Amino acid dipepetide frequency for Marinoscillum sp. 108

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.142AlaAla: 5.142 ± 0.077	0.608AlaCys: 0.608 ± 0.022	4.04AlaAsp: 4.04 ± 0.059	4.52AlaGlu: 4.52 ± 0.069	3.507AlaPhe: 3.507 ± 0.053	5.416AlaGly: 5.416 ± 0.083	1.287AlaHis: 1.287 ± 0.032	4.778AlaIle: 4.778 ± 0.061	3.559AlaLys: 3.559 ± 0.063	6.876AlaLeu: 6.876 ± 0.081	1.729AlaMet: 1.729 ± 0.038	3.303AlaAsn: 3.303 ± 0.058	2.346AlaPro: 2.346 ± 0.046	2.735AlaGln: 2.735 ± 0.039	2.747AlaArg: 2.747 ± 0.047	4.882AlaSer: 4.882 ± 0.076	3.992AlaThr: 3.992 ± 0.068	4.333AlaVal: 4.333 ± 0.057	0.81AlaTrp: 0.81 ± 0.024	2.792AlaTyr: 2.792 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.472CysAla: 0.472 ± 0.017	0.098CysCys: 0.098 ± 0.008	0.417CysAsp: 0.417 ± 0.024	0.481CysGlu: 0.481 ± 0.018	0.387CysPhe: 0.387 ± 0.016	0.612CysGly: 0.612 ± 0.021	0.172CysHis: 0.172 ± 0.01	0.44CysIle: 0.44 ± 0.018	0.348CysLys: 0.348 ± 0.017	0.615CysLeu: 0.615 ± 0.022	0.174CysMet: 0.174 ± 0.011	0.284CysAsn: 0.284 ± 0.015	0.3CysPro: 0.3 ± 0.013	0.252CysGln: 0.252 ± 0.014	0.237CysArg: 0.237 ± 0.011	0.489CysSer: 0.489 ± 0.02	0.406CysThr: 0.406 ± 0.02	0.4CysVal: 0.4 ± 0.014	0.077CysTrp: 0.077 ± 0.007	0.255CysTyr: 0.255 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.704AspAla: 3.704 ± 0.053	0.388AspCys: 0.388 ± 0.02	3.129AspAsp: 3.129 ± 0.062	3.976AspGlu: 3.976 ± 0.065	3.626AspPhe: 3.626 ± 0.045	4.605AspGly: 4.605 ± 0.117	1.348AspHis: 1.348 ± 0.033	3.824AspIle: 3.824 ± 0.056	3.052AspLys: 3.052 ± 0.05	6.041AspLeu: 6.041 ± 0.082	1.25AspMet: 1.25 ± 0.03	2.569AspAsn: 2.569 ± 0.054	2.609AspPro: 2.609 ± 0.046	2.601AspGln: 2.601 ± 0.045	2.435AspArg: 2.435 ± 0.042	3.312AspSer: 3.312 ± 0.059	2.691AspThr: 2.691 ± 0.048	3.552AspVal: 3.552 ± 0.049	0.867AspTrp: 0.867 ± 0.027	2.706AspTyr: 2.706 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	4.983GluAla: 4.983 ± 0.065	0.334GluCys: 0.334 ± 0.017	3.728GluAsp: 3.728 ± 0.058	4.93GluGlu: 4.93 ± 0.089	2.659GluPhe: 2.659 ± 0.045	4.329GluGly: 4.329 ± 0.052	1.208GluHis: 1.208 ± 0.032	5.02GluIle: 5.02 ± 0.064	4.477GluLys: 4.477 ± 0.076	6.427GluLeu: 6.427 ± 0.082	1.746GluMet: 1.746 ± 0.035	3.51GluAsn: 3.51 ± 0.041	1.957GluPro: 1.957 ± 0.035	2.357GluGln: 2.357 ± 0.045	2.818GluArg: 2.818 ± 0.051	3.981GluSer: 3.981 ± 0.051	3.375GluThr: 3.375 ± 0.054	5.178GluVal: 5.178 ± 0.062	0.774GluTrp: 0.774 ± 0.021	2.408GluTyr: 2.408 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.971PheAla: 2.971 ± 0.048	0.377PheCys: 0.377 ± 0.015	3.358PheAsp: 3.358 ± 0.05	3.392PheGlu: 3.392 ± 0.049	2.499PhePhe: 2.499 ± 0.045	3.711PheGly: 3.711 ± 0.051	0.933PheHis: 0.933 ± 0.028	3.211PheIle: 3.211 ± 0.049	2.553PheLys: 2.553 ± 0.044	4.463PheLeu: 4.463 ± 0.064	1.086PheMet: 1.086 ± 0.028	2.521PheAsn: 2.521 ± 0.045	1.732PhePro: 1.732 ± 0.028	1.737PheGln: 1.737 ± 0.033	2.036PheArg: 2.036 ± 0.039	3.924PheSer: 3.924 ± 0.057	3.122PheThr: 3.122 ± 0.05	2.929PheVal: 2.929 ± 0.043	0.642PheTrp: 0.642 ± 0.021	2.034PheTyr: 2.034 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.167GlyAla: 5.167 ± 0.07	0.64GlyCys: 0.64 ± 0.023	4.228GlyAsp: 4.228 ± 0.085	4.276GlyGlu: 4.276 ± 0.06	3.728GlyPhe: 3.728 ± 0.052	5.541GlyGly: 5.541 ± 0.078	1.337GlyHis: 1.337 ± 0.029	5.135GlyIle: 5.135 ± 0.06	4.198GlyLys: 4.198 ± 0.061	6.814GlyLeu: 6.814 ± 0.08	1.839GlyMet: 1.839 ± 0.037	3.604GlyAsn: 3.604 ± 0.073	1.754GlyPro: 1.754 ± 0.035	2.589GlyGln: 2.589 ± 0.041	2.757GlyArg: 2.757 ± 0.047	5.017GlySer: 5.017 ± 0.089	4.599GlyThr: 4.599 ± 0.088	5.142GlyVal: 5.142 ± 0.062	1.023GlyTrp: 1.023 ± 0.03	3.086GlyTyr: 3.086 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.122HisAla: 1.122 ± 0.027	0.19HisCys: 0.19 ± 0.011	0.912HisAsp: 0.912 ± 0.025	1.189HisGlu: 1.189 ± 0.031	1.284HisPhe: 1.284 ± 0.031	1.256HisGly: 1.256 ± 0.035	0.598HisHis: 0.598 ± 0.022	1.268HisIle: 1.268 ± 0.032	0.886HisLys: 0.886 ± 0.022	2.117HisLeu: 2.117 ± 0.043	0.446HisMet: 0.446 ± 0.019	0.762HisAsn: 0.762 ± 0.024	1.053HisPro: 1.053 ± 0.027	0.949HisGln: 0.949 ± 0.028	0.822HisArg: 0.822 ± 0.023	1.21HisSer: 1.21 ± 0.029	1.019HisThr: 1.019 ± 0.025	1.074HisVal: 1.074 ± 0.024	0.272HisTrp: 0.272 ± 0.013	0.852HisTyr: 0.852 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.897IleAla: 4.897 ± 0.057	0.504IleCys: 0.504 ± 0.018	4.159IleAsp: 4.159 ± 0.053	4.407IleGlu: 4.407 ± 0.067	3.085IlePhe: 3.085 ± 0.048	5.019IleGly: 5.019 ± 0.065	1.414IleHis: 1.414 ± 0.033	4.383IleIle: 4.383 ± 0.073	4.019IleLys: 4.019 ± 0.066	6.319IleLeu: 6.319 ± 0.084	1.282IleMet: 1.282 ± 0.033	3.63IleAsn: 3.63 ± 0.054	2.979IlePro: 2.979 ± 0.048	2.415IleGln: 2.415 ± 0.04	3.18IleArg: 3.18 ± 0.045	5.576IleSer: 5.576 ± 0.071	4.44IleThr: 4.44 ± 0.07	3.987IleVal: 3.987 ± 0.056	0.77IleTrp: 0.77 ± 0.026	2.685IleTyr: 2.685 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.243LysAla: 4.243 ± 0.069	0.279LysCys: 0.279 ± 0.013	3.325LysAsp: 3.325 ± 0.061	4.442LysGlu: 4.442 ± 0.074	2.15LysPhe: 2.15 ± 0.04	3.824LysGly: 3.824 ± 0.057	1.041LysHis: 1.041 ± 0.027	4.152LysIle: 4.152 ± 0.066	4.266LysLys: 4.266 ± 0.071	5.19LysLeu: 5.19 ± 0.072	1.649LysMet: 1.649 ± 0.036	3.03LysAsn: 3.03 ± 0.046	2.091LysPro: 2.091 ± 0.041	1.854LysGln: 1.854 ± 0.039	2.419LysArg: 2.419 ± 0.048	3.938LysSer: 3.938 ± 0.057	3.296LysThr: 3.296 ± 0.041	4.112LysVal: 4.112 ± 0.052	0.706LysTrp: 0.706 ± 0.02	2.361LysTyr: 2.361 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	6.65LeuAla: 6.65 ± 0.073	0.671LeuCys: 0.671 ± 0.019	5.405LeuAsp: 5.405 ± 0.062	6.233LeuGlu: 6.233 ± 0.085	4.478LeuPhe: 4.478 ± 0.067	6.398LeuGly: 6.398 ± 0.072	1.646LeuHis: 1.646 ± 0.038	6.968LeuIle: 6.968 ± 0.084	6.343LeuLys: 6.343 ± 0.081	8.95LeuLeu: 8.95 ± 0.117	2.389LeuMet: 2.389 ± 0.043	4.904LeuAsn: 4.904 ± 0.064	3.778LeuPro: 3.778 ± 0.051	3.175LeuGln: 3.175 ± 0.052	3.768LeuArg: 3.768 ± 0.051	7.665LeuSer: 7.665 ± 0.089	5.903LeuThr: 5.903 ± 0.076	5.977LeuVal: 5.977 ± 0.066	0.985LeuTrp: 0.985 ± 0.027	3.294LeuTyr: 3.294 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.901MetAla: 1.901 ± 0.034	0.127MetCys: 0.127 ± 0.009	1.424MetAsp: 1.424 ± 0.03	1.63MetGlu: 1.63 ± 0.034	0.728MetPhe: 0.728 ± 0.025	1.697MetGly: 1.697 ± 0.032	0.407MetHis: 0.407 ± 0.016	1.732MetIle: 1.732 ± 0.037	1.96MetLys: 1.96 ± 0.039	1.988MetLeu: 1.988 ± 0.042	0.707MetMet: 0.707 ± 0.025	1.271MetAsn: 1.271 ± 0.027	0.933MetPro: 0.933 ± 0.027	0.691MetGln: 0.691 ± 0.02	1.078MetArg: 1.078 ± 0.028	1.601MetSer: 1.601 ± 0.031	1.361MetThr: 1.361 ± 0.028	1.715MetVal: 1.715 ± 0.032	0.193MetTrp: 0.193 ± 0.01	0.642MetTyr: 0.642 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.347AsnAla: 3.347 ± 0.052	0.356AsnCys: 0.356 ± 0.018	2.856AsnAsp: 2.856 ± 0.06	3.12AsnGlu: 3.12 ± 0.047	2.323AsnPhe: 2.323 ± 0.046	3.852AsnGly: 3.852 ± 0.063	1.024AsnHis: 1.024 ± 0.025	3.393AsnIle: 3.393 ± 0.057	2.511AsnLys: 2.511 ± 0.043	4.795AsnLeu: 4.795 ± 0.064	1.096AsnMet: 1.096 ± 0.025	2.535AsnAsn: 2.535 ± 0.058	2.617AsnPro: 2.617 ± 0.048	2.188AsnGln: 2.188 ± 0.041	2.06AsnArg: 2.06 ± 0.038	3.132AsnSer: 3.132 ± 0.055	2.946AsnThr: 2.946 ± 0.06	2.914AsnVal: 2.914 ± 0.05	0.711AsnTrp: 0.711 ± 0.025	2.262AsnTyr: 2.262 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.688ProAla: 2.688 ± 0.039	0.187ProCys: 0.187 ± 0.012	2.673ProAsp: 2.673 ± 0.041	3.258ProGlu: 3.258 ± 0.046	1.845ProPhe: 1.845 ± 0.034	2.79ProGly: 2.79 ± 0.047	0.681ProHis: 0.681 ± 0.023	2.448ProIle: 2.448 ± 0.044	2.034ProLys: 2.034 ± 0.04	3.163ProLeu: 3.163 ± 0.045	0.862ProMet: 0.862 ± 0.026	1.975ProAsn: 1.975 ± 0.038	1.115ProPro: 1.115 ± 0.031	1.22ProGln: 1.22 ± 0.027	1.18ProArg: 1.18 ± 0.029	2.478ProSer: 2.478 ± 0.044	2.157ProThr: 2.157 ± 0.039	2.859ProVal: 2.859 ± 0.046	0.448ProTrp: 0.448 ± 0.02	1.503ProTyr: 1.503 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.453GlnAla: 2.453 ± 0.043	0.19GlnCys: 0.19 ± 0.012	1.828GlnAsp: 1.828 ± 0.032	2.465GlnGlu: 2.465 ± 0.041	1.635GlnPhe: 1.635 ± 0.029	2.211GlnGly: 2.211 ± 0.044	0.665GlnHis: 0.665 ± 0.019	2.536GlnIle: 2.536 ± 0.043	2.458GlnLys: 2.458 ± 0.046	3.76GlnLeu: 3.76 ± 0.06	1.005GlnMet: 1.005 ± 0.026	1.961GlnAsn: 1.961 ± 0.036	1.344GlnPro: 1.344 ± 0.03	1.515GlnGln: 1.515 ± 0.033	1.477GlnArg: 1.477 ± 0.03	2.421GlnSer: 2.421 ± 0.042	2.049GlnThr: 2.049 ± 0.039	2.47GlnVal: 2.47 ± 0.043	0.515GlnTrp: 0.515 ± 0.02	1.528GlnTyr: 1.528 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.593ArgAla: 2.593 ± 0.042	0.221ArgCys: 0.221 ± 0.012	2.128ArgAsp: 2.128 ± 0.043	2.739ArgGlu: 2.739 ± 0.053	2.125ArgPhe: 2.125 ± 0.036	2.276ArgGly: 2.276 ± 0.036	0.738ArgHis: 0.738 ± 0.022	3.063ArgIle: 3.063 ± 0.046	2.887ArgLys: 2.887 ± 0.047	4.041ArgLeu: 4.041 ± 0.061	1.191ArgMet: 1.191 ± 0.032	2.146ArgAsn: 2.146 ± 0.037	1.409ArgPro: 1.409 ± 0.031	1.442ArgGln: 1.442 ± 0.034	1.692ArgArg: 1.692 ± 0.037	2.616ArgSer: 2.616 ± 0.04	2.098ArgThr: 2.098 ± 0.041	2.781ArgVal: 2.781 ± 0.043	0.543ArgTrp: 0.543 ± 0.019	1.801ArgTyr: 1.801 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.895SerAla: 4.895 ± 0.07	0.542SerCys: 0.542 ± 0.02	4.105SerAsp: 4.105 ± 0.062	4.394SerGlu: 4.394 ± 0.058	3.808SerPhe: 3.808 ± 0.052	6.193SerGly: 6.193 ± 0.102	1.27SerHis: 1.27 ± 0.028	4.829SerIle: 4.829 ± 0.064	3.539SerLys: 3.539 ± 0.051	6.818SerLeu: 6.818 ± 0.087	1.531SerMet: 1.531 ± 0.034	3.262SerAsn: 3.262 ± 0.062	2.571SerPro: 2.571 ± 0.047	2.369SerGln: 2.369 ± 0.036	2.747SerArg: 2.747 ± 0.046	4.956SerSer: 4.956 ± 0.095	3.871SerThr: 3.871 ± 0.068	4.617SerVal: 4.617 ± 0.062	0.946SerTrp: 0.946 ± 0.026	2.819SerTyr: 2.819 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.113ThrAla: 4.113 ± 0.068	0.342ThrCys: 0.342 ± 0.015	3.431ThrAsp: 3.431 ± 0.064	3.352ThrGlu: 3.352 ± 0.053	3.077ThrPhe: 3.077 ± 0.059	4.621ThrGly: 4.621 ± 0.077	1.13ThrHis: 1.13 ± 0.03	4.233ThrIle: 4.233 ± 0.071	2.735ThrLys: 2.735 ± 0.047	5.787ThrLeu: 5.787 ± 0.074	1.111ThrMet: 1.111 ± 0.026	2.762ThrAsn: 2.762 ± 0.053	2.562ThrPro: 2.562 ± 0.041	1.883ThrGln: 1.883 ± 0.035	2.088ThrArg: 2.088 ± 0.031	4.075ThrSer: 4.075 ± 0.063	3.339ThrThr: 3.339 ± 0.064	3.939ThrVal: 3.939 ± 0.07	0.729ThrTrp: 0.729 ± 0.023	2.568ThrTyr: 2.568 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	4.613ValAla: 4.613 ± 0.055	0.471ValCys: 0.471 ± 0.017	3.868ValAsp: 3.868 ± 0.059	3.993ValGlu: 3.993 ± 0.054	3.351ValPhe: 3.351 ± 0.053	4.475ValGly: 4.475 ± 0.06	1.096ValHis: 1.096 ± 0.027	4.765ValIle: 4.765 ± 0.061	3.82ValLys: 3.82 ± 0.059	6.131ValLeu: 6.131 ± 0.053	1.563ValMet: 1.563 ± 0.033	3.367ValAsn: 3.367 ± 0.055	2.424ValPro: 2.424 ± 0.039	2.004ValGln: 2.004 ± 0.04	2.584ValArg: 2.584 ± 0.04	5.207ValSer: 5.207 ± 0.073	4.12ValThr: 4.12 ± 0.071	4.61ValVal: 4.61 ± 0.068	0.729ValTrp: 0.729 ± 0.02	2.531ValTyr: 2.531 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.828TrpAla: 0.828 ± 0.027	0.091TrpCys: 0.091 ± 0.008	0.721TrpAsp: 0.721 ± 0.023	0.801TrpGlu: 0.801 ± 0.024	0.551TrpPhe: 0.551 ± 0.02	0.89TrpGly: 0.89 ± 0.028	0.279TrpHis: 0.279 ± 0.014	0.816TrpIle: 0.816 ± 0.023	0.755TrpLys: 0.755 ± 0.024	1.138TrpLeu: 1.138 ± 0.03	0.361TrpMet: 0.361 ± 0.013	0.668TrpAsn: 0.668 ± 0.02	0.37TrpPro: 0.37 ± 0.017	0.469TrpGln: 0.469 ± 0.018	0.511TrpArg: 0.511 ± 0.021	0.873TrpSer: 0.873 ± 0.029	0.736TrpThr: 0.736 ± 0.028	0.898TrpVal: 0.898 ± 0.025	0.215TrpTrp: 0.215 ± 0.013	0.524TrpTyr: 0.524 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.621TyrAla: 2.621 ± 0.04	0.3TyrCys: 0.3 ± 0.015	2.551TyrAsp: 2.551 ± 0.048	2.599TyrGlu: 2.599 ± 0.046	2.385TyrPhe: 2.385 ± 0.043	2.759TyrGly: 2.759 ± 0.047	1.007TyrHis: 1.007 ± 0.026	2.155TyrIle: 2.155 ± 0.04	1.969TyrLys: 1.969 ± 0.038	4.149TyrLeu: 4.149 ± 0.056	0.768TyrMet: 0.768 ± 0.018	1.971TyrAsn: 1.971 ± 0.046	1.622TyrPro: 1.622 ± 0.034	2.036TyrGln: 2.036 ± 0.034	1.894TyrArg: 1.894 ± 0.042	2.732TyrSer: 2.732 ± 0.051	2.357TyrThr: 2.357 ± 0.048	2.235TyrVal: 2.235 ± 0.04	0.542TyrTrp: 0.542 ± 0.016	1.886TyrTyr: 1.886 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4475 proteins (1608423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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