Amino acid dipepetide frequency for Pedobacter psychrophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.586AlaAla: 4.586 ± 0.077	0.56AlaCys: 0.56 ± 0.025	3.776AlaAsp: 3.776 ± 0.061	3.647AlaGlu: 3.647 ± 0.064	3.447AlaPhe: 3.447 ± 0.056	4.549AlaGly: 4.549 ± 0.069	0.915AlaHis: 0.915 ± 0.031	5.611AlaIle: 5.611 ± 0.074	5.103AlaLys: 5.103 ± 0.081	6.053AlaLeu: 6.053 ± 0.093	1.455AlaMet: 1.455 ± 0.036	4.087AlaAsn: 4.087 ± 0.078	1.847AlaPro: 1.847 ± 0.044	2.513AlaGln: 2.513 ± 0.05	1.788AlaArg: 1.788 ± 0.042	4.093AlaSer: 4.093 ± 0.06	3.809AlaThr: 3.809 ± 0.085	3.919AlaVal: 3.919 ± 0.066	0.656AlaTrp: 0.656 ± 0.027	2.554AlaTyr: 2.554 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.445CysAla: 0.445 ± 0.021	0.116CysCys: 0.116 ± 0.011	0.409CysAsp: 0.409 ± 0.018	0.432CysGlu: 0.432 ± 0.019	0.447CysPhe: 0.447 ± 0.019	0.585CysGly: 0.585 ± 0.022	0.155CysHis: 0.155 ± 0.011	0.627CysIle: 0.627 ± 0.023	0.516CysLys: 0.516 ± 0.018	0.749CysLeu: 0.749 ± 0.024	0.139CysMet: 0.139 ± 0.012	0.427CysAsn: 0.427 ± 0.025	0.295CysPro: 0.295 ± 0.016	0.194CysGln: 0.194 ± 0.013	0.213CysArg: 0.213 ± 0.013	0.512CysSer: 0.512 ± 0.023	0.391CysThr: 0.391 ± 0.023	0.426CysVal: 0.426 ± 0.022	0.067CysTrp: 0.067 ± 0.008	0.317CysTyr: 0.317 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.727AspAla: 3.727 ± 0.065	0.397AspCys: 0.397 ± 0.021	2.908AspAsp: 2.908 ± 0.057	3.565AspGlu: 3.565 ± 0.062	3.715AspPhe: 3.715 ± 0.06	3.808AspGly: 3.808 ± 0.077	0.818AspHis: 0.818 ± 0.031	4.235AspIle: 4.235 ± 0.07	4.589AspLys: 4.589 ± 0.073	5.585AspLeu: 5.585 ± 0.076	1.034AspMet: 1.034 ± 0.031	3.126AspAsn: 3.126 ± 0.051	1.681AspPro: 1.681 ± 0.04	1.687AspGln: 1.687 ± 0.041	1.75AspArg: 1.75 ± 0.038	2.954AspSer: 2.954 ± 0.062	2.277AspThr: 2.277 ± 0.055	3.453AspVal: 3.453 ± 0.053	0.751AspTrp: 0.751 ± 0.026	2.672AspTyr: 2.672 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	3.702GluAla: 3.702 ± 0.058	0.335GluCys: 0.335 ± 0.019	3.032GluAsp: 3.032 ± 0.062	4.118GluGlu: 4.118 ± 0.077	2.679GluPhe: 2.679 ± 0.051	3.198GluGly: 3.198 ± 0.062	0.909GluHis: 0.909 ± 0.028	5.501GluIle: 5.501 ± 0.07	5.66GluLys: 5.66 ± 0.09	5.622GluLeu: 5.622 ± 0.083	1.52GluMet: 1.52 ± 0.039	4.371GluAsn: 4.371 ± 0.072	1.48GluPro: 1.48 ± 0.037	2.034GluGln: 2.034 ± 0.046	2.196GluArg: 2.196 ± 0.042	3.049GluSer: 3.049 ± 0.056	3.136GluThr: 3.136 ± 0.051	3.744GluVal: 3.744 ± 0.06	0.587GluTrp: 0.587 ± 0.025	1.921GluTyr: 1.921 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.365PheAla: 3.365 ± 0.064	0.483PheCys: 0.483 ± 0.019	3.332PheAsp: 3.332 ± 0.049	3.112PheGlu: 3.112 ± 0.053	2.814PhePhe: 2.814 ± 0.066	3.67PheGly: 3.67 ± 0.072	0.778PheHis: 0.778 ± 0.026	4.284PheIle: 4.284 ± 0.066	4.308PheLys: 4.308 ± 0.062	4.928PheLeu: 4.928 ± 0.076	1.076PheMet: 1.076 ± 0.032	3.669PheAsn: 3.669 ± 0.06	1.779PhePro: 1.779 ± 0.047	1.509PheGln: 1.509 ± 0.035	1.631PheArg: 1.631 ± 0.048	4.106PheSer: 4.106 ± 0.065	3.16PheThr: 3.16 ± 0.053	2.858PheVal: 2.858 ± 0.051	0.601PheTrp: 0.601 ± 0.023	2.405PheTyr: 2.405 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.213GlyAla: 4.213 ± 0.079	0.568GlyCys: 0.568 ± 0.025	3.217GlyAsp: 3.217 ± 0.067	3.397GlyGlu: 3.397 ± 0.056	4.036GlyPhe: 4.036 ± 0.076	4.797GlyGly: 4.797 ± 0.12	0.982GlyHis: 0.982 ± 0.032	5.631GlyIle: 5.631 ± 0.087	5.365GlyLys: 5.365 ± 0.071	6.187GlyLeu: 6.187 ± 0.08	1.469GlyMet: 1.469 ± 0.035	4.006GlyAsn: 4.006 ± 0.073	1.308GlyPro: 1.308 ± 0.039	1.858GlyGln: 1.858 ± 0.04	2.115GlyArg: 2.115 ± 0.052	4.091GlySer: 4.091 ± 0.077	3.88GlyThr: 3.88 ± 0.089	4.011GlyVal: 4.011 ± 0.062	0.747GlyTrp: 0.747 ± 0.027	2.881GlyTyr: 2.881 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	0.791HisAla: 0.791 ± 0.025	0.167HisCys: 0.167 ± 0.012	0.746HisAsp: 0.746 ± 0.027	0.819HisGlu: 0.819 ± 0.027	1.086HisPhe: 1.086 ± 0.028	0.976HisGly: 0.976 ± 0.03	0.444HisHis: 0.444 ± 0.019	1.272HisIle: 1.272 ± 0.034	0.953HisLys: 0.953 ± 0.029	1.701HisLeu: 1.701 ± 0.04	0.237HisMet: 0.237 ± 0.014	0.833HisAsn: 0.833 ± 0.026	0.839HisPro: 0.839 ± 0.028	0.955HisGln: 0.955 ± 0.032	0.575HisArg: 0.575 ± 0.027	0.909HisSer: 0.909 ± 0.027	0.763HisThr: 0.763 ± 0.026	0.753HisVal: 0.753 ± 0.023	0.182HisTrp: 0.182 ± 0.014	0.73HisTyr: 0.73 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.823IleAla: 5.823 ± 0.076	0.783IleCys: 0.783 ± 0.03	4.92IleAsp: 4.92 ± 0.072	4.995IleGlu: 4.995 ± 0.077	4.067IlePhe: 4.067 ± 0.071	5.22IleGly: 5.22 ± 0.077	1.277IleHis: 1.277 ± 0.034	7.1IleIle: 7.1 ± 0.124	6.954IleLys: 6.954 ± 0.09	7.697IleLeu: 7.697 ± 0.093	1.482IleMet: 1.482 ± 0.037	5.78IleAsn: 5.78 ± 0.075	3.21IlePro: 3.21 ± 0.057	2.442IleGln: 2.442 ± 0.051	2.522IleArg: 2.522 ± 0.047	6.282IleSer: 6.282 ± 0.078	4.921IleThr: 4.921 ± 0.071	4.329IleVal: 4.329 ± 0.064	0.783IleTrp: 0.783 ± 0.03	3.251IleTyr: 3.251 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.241LysAla: 5.241 ± 0.075	0.343LysCys: 0.343 ± 0.018	4.885LysAsp: 4.885 ± 0.08	5.758LysGlu: 5.758 ± 0.08	3.407LysPhe: 3.407 ± 0.055	4.835LysGly: 4.835 ± 0.069	1.221LysHis: 1.221 ± 0.031	7.104LysIle: 7.104 ± 0.091	6.682LysLys: 6.682 ± 0.093	7.119LysLeu: 7.119 ± 0.081	2.057LysMet: 2.057 ± 0.047	5.909LysAsn: 5.909 ± 0.092	2.859LysPro: 2.859 ± 0.053	2.807LysGln: 2.807 ± 0.054	2.607LysArg: 2.607 ± 0.049	5.206LysSer: 5.206 ± 0.075	4.763LysThr: 4.763 ± 0.074	4.852LysVal: 4.852 ± 0.066	0.799LysTrp: 0.799 ± 0.028	3.209LysTyr: 3.209 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	6.14LeuAla: 6.14 ± 0.08	0.698LeuCys: 0.698 ± 0.028	4.956LeuAsp: 4.956 ± 0.07	5.317LeuGlu: 5.317 ± 0.074	4.811LeuPhe: 4.811 ± 0.09	5.774LeuGly: 5.774 ± 0.082	1.352LeuHis: 1.352 ± 0.036	8.06LeuIle: 8.06 ± 0.095	8.751LeuLys: 8.751 ± 0.108	8.582LeuLeu: 8.582 ± 0.109	2.131LeuMet: 2.131 ± 0.046	6.895LeuAsn: 6.895 ± 0.098	3.696LeuPro: 3.696 ± 0.054	3.131LeuGln: 3.131 ± 0.064	3.103LeuArg: 3.103 ± 0.053	7.096LeuSer: 7.096 ± 0.081	5.162LeuThr: 5.162 ± 0.076	5.049LeuVal: 5.049 ± 0.064	0.842LeuTrp: 0.842 ± 0.029	3.055LeuTyr: 3.055 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.592MetAla: 1.592 ± 0.039	0.129MetCys: 0.129 ± 0.01	1.198MetAsp: 1.198 ± 0.036	1.222MetGlu: 1.222 ± 0.033	0.843MetPhe: 0.843 ± 0.03	1.373MetGly: 1.373 ± 0.033	0.306MetHis: 0.306 ± 0.018	1.667MetIle: 1.667 ± 0.04	2.071MetLys: 2.071 ± 0.043	1.846MetLeu: 1.846 ± 0.047	0.601MetMet: 0.601 ± 0.026	1.199MetAsn: 1.199 ± 0.031	0.9MetPro: 0.9 ± 0.029	0.806MetGln: 0.806 ± 0.026	0.795MetArg: 0.795 ± 0.026	1.265MetSer: 1.265 ± 0.033	0.952MetThr: 0.952 ± 0.026	1.36MetVal: 1.36 ± 0.038	0.184MetTrp: 0.184 ± 0.014	0.564MetTyr: 0.564 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.966AsnAla: 3.966 ± 0.059	0.484AsnCys: 0.484 ± 0.021	3.35AsnAsp: 3.35 ± 0.059	3.465AsnGlu: 3.465 ± 0.059	3.529AsnPhe: 3.529 ± 0.054	4.558AsnGly: 4.558 ± 0.089	1.228AsnHis: 1.228 ± 0.035	5.553AsnIle: 5.553 ± 0.084	4.962AsnLys: 4.962 ± 0.074	6.461AsnLeu: 6.461 ± 0.079	1.22AsnMet: 1.22 ± 0.031	4.473AsnAsn: 4.473 ± 0.08	3.075AsnPro: 3.075 ± 0.05	2.947AsnGln: 2.947 ± 0.056	2.133AsnArg: 2.133 ± 0.044	4.206AsnSer: 4.206 ± 0.073	3.477AsnThr: 3.477 ± 0.07	3.412AsnVal: 3.412 ± 0.052	0.822AsnTrp: 0.822 ± 0.028	3.274AsnTyr: 3.274 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.169ProAla: 2.169 ± 0.044	0.199ProCys: 0.199 ± 0.012	2.035ProAsp: 2.035 ± 0.044	2.43ProGlu: 2.43 ± 0.047	1.972ProPhe: 1.972 ± 0.043	1.94ProGly: 1.94 ± 0.044	0.608ProHis: 0.608 ± 0.023	2.936ProIle: 2.936 ± 0.052	2.505ProLys: 2.505 ± 0.051	3.074ProLeu: 3.074 ± 0.053	0.631ProMet: 0.631 ± 0.027	2.47ProAsn: 2.47 ± 0.051	0.816ProPro: 0.816 ± 0.032	1.31ProGln: 1.31 ± 0.035	0.893ProArg: 0.893 ± 0.031	2.304ProSer: 2.304 ± 0.044	2.045ProThr: 2.045 ± 0.048	2.282ProVal: 2.282 ± 0.043	0.332ProTrp: 0.332 ± 0.017	1.48ProTyr: 1.48 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	2.138GlnAla: 2.138 ± 0.046	0.15GlnCys: 0.15 ± 0.011	1.672GlnAsp: 1.672 ± 0.038	2.133GlnGlu: 2.133 ± 0.044	1.78GlnPhe: 1.78 ± 0.044	1.782GlnGly: 1.782 ± 0.041	0.571GlnHis: 0.571 ± 0.022	3.1GlnIle: 3.1 ± 0.055	3.221GlnLys: 3.221 ± 0.067	3.472GlnLeu: 3.472 ± 0.056	0.768GlnMet: 0.768 ± 0.024	2.611GlnAsn: 2.611 ± 0.053	1.135GlnPro: 1.135 ± 0.033	1.646GlnGln: 1.646 ± 0.049	1.146GlnArg: 1.146 ± 0.031	2.188GlnSer: 2.188 ± 0.043	2.123GlnThr: 2.123 ± 0.045	1.853GlnVal: 1.853 ± 0.046	0.343GlnTrp: 0.343 ± 0.018	1.314GlnTyr: 1.314 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.829ArgAla: 1.829 ± 0.049	0.194ArgCys: 0.194 ± 0.012	1.732ArgAsp: 1.732 ± 0.041	1.892ArgGlu: 1.892 ± 0.04	1.892ArgPhe: 1.892 ± 0.037	1.853ArgGly: 1.853 ± 0.046	0.444ArgHis: 0.444 ± 0.018	2.767ArgIle: 2.767 ± 0.048	2.629ArgLys: 2.629 ± 0.054	3.14ArgLeu: 3.14 ± 0.063	0.78ArgMet: 0.78 ± 0.027	2.087ArgAsn: 2.087 ± 0.046	1.065ArgPro: 1.065 ± 0.04	1.016ArgGln: 1.016 ± 0.023	1.14ArgArg: 1.14 ± 0.035	1.841ArgSer: 1.841 ± 0.039	1.683ArgThr: 1.683 ± 0.036	1.934ArgVal: 1.934 ± 0.037	0.404ArgTrp: 0.404 ± 0.021	1.475ArgTyr: 1.475 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.118SerAla: 4.118 ± 0.07	0.575SerCys: 0.575 ± 0.021	3.362SerAsp: 3.362 ± 0.054	3.575SerGlu: 3.575 ± 0.055	4.075SerPhe: 4.075 ± 0.063	4.648SerGly: 4.648 ± 0.084	0.988SerHis: 0.988 ± 0.03	5.579SerIle: 5.579 ± 0.074	5.05SerLys: 5.05 ± 0.07	6.662SerLeu: 6.662 ± 0.081	1.16SerMet: 1.16 ± 0.033	4.096SerAsn: 4.096 ± 0.075	2.211SerPro: 2.211 ± 0.049	2.259SerGln: 2.259 ± 0.043	2.015SerArg: 2.015 ± 0.042	4.606SerSer: 4.606 ± 0.073	3.558SerThr: 3.558 ± 0.077	3.929SerVal: 3.929 ± 0.063	0.663SerTrp: 0.663 ± 0.024	2.881SerTyr: 2.881 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.959ThrAla: 3.959 ± 0.083	0.316ThrCys: 0.316 ± 0.018	3.165ThrAsp: 3.165 ± 0.056	3.0ThrGlu: 3.0 ± 0.057	2.982ThrPhe: 2.982 ± 0.066	4.211ThrGly: 4.211 ± 0.09	0.852ThrHis: 0.852 ± 0.027	4.544ThrIle: 4.544 ± 0.065	3.781ThrLys: 3.781 ± 0.052	5.223ThrLeu: 5.223 ± 0.069	0.889ThrMet: 0.889 ± 0.033	3.301ThrAsn: 3.301 ± 0.063	2.331ThrPro: 2.331 ± 0.051	1.924ThrGln: 1.924 ± 0.045	1.514ThrArg: 1.514 ± 0.034	3.85ThrSer: 3.85 ± 0.068	3.331ThrThr: 3.331 ± 0.082	3.457ThrVal: 3.457 ± 0.068	0.575ThrTrp: 0.575 ± 0.026	2.296ThrTyr: 2.296 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	3.963ValAla: 3.963 ± 0.065	0.518ValCys: 0.518 ± 0.023	3.168ValAsp: 3.168 ± 0.055	3.209ValGlu: 3.209 ± 0.061	3.169ValPhe: 3.169 ± 0.051	3.644ValGly: 3.644 ± 0.063	0.799ValHis: 0.799 ± 0.027	4.728ValIle: 4.728 ± 0.071	4.809ValLys: 4.809 ± 0.07	5.436ValLeu: 5.436 ± 0.071	1.28ValMet: 1.28 ± 0.038	3.908ValAsn: 3.908 ± 0.068	1.981ValPro: 1.981 ± 0.035	1.567ValGln: 1.567 ± 0.037	1.778ValArg: 1.778 ± 0.041	4.081ValSer: 4.081 ± 0.061	3.215ValThr: 3.215 ± 0.057	3.587ValVal: 3.587 ± 0.058	0.61ValTrp: 0.61 ± 0.025	2.38ValTyr: 2.38 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.631TrpAla: 0.631 ± 0.023	0.1TrpCys: 0.1 ± 0.009	0.638TrpAsp: 0.638 ± 0.029	0.638TrpGlu: 0.638 ± 0.027	0.583TrpPhe: 0.583 ± 0.023	0.695TrpGly: 0.695 ± 0.025	0.227TrpHis: 0.227 ± 0.015	0.78TrpIle: 0.78 ± 0.028	0.799TrpLys: 0.799 ± 0.028	1.006TrpLeu: 1.006 ± 0.032	0.301TrpMet: 0.301 ± 0.019	0.701TrpAsn: 0.701 ± 0.022	0.306TrpPro: 0.306 ± 0.017	0.429TrpGln: 0.429 ± 0.018	0.392TrpArg: 0.392 ± 0.021	0.618TrpSer: 0.618 ± 0.026	0.557TrpThr: 0.557 ± 0.024	0.58TrpVal: 0.58 ± 0.024	0.157TrpTrp: 0.157 ± 0.013	0.407TrpTyr: 0.407 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.57TyrAla: 2.57 ± 0.054	0.346TyrCys: 0.346 ± 0.02	2.232TyrAsp: 2.232 ± 0.043	2.067TyrGlu: 2.067 ± 0.045	2.534TyrPhe: 2.534 ± 0.044	2.644TyrGly: 2.644 ± 0.049	0.856TyrHis: 0.856 ± 0.026	2.757TyrIle: 2.757 ± 0.049	2.955TyrLys: 2.955 ± 0.048	4.061TyrLeu: 4.061 ± 0.062	0.644TyrMet: 0.644 ± 0.026	2.647TyrAsn: 2.647 ± 0.062	1.62TyrPro: 1.62 ± 0.039	2.11TyrGln: 2.11 ± 0.047	1.49TyrArg: 1.49 ± 0.037	2.753TyrSer: 2.753 ± 0.06	2.299TyrThr: 2.299 ± 0.052	2.042TyrVal: 2.042 ± 0.045	0.44TyrTrp: 0.44 ± 0.017	1.795TyrTyr: 1.795 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3388 proteins (1174662 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---