Amino acid dipepetide frequency for Streptococcus phage Javan261

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.519AlaAla: 4.519 ± 1.422
0.387AlaCys: 0.387 ± 0.182
3.486AlaAsp: 3.486 ± 0.696
4.132AlaGlu: 4.132 ± 0.608
2.582AlaPhe: 2.582 ± 0.631
4.777AlaGly: 4.777 ± 0.81
0.904AlaHis: 0.904 ± 0.267
3.873AlaIle: 3.873 ± 1.136
5.423AlaLys: 5.423 ± 0.952
5.165AlaLeu: 5.165 ± 1.42
1.291AlaMet: 1.291 ± 0.546
2.582AlaAsn: 2.582 ± 0.557
1.033AlaPro: 1.033 ± 0.364
1.42AlaGln: 1.42 ± 0.377
3.228AlaArg: 3.228 ± 0.59
4.132AlaSer: 4.132 ± 1.002
4.39AlaThr: 4.39 ± 0.73
5.423AlaVal: 5.423 ± 0.864
0.516AlaTrp: 0.516 ± 0.301
3.099AlaTyr: 3.099 ± 0.556
0.0AlaXaa: 0.0 ± 0.0
Cys
0.258CysAla: 0.258 ± 0.194
0.258CysCys: 0.258 ± 0.174
0.646CysAsp: 0.646 ± 0.282
0.775CysGlu: 0.775 ± 0.331
0.129CysPhe: 0.129 ± 0.155
1.162CysGly: 1.162 ± 0.484
0.387CysHis: 0.387 ± 0.245
0.516CysIle: 0.516 ± 0.361
0.258CysLys: 0.258 ± 0.163
0.775CysLeu: 0.775 ± 0.287
0.258CysMet: 0.258 ± 0.204
0.516CysAsn: 0.516 ± 0.246
0.387CysPro: 0.387 ± 0.224
1.162CysGln: 1.162 ± 0.485
0.129CysArg: 0.129 ± 0.148
0.516CysSer: 0.516 ± 0.307
0.258CysThr: 0.258 ± 0.19
0.904CysVal: 0.904 ± 0.347
0.129CysTrp: 0.129 ± 0.121
0.387CysTyr: 0.387 ± 0.323
0.0CysXaa: 0.0 ± 0.0
Asp
3.357AspAla: 3.357 ± 0.699
0.387AspCys: 0.387 ± 0.217
2.711AspAsp: 2.711 ± 0.774
5.681AspGlu: 5.681 ± 0.843
1.679AspPhe: 1.679 ± 0.353
4.003AspGly: 4.003 ± 0.785
0.775AspHis: 0.775 ± 0.307
3.615AspIle: 3.615 ± 0.796
4.519AspLys: 4.519 ± 0.816
4.648AspLeu: 4.648 ± 0.875
2.066AspMet: 2.066 ± 0.469
2.066AspAsn: 2.066 ± 0.599
1.291AspPro: 1.291 ± 0.459
0.646AspGln: 0.646 ± 0.291
2.97AspArg: 2.97 ± 0.632
3.099AspSer: 3.099 ± 0.728
3.873AspThr: 3.873 ± 1.029
2.453AspVal: 2.453 ± 0.498
0.516AspTrp: 0.516 ± 0.303
1.679AspTyr: 1.679 ± 0.491
0.0AspXaa: 0.0 ± 0.0
Glu
2.97GluAla: 2.97 ± 0.687
0.646GluCys: 0.646 ± 0.287
3.486GluAsp: 3.486 ± 0.671
6.198GluGlu: 6.198 ± 1.526
2.711GluPhe: 2.711 ± 0.517
3.615GluGly: 3.615 ± 0.584
1.42GluHis: 1.42 ± 0.475
4.648GluIle: 4.648 ± 0.771
6.327GluLys: 6.327 ± 1.068
8.005GluLeu: 8.005 ± 1.283
2.841GluMet: 2.841 ± 0.526
5.294GluAsn: 5.294 ± 0.882
2.066GluPro: 2.066 ± 0.542
5.165GluGln: 5.165 ± 0.719
2.97GluArg: 2.97 ± 0.676
3.615GluSer: 3.615 ± 0.605
3.615GluThr: 3.615 ± 0.545
6.198GluVal: 6.198 ± 0.97
0.904GluTrp: 0.904 ± 0.343
1.808GluTyr: 1.808 ± 0.384
0.0GluXaa: 0.0 ± 0.0
Phe
2.453PheAla: 2.453 ± 0.599
0.258PheCys: 0.258 ± 0.166
2.711PheAsp: 2.711 ± 0.768
2.324PheGlu: 2.324 ± 0.612
1.033PhePhe: 1.033 ± 0.382
3.615PheGly: 3.615 ± 0.589
0.516PheHis: 0.516 ± 0.24
2.841PheIle: 2.841 ± 0.863
3.873PheLys: 3.873 ± 0.936
2.582PheLeu: 2.582 ± 0.497
0.516PheMet: 0.516 ± 0.277
2.97PheAsn: 2.97 ± 0.715
0.775PhePro: 0.775 ± 0.4
1.033PheGln: 1.033 ± 0.309
1.937PheArg: 1.937 ± 0.541
2.195PheSer: 2.195 ± 0.499
1.679PheThr: 1.679 ± 0.495
1.808PheVal: 1.808 ± 0.369
0.258PheTrp: 0.258 ± 0.183
2.453PheTyr: 2.453 ± 0.646
0.0PheXaa: 0.0 ± 0.0
Gly
4.777GlyAla: 4.777 ± 1.044
0.258GlyCys: 0.258 ± 0.174
3.873GlyAsp: 3.873 ± 0.79
3.873GlyGlu: 3.873 ± 0.721
3.357GlyPhe: 3.357 ± 0.655
4.519GlyGly: 4.519 ± 0.866
1.162GlyHis: 1.162 ± 0.414
5.423GlyIle: 5.423 ± 0.758
5.165GlyLys: 5.165 ± 0.583
4.648GlyLeu: 4.648 ± 0.839
1.679GlyMet: 1.679 ± 0.483
5.165GlyAsn: 5.165 ± 0.641
0.387GlyPro: 0.387 ± 0.281
2.195GlyGln: 2.195 ± 0.512
3.228GlyArg: 3.228 ± 0.627
3.873GlySer: 3.873 ± 0.893
5.552GlyThr: 5.552 ± 1.105
4.261GlyVal: 4.261 ± 0.656
0.775GlyTrp: 0.775 ± 0.31
3.615GlyTyr: 3.615 ± 0.7
0.0GlyXaa: 0.0 ± 0.0
His
0.904HisAla: 0.904 ± 0.388
0.129HisCys: 0.129 ± 0.155
0.904HisAsp: 0.904 ± 0.345
0.904HisGlu: 0.904 ± 0.325
1.033HisPhe: 1.033 ± 0.379
1.42HisGly: 1.42 ± 0.527
0.775HisHis: 0.775 ± 0.278
0.904HisIle: 0.904 ± 0.362
0.775HisLys: 0.775 ± 0.312
2.195HisLeu: 2.195 ± 0.576
0.516HisMet: 0.516 ± 0.314
1.162HisAsn: 1.162 ± 0.339
0.775HisPro: 0.775 ± 0.274
0.904HisGln: 0.904 ± 0.318
1.291HisArg: 1.291 ± 0.431
1.291HisSer: 1.291 ± 0.421
1.549HisThr: 1.549 ± 0.457
1.42HisVal: 1.42 ± 0.387
0.258HisTrp: 0.258 ± 0.182
0.646HisTyr: 0.646 ± 0.275
0.0HisXaa: 0.0 ± 0.0
Ile
4.777IleAla: 4.777 ± 0.88
0.775IleCys: 0.775 ± 0.361
3.357IleAsp: 3.357 ± 0.504
5.423IleGlu: 5.423 ± 0.833
2.711IlePhe: 2.711 ± 0.827
4.39IleGly: 4.39 ± 0.848
0.904IleHis: 0.904 ± 0.334
4.132IleIle: 4.132 ± 0.917
5.294IleLys: 5.294 ± 0.96
5.423IleLeu: 5.423 ± 0.768
1.42IleMet: 1.42 ± 0.514
2.711IleAsn: 2.711 ± 0.727
2.97IlePro: 2.97 ± 0.691
3.099IleGln: 3.099 ± 0.666
3.357IleArg: 3.357 ± 0.623
5.036IleSer: 5.036 ± 1.075
4.519IleThr: 4.519 ± 0.953
3.744IleVal: 3.744 ± 0.729
1.808IleTrp: 1.808 ± 0.81
3.099IleTyr: 3.099 ± 0.493
0.0IleXaa: 0.0 ± 0.0
Lys
3.744LysAla: 3.744 ± 0.765
0.387LysCys: 0.387 ± 0.203
3.099LysAsp: 3.099 ± 0.583
7.36LysGlu: 7.36 ± 1.219
2.841LysPhe: 2.841 ± 0.586
5.423LysGly: 5.423 ± 0.887
1.549LysHis: 1.549 ± 0.388
4.39LysIle: 4.39 ± 0.63
6.585LysLys: 6.585 ± 1.161
6.585LysLeu: 6.585 ± 0.916
2.453LysMet: 2.453 ± 0.619
4.132LysAsn: 4.132 ± 0.937
2.453LysPro: 2.453 ± 0.619
5.165LysGln: 5.165 ± 0.733
2.582LysArg: 2.582 ± 0.562
5.165LysSer: 5.165 ± 0.666
3.486LysThr: 3.486 ± 0.617
6.068LysVal: 6.068 ± 0.887
0.904LysTrp: 0.904 ± 0.296
2.066LysTyr: 2.066 ± 0.534
0.0LysXaa: 0.0 ± 0.0
Leu
5.681LeuAla: 5.681 ± 1.002
1.033LeuCys: 1.033 ± 0.43
5.423LeuAsp: 5.423 ± 1.029
7.489LeuGlu: 7.489 ± 1.001
3.873LeuPhe: 3.873 ± 0.686
6.198LeuGly: 6.198 ± 0.949
2.066LeuHis: 2.066 ± 0.534
4.777LeuIle: 4.777 ± 1.219
5.165LeuLys: 5.165 ± 1.272
9.167LeuLeu: 9.167 ± 1.276
2.97LeuMet: 2.97 ± 0.66
4.003LeuAsn: 4.003 ± 0.585
4.261LeuPro: 4.261 ± 0.731
4.648LeuGln: 4.648 ± 0.856
2.195LeuArg: 2.195 ± 0.687
6.068LeuSer: 6.068 ± 0.937
5.681LeuThr: 5.681 ± 0.919
3.615LeuVal: 3.615 ± 0.536
1.549LeuTrp: 1.549 ± 0.353
2.324LeuTyr: 2.324 ± 0.724
0.0LeuXaa: 0.0 ± 0.0
Met
2.195MetAla: 2.195 ± 0.504
0.258MetCys: 0.258 ± 0.194
1.162MetAsp: 1.162 ± 0.352
2.066MetGlu: 2.066 ± 0.545
0.775MetPhe: 0.775 ± 0.31
0.775MetGly: 0.775 ± 0.344
0.129MetHis: 0.129 ± 0.121
1.42MetIle: 1.42 ± 0.516
2.97MetLys: 2.97 ± 0.552
1.937MetLeu: 1.937 ± 0.424
0.516MetMet: 0.516 ± 0.326
1.679MetAsn: 1.679 ± 0.601
0.516MetPro: 0.516 ± 0.254
0.904MetGln: 0.904 ± 0.242
0.646MetArg: 0.646 ± 0.331
2.711MetSer: 2.711 ± 0.536
2.711MetThr: 2.711 ± 0.677
1.808MetVal: 1.808 ± 0.536
0.516MetTrp: 0.516 ± 0.257
0.646MetTyr: 0.646 ± 0.314
0.0MetXaa: 0.0 ± 0.0
Asn
3.228AsnAla: 3.228 ± 0.661
0.904AsnCys: 0.904 ± 0.4
2.711AsnAsp: 2.711 ± 0.709
3.228AsnGlu: 3.228 ± 0.717
1.42AsnPhe: 1.42 ± 0.371
5.423AsnGly: 5.423 ± 0.706
1.033AsnHis: 1.033 ± 0.369
4.132AsnIle: 4.132 ± 0.634
3.228AsnLys: 3.228 ± 0.454
3.486AsnLeu: 3.486 ± 0.581
1.937AsnMet: 1.937 ± 0.566
2.453AsnAsn: 2.453 ± 0.531
1.937AsnPro: 1.937 ± 0.469
2.066AsnGln: 2.066 ± 0.575
2.97AsnArg: 2.97 ± 0.605
3.357AsnSer: 3.357 ± 0.558
3.873AsnThr: 3.873 ± 0.946
3.228AsnVal: 3.228 ± 0.619
1.033AsnTrp: 1.033 ± 0.388
1.033AsnTyr: 1.033 ± 0.34
0.0AsnXaa: 0.0 ± 0.0
Pro
1.549ProAla: 1.549 ± 0.481
0.516ProCys: 0.516 ± 0.292
0.904ProAsp: 0.904 ± 0.303
2.582ProGlu: 2.582 ± 0.665
1.291ProPhe: 1.291 ± 0.432
0.904ProGly: 0.904 ± 0.415
0.775ProHis: 0.775 ± 0.337
2.324ProIle: 2.324 ± 0.471
1.679ProLys: 1.679 ± 0.443
2.195ProLeu: 2.195 ± 0.638
0.646ProMet: 0.646 ± 0.232
1.42ProAsn: 1.42 ± 0.416
1.033ProPro: 1.033 ± 0.417
1.42ProGln: 1.42 ± 0.351
1.033ProArg: 1.033 ± 0.346
2.324ProSer: 2.324 ± 0.438
3.873ProThr: 3.873 ± 0.804
1.42ProVal: 1.42 ± 0.401
0.0ProTrp: 0.0 ± 0.0
1.808ProTyr: 1.808 ± 0.401
0.0ProXaa: 0.0 ± 0.0
Gln
2.711GlnAla: 2.711 ± 0.552
0.516GlnCys: 0.516 ± 0.236
1.679GlnAsp: 1.679 ± 0.473
2.711GlnGlu: 2.711 ± 0.634
1.42GlnPhe: 1.42 ± 0.344
2.711GlnGly: 2.711 ± 0.576
0.387GlnHis: 0.387 ± 0.187
2.324GlnIle: 2.324 ± 0.528
3.744GlnLys: 3.744 ± 0.807
3.357GlnLeu: 3.357 ± 0.72
0.904GlnMet: 0.904 ± 0.33
2.582GlnAsn: 2.582 ± 0.526
1.549GlnPro: 1.549 ± 0.461
1.679GlnGln: 1.679 ± 0.539
1.162GlnArg: 1.162 ± 0.434
4.519GlnSer: 4.519 ± 0.797
2.195GlnThr: 2.195 ± 0.686
3.486GlnVal: 3.486 ± 0.39
0.775GlnTrp: 0.775 ± 0.287
1.679GlnTyr: 1.679 ± 0.419
0.0GlnXaa: 0.0 ± 0.0
Arg
1.549ArgAla: 1.549 ± 0.431
1.033ArgCys: 1.033 ± 0.355
1.808ArgAsp: 1.808 ± 0.499
2.582ArgGlu: 2.582 ± 0.597
2.711ArgPhe: 2.711 ± 0.58
2.195ArgGly: 2.195 ± 0.613
1.162ArgHis: 1.162 ± 0.366
2.711ArgIle: 2.711 ± 0.594
3.744ArgLys: 3.744 ± 0.768
5.294ArgLeu: 5.294 ± 0.666
1.291ArgMet: 1.291 ± 0.33
2.324ArgAsn: 2.324 ± 0.682
1.033ArgPro: 1.033 ± 0.423
1.291ArgGln: 1.291 ± 0.623
1.679ArgArg: 1.679 ± 0.564
3.099ArgSer: 3.099 ± 0.683
2.453ArgThr: 2.453 ± 0.565
3.099ArgVal: 3.099 ± 0.634
0.387ArgTrp: 0.387 ± 0.417
1.549ArgTyr: 1.549 ± 0.492
0.0ArgXaa: 0.0 ± 0.0
Ser
4.261SerAla: 4.261 ± 0.813
0.516SerCys: 0.516 ± 0.282
4.003SerAsp: 4.003 ± 0.747
5.036SerGlu: 5.036 ± 0.711
2.582SerPhe: 2.582 ± 0.504
4.648SerGly: 4.648 ± 0.916
1.549SerHis: 1.549 ± 0.434
5.552SerIle: 5.552 ± 0.67
4.132SerLys: 4.132 ± 0.649
5.552SerLeu: 5.552 ± 0.772
1.808SerMet: 1.808 ± 0.525
3.099SerAsn: 3.099 ± 0.711
2.453SerPro: 2.453 ± 0.47
2.453SerGln: 2.453 ± 0.557
3.228SerArg: 3.228 ± 0.759
4.648SerSer: 4.648 ± 0.81
5.036SerThr: 5.036 ± 1.149
4.003SerVal: 4.003 ± 0.714
0.775SerTrp: 0.775 ± 0.349
2.324SerTyr: 2.324 ± 0.541
0.0SerXaa: 0.0 ± 0.0
Thr
4.777ThrAla: 4.777 ± 0.817
0.516ThrCys: 0.516 ± 0.223
3.357ThrAsp: 3.357 ± 0.603
3.228ThrGlu: 3.228 ± 0.528
1.937ThrPhe: 1.937 ± 0.395
4.519ThrGly: 4.519 ± 0.864
1.291ThrHis: 1.291 ± 0.356
6.456ThrIle: 6.456 ± 1.555
4.777ThrLys: 4.777 ± 0.85
7.23ThrLeu: 7.23 ± 1.052
0.904ThrMet: 0.904 ± 0.258
2.195ThrAsn: 2.195 ± 0.759
1.937ThrPro: 1.937 ± 0.526
1.808ThrGln: 1.808 ± 0.497
3.099ThrArg: 3.099 ± 0.789
4.519ThrSer: 4.519 ± 1.013
4.519ThrThr: 4.519 ± 0.922
5.939ThrVal: 5.939 ± 1.451
0.904ThrTrp: 0.904 ± 0.336
2.453ThrTyr: 2.453 ± 0.702
0.0ThrXaa: 0.0 ± 0.0
Val
5.81ValAla: 5.81 ± 1.07
0.646ValCys: 0.646 ± 0.285
4.003ValAsp: 4.003 ± 0.736
4.777ValGlu: 4.777 ± 0.75
1.679ValPhe: 1.679 ± 0.591
3.873ValGly: 3.873 ± 0.85
1.549ValHis: 1.549 ± 0.421
5.294ValIle: 5.294 ± 0.908
5.165ValLys: 5.165 ± 0.828
5.939ValLeu: 5.939 ± 1.001
1.162ValMet: 1.162 ± 0.355
3.228ValAsn: 3.228 ± 0.749
1.291ValPro: 1.291 ± 0.336
1.937ValGln: 1.937 ± 0.516
3.357ValArg: 3.357 ± 0.803
4.132ValSer: 4.132 ± 0.836
3.357ValThr: 3.357 ± 0.604
3.228ValVal: 3.228 ± 0.723
0.904ValTrp: 0.904 ± 0.395
2.582ValTyr: 2.582 ± 0.627
0.0ValXaa: 0.0 ± 0.0
Trp
0.646TrpAla: 0.646 ± 0.314
0.129TrpCys: 0.129 ± 0.121
0.775TrpAsp: 0.775 ± 0.324
1.291TrpGlu: 1.291 ± 0.536
0.516TrpPhe: 0.516 ± 0.262
0.904TrpGly: 0.904 ± 0.348
0.516TrpHis: 0.516 ± 0.234
0.646TrpIle: 0.646 ± 0.252
1.162TrpLys: 1.162 ± 0.277
1.033TrpLeu: 1.033 ± 0.364
0.387TrpMet: 0.387 ± 0.207
1.291TrpAsn: 1.291 ± 0.774
0.0TrpPro: 0.0 ± 0.0
0.775TrpGln: 0.775 ± 0.254
0.258TrpArg: 0.258 ± 0.175
0.904TrpSer: 0.904 ± 0.497
0.904TrpThr: 0.904 ± 0.318
0.258TrpVal: 0.258 ± 0.193
0.0TrpTrp: 0.0 ± 0.0
0.904TrpTyr: 0.904 ± 0.357
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.195TyrAla: 2.195 ± 0.64
0.258TyrCys: 0.258 ± 0.165
1.937TyrAsp: 1.937 ± 0.494
2.841TyrGlu: 2.841 ± 0.494
1.549TyrPhe: 1.549 ± 0.437
2.841TyrGly: 2.841 ± 0.598
0.904TyrHis: 0.904 ± 0.247
2.97TyrIle: 2.97 ± 0.522
2.453TyrLys: 2.453 ± 0.554
2.97TyrLeu: 2.97 ± 0.696
0.646TyrMet: 0.646 ± 0.309
1.808TyrAsn: 1.808 ± 0.49
1.549TyrPro: 1.549 ± 0.431
2.324TyrGln: 2.324 ± 0.525
1.679TyrArg: 1.679 ± 0.401
2.453TyrSer: 2.453 ± 0.531
2.841TyrThr: 2.841 ± 0.758
1.549TyrVal: 1.549 ± 0.373
0.387TyrTrp: 0.387 ± 0.21
1.162TyrTyr: 1.162 ± 0.343
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 31 proteins (7746 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski