Amino acid dipepetide frequency for Cronobacter phage vB_CsaM_GAP31

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.717AlaAla: 5.717 ± 0.452
0.779AlaCys: 0.779 ± 0.146
4.916AlaAsp: 4.916 ± 0.361
4.627AlaGlu: 4.627 ± 0.303
3.026AlaPhe: 3.026 ± 0.27
5.317AlaGly: 5.317 ± 0.425
1.224AlaHis: 1.224 ± 0.163
3.782AlaIle: 3.782 ± 0.259
5.406AlaLys: 5.406 ± 0.383
5.517AlaLeu: 5.517 ± 0.364
2.425AlaMet: 2.425 ± 0.242
3.248AlaAsn: 3.248 ± 0.305
2.581AlaPro: 2.581 ± 0.295
2.492AlaGln: 2.492 ± 0.236
3.804AlaArg: 3.804 ± 0.362
3.982AlaSer: 3.982 ± 0.35
4.561AlaThr: 4.561 ± 0.395
4.627AlaVal: 4.627 ± 0.325
1.446AlaTrp: 1.446 ± 0.188
3.026AlaTyr: 3.026 ± 0.292
0.0AlaXaa: 0.0 ± 0.0
Cys
0.868CysAla: 0.868 ± 0.136
0.245CysCys: 0.245 ± 0.076
1.023CysAsp: 1.023 ± 0.143
0.734CysGlu: 0.734 ± 0.128
0.823CysPhe: 0.823 ± 0.131
1.09CysGly: 1.09 ± 0.168
0.378CysHis: 0.378 ± 0.099
0.645CysIle: 0.645 ± 0.102
0.934CysLys: 0.934 ± 0.17
1.023CysLeu: 1.023 ± 0.143
0.311CysMet: 0.311 ± 0.081
0.712CysAsn: 0.712 ± 0.134
0.423CysPro: 0.423 ± 0.131
0.4CysGln: 0.4 ± 0.085
0.734CysArg: 0.734 ± 0.154
0.712CysSer: 0.712 ± 0.149
0.578CysThr: 0.578 ± 0.128
0.734CysVal: 0.734 ± 0.126
0.178CysTrp: 0.178 ± 0.054
0.356CysTyr: 0.356 ± 0.084
0.0CysXaa: 0.0 ± 0.0
Asp
4.383AspAla: 4.383 ± 0.311
0.534AspCys: 0.534 ± 0.117
4.116AspAsp: 4.116 ± 0.354
4.138AspGlu: 4.138 ± 0.3
3.426AspPhe: 3.426 ± 0.316
5.74AspGly: 5.74 ± 0.426
1.357AspHis: 1.357 ± 0.184
3.559AspIle: 3.559 ± 0.343
3.915AspLys: 3.915 ± 0.358
5.584AspLeu: 5.584 ± 0.378
1.713AspMet: 1.713 ± 0.206
3.226AspAsn: 3.226 ± 0.294
2.937AspPro: 2.937 ± 0.284
2.091AspGln: 2.091 ± 0.236
2.914AspArg: 2.914 ± 0.265
3.292AspSer: 3.292 ± 0.26
3.292AspThr: 3.292 ± 0.24
4.716AspVal: 4.716 ± 0.336
1.29AspTrp: 1.29 ± 0.201
3.203AspTyr: 3.203 ± 0.318
0.0AspXaa: 0.0 ± 0.0
Glu
5.428GluAla: 5.428 ± 0.404
1.001GluCys: 1.001 ± 0.161
3.96GluAsp: 3.96 ± 0.27
5.028GluGlu: 5.028 ± 0.423
2.848GluPhe: 2.848 ± 0.301
3.96GluGly: 3.96 ± 0.293
1.246GluHis: 1.246 ± 0.184
3.982GluIle: 3.982 ± 0.302
4.872GluLys: 4.872 ± 0.436
5.784GluLeu: 5.784 ± 0.391
2.625GluMet: 2.625 ± 0.238
3.048GluAsn: 3.048 ± 0.243
1.579GluPro: 1.579 ± 0.182
2.38GluGln: 2.38 ± 0.248
3.604GluArg: 3.604 ± 0.272
3.493GluSer: 3.493 ± 0.314
3.159GluThr: 3.159 ± 0.282
4.093GluVal: 4.093 ± 0.317
1.268GluTrp: 1.268 ± 0.184
2.403GluTyr: 2.403 ± 0.274
0.0GluXaa: 0.0 ± 0.0
Phe
2.848PheAla: 2.848 ± 0.221
0.734PheCys: 0.734 ± 0.126
3.115PheAsp: 3.115 ± 0.264
2.336PheGlu: 2.336 ± 0.262
1.78PhePhe: 1.78 ± 0.207
3.337PheGly: 3.337 ± 0.293
0.734PheHis: 0.734 ± 0.117
2.536PheIle: 2.536 ± 0.237
2.403PheLys: 2.403 ± 0.262
3.159PheLeu: 3.159 ± 0.274
1.157PheMet: 1.157 ± 0.179
2.291PheAsn: 2.291 ± 0.223
1.579PhePro: 1.579 ± 0.177
1.402PheGln: 1.402 ± 0.192
2.002PheArg: 2.002 ± 0.229
3.026PheSer: 3.026 ± 0.309
2.625PheThr: 2.625 ± 0.24
3.203PheVal: 3.203 ± 0.264
0.845PheTrp: 0.845 ± 0.164
1.491PheTyr: 1.491 ± 0.176
0.0PheXaa: 0.0 ± 0.0
Gly
4.249GlyAla: 4.249 ± 0.375
0.868GlyCys: 0.868 ± 0.134
4.627GlyAsp: 4.627 ± 0.464
4.516GlyGlu: 4.516 ± 0.302
3.404GlyPhe: 3.404 ± 0.289
5.206GlyGly: 5.206 ± 0.555
0.979GlyHis: 0.979 ± 0.151
4.16GlyIle: 4.16 ± 0.335
5.539GlyLys: 5.539 ± 0.412
5.117GlyLeu: 5.117 ± 0.389
2.158GlyMet: 2.158 ± 0.189
3.938GlyAsn: 3.938 ± 0.334
1.98GlyPro: 1.98 ± 0.578
2.536GlyGln: 2.536 ± 0.232
3.003GlyArg: 3.003 ± 0.311
4.182GlySer: 4.182 ± 0.395
4.36GlyThr: 4.36 ± 0.362
5.361GlyVal: 5.361 ± 0.427
1.557GlyTrp: 1.557 ± 0.191
3.203GlyTyr: 3.203 ± 0.271
0.0GlyXaa: 0.0 ± 0.0
His
1.023HisAla: 1.023 ± 0.143
0.334HisCys: 0.334 ± 0.09
0.912HisAsp: 0.912 ± 0.161
1.424HisGlu: 1.424 ± 0.198
0.89HisPhe: 0.89 ± 0.146
1.402HisGly: 1.402 ± 0.208
0.534HisHis: 0.534 ± 0.121
1.112HisIle: 1.112 ± 0.163
1.112HisLys: 1.112 ± 0.13
1.402HisLeu: 1.402 ± 0.167
0.578HisMet: 0.578 ± 0.12
1.046HisAsn: 1.046 ± 0.161
0.868HisPro: 0.868 ± 0.154
0.445HisGln: 0.445 ± 0.097
0.845HisArg: 0.845 ± 0.147
1.09HisSer: 1.09 ± 0.165
1.179HisThr: 1.179 ± 0.183
1.135HisVal: 1.135 ± 0.178
0.4HisTrp: 0.4 ± 0.107
0.756HisTyr: 0.756 ± 0.143
0.0HisXaa: 0.0 ± 0.0
Ile
4.093IleAla: 4.093 ± 0.319
0.734IleCys: 0.734 ± 0.114
4.116IleAsp: 4.116 ± 0.365
3.96IleGlu: 3.96 ± 0.335
2.225IlePhe: 2.225 ± 0.209
3.359IleGly: 3.359 ± 0.297
1.379IleHis: 1.379 ± 0.176
3.648IleIle: 3.648 ± 0.312
3.559IleLys: 3.559 ± 0.339
4.271IleLeu: 4.271 ± 0.294
1.335IleMet: 1.335 ± 0.163
2.803IleAsn: 2.803 ± 0.271
2.714IlePro: 2.714 ± 0.238
2.136IleGln: 2.136 ± 0.21
3.092IleArg: 3.092 ± 0.278
3.715IleSer: 3.715 ± 0.253
3.76IleThr: 3.76 ± 0.284
3.96IleVal: 3.96 ± 0.284
0.845IleTrp: 0.845 ± 0.143
1.935IleTyr: 1.935 ± 0.203
0.0IleXaa: 0.0 ± 0.0
Lys
5.895LysAla: 5.895 ± 0.496
0.734LysCys: 0.734 ± 0.154
4.939LysAsp: 4.939 ± 0.439
5.05LysGlu: 5.05 ± 0.392
2.603LysPhe: 2.603 ± 0.261
4.182LysGly: 4.182 ± 0.46
1.446LysHis: 1.446 ± 0.221
3.849LysIle: 3.849 ± 0.285
4.405LysLys: 4.405 ± 0.406
4.783LysLeu: 4.783 ± 0.338
2.514LysMet: 2.514 ± 0.214
3.248LysAsn: 3.248 ± 0.252
2.647LysPro: 2.647 ± 0.287
2.581LysGln: 2.581 ± 0.263
3.426LysArg: 3.426 ± 0.295
3.315LysSer: 3.315 ± 0.241
3.849LysThr: 3.849 ± 0.287
5.206LysVal: 5.206 ± 0.365
1.046LysTrp: 1.046 ± 0.174
2.692LysTyr: 2.692 ± 0.255
0.0LysXaa: 0.0 ± 0.0
Leu
5.829LeuAla: 5.829 ± 0.35
1.335LeuCys: 1.335 ± 0.185
5.317LeuAsp: 5.317 ± 0.298
5.784LeuGlu: 5.784 ± 0.435
2.937LeuPhe: 2.937 ± 0.287
4.449LeuGly: 4.449 ± 0.335
1.335LeuHis: 1.335 ± 0.205
4.36LeuIle: 4.36 ± 0.312
5.584LeuLys: 5.584 ± 0.364
5.918LeuLeu: 5.918 ± 0.435
2.136LeuMet: 2.136 ± 0.197
3.693LeuAsn: 3.693 ± 0.294
3.315LeuPro: 3.315 ± 0.262
2.67LeuGln: 2.67 ± 0.253
4.182LeuArg: 4.182 ± 0.295
5.139LeuSer: 5.139 ± 0.303
4.916LeuThr: 4.916 ± 0.358
5.05LeuVal: 5.05 ± 0.34
1.224LeuTrp: 1.224 ± 0.177
3.159LeuTyr: 3.159 ± 0.282
0.0LeuXaa: 0.0 ± 0.0
Met
2.492MetAla: 2.492 ± 0.264
0.334MetCys: 0.334 ± 0.08
1.491MetAsp: 1.491 ± 0.192
1.691MetGlu: 1.691 ± 0.19
1.157MetPhe: 1.157 ± 0.137
1.713MetGly: 1.713 ± 0.211
0.378MetHis: 0.378 ± 0.087
2.002MetIle: 2.002 ± 0.213
2.981MetLys: 2.981 ± 0.246
2.136MetLeu: 2.136 ± 0.187
1.09MetMet: 1.09 ± 0.161
1.424MetAsn: 1.424 ± 0.187
0.868MetPro: 0.868 ± 0.149
0.89MetGln: 0.89 ± 0.171
1.179MetArg: 1.179 ± 0.175
2.447MetSer: 2.447 ± 0.236
2.069MetThr: 2.069 ± 0.227
1.913MetVal: 1.913 ± 0.205
0.445MetTrp: 0.445 ± 0.102
1.246MetTyr: 1.246 ± 0.162
0.0MetXaa: 0.0 ± 0.0
Asn
3.515AsnAla: 3.515 ± 0.265
0.512AsnCys: 0.512 ± 0.098
2.825AsnAsp: 2.825 ± 0.255
2.425AsnGlu: 2.425 ± 0.238
2.069AsnPhe: 2.069 ± 0.191
4.516AsnGly: 4.516 ± 0.409
0.868AsnHis: 0.868 ± 0.146
2.937AsnIle: 2.937 ± 0.285
3.115AsnLys: 3.115 ± 0.244
3.76AsnLeu: 3.76 ± 0.333
1.491AsnMet: 1.491 ± 0.217
2.136AsnAsn: 2.136 ± 0.21
2.603AsnPro: 2.603 ± 0.215
1.579AsnGln: 1.579 ± 0.207
2.202AsnArg: 2.202 ± 0.2
2.514AsnSer: 2.514 ± 0.263
2.803AsnThr: 2.803 ± 0.3
3.026AsnVal: 3.026 ± 0.272
0.979AsnTrp: 0.979 ± 0.172
1.869AsnTyr: 1.869 ± 0.231
0.0AsnXaa: 0.0 ± 0.0
Pro
2.425ProAla: 2.425 ± 0.208
0.356ProCys: 0.356 ± 0.089
2.803ProAsp: 2.803 ± 0.273
3.582ProGlu: 3.582 ± 0.315
1.891ProPhe: 1.891 ± 0.189
2.247ProGly: 2.247 ± 0.223
0.756ProHis: 0.756 ± 0.132
1.757ProIle: 1.757 ± 0.195
2.425ProLys: 2.425 ± 0.257
2.825ProLeu: 2.825 ± 0.282
0.823ProMet: 0.823 ± 0.125
1.624ProAsn: 1.624 ± 0.216
1.224ProPro: 1.224 ± 0.177
1.78ProGln: 1.78 ± 0.302
1.535ProArg: 1.535 ± 0.204
2.18ProSer: 2.18 ± 0.177
2.225ProThr: 2.225 ± 0.192
3.493ProVal: 3.493 ± 0.293
0.467ProTrp: 0.467 ± 0.099
1.646ProTyr: 1.646 ± 0.199
0.0ProXaa: 0.0 ± 0.0
Gln
2.647GlnAla: 2.647 ± 0.284
0.445GlnCys: 0.445 ± 0.121
1.958GlnAsp: 1.958 ± 0.189
2.38GlnGlu: 2.38 ± 0.225
1.424GlnPhe: 1.424 ± 0.151
2.425GlnGly: 2.425 ± 0.536
0.623GlnHis: 0.623 ± 0.111
1.98GlnIle: 1.98 ± 0.214
2.247GlnLys: 2.247 ± 0.224
2.425GlnLeu: 2.425 ± 0.27
1.023GlnMet: 1.023 ± 0.165
1.668GlnAsn: 1.668 ± 0.204
0.979GlnPro: 0.979 ± 0.149
1.579GlnGln: 1.579 ± 0.228
1.802GlnArg: 1.802 ± 0.2
2.225GlnSer: 2.225 ± 0.222
2.358GlnThr: 2.358 ± 0.243
2.403GlnVal: 2.403 ± 0.246
0.556GlnTrp: 0.556 ± 0.104
1.491GlnTyr: 1.491 ± 0.196
0.0GlnXaa: 0.0 ± 0.0
Arg
2.87ArgAla: 2.87 ± 0.309
0.845ArgCys: 0.845 ± 0.178
3.626ArgAsp: 3.626 ± 0.292
3.181ArgGlu: 3.181 ± 0.3
1.958ArgPhe: 1.958 ± 0.228
3.359ArgGly: 3.359 ± 0.305
0.957ArgHis: 0.957 ± 0.147
2.914ArgIle: 2.914 ± 0.28
3.493ArgLys: 3.493 ± 0.292
4.538ArgLeu: 4.538 ± 0.347
1.379ArgMet: 1.379 ± 0.181
2.625ArgAsn: 2.625 ± 0.22
1.713ArgPro: 1.713 ± 0.203
1.602ArgGln: 1.602 ± 0.209
2.937ArgArg: 2.937 ± 0.312
2.647ArgSer: 2.647 ± 0.283
2.536ArgThr: 2.536 ± 0.233
3.359ArgVal: 3.359 ± 0.286
0.89ArgTrp: 0.89 ± 0.15
1.802ArgTyr: 1.802 ± 0.204
0.0ArgXaa: 0.0 ± 0.0
Ser
4.316SerAla: 4.316 ± 0.342
0.578SerCys: 0.578 ± 0.112
3.826SerAsp: 3.826 ± 0.298
3.003SerGlu: 3.003 ± 0.271
2.625SerPhe: 2.625 ± 0.242
4.961SerGly: 4.961 ± 0.35
1.135SerHis: 1.135 ± 0.154
3.737SerIle: 3.737 ± 0.302
4.027SerLys: 4.027 ± 0.312
4.405SerLeu: 4.405 ± 0.356
1.713SerMet: 1.713 ± 0.199
2.759SerAsn: 2.759 ± 0.253
2.091SerPro: 2.091 ± 0.217
1.958SerGln: 1.958 ± 0.206
3.026SerArg: 3.026 ± 0.252
3.982SerSer: 3.982 ± 0.374
3.159SerThr: 3.159 ± 0.377
4.16SerVal: 4.16 ± 0.333
0.89SerTrp: 0.89 ± 0.14
2.291SerTyr: 2.291 ± 0.217
0.0SerXaa: 0.0 ± 0.0
Thr
4.538ThrAla: 4.538 ± 0.428
0.578ThrCys: 0.578 ± 0.121
3.582ThrAsp: 3.582 ± 0.315
3.604ThrGlu: 3.604 ± 0.267
2.492ThrPhe: 2.492 ± 0.202
4.961ThrGly: 4.961 ± 0.491
1.135ThrHis: 1.135 ± 0.154
3.782ThrIle: 3.782 ± 0.293
3.915ThrLys: 3.915 ± 0.304
4.872ThrLeu: 4.872 ± 0.372
1.424ThrMet: 1.424 ± 0.181
2.469ThrAsn: 2.469 ± 0.261
3.07ThrPro: 3.07 ± 0.25
1.913ThrGln: 1.913 ± 0.194
2.314ThrArg: 2.314 ± 0.212
2.892ThrSer: 2.892 ± 0.316
4.138ThrThr: 4.138 ± 0.521
5.117ThrVal: 5.117 ± 0.479
1.201ThrTrp: 1.201 ± 0.161
2.069ThrTyr: 2.069 ± 0.176
0.0ThrXaa: 0.0 ± 0.0
Val
5.495ValAla: 5.495 ± 0.398
1.023ValCys: 1.023 ± 0.172
4.516ValAsp: 4.516 ± 0.305
4.783ValGlu: 4.783 ± 0.41
2.87ValPhe: 2.87 ± 0.246
4.894ValGly: 4.894 ± 0.346
1.023ValHis: 1.023 ± 0.195
4.093ValIle: 4.093 ± 0.314
4.827ValLys: 4.827 ± 0.375
5.25ValLeu: 5.25 ± 0.37
2.158ValMet: 2.158 ± 0.244
3.27ValAsn: 3.27 ± 0.3
2.558ValPro: 2.558 ± 0.23
2.158ValGln: 2.158 ± 0.189
3.537ValArg: 3.537 ± 0.256
4.338ValSer: 4.338 ± 0.385
5.028ValThr: 5.028 ± 0.477
6.273ValVal: 6.273 ± 0.428
1.023ValTrp: 1.023 ± 0.167
2.447ValTyr: 2.447 ± 0.233
0.0ValXaa: 0.0 ± 0.0
Trp
1.201TrpAla: 1.201 ± 0.165
0.356TrpCys: 0.356 ± 0.085
1.112TrpAsp: 1.112 ± 0.184
1.157TrpGlu: 1.157 ± 0.17
0.69TrpPhe: 0.69 ± 0.172
1.046TrpGly: 1.046 ± 0.182
0.267TrpHis: 0.267 ± 0.073
0.89TrpIle: 0.89 ± 0.153
1.09TrpLys: 1.09 ± 0.156
1.735TrpLeu: 1.735 ± 0.206
0.845TrpMet: 0.845 ± 0.129
0.89TrpAsn: 0.89 ± 0.156
0.578TrpPro: 0.578 ± 0.108
0.623TrpGln: 0.623 ± 0.118
0.623TrpArg: 0.623 ± 0.132
1.201TrpSer: 1.201 ± 0.185
1.112TrpThr: 1.112 ± 0.205
1.135TrpVal: 1.135 ± 0.162
0.467TrpTrp: 0.467 ± 0.119
0.868TrpTyr: 0.868 ± 0.129
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.67TyrAla: 2.67 ± 0.238
0.578TyrCys: 0.578 ± 0.122
2.647TyrAsp: 2.647 ± 0.245
2.358TyrGlu: 2.358 ± 0.235
1.468TyrPhe: 1.468 ± 0.181
2.781TyrGly: 2.781 ± 0.224
0.734TyrHis: 0.734 ± 0.135
1.913TyrIle: 1.913 ± 0.246
2.558TyrLys: 2.558 ± 0.267
3.826TyrLeu: 3.826 ± 0.304
1.023TyrMet: 1.023 ± 0.142
1.624TyrAsn: 1.624 ± 0.182
1.757TyrPro: 1.757 ± 0.198
1.424TyrGln: 1.424 ± 0.186
2.469TyrArg: 2.469 ± 0.25
2.269TyrSer: 2.269 ± 0.217
2.358TyrThr: 2.358 ± 0.208
2.625TyrVal: 2.625 ± 0.216
0.868TyrTrp: 0.868 ± 0.125
1.268TyrTyr: 1.268 ± 0.174
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 269 proteins (44952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski