Amino acid dipepetide frequency for Aurantimonas sp. Leaf443

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.209AlaAla: 21.209 ± 0.262	1.129AlaCys: 1.129 ± 0.036	7.295AlaAsp: 7.295 ± 0.101	8.619AlaGlu: 8.619 ± 0.107	5.37AlaPhe: 5.37 ± 0.079	12.876AlaGly: 12.876 ± 0.136	2.187AlaHis: 2.187 ± 0.055	6.58AlaIle: 6.58 ± 0.082	3.489AlaLys: 3.489 ± 0.069	15.96AlaLeu: 15.96 ± 0.162	3.957AlaMet: 3.957 ± 0.065	2.526AlaAsn: 2.526 ± 0.047	7.116AlaPro: 7.116 ± 0.114	3.67AlaGln: 3.67 ± 0.067	11.318AlaArg: 11.318 ± 0.132	7.043AlaSer: 7.043 ± 0.098	6.308AlaThr: 6.308 ± 0.081	9.695AlaVal: 9.695 ± 0.103	1.263AlaTrp: 1.263 ± 0.036	2.651AlaTyr: 2.651 ± 0.054	0.001AlaXaa: 0.001 ± 0.001
Cys	0.933CysAla: 0.933 ± 0.032	0.073CysCys: 0.073 ± 0.009	0.524CysAsp: 0.524 ± 0.022	0.448CysGlu: 0.448 ± 0.019	0.29CysPhe: 0.29 ± 0.015	0.953CysGly: 0.953 ± 0.031	0.209CysHis: 0.209 ± 0.014	0.323CysIle: 0.323 ± 0.017	0.138CysLys: 0.138 ± 0.011	0.809CysLeu: 0.809 ± 0.03	0.114CysMet: 0.114 ± 0.01	0.143CysAsn: 0.143 ± 0.013	0.398CysPro: 0.398 ± 0.019	0.161CysGln: 0.161 ± 0.012	0.67CysArg: 0.67 ± 0.026	0.342CysSer: 0.342 ± 0.018	0.312CysThr: 0.312 ± 0.018	0.622CysVal: 0.622 ± 0.023	0.069CysTrp: 0.069 ± 0.008	0.132CysTyr: 0.132 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.352AspAla: 7.352 ± 0.089	0.495AspCys: 0.495 ± 0.024	2.739AspAsp: 2.739 ± 0.063	3.777AspGlu: 3.777 ± 0.069	2.089AspPhe: 2.089 ± 0.043	5.503AspGly: 5.503 ± 0.081	1.106AspHis: 1.106 ± 0.034	2.653AspIle: 2.653 ± 0.051	1.29AspLys: 1.29 ± 0.039	6.625AspLeu: 6.625 ± 0.088	1.163AspMet: 1.163 ± 0.033	0.955AspAsn: 0.955 ± 0.034	3.59AspPro: 3.59 ± 0.062	1.272AspGln: 1.272 ± 0.033	4.69AspArg: 4.69 ± 0.082	1.664AspSer: 1.664 ± 0.043	2.401AspThr: 2.401 ± 0.056	4.019AspVal: 4.019 ± 0.058	0.947AspTrp: 0.947 ± 0.029	1.364AspTyr: 1.364 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	10.027GluAla: 10.027 ± 0.118	0.29GluCys: 0.29 ± 0.017	2.979GluAsp: 2.979 ± 0.062	3.562GluGlu: 3.562 ± 0.062	1.623GluPhe: 1.623 ± 0.043	5.198GluGly: 5.198 ± 0.074	1.009GluHis: 1.009 ± 0.033	3.735GluIle: 3.735 ± 0.064	2.003GluLys: 2.003 ± 0.054	4.727GluLeu: 4.727 ± 0.077	1.451GluMet: 1.451 ± 0.035	1.337GluAsn: 1.337 ± 0.034	3.068GluPro: 3.068 ± 0.054	1.432GluGln: 1.432 ± 0.037	6.124GluArg: 6.124 ± 0.083	2.354GluSer: 2.354 ± 0.049	4.308GluThr: 4.308 ± 0.061	3.641GluVal: 3.641 ± 0.059	0.557GluTrp: 0.557 ± 0.025	0.731GluTyr: 0.731 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	5.12PheAla: 5.12 ± 0.077	0.38PheCys: 0.38 ± 0.019	2.755PheAsp: 2.755 ± 0.055	2.433PheGlu: 2.433 ± 0.049	1.423PhePhe: 1.423 ± 0.04	3.784PheGly: 3.784 ± 0.064	0.752PheHis: 0.752 ± 0.031	1.269PheIle: 1.269 ± 0.037	0.797PheLys: 0.797 ± 0.023	3.681PheLeu: 3.681 ± 0.064	0.73PheMet: 0.73 ± 0.027	0.775PheAsn: 0.775 ± 0.03	1.553PhePro: 1.553 ± 0.035	0.944PheGln: 0.944 ± 0.03	2.35PheArg: 2.35 ± 0.052	2.135PheSer: 2.135 ± 0.043	1.815PheThr: 1.815 ± 0.044	3.32PheVal: 3.32 ± 0.06	0.482PheTrp: 0.482 ± 0.022	0.82PheTyr: 0.82 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	11.653GlyAla: 11.653 ± 0.113	0.766GlyCys: 0.766 ± 0.029	4.461GlyAsp: 4.461 ± 0.069	5.811GlyGlu: 5.811 ± 0.079	3.795GlyPhe: 3.795 ± 0.062	7.963GlyGly: 7.963 ± 0.112	1.87GlyHis: 1.87 ± 0.043	4.363GlyIle: 4.363 ± 0.068	2.451GlyLys: 2.451 ± 0.062	10.2GlyLeu: 10.2 ± 0.114	2.033GlyMet: 2.033 ± 0.058	1.769GlyAsn: 1.769 ± 0.054	4.092GlyPro: 4.092 ± 0.067	2.598GlyGln: 2.598 ± 0.056	7.519GlyArg: 7.519 ± 0.089	4.534GlySer: 4.534 ± 0.07	5.306GlyThr: 5.306 ± 0.072	5.997GlyVal: 5.997 ± 0.084	1.22GlyTrp: 1.22 ± 0.034	2.029GlyTyr: 2.029 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.281HisAla: 2.281 ± 0.052	0.212HisCys: 0.212 ± 0.015	1.059HisAsp: 1.059 ± 0.037	1.046HisGlu: 1.046 ± 0.031	0.766HisPhe: 0.766 ± 0.029	1.949HisGly: 1.949 ± 0.055	0.529HisHis: 0.529 ± 0.026	0.664HisIle: 0.664 ± 0.024	0.318HisLys: 0.318 ± 0.018	1.994HisLeu: 1.994 ± 0.039	0.437HisMet: 0.437 ± 0.019	0.311HisAsn: 0.311 ± 0.016	1.279HisPro: 1.279 ± 0.036	0.449HisGln: 0.449 ± 0.021	1.515HisArg: 1.515 ± 0.042	0.739HisSer: 0.739 ± 0.026	0.658HisThr: 0.658 ± 0.021	1.51HisVal: 1.51 ± 0.035	0.254HisTrp: 0.254 ± 0.014	0.444HisTyr: 0.444 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.369IleAla: 7.369 ± 0.082	0.417IleCys: 0.417 ± 0.02	3.279IleAsp: 3.279 ± 0.062	3.577IleGlu: 3.577 ± 0.058	1.484IlePhe: 1.484 ± 0.044	4.631IleGly: 4.631 ± 0.064	0.826IleHis: 0.826 ± 0.03	1.383IleIle: 1.383 ± 0.046	0.909IleLys: 0.909 ± 0.031	4.644IleLeu: 4.644 ± 0.066	0.744IleMet: 0.744 ± 0.03	0.943IleAsn: 0.943 ± 0.03	1.878IlePro: 1.878 ± 0.044	0.909IleGln: 0.909 ± 0.031	2.948IleArg: 2.948 ± 0.057	2.152IleSer: 2.152 ± 0.05	1.901IleThr: 1.901 ± 0.039	4.59IleVal: 4.59 ± 0.072	0.442IleTrp: 0.442 ± 0.023	0.861IleTyr: 0.861 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.232LysAla: 4.232 ± 0.065	0.111LysCys: 0.111 ± 0.01	1.461LysAsp: 1.461 ± 0.042	1.255LysGlu: 1.255 ± 0.041	0.643LysPhe: 0.643 ± 0.023	2.553LysGly: 2.553 ± 0.06	0.376LysHis: 0.376 ± 0.021	1.308LysIle: 1.308 ± 0.041	0.857LysLys: 0.857 ± 0.036	2.488LysLeu: 2.488 ± 0.048	0.57LysMet: 0.57 ± 0.026	0.568LysAsn: 0.568 ± 0.028	1.636LysPro: 1.636 ± 0.042	0.562LysGln: 0.562 ± 0.021	2.079LysArg: 2.079 ± 0.047	1.362LysSer: 1.362 ± 0.035	1.508LysThr: 1.508 ± 0.04	1.994LysVal: 1.994 ± 0.051	0.232LysTrp: 0.232 ± 0.014	0.412LysTyr: 0.412 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.807LeuAla: 15.807 ± 0.183	0.98LeuCys: 0.98 ± 0.025	6.365LeuAsp: 6.365 ± 0.092	5.563LeuGlu: 5.563 ± 0.087	3.831LeuPhe: 3.831 ± 0.072	9.053LeuGly: 9.053 ± 0.101	1.736LeuHis: 1.736 ± 0.043	3.725LeuIle: 3.725 ± 0.068	3.314LeuLys: 3.314 ± 0.059	9.952LeuLeu: 9.952 ± 0.133	2.188LeuMet: 2.188 ± 0.044	2.094LeuAsn: 2.094 ± 0.046	5.722LeuPro: 5.722 ± 0.076	2.564LeuGln: 2.564 ± 0.048	7.402LeuArg: 7.402 ± 0.083	7.265LeuSer: 7.265 ± 0.091	5.418LeuThr: 5.418 ± 0.079	9.132LeuVal: 9.132 ± 0.114	1.076LeuTrp: 1.076 ± 0.031	2.037LeuTyr: 2.037 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.251MetAla: 3.251 ± 0.065	0.103MetCys: 0.103 ± 0.009	1.148MetAsp: 1.148 ± 0.031	1.245MetGlu: 1.245 ± 0.032	0.525MetPhe: 0.525 ± 0.022	1.778MetGly: 1.778 ± 0.045	0.346MetHis: 0.346 ± 0.018	1.21MetIle: 1.21 ± 0.038	0.831MetLys: 0.831 ± 0.028	2.106MetLeu: 2.106 ± 0.041	0.599MetMet: 0.599 ± 0.023	0.653MetAsn: 0.653 ± 0.02	1.469MetPro: 1.469 ± 0.036	0.679MetGln: 0.679 ± 0.023	1.951MetArg: 1.951 ± 0.047	1.441MetSer: 1.441 ± 0.035	1.812MetThr: 1.812 ± 0.041	1.576MetVal: 1.576 ± 0.039	0.129MetTrp: 0.129 ± 0.012	0.227MetTyr: 0.227 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.902AsnAla: 2.902 ± 0.052	0.17AsnCys: 0.17 ± 0.012	1.114AsnAsp: 1.114 ± 0.039	1.125AsnGlu: 1.125 ± 0.036	0.798AsnPhe: 0.798 ± 0.029	2.018AsnGly: 2.018 ± 0.044	0.391AsnHis: 0.391 ± 0.018	0.976AsnIle: 0.976 ± 0.033	0.437AsnLys: 0.437 ± 0.023	2.019AsnLeu: 2.019 ± 0.043	0.452AsnMet: 0.452 ± 0.025	0.44AsnAsn: 0.44 ± 0.02	1.489AsnPro: 1.489 ± 0.04	0.547AsnGln: 0.547 ± 0.027	1.58AsnArg: 1.58 ± 0.041	0.832AsnSer: 0.832 ± 0.027	0.948AsnThr: 0.948 ± 0.029	1.662AsnVal: 1.662 ± 0.035	0.286AsnTrp: 0.286 ± 0.015	0.528AsnTyr: 0.528 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.788ProAla: 7.788 ± 0.111	0.298ProCys: 0.298 ± 0.016	3.717ProAsp: 3.717 ± 0.061	3.596ProGlu: 3.596 ± 0.053	2.172ProPhe: 2.172 ± 0.047	5.016ProGly: 5.016 ± 0.07	0.991ProHis: 0.991 ± 0.03	2.178ProIle: 2.178 ± 0.044	1.455ProLys: 1.455 ± 0.039	5.108ProLeu: 5.108 ± 0.075	1.164ProMet: 1.164 ± 0.033	1.147ProAsn: 1.147 ± 0.03	2.487ProPro: 2.487 ± 0.063	1.711ProGln: 1.711 ± 0.037	3.397ProArg: 3.397 ± 0.06	2.838ProSer: 2.838 ± 0.06	2.43ProThr: 2.43 ± 0.051	4.4ProVal: 4.4 ± 0.064	0.546ProTrp: 0.546 ± 0.023	1.155ProTyr: 1.155 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.947GlnAla: 3.947 ± 0.062	0.143GlnCys: 0.143 ± 0.012	1.297GlnAsp: 1.297 ± 0.038	1.36GlnGlu: 1.36 ± 0.036	0.879GlnPhe: 0.879 ± 0.03	2.197GlnGly: 2.197 ± 0.044	0.381GlnHis: 0.381 ± 0.017	1.54GlnIle: 1.54 ± 0.037	0.887GlnLys: 0.887 ± 0.03	2.24GlnLeu: 2.24 ± 0.047	0.747GlnMet: 0.747 ± 0.026	0.675GlnAsn: 0.675 ± 0.027	1.367GlnPro: 1.367 ± 0.036	0.755GlnGln: 0.755 ± 0.035	2.211GlnArg: 2.211 ± 0.049	1.482GlnSer: 1.482 ± 0.039	1.676GlnThr: 1.676 ± 0.042	1.864GlnVal: 1.864 ± 0.04	0.274GlnTrp: 0.274 ± 0.015	0.462GlnTyr: 0.462 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.674ArgAla: 9.674 ± 0.123	0.462ArgCys: 0.462 ± 0.021	4.206ArgAsp: 4.206 ± 0.066	4.74ArgGlu: 4.74 ± 0.07	3.344ArgPhe: 3.344 ± 0.055	5.419ArgGly: 5.419 ± 0.07	1.825ArgHis: 1.825 ± 0.045	4.115ArgIle: 4.115 ± 0.065	1.761ArgLys: 1.761 ± 0.043	9.671ArgLeu: 9.671 ± 0.116	1.951ArgMet: 1.951 ± 0.045	1.602ArgAsn: 1.602 ± 0.037	4.508ArgPro: 4.508 ± 0.067	2.494ArgGln: 2.494 ± 0.053	7.545ArgArg: 7.545 ± 0.105	4.038ArgSer: 4.038 ± 0.067	3.702ArgThr: 3.702 ± 0.055	5.105ArgVal: 5.105 ± 0.066	0.919ArgTrp: 0.919 ± 0.029	1.591ArgTyr: 1.591 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.626SerAla: 6.626 ± 0.083	0.335SerCys: 0.335 ± 0.017	2.755SerAsp: 2.755 ± 0.048	2.583SerGlu: 2.583 ± 0.058	2.185SerPhe: 2.185 ± 0.046	5.621SerGly: 5.621 ± 0.084	0.925SerHis: 0.925 ± 0.029	2.618SerIle: 2.618 ± 0.058	1.174SerLys: 1.174 ± 0.033	5.504SerLeu: 5.504 ± 0.08	1.204SerMet: 1.204 ± 0.033	1.155SerAsn: 1.155 ± 0.031	2.858SerPro: 2.858 ± 0.056	1.562SerGln: 1.562 ± 0.043	3.844SerArg: 3.844 ± 0.066	2.61SerSer: 2.61 ± 0.061	2.408SerThr: 2.408 ± 0.047	4.052SerVal: 4.052 ± 0.061	0.596SerTrp: 0.596 ± 0.022	1.047SerTyr: 1.047 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.316ThrAla: 6.316 ± 0.095	0.374ThrCys: 0.374 ± 0.016	2.517ThrAsp: 2.517 ± 0.051	2.346ThrGlu: 2.346 ± 0.05	1.948ThrPhe: 1.948 ± 0.043	5.266ThrGly: 5.266 ± 0.068	0.927ThrHis: 0.927 ± 0.031	2.963ThrIle: 2.963 ± 0.06	1.197ThrLys: 1.197 ± 0.038	6.101ThrLeu: 6.101 ± 0.088	1.192ThrMet: 1.192 ± 0.031	1.069ThrAsn: 1.069 ± 0.032	3.304ThrPro: 3.304 ± 0.057	1.373ThrGln: 1.373 ± 0.037	3.642ThrArg: 3.642 ± 0.058	2.502ThrSer: 2.502 ± 0.046	2.523ThrThr: 2.523 ± 0.059	4.484ThrVal: 4.484 ± 0.073	0.497ThrTrp: 0.497 ± 0.022	1.097ThrTyr: 1.097 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.256ValAla: 10.256 ± 0.108	0.617ValCys: 0.617 ± 0.026	4.195ValAsp: 4.195 ± 0.069	5.358ValGlu: 5.358 ± 0.076	2.873ValPhe: 2.873 ± 0.051	5.927ValGly: 5.927 ± 0.079	1.339ValHis: 1.339 ± 0.038	3.059ValIle: 3.059 ± 0.067	2.056ValLys: 2.056 ± 0.049	7.948ValLeu: 7.948 ± 0.102	1.691ValMet: 1.691 ± 0.041	1.763ValAsn: 1.763 ± 0.038	4.181ValPro: 4.181 ± 0.07	1.739ValGln: 1.739 ± 0.042	5.073ValArg: 5.073 ± 0.07	4.711ValSer: 4.711 ± 0.068	4.601ValThr: 4.601 ± 0.072	6.367ValVal: 6.367 ± 0.098	0.846ValTrp: 0.846 ± 0.027	1.471ValTyr: 1.471 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.007TrpAla: 1.007 ± 0.031	0.12TrpCys: 0.12 ± 0.012	0.509TrpAsp: 0.509 ± 0.022	0.461TrpGlu: 0.461 ± 0.023	0.463TrpPhe: 0.463 ± 0.023	0.704TrpGly: 0.704 ± 0.027	0.27TrpHis: 0.27 ± 0.015	0.521TrpIle: 0.521 ± 0.024	0.35TrpLys: 0.35 ± 0.017	1.382TrpLeu: 1.382 ± 0.037	0.346TrpMet: 0.346 ± 0.017	0.344TrpAsn: 0.344 ± 0.018	0.632TrpPro: 0.632 ± 0.024	0.431TrpGln: 0.431 ± 0.023	1.106TrpArg: 1.106 ± 0.034	0.695TrpSer: 0.695 ± 0.027	0.726TrpThr: 0.726 ± 0.03	0.588TrpVal: 0.588 ± 0.025	0.18TrpTrp: 0.18 ± 0.013	0.253TrpTyr: 0.253 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.509TyrAla: 2.509 ± 0.043	0.188TyrCys: 0.188 ± 0.013	1.318TyrAsp: 1.318 ± 0.036	1.252TyrGlu: 1.252 ± 0.036	0.82TyrPhe: 0.82 ± 0.025	2.021TyrGly: 2.021 ± 0.043	0.418TyrHis: 0.418 ± 0.02	0.702TyrIle: 0.702 ± 0.025	0.492TyrLys: 0.492 ± 0.022	2.066TyrLeu: 2.066 ± 0.047	0.348TyrMet: 0.348 ± 0.018	0.442TyrAsn: 0.442 ± 0.022	0.97TyrPro: 0.97 ± 0.032	0.529TyrGln: 0.529 ± 0.022	1.705TyrArg: 1.705 ± 0.04	0.926TyrSer: 0.926 ± 0.031	0.876TyrThr: 0.876 ± 0.035	1.455TyrVal: 1.455 ± 0.034	0.273TyrTrp: 0.273 ± 0.02	0.535TyrTyr: 0.535 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3439 proteins (1115558 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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