± 0.076
5.184AspGly: 5.184 ± 0.113
0.853AspHis: 0.853 ± 0.037
3.472AspIle: 3.472 ± 0.081
2.873AspLys: 2.873 ± 0.078
4.838AspLeu: 4.838 ± 0.086
1.241AspMet: 1.241 ± 0.042
1.955AspAsn: 1.955 ± 0.057
2.063AspPro: 2.063 ± 0.063
1.184AspGln: 1.184 ± 0.04
2.27AspArg: 2.27 ± 0.058
2.608AspSer: 2.608 ± 0.056
3.181AspThr: 3.181 ± 0.075
3.204AspVal: 3.204 ± 0.083
0.897AspTrp: 0.897 ± 0.041
1.906AspTyr: 1.906 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
6.696GluAla: 6.696 ± 0.12
0.468GluCys: 0.468 ± 0.028
2.442GluAsp: 2.442 ± 0.06
3.333GluGlu: 3.333 ± 0.093
2.016GluPhe: 2.016 ± 0.055
3.699GluGly: 3.699 ± 0.092
1.451GluHis: 1.451 ± 0.05
3.535GluIle: 3.535 ± 0.079
3.576GluLys: 3.576 ± 0.082
5.224GluLeu: 5.224 ± 0.1
1.532GluMet: 1.532 ± 0.054
2.985GluAsn: 2.985 ± 0.076
2.053GluPro: 2.053 ± 0.063
2.856GluGln: 2.856 ± 0.072
3.994GluArg: 3.994 ± 0.08
2.751GluSer: 2.751 ± 0.062
3.696GluThr: 3.696 ± 0.073
3.129GluVal: 3.129 ± 0.079
0.768GluTrp: 0.768 ± 0.032
1.587GluTyr: 1.587 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
5.479PheAla: 5.479 ± 0.117
0.66PheCys: 0.66 ± 0.032
2.735PheAsp: 2.735 ± 0.068
2.03PheGlu: 2.03 ± 0.052
2.036PhePhe: 2.036 ± 0.068
3.914PheGly: 3.914 ± 0.099
0.857PheHis: 0.857 ± 0.04
1.8PheIle: 1.8 ± 0.057
1.615PheLys: 1.615 ± 0.048
3.587PheLeu: 3.587 ± 0.085
0.908PheMet: 0.908 ± 0.04
1.449PheAsn: 1.449 ± 0.046
1.637PhePro: 1.637 ± 0.055
1.611PheGln: 1.611 ± 0.05
2.3PheArg: 2.3 ± 0.064
2.616PheSer: 2.616 ± 0.056
1.977PheThr: 1.977 ± 0.053
2.992PheVal: 2.992 ± 0.076
0.556PheTrp: 0.556 ± 0.034
1.256PheTyr: 1.256 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
7.272GlyAla: 7.272 ± 0.13
1.009GlyCys: 1.009 ± 0.041
3.652GlyAsp: 3.652 ± 0.096
4.682GlyGlu: 4.682 ± 0.095
3.962GlyPhe: 3.962 ± 0.086
7.753GlyGly: 7.753 ± 0.161
1.613GlyHis: 1.613 ± 0.053
4.694GlyIle: 4.694 ± 0.092
4.957GlyLys: 4.957 ± 0.094
8.009GlyLeu: 8.009 ± 0.107
2.135GlyMet: 2.135 ± 0.055
2.794GlyAsn: 2.794 ± 0.078
1.029GlyPro: 1.029 ± 0.043
2.997GlyGln: 2.997 ± 0.068
6.094GlyArg: 6.094 ± 0.106
4.662GlySer: 4.662 ± 0.114
3.588GlyThr: 3.588 ± 0.078
5.264GlyVal: 5.264 ± 0.109
1.218GlyTrp: 1.218 ± 0.047
2.363GlyTyr: 2.363 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
2.129HisAla: 2.129 ± 0.064
0.265HisCys: 0.265 ± 0.02
1.036HisAsp: 1.036 ± 0.036
1.116HisGlu: 1.116 ± 0.041
0.947HisPhe: 0.947 ± 0.044
2.159HisGly: 2.159 ± 0.066
0.571HisHis: 0.571 ± 0.03
1.451HisIle: 1.451 ± 0.048
0.864HisLys: 0.864 ± 0.036
1.919HisLeu: 1.919 ± 0.054
0.389HisMet: 0.389 ± 0.024
0.767HisAsn: 0.767 ± 0.034
1.408HisPro: 1.408 ± 0.047
0.769HisGln: 0.769 ± 0.038
1.29HisArg: 1.29 ± 0.05
1.124HisSer: 1.124 ± 0.04
1.343HisThr: 1.343 ± 0.049
1.005HisVal: 1.005 ± 0.043
0.318HisTrp: 0.318 ± 0.021
0.767HisTyr: 0.767 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.891IleAla: 5.891 ± 0.098
0.528IleCys: 0.528 ± 0.023
3.097IleAsp: 3.097 ± 0.074
3.127IleGlu: 3.127 ± 0.088
1.692IlePhe: 1.692 ± 0.053
4.493IleGly: 4.493 ± 0.093
0.957IleHis: 0.957 ± 0.038
2.447IleIle: 2.447 ± 0.063
2.111IleLys: 2.111 ± 0.067
4.389IleLeu: 4.389 ± 0.082
1.076IleMet: 1.076 ± 0.043
1.786IleAsn: 1.786 ± 0.06
2.297IlePro: 2.297 ± 0.059
1.476IleGln: 1.476 ± 0.044
3.354IleArg: 3.354 ± 0.071
2.687IleSer: 2.687 ± 0.066
2.725IleThr: 2.725 ± 0.07
3.52IleVal: 3.52 ± 0.073
0.487IleTrp: 0.487 ± 0.025
1.259IleTyr: 1.259 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
5.048LysAla: 5.048 ± 0.089
0.273LysCys: 0.273 ± 0.023
2.202LysAsp: 2.202 ± 0.064
2.622LysGlu: 2.622 ± 0.064
1.331LysPhe: 1.331 ± 0.051
3.334LysGly: 3.334 ± 0.091
1.092LysHis: 1.092 ± 0.038
2.825LysIle: 2.825 ± 0.069
2.788LysLys: 2.788 ± 0.073
4.447LysLeu: 4.447 ± 0.084
1.353LysMet: 1.353 ± 0.048
2.402LysAsn: 2.402 ± 0.066
2.595LysPro: 2.595 ± 0.069
2.393LysGln: 2.393 ± 0.067
2.991LysArg: 2.991 ± 0.074
2.328LysSer: 2.328 ± 0.056
3.527LysThr: 3.527 ± 0.073
2.515LysVal: 2.515 ± 0.068
0.518LysTrp: 0.518 ± 0.028
1.171LysTyr: 1.171 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
12.365LeuAla: 12.365 ± 0.192
1.141LeuCys: 1.141 ± 0.047
5.166LeuAsp: 5.166 ± 0.09
4.696LeuGlu: 4.696 ± 0.095
4.308LeuPhe: 4.308 ± 0.099
6.863LeuGly: 6.863 ± 0.114
2.275LeuHis: 2.275 ± 0.064
4.781LeuIle: 4.781 ± 0.099
5.316LeuLys: 5.316 ± 0.092
10.597LeuLeu: 10.597 ± 0.209
2.341LeuMet: 2.341 ± 0.064
3.699LeuAsn: 3.699 ± 0.077
6.198LeuPro: 6.198 ± 0.11
3.826LeuGln: 3.826 ± 0.079
5.894LeuArg: 5.894 ± 0.096
6.281LeuSer: 6.281 ± 0.112
4.887LeuThr: 4.887 ± 0.084
5.669LeuVal: 5.669 ± 0.113
1.224LeuTrp: 1.224 ± 0.051
2.586LeuTyr: 2.586 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.474MetAla: 2.474 ± 0.06
0.234MetCys: 0.234 ± 0.019
0.999MetAsp: 0.999 ± 0.041
1.062MetGlu: 1.062 ± 0.044
0.835MetPhe: 0.835 ± 0.035
1.564MetGly: 1.564 ± 0.049
0.466MetHis: 0.466 ± 0.031
1.038MetIle: 1.038 ± 0.043
1.375MetLys: 1.375 ± 0.045
2.477MetLeu: 2.477 ± 0.067
0.725MetMet: 0.725 ± 0.039
1.083MetAsn: 1.083 ± 0.038
1.471MetPro: 1.471 ± 0.048
1.184MetGln: 1.184 ± 0.046
1.566MetArg: 1.566 ± 0.048
1.482MetSer: 1.482 ± 0.044
1.276MetThr: 1.276 ± 0.038
1.424MetVal: 1.424 ± 0.045
0.261MetTrp: 0.261 ± 0.021
0.468MetTyr: 0.468 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.84AsnAla: 3.84 ± 0.082
0.295AsnCys: 0.295 ± 0.022
1.635AsnAsp: 1.635 ± 0.06
1.774AsnGlu: 1.774 ± 0.059
1.195AsnPhe: 1.195 ± 0.039
3.493AsnGly: 3.493 ± 0.087
0.748AsnHis: 0.748 ± 0.033
2.331AsnIle: 2.331 ± 0.065
1.59AsnLys: 1.59 ± 0.057
3.292AsnLeu: 3.292 ± 0.072
0.752AsnMet: 0.752 ± 0.031
1.259AsnAsn: 1.259 ± 0.059
2.349AsnPro: 2.349 ± 0.059
1.222AsnGln: 1.222 ± 0.046
2.51AsnArg: 2.51 ± 0.067
1.681AsnSer: 1.681 ± 0.056
1.994AsnThr: 1.994 ± 0.057
2.141AsnVal: 2.141 ± 0.064
0.485AsnTrp: 0.485 ± 0.028
0.918AsnTyr: 0.918 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
6.0ProAla: 6.0 ± 0.128
0.467ProCys: 0.467 ± 0.028
3.024ProAsp: 3.024 ± 0.067
3.577ProGlu: 3.577 ± 0.081
2.114ProPhe: 2.114 ± 0.06
2.011ProGly: 2.011 ± 0.051
1.204ProHis: 1.204 ± 0.04
1.587ProIle: 1.587 ± 0.043
1.996ProLys: 1.996 ± 0.061
4.476ProLeu: 4.476 ± 0.091
1.043ProMet: 1.043 ± 0.038
1.523ProAsn: 1.523 ± 0.055
2.406ProPro: 2.406 ± 0.07
2.649ProGln: 2.649 ± 0.069
2.128ProArg: 2.128 ± 0.054
2.652ProSer: 2.652 ± 0.063
1.921ProThr: 1.921 ± 0.053
3.557ProVal: 3.557 ± 0.079
0.429ProTrp: 0.429 ± 0.025
1.339ProTyr: 1.339 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
5.129GlnAla: 5.129 ± 0.093
0.307GlnCys: 0.307 ± 0.023
1.82GlnAsp: 1.82 ± 0.053
2.203GlnGlu: 2.203 ± 0.06
1.238GlnPhe: 1.238 ± 0.047
2.816GlnGly: 2.816 ± 0.065
0.967GlnHis: 0.967 ± 0.047
2.354GlnIle: 2.354 ± 0.061
2.048GlnLys: 2.048 ± 0.058
3.068GlnLeu: 3.068 ± 0.076
1.075GlnMet: 1.075 ± 0.037
1.996GlnAsn: 1.996 ± 0.062
1.881GlnPro: 1.881 ± 0.064
2.162GlnGln: 2.162 ± 0.086
2.335GlnArg: 2.335 ± 0.057
2.389GlnSer: 2.389 ± 0.06
3.696GlnThr: 3.696 ± 0.075
2.187GlnVal: 2.187 ± 0.054
0.52GlnTrp: 0.52 ± 0.029
1.136GlnTyr: 1.136 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
5.784ArgAla: 5.784 ± 0.101
0.596ArgCys: 0.596 ± 0.031
2.86ArgAsp: 2.86 ± 0.068
3.871ArgGlu: 3.871 ± 0.074
3.245ArgPhe: 3.245 ± 0.077
4.013ArgGly: 4.013 ± 0.084
1.709ArgHis: 1.709 ± 0.055
3.425ArgIle: 3.425 ± 0.068
2.643ArgLys: 2.643 ± 0.063
7.364ArgLeu: 7.364 ± 0.113
1.412ArgMet: 1.412 ± 0.038
2.09ArgAsn: 2.09 ± 0.056
3.567ArgPro: 3.567 ± 0.089
3.156ArgGln: 3.156 ± 0.084
5.268ArgArg: 5.268 ± 0.109
3.002ArgSer: 3.002 ± 0.066
2.559ArgThr: 2.559 ± 0.067
3.542ArgVal: 3.542 ± 0.06
0.73ArgTrp: 0.73 ± 0.035
2.165ArgTyr: 2.165 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
5.932SerAla: 5.932 ± 0.091
0.569SerCys: 0.569 ± 0.03
3.359SerAsp: 3.359 ± 0.069
3.437SerGlu: 3.437 ± 0.074
2.248SerPhe: 2.248 ± 0.068
5.388SerGly: 5.388 ± 0.097
1.055SerHis: 1.055 ± 0.041
2.307SerIle: 2.307 ± 0.062
2.041SerLys: 2.041 ± 0.057
5.319SerLeu: 5.319 ± 0.088
1.035SerMet: 1.035 ± 0.04
1.505SerAsn: 1.505 ± 0.053
2.398SerPro: 2.398 ± 0.061
1.773SerGln: 1.773 ± 0.058
3.452SerArg: 3.452 ± 0.079
2.622SerSer: 2.622 ± 0.071
2.148SerThr: 2.148 ± 0.054
3.813SerVal: 3.813 ± 0.079
0.595SerTrp: 0.595 ± 0.031
1.465SerTyr: 1.465 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
7.204ThrAla: 7.204 ± 0.107
0.446ThrCys: 0.446 ± 0.026
2.794ThrAsp: 2.794 ± 0.072
2.62ThrGlu: 2.62 ± 0.065
1.803ThrPhe: 1.803 ± 0.047
4.125ThrGly: 4.125 ± 0.086
1.042ThrHis: 1.042 ± 0.041
2.134ThrIle: 2.134 ± 0.059
1.561ThrLys: 1.561 ± 0.053
5.834ThrLeu: 5.834 ± 0.095
0.962ThrMet: 0.962 ± 0.035
1.371ThrAsn: 1.371 ± 0.042
2.997ThrPro: 2.997 ± 0.068
1.848ThrGln: 1.848 ± 0.054
2.832ThrArg: 2.832 ± 0.062
2.033ThrSer: 2.033 ± 0.056
1.946ThrThr: 1.946 ± 0.058
4.49ThrVal: 4.49 ± 0.079
0.463ThrTrp: 0.463 ± 0.024
1.171ThrTyr: 1.171 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
6.565ValAla: 6.565 ± 0.129
1.052ValCys: 1.052 ± 0.041
2.907ValAsp: 2.907 ± 0.081
3.672ValGlu: 3.672 ± 0.081
3.422ValPhe: 3.422 ± 0.083
5.039ValGly: 5.039 ± 0.116
1.32ValHis: 1.32 ± 0.047
3.174ValIle: 3.174 ± 0.076
3.329ValLys: 3.329 ± 0.073
7.252ValLeu: 7.252 ± 0.127
1.997ValMet: 1.997 ± 0.054
2.105ValAsn: 2.105 ± 0.064
2.876ValPro: 2.876 ± 0.062
2.319ValGln: 2.319 ± 0.058
4.294ValArg: 4.294 ± 0.087
4.467ValSer: 4.467 ± 0.091
2.785ValThr: 2.785 ± 0.072
4.419ValVal: 4.419 ± 0.097
0.955ValTrp: 0.955 ± 0.032
1.882ValTyr: 1.882 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.019TrpAla: 1.019 ± 0.042
0.146TrpCys: 0.146 ± 0.012
0.522TrpAsp: 0.522 ± 0.028
0.51TrpGlu: 0.51 ± 0.027
0.633TrpPhe: 0.633 ± 0.032
0.774TrpGly: 0.774 ± 0.033
0.41TrpHis: 0.41 ± 0.027
0.6TrpIle: 0.6 ± 0.027
0.493TrpLys: 0.493 ± 0.026
1.926TrpLeu: 1.926 ± 0.06
0.3TrpMet: 0.3 ± 0.02
0.362TrpAsn: 0.362 ± 0.022
0.464TrpPro: 0.464 ± 0.032
1.082TrpGln: 1.082 ± 0.046
1.029TrpArg: 1.029 ± 0.042
0.493TrpSer: 0.493 ± 0.028
0.525TrpThr: 0.525 ± 0.025
0.683TrpVal: 0.683 ± 0.031
0.177TrpTrp: 0.177 ± 0.018
0.352TrpTyr: 0.352 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.992TyrAla: 2.992 ± 0.075
0.351TyrCys: 0.351 ± 0.021
1.444TyrAsp: 1.444 ± 0.049
1.429TyrGlu: 1.429 ± 0.049
1.261TyrPhe: 1.261 ± 0.048
2.488TyrGly: 2.488 ± 0.055
0.617TyrHis: 0.617 ± 0.029
1.307TyrIle: 1.307 ± 0.046
1.084TyrLys: 1.084 ± 0.038
2.918TyrLeu: 2.918 ± 0.065
0.464TyrMet: 0.464 ± 0.029
0.955TyrAsn: 0.955 ± 0.043
1.316TyrPro: 1.316 ± 0.045
1.123TyrGln: 1.123 ± 0.043
2.234TyrArg: 2.234 ± 0.069
1.449TyrSer: 1.449 ± 0.045
1.657TyrThr: 1.657 ± 0.063
1.476TyrVal: 1.476 ± 0.048
0.422TyrTrp: 0.422 ± 0.021
0.863TyrTyr: 0.863 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2879 proteins (704475 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski