Amino acid dipepetide frequency for Corynebacterium kutscheri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.113AlaAla: 12.113 ± 0.197
0.932AlaCys: 0.932 ± 0.039
5.616AlaAsp: 5.616 ± 0.101
6.836AlaGlu: 6.836 ± 0.126
3.349AlaPhe: 3.349 ± 0.095
8.499AlaGly: 8.499 ± 0.139
2.669AlaHis: 2.669 ± 0.068
6.424AlaIle: 6.424 ± 0.105
3.905AlaLys: 3.905 ± 0.095
10.956AlaLeu: 10.956 ± 0.156
2.508AlaMet: 2.508 ± 0.059
2.869AlaAsn: 2.869 ± 0.066
4.265AlaPro: 4.265 ± 0.102
4.983AlaGln: 4.983 ± 0.112
5.784AlaArg: 5.784 ± 0.104
5.665AlaSer: 5.665 ± 0.086
6.867AlaThr: 6.867 ± 0.11
8.072AlaVal: 8.072 ± 0.119
1.201AlaTrp: 1.201 ± 0.045
2.374AlaTyr: 2.374 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.95CysAla: 0.95 ± 0.044
0.081CysCys: 0.081 ± 0.012
0.437CysAsp: 0.437 ± 0.027
0.382CysGlu: 0.382 ± 0.027
0.279CysPhe: 0.279 ± 0.023
0.76CysGly: 0.76 ± 0.031
0.182CysHis: 0.182 ± 0.018
0.437CysIle: 0.437 ± 0.025
0.161CysLys: 0.161 ± 0.014
0.712CysLeu: 0.712 ± 0.033
0.144CysMet: 0.144 ± 0.014
0.21CysAsn: 0.21 ± 0.019
0.374CysPro: 0.374 ± 0.025
0.266CysGln: 0.266 ± 0.021
0.349CysArg: 0.349 ± 0.024
0.616CysSer: 0.616 ± 0.033
0.612CysThr: 0.612 ± 0.04
0.642CysVal: 0.642 ± 0.03
0.101CysTrp: 0.101 ± 0.013
0.171CysTyr: 0.171 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.506AspAla: 5.506 ± 0.108
0.419AspCys: 0.419 ± 0.027
3.099AspAsp: 3.099 ± 0.079
3.763AspGlu: 3.763 ± 0.085
2.08AspPhe: 2.08 ± 0.059
4.171AspGly: 4.171 ± 0.099
1.166AspHis: 1.166 ± 0.046
3.797AspIle: 3.797 ± 0.069
2.203AspLys: 2.203 ± 0.06
5.061AspLeu: 5.061 ± 0.094
1.16AspMet: 1.16 ± 0.04
2.09AspAsn: 2.09 ± 0.06
3.288AspPro: 3.288 ± 0.078
1.88AspGln: 1.88 ± 0.052
2.951AspArg: 2.951 ± 0.082
3.267AspSer: 3.267 ± 0.078
3.36AspThr: 3.36 ± 0.08
3.92AspVal: 3.92 ± 0.094
0.678AspTrp: 0.678 ± 0.032
1.594AspTyr: 1.594 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.752GluAla: 5.752 ± 0.113
0.401GluCys: 0.401 ± 0.026
2.902GluAsp: 2.902 ± 0.079
4.368GluGlu: 4.368 ± 0.099
2.141GluPhe: 2.141 ± 0.069
3.298GluGly: 3.298 ± 0.073
1.551GluHis: 1.551 ± 0.05
4.235GluIle: 4.235 ± 0.08
3.459GluLys: 3.459 ± 0.094
7.036GluLeu: 7.036 ± 0.112
1.159GluMet: 1.159 ± 0.041
2.328GluAsn: 2.328 ± 0.061
2.266GluPro: 2.266 ± 0.072
2.846GluGln: 2.846 ± 0.075
3.126GluArg: 3.126 ± 0.078
3.031GluSer: 3.031 ± 0.066
3.465GluThr: 3.465 ± 0.085
4.745GluVal: 4.745 ± 0.086
0.567GluTrp: 0.567 ± 0.03
1.581GluTyr: 1.581 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.668PheAla: 3.668 ± 0.08
0.279PheCys: 0.279 ± 0.023
2.467PheAsp: 2.467 ± 0.055
1.83PheGlu: 1.83 ± 0.059
1.506PhePhe: 1.506 ± 0.059
3.232PheGly: 3.232 ± 0.078
0.751PheHis: 0.751 ± 0.036
2.413PheIle: 2.413 ± 0.062
1.077PheLys: 1.077 ± 0.054
3.273PheLeu: 3.273 ± 0.083
0.754PheMet: 0.754 ± 0.039
1.286PheAsn: 1.286 ± 0.045
1.497PhePro: 1.497 ± 0.05
0.953PheGln: 0.953 ± 0.038
1.503PheArg: 1.503 ± 0.045
2.861PheSer: 2.861 ± 0.08
2.268PheThr: 2.268 ± 0.074
2.502PheVal: 2.502 ± 0.059
0.461PheTrp: 0.461 ± 0.024
0.971PheTyr: 0.971 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
7.264GlyAla: 7.264 ± 0.104
0.69GlyCys: 0.69 ± 0.037
3.754GlyAsp: 3.754 ± 0.087
4.487GlyGlu: 4.487 ± 0.093
3.28GlyPhe: 3.28 ± 0.072
5.835GlyGly: 5.835 ± 0.102
1.821GlyHis: 1.821 ± 0.058
5.335GlyIle: 5.335 ± 0.091
3.229GlyLys: 3.229 ± 0.077
7.713GlyLeu: 7.713 ± 0.127
2.036GlyMet: 2.036 ± 0.057
2.452GlyAsn: 2.452 ± 0.061
2.21GlyPro: 2.21 ± 0.07
2.805GlyGln: 2.805 ± 0.073
3.931GlyArg: 3.931 ± 0.08
4.942GlySer: 4.942 ± 0.088
4.813GlyThr: 4.813 ± 0.094
6.28GlyVal: 6.28 ± 0.096
1.141GlyTrp: 1.141 ± 0.043
2.212GlyTyr: 2.212 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
2.183HisAla: 2.183 ± 0.062
0.222HisCys: 0.222 ± 0.018
1.331HisAsp: 1.331 ± 0.043
1.22HisGlu: 1.22 ± 0.047
0.741HisPhe: 0.741 ± 0.032
1.829HisGly: 1.829 ± 0.054
0.688HisHis: 0.688 ± 0.034
1.51HisIle: 1.51 ± 0.053
0.729HisLys: 0.729 ± 0.03
1.959HisLeu: 1.959 ± 0.065
0.548HisMet: 0.548 ± 0.03
0.948HisAsn: 0.948 ± 0.041
1.346HisPro: 1.346 ± 0.044
0.772HisGln: 0.772 ± 0.035
1.543HisArg: 1.543 ± 0.052
1.417HisSer: 1.417 ± 0.05
1.537HisThr: 1.537 ± 0.053
1.464HisVal: 1.464 ± 0.046
0.305HisTrp: 0.305 ± 0.021
0.7HisTyr: 0.7 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
7.958IleAla: 7.958 ± 0.119
0.553IleCys: 0.553 ± 0.03
4.412IleAsp: 4.412 ± 0.079
3.736IleGlu: 3.736 ± 0.083
2.331IlePhe: 2.331 ± 0.071
5.18IleGly: 5.18 ± 0.118
1.256IleHis: 1.256 ± 0.047
4.224IleIle: 4.224 ± 0.102
2.029IleLys: 2.029 ± 0.05
5.02IleLeu: 5.02 ± 0.113
1.279IleMet: 1.279 ± 0.042
2.46IleAsn: 2.46 ± 0.068
3.322IlePro: 3.322 ± 0.081
1.73IleGln: 1.73 ± 0.05
2.935IleArg: 2.935 ± 0.065
4.235IleSer: 4.235 ± 0.091
4.481IleThr: 4.481 ± 0.09
5.145IleVal: 5.145 ± 0.103
0.616IleTrp: 0.616 ± 0.037
1.396IleTyr: 1.396 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
3.512LysAla: 3.512 ± 0.083
0.182LysCys: 0.182 ± 0.017
2.207LysAsp: 2.207 ± 0.076
2.6LysGlu: 2.6 ± 0.077
1.082LysPhe: 1.082 ± 0.053
2.192LysGly: 2.192 ± 0.072
0.79LysHis: 0.79 ± 0.033
2.404LysIle: 2.404 ± 0.061
2.458LysLys: 2.458 ± 0.076
3.474LysLeu: 3.474 ± 0.073
0.786LysMet: 0.786 ± 0.036
1.875LysAsn: 1.875 ± 0.058
1.772LysPro: 1.772 ± 0.066
1.63LysGln: 1.63 ± 0.055
2.075LysArg: 2.075 ± 0.057
1.839LysSer: 1.839 ± 0.056
2.485LysThr: 2.485 ± 0.065
2.915LysVal: 2.915 ± 0.075
0.454LysTrp: 0.454 ± 0.024
0.894LysTyr: 0.894 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
11.611LeuAla: 11.611 ± 0.164
0.828LeuCys: 0.828 ± 0.039
5.521LeuAsp: 5.521 ± 0.101
4.855LeuGlu: 4.855 ± 0.09
3.283LeuPhe: 3.283 ± 0.082
8.172LeuGly: 8.172 ± 0.134
2.107LeuHis: 2.107 ± 0.063
6.615LeuIle: 6.615 ± 0.12
3.241LeuLys: 3.241 ± 0.084
9.174LeuLeu: 9.174 ± 0.159
1.902LeuMet: 1.902 ± 0.053
3.145LeuAsn: 3.145 ± 0.065
4.957LeuPro: 4.957 ± 0.089
2.534LeuGln: 2.534 ± 0.071
5.673LeuArg: 5.673 ± 0.1
7.123LeuSer: 7.123 ± 0.113
5.803LeuThr: 5.803 ± 0.087
7.513LeuVal: 7.513 ± 0.13
1.162LeuTrp: 1.162 ± 0.047
2.03LeuTyr: 2.03 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.263MetAla: 2.263 ± 0.067
0.158MetCys: 0.158 ± 0.015
0.965MetAsp: 0.965 ± 0.041
0.923MetGlu: 0.923 ± 0.042
0.727MetPhe: 0.727 ± 0.034
1.524MetGly: 1.524 ± 0.049
0.514MetHis: 0.514 ± 0.027
1.417MetIle: 1.417 ± 0.045
0.768MetLys: 0.768 ± 0.038
2.228MetLeu: 2.228 ± 0.067
0.49MetMet: 0.49 ± 0.023
0.848MetAsn: 0.848 ± 0.037
1.073MetPro: 1.073 ± 0.041
0.769MetGln: 0.769 ± 0.036
1.39MetArg: 1.39 ± 0.052
1.767MetSer: 1.767 ± 0.052
1.557MetThr: 1.557 ± 0.046
1.739MetVal: 1.739 ± 0.054
0.284MetTrp: 0.284 ± 0.021
0.448MetTyr: 0.448 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.201AsnAla: 3.201 ± 0.069
0.231AsnCys: 0.231 ± 0.021
1.862AsnAsp: 1.862 ± 0.064
1.923AsnGlu: 1.923 ± 0.059
1.232AsnPhe: 1.232 ± 0.045
2.443AsnGly: 2.443 ± 0.071
0.723AsnHis: 0.723 ± 0.036
2.084AsnIle: 2.084 ± 0.062
1.494AsnLys: 1.494 ± 0.052
2.92AsnLeu: 2.92 ± 0.06
0.672AsnMet: 0.672 ± 0.032
1.525AsnAsn: 1.525 ± 0.063
2.266AsnPro: 2.266 ± 0.061
1.425AsnGln: 1.425 ± 0.044
1.782AsnArg: 1.782 ± 0.058
2.203AsnSer: 2.203 ± 0.07
2.292AsnThr: 2.292 ± 0.058
2.158AsnVal: 2.158 ± 0.06
0.514AsnTrp: 0.514 ± 0.028
0.99AsnTyr: 0.99 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
4.798ProAla: 4.798 ± 0.091
0.246ProCys: 0.246 ± 0.02
2.67ProAsp: 2.67 ± 0.066
3.618ProGlu: 3.618 ± 0.075
1.497ProPhe: 1.497 ± 0.052
3.712ProGly: 3.712 ± 0.073
1.25ProHis: 1.25 ± 0.046
2.78ProIle: 2.78 ± 0.059
1.557ProLys: 1.557 ± 0.046
4.132ProLeu: 4.132 ± 0.085
0.923ProMet: 0.923 ± 0.039
1.405ProAsn: 1.405 ± 0.041
1.683ProPro: 1.683 ± 0.06
2.012ProGln: 2.012 ± 0.058
2.341ProArg: 2.341 ± 0.062
2.655ProSer: 2.655 ± 0.077
3.38ProThr: 3.38 ± 0.084
3.964ProVal: 3.964 ± 0.078
0.604ProTrp: 0.604 ± 0.035
1.086ProTyr: 1.086 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
4.347GlnAla: 4.347 ± 0.105
0.243GlnCys: 0.243 ± 0.021
1.54GlnAsp: 1.54 ± 0.056
2.425GlnGlu: 2.425 ± 0.063
1.056GlnPhe: 1.056 ± 0.042
2.392GlnGly: 2.392 ± 0.063
0.897GlnHis: 0.897 ± 0.039
2.125GlnIle: 2.125 ± 0.06
1.343GlnLys: 1.343 ± 0.046
4.436GlnLeu: 4.436 ± 0.094
0.733GlnMet: 0.733 ± 0.032
1.013GlnAsn: 1.013 ± 0.039
1.952GlnPro: 1.952 ± 0.056
1.823GlnGln: 1.823 ± 0.059
2.926GlnArg: 2.926 ± 0.084
1.887GlnSer: 1.887 ± 0.062
1.79GlnThr: 1.79 ± 0.058
2.828GlnVal: 2.828 ± 0.073
0.708GlnTrp: 0.708 ± 0.034
0.78GlnTyr: 0.78 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
5.063ArgAla: 5.063 ± 0.089
0.392ArgCys: 0.392 ± 0.025
2.888ArgAsp: 2.888 ± 0.079
3.39ArgGlu: 3.39 ± 0.082
2.038ArgPhe: 2.038 ± 0.056
3.928ArgGly: 3.928 ± 0.092
1.225ArgHis: 1.225 ± 0.04
3.725ArgIle: 3.725 ± 0.081
2.256ArgLys: 2.256 ± 0.062
5.171ArgLeu: 5.171 ± 0.096
1.516ArgMet: 1.516 ± 0.053
1.908ArgAsn: 1.908 ± 0.054
2.296ArgPro: 2.296 ± 0.066
2.087ArgGln: 2.087 ± 0.058
4.084ArgArg: 4.084 ± 0.1
3.295ArgSer: 3.295 ± 0.077
3.298ArgThr: 3.298 ± 0.081
3.845ArgVal: 3.845 ± 0.072
0.838ArgTrp: 0.838 ± 0.033
1.615ArgTyr: 1.615 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.51SerAla: 6.51 ± 0.109
0.497SerCys: 0.497 ± 0.028
3.425SerAsp: 3.425 ± 0.079
3.557SerGlu: 3.557 ± 0.072
2.502SerPhe: 2.502 ± 0.061
5.342SerGly: 5.342 ± 0.09
1.34SerHis: 1.34 ± 0.047
3.555SerIle: 3.555 ± 0.077
2.017SerLys: 2.017 ± 0.067
6.023SerLeu: 6.023 ± 0.093
1.609SerMet: 1.609 ± 0.05
1.821SerAsn: 1.821 ± 0.057
2.821SerPro: 2.821 ± 0.067
2.379SerGln: 2.379 ± 0.064
3.004SerArg: 3.004 ± 0.07
4.37SerSer: 4.37 ± 0.113
4.505SerThr: 4.505 ± 0.108
4.598SerVal: 4.598 ± 0.092
1.005SerTrp: 1.005 ± 0.044
1.694SerTyr: 1.694 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
6.791ThrAla: 6.791 ± 0.103
0.511ThrCys: 0.511 ± 0.034
3.476ThrAsp: 3.476 ± 0.08
3.542ThrGlu: 3.542 ± 0.085
2.25ThrPhe: 2.25 ± 0.063
5.145ThrGly: 5.145 ± 0.09
1.57ThrHis: 1.57 ± 0.049
4.044ThrIle: 4.044 ± 0.094
2.269ThrLys: 2.269 ± 0.069
6.062ThrLeu: 6.062 ± 0.09
1.34ThrMet: 1.34 ± 0.047
2.192ThrAsn: 2.192 ± 0.066
3.682ThrPro: 3.682 ± 0.082
2.479ThrGln: 2.479 ± 0.067
2.945ThrArg: 2.945 ± 0.068
3.972ThrSer: 3.972 ± 0.085
5.267ThrThr: 5.267 ± 0.184
5.001ThrVal: 5.001 ± 0.087
0.921ThrTrp: 0.921 ± 0.035
1.545ThrTyr: 1.545 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
8.6ValAla: 8.6 ± 0.121
0.661ValCys: 0.661 ± 0.034
4.795ValAsp: 4.795 ± 0.092
4.783ValGlu: 4.783 ± 0.09
2.657ValPhe: 2.657 ± 0.071
5.632ValGly: 5.632 ± 0.1
1.681ValHis: 1.681 ± 0.049
5.087ValIle: 5.087 ± 0.09
2.373ValLys: 2.373 ± 0.071
7.716ValLeu: 7.716 ± 0.11
1.567ValMet: 1.567 ± 0.046
2.32ValAsn: 2.32 ± 0.068
3.428ValPro: 3.428 ± 0.074
2.084ValGln: 2.084 ± 0.05
4.051ValArg: 4.051 ± 0.083
5.044ValSer: 5.044 ± 0.095
4.95ValThr: 4.95 ± 0.101
6.942ValVal: 6.942 ± 0.134
0.84ValTrp: 0.84 ± 0.038
1.691ValTyr: 1.691 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
1.228TrpAla: 1.228 ± 0.047
0.129TrpCys: 0.129 ± 0.014
0.648TrpAsp: 0.648 ± 0.031
0.679TrpGlu: 0.679 ± 0.032
0.562TrpPhe: 0.562 ± 0.03
0.795TrpGly: 0.795 ± 0.036
0.311TrpHis: 0.311 ± 0.023
0.798TrpIle: 0.798 ± 0.032
0.389TrpLys: 0.389 ± 0.025
1.683TrpLeu: 1.683 ± 0.056
0.337TrpMet: 0.337 ± 0.023
0.434TrpAsn: 0.434 ± 0.027
0.551TrpPro: 0.551 ± 0.028
0.685TrpGln: 0.685 ± 0.032
0.872TrpArg: 0.872 ± 0.033
0.748TrpSer: 0.748 ± 0.031
0.685TrpThr: 0.685 ± 0.036
0.948TrpVal: 0.948 ± 0.042
0.323TrpTrp: 0.323 ± 0.024
0.302TrpTyr: 0.302 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.57TyrAla: 2.57 ± 0.067
0.209TyrCys: 0.209 ± 0.017
1.44TyrAsp: 1.44 ± 0.044
1.339TyrGlu: 1.339 ± 0.045
0.96TyrPhe: 0.96 ± 0.039
2.149TyrGly: 2.149 ± 0.063
0.503TyrHis: 0.503 ± 0.032
1.288TyrIle: 1.288 ± 0.045
0.672TyrLys: 0.672 ± 0.039
2.499TyrLeu: 2.499 ± 0.063
0.385TyrMet: 0.385 ± 0.026
0.808TyrAsn: 0.808 ± 0.039
1.265TyrPro: 1.265 ± 0.048
1.103TyrGln: 1.103 ± 0.039
1.596TyrArg: 1.596 ± 0.051
1.635TyrSer: 1.635 ± 0.054
1.588TyrThr: 1.588 ± 0.059
1.68TyrVal: 1.68 ± 0.056
0.386TyrTrp: 0.386 ± 0.024
0.715TyrTyr: 0.715 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2047 proteins (665480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski