Amino acid dipepetide frequency for Streptococcus infantis SK970

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.394AlaAla: 5.394 ± 0.14
0.48AlaCys: 0.48 ± 0.027
4.153AlaAsp: 4.153 ± 0.109
5.419AlaGlu: 5.419 ± 0.118
3.333AlaPhe: 3.333 ± 0.084
5.307AlaGly: 5.307 ± 0.093
1.263AlaHis: 1.263 ± 0.055
5.516AlaIle: 5.516 ± 0.099
5.25AlaLys: 5.25 ± 0.118
7.295AlaLeu: 7.295 ± 0.139
1.861AlaMet: 1.861 ± 0.062
3.12AlaAsn: 3.12 ± 0.083
2.314AlaPro: 2.314 ± 0.081
3.074AlaGln: 3.074 ± 0.096
2.867AlaArg: 2.867 ± 0.075
4.611AlaSer: 4.611 ± 0.092
4.398AlaThr: 4.398 ± 0.129
5.215AlaVal: 5.215 ± 0.114
0.643AlaTrp: 0.643 ± 0.034
2.582AlaTyr: 2.582 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.296CysAla: 0.296 ± 0.026
0.06CysCys: 0.06 ± 0.012
0.298CysAsp: 0.298 ± 0.025
0.278CysGlu: 0.278 ± 0.026
0.23CysPhe: 0.23 ± 0.021
0.478CysGly: 0.478 ± 0.031
0.167CysHis: 0.167 ± 0.021
0.354CysIle: 0.354 ± 0.025
0.303CysLys: 0.303 ± 0.027
0.597CysLeu: 0.597 ± 0.04
0.145CysMet: 0.145 ± 0.015
0.19CysAsn: 0.19 ± 0.021
0.255CysPro: 0.255 ± 0.023
0.34CysGln: 0.34 ± 0.027
0.248CysArg: 0.248 ± 0.02
0.333CysSer: 0.333 ± 0.025
0.239CysThr: 0.239 ± 0.023
0.307CysVal: 0.307 ± 0.023
0.053CysTrp: 0.053 ± 0.009
0.26CysTyr: 0.26 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.758AspAla: 3.758 ± 0.084
0.291AspCys: 0.291 ± 0.023
2.784AspAsp: 2.784 ± 0.082
4.315AspGlu: 4.315 ± 0.098
3.253AspPhe: 3.253 ± 0.08
4.178AspGly: 4.178 ± 0.114
1.028AspHis: 1.028 ± 0.048
4.143AspIle: 4.143 ± 0.092
4.593AspLys: 4.593 ± 0.11
5.909AspLeu: 5.909 ± 0.111
1.469AspMet: 1.469 ± 0.049
2.323AspAsn: 2.323 ± 0.078
1.859AspPro: 1.859 ± 0.084
2.25AspGln: 2.25 ± 0.072
2.123AspArg: 2.123 ± 0.059
3.096AspSer: 3.096 ± 0.076
2.72AspThr: 2.72 ± 0.076
3.78AspVal: 3.78 ± 0.095
0.64AspTrp: 0.64 ± 0.037
2.871AspTyr: 2.871 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
5.688GluAla: 5.688 ± 0.127
0.322GluCys: 0.322 ± 0.028
3.974GluAsp: 3.974 ± 0.104
6.717GluGlu: 6.717 ± 0.167
3.009GluPhe: 3.009 ± 0.088
4.109GluGly: 4.109 ± 0.083
1.295GluHis: 1.295 ± 0.063
5.532GluIle: 5.532 ± 0.113
6.634GluLys: 6.634 ± 0.12
7.247GluLeu: 7.247 ± 0.133
1.866GluMet: 1.866 ± 0.053
4.267GluAsn: 4.267 ± 0.092
1.944GluPro: 1.944 ± 0.105
2.995GluGln: 2.995 ± 0.084
3.361GluArg: 3.361 ± 0.087
3.636GluSer: 3.636 ± 0.086
4.084GluThr: 4.084 ± 0.086
5.248GluVal: 5.248 ± 0.114
0.68GluTrp: 0.68 ± 0.037
2.249GluTyr: 2.249 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
3.25PheAla: 3.25 ± 0.081
0.285PheCys: 0.285 ± 0.026
3.067PheAsp: 3.067 ± 0.075
3.285PheGlu: 3.285 ± 0.086
2.018PhePhe: 2.018 ± 0.078
3.034PheGly: 3.034 ± 0.08
0.813PheHis: 0.813 ± 0.038
2.993PheIle: 2.993 ± 0.089
2.575PheLys: 2.575 ± 0.059
4.651PheLeu: 4.651 ± 0.116
1.129PheMet: 1.129 ± 0.043
1.972PheAsn: 1.972 ± 0.07
1.511PhePro: 1.511 ± 0.054
1.63PheGln: 1.63 ± 0.061
1.474PheArg: 1.474 ± 0.05
3.083PheSer: 3.083 ± 0.069
2.557PheThr: 2.557 ± 0.077
3.147PheVal: 3.147 ± 0.086
0.493PheTrp: 0.493 ± 0.028
1.898PheTyr: 1.898 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.71GlyAla: 4.71 ± 0.102
0.386GlyCys: 0.386 ± 0.027
3.512GlyAsp: 3.512 ± 0.089
4.111GlyGlu: 4.111 ± 0.104
3.22GlyPhe: 3.22 ± 0.094
4.198GlyGly: 4.198 ± 0.127
1.301GlyHis: 1.301 ± 0.053
5.247GlyIle: 5.247 ± 0.111
4.77GlyLys: 4.77 ± 0.091
6.533GlyLeu: 6.533 ± 0.123
1.77GlyMet: 1.77 ± 0.051
2.791GlyAsn: 2.791 ± 0.074
1.375GlyPro: 1.375 ± 0.052
2.964GlyGln: 2.964 ± 0.083
2.739GlyArg: 2.739 ± 0.077
3.719GlySer: 3.719 ± 0.091
4.028GlyThr: 4.028 ± 0.145
5.068GlyVal: 5.068 ± 0.107
0.67GlyTrp: 0.67 ± 0.051
2.615GlyTyr: 2.615 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.15HisAla: 1.15 ± 0.046
0.096HisCys: 0.096 ± 0.015
0.967HisAsp: 0.967 ± 0.041
1.173HisGlu: 1.173 ± 0.052
0.976HisPhe: 0.976 ± 0.039
1.288HisGly: 1.288 ± 0.056
0.542HisHis: 0.542 ± 0.037
1.27HisIle: 1.27 ± 0.054
1.038HisLys: 1.038 ± 0.043
1.983HisLeu: 1.983 ± 0.061
0.413HisMet: 0.413 ± 0.027
0.714HisAsn: 0.714 ± 0.037
0.911HisPro: 0.911 ± 0.048
0.815HisGln: 0.815 ± 0.033
0.81HisArg: 0.81 ± 0.037
1.01HisSer: 1.01 ± 0.042
0.902HisThr: 0.902 ± 0.04
1.157HisVal: 1.157 ± 0.052
0.17HisTrp: 0.17 ± 0.017
0.92HisTyr: 0.92 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.608IleAla: 5.608 ± 0.12
0.521IleCys: 0.521 ± 0.035
4.18IleAsp: 4.18 ± 0.1
5.112IleGlu: 5.112 ± 0.109
3.377IlePhe: 3.377 ± 0.096
4.708IleGly: 4.708 ± 0.1
1.34IleHis: 1.34 ± 0.046
4.765IleIle: 4.765 ± 0.127
4.476IleLys: 4.476 ± 0.091
7.1IleLeu: 7.1 ± 0.156
1.527IleMet: 1.527 ± 0.058
2.84IleAsn: 2.84 ± 0.085
2.876IlePro: 2.876 ± 0.073
2.879IleGln: 2.879 ± 0.082
2.94IleArg: 2.94 ± 0.071
4.729IleSer: 4.729 ± 0.105
3.806IleThr: 3.806 ± 0.088
4.621IleVal: 4.621 ± 0.104
0.624IleTrp: 0.624 ± 0.032
2.575IleTyr: 2.575 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
5.217LysAla: 5.217 ± 0.114
0.204LysCys: 0.204 ± 0.021
4.412LysAsp: 4.412 ± 0.09
6.553LysGlu: 6.553 ± 0.116
2.151LysPhe: 2.151 ± 0.075
4.15LysGly: 4.15 ± 0.096
1.224LysHis: 1.224 ± 0.046
4.756LysIle: 4.756 ± 0.104
5.185LysLys: 5.185 ± 0.102
6.039LysLeu: 6.039 ± 0.111
1.938LysMet: 1.938 ± 0.06
3.585LysAsn: 3.585 ± 0.088
2.371LysPro: 2.371 ± 0.096
2.92LysGln: 2.92 ± 0.082
3.197LysArg: 3.197 ± 0.089
3.891LysSer: 3.891 ± 0.094
3.982LysThr: 3.982 ± 0.082
4.775LysVal: 4.775 ± 0.105
0.673LysTrp: 0.673 ± 0.045
2.27LysTyr: 2.27 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
8.456LeuAla: 8.456 ± 0.132
0.498LeuCys: 0.498 ± 0.032
5.799LeuAsp: 5.799 ± 0.118
7.336LeuGlu: 7.336 ± 0.14
4.159LeuPhe: 4.159 ± 0.105
6.409LeuGly: 6.409 ± 0.13
1.556LeuHis: 1.556 ± 0.055
6.198LeuIle: 6.198 ± 0.133
6.62LeuLys: 6.62 ± 0.117
9.561LeuLeu: 9.561 ± 0.203
2.362LeuMet: 2.362 ± 0.065
4.175LeuAsn: 4.175 ± 0.091
4.031LeuPro: 4.031 ± 0.08
3.469LeuGln: 3.469 ± 0.089
3.797LeuArg: 3.797 ± 0.105
6.967LeuSer: 6.967 ± 0.125
6.087LeuThr: 6.087 ± 0.113
6.891LeuVal: 6.891 ± 0.134
0.711LeuTrp: 0.711 ± 0.037
3.071LeuTyr: 3.071 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
1.848MetAla: 1.848 ± 0.061
0.131MetCys: 0.131 ± 0.014
1.43MetAsp: 1.43 ± 0.049
1.575MetGlu: 1.575 ± 0.059
0.81MetPhe: 0.81 ± 0.043
1.648MetGly: 1.648 ± 0.063
0.322MetHis: 0.322 ± 0.023
2.004MetIle: 2.004 ± 0.068
2.061MetLys: 2.061 ± 0.065
2.238MetLeu: 2.238 ± 0.067
0.707MetMet: 0.707 ± 0.039
1.329MetAsn: 1.329 ± 0.05
0.755MetPro: 0.755 ± 0.035
0.854MetGln: 0.854 ± 0.038
0.994MetArg: 0.994 ± 0.043
1.604MetSer: 1.604 ± 0.064
1.876MetThr: 1.876 ± 0.053
1.667MetVal: 1.667 ± 0.057
0.165MetTrp: 0.165 ± 0.017
0.594MetTyr: 0.594 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.122AsnAla: 3.122 ± 0.09
0.26AsnCys: 0.26 ± 0.023
2.325AsnAsp: 2.325 ± 0.077
2.587AsnGlu: 2.587 ± 0.064
2.024AsnPhe: 2.024 ± 0.059
3.51AsnGly: 3.51 ± 0.101
1.017AsnHis: 1.017 ± 0.041
3.048AsnIle: 3.048 ± 0.089
2.814AsnLys: 2.814 ± 0.09
4.52AsnLeu: 4.52 ± 0.103
1.193AsnMet: 1.193 ± 0.043
1.905AsnAsn: 1.905 ± 0.096
2.381AsnPro: 2.381 ± 0.072
2.265AsnGln: 2.265 ± 0.066
2.103AsnArg: 2.103 ± 0.07
2.513AsnSer: 2.513 ± 0.073
2.238AsnThr: 2.238 ± 0.067
2.709AsnVal: 2.709 ± 0.072
0.581AsnTrp: 0.581 ± 0.037
1.876AsnTyr: 1.876 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.553ProAla: 2.553 ± 0.106
0.184ProCys: 0.184 ± 0.019
2.229ProAsp: 2.229 ± 0.081
3.344ProGlu: 3.344 ± 0.125
1.602ProPhe: 1.602 ± 0.069
1.93ProGly: 1.93 ± 0.072
0.707ProHis: 0.707 ± 0.037
2.436ProIle: 2.436 ± 0.072
2.155ProLys: 2.155 ± 0.075
2.83ProLeu: 2.83 ± 0.07
0.765ProMet: 0.765 ± 0.04
1.657ProAsn: 1.657 ± 0.069
0.62ProPro: 0.62 ± 0.049
1.364ProGln: 1.364 ± 0.054
1.067ProArg: 1.067 ± 0.04
2.266ProSer: 2.266 ± 0.083
2.318ProThr: 2.318 ± 0.143
2.741ProVal: 2.741 ± 0.092
0.285ProTrp: 0.285 ± 0.023
1.398ProTyr: 1.398 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
3.705GlnAla: 3.705 ± 0.093
0.122GlnCys: 0.122 ± 0.016
2.266GlnAsp: 2.266 ± 0.071
3.68GlnGlu: 3.68 ± 0.096
1.65GlnPhe: 1.65 ± 0.059
2.392GlnGly: 2.392 ± 0.069
0.663GlnHis: 0.663 ± 0.037
2.823GlnIle: 2.823 ± 0.074
2.947GlnLys: 2.947 ± 0.076
4.02GlnLeu: 4.02 ± 0.096
1.021GlnMet: 1.021 ± 0.038
1.839GlnAsn: 1.839 ± 0.056
1.283GlnPro: 1.283 ± 0.055
1.4GlnGln: 1.4 ± 0.054
1.402GlnArg: 1.402 ± 0.055
2.185GlnSer: 2.185 ± 0.063
2.355GlnThr: 2.355 ± 0.068
3.298GlnVal: 3.298 ± 0.087
0.34GlnTrp: 0.34 ± 0.026
1.285GlnTyr: 1.285 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
2.461ArgAla: 2.461 ± 0.069
0.195ArgCys: 0.195 ± 0.02
2.25ArgAsp: 2.25 ± 0.072
3.255ArgGlu: 3.255 ± 0.1
2.098ArgPhe: 2.098 ± 0.071
2.298ArgGly: 2.298 ± 0.064
0.748ArgHis: 0.748 ± 0.036
2.959ArgIle: 2.959 ± 0.078
3.106ArgLys: 3.106 ± 0.083
4.035ArgLeu: 4.035 ± 0.099
1.118ArgMet: 1.118 ± 0.043
1.829ArgAsn: 1.829 ± 0.062
1.315ArgPro: 1.315 ± 0.049
1.79ArgGln: 1.79 ± 0.066
1.926ArgArg: 1.926 ± 0.08
2.121ArgSer: 2.121 ± 0.07
2.047ArgThr: 2.047 ± 0.064
2.773ArgVal: 2.773 ± 0.082
0.321ArgTrp: 0.321 ± 0.024
1.71ArgTyr: 1.71 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.783SerAla: 3.783 ± 0.095
0.388SerCys: 0.388 ± 0.031
3.48SerAsp: 3.48 ± 0.095
3.859SerGlu: 3.859 ± 0.09
2.947SerPhe: 2.947 ± 0.087
4.288SerGly: 4.288 ± 0.098
1.2SerHis: 1.2 ± 0.046
4.244SerIle: 4.244 ± 0.1
3.943SerLys: 3.943 ± 0.094
6.494SerLeu: 6.494 ± 0.121
1.48SerMet: 1.48 ± 0.053
2.674SerAsn: 2.674 ± 0.068
1.979SerPro: 1.979 ± 0.062
2.807SerGln: 2.807 ± 0.075
2.468SerArg: 2.468 ± 0.066
4.091SerSer: 4.091 ± 0.113
3.322SerThr: 3.322 ± 0.104
4.067SerVal: 4.067 ± 0.095
0.624SerTrp: 0.624 ± 0.033
2.667SerTyr: 2.667 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
4.261ThrAla: 4.261 ± 0.121
0.331ThrCys: 0.331 ± 0.026
3.294ThrAsp: 3.294 ± 0.089
3.873ThrGlu: 3.873 ± 0.107
2.621ThrPhe: 2.621 ± 0.084
4.299ThrGly: 4.299 ± 0.118
0.944ThrHis: 0.944 ± 0.042
4.368ThrIle: 4.368 ± 0.088
3.521ThrLys: 3.521 ± 0.094
5.183ThrLeu: 5.183 ± 0.103
1.187ThrMet: 1.187 ± 0.046
2.507ThrAsn: 2.507 ± 0.074
2.64ThrPro: 2.64 ± 0.189
1.923ThrGln: 1.923 ± 0.068
2.047ThrArg: 2.047 ± 0.06
3.836ThrSer: 3.836 ± 0.118
4.189ThrThr: 4.189 ± 0.366
4.639ThrVal: 4.639 ± 0.176
0.507ThrTrp: 0.507 ± 0.03
2.27ThrTyr: 2.27 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
5.823ValAla: 5.823 ± 0.117
0.395ValCys: 0.395 ± 0.026
4.079ValAsp: 4.079 ± 0.086
5.374ValGlu: 5.374 ± 0.108
2.984ValPhe: 2.984 ± 0.091
4.502ValGly: 4.502 ± 0.101
1.154ValHis: 1.154 ± 0.05
4.965ValIle: 4.965 ± 0.102
4.536ValLys: 4.536 ± 0.098
6.724ValLeu: 6.724 ± 0.104
1.604ValMet: 1.604 ± 0.058
3.087ValAsn: 3.087 ± 0.084
2.436ValPro: 2.436 ± 0.095
2.327ValGln: 2.327 ± 0.068
2.725ValArg: 2.725 ± 0.08
4.345ValSer: 4.345 ± 0.09
4.768ValThr: 4.768 ± 0.169
5.077ValVal: 5.077 ± 0.11
0.542ValTrp: 0.542 ± 0.033
2.424ValTyr: 2.424 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.542TrpAla: 0.542 ± 0.028
0.051TrpCys: 0.051 ± 0.009
0.571TrpAsp: 0.571 ± 0.037
0.587TrpGlu: 0.587 ± 0.034
0.475TrpPhe: 0.475 ± 0.032
0.587TrpGly: 0.587 ± 0.032
0.154TrpHis: 0.154 ± 0.016
0.656TrpIle: 0.656 ± 0.034
0.689TrpLys: 0.689 ± 0.037
0.973TrpLeu: 0.973 ± 0.045
0.276TrpMet: 0.276 ± 0.024
0.549TrpAsn: 0.549 ± 0.031
0.17TrpPro: 0.17 ± 0.016
0.42TrpGln: 0.42 ± 0.026
0.36TrpArg: 0.36 ± 0.025
0.595TrpSer: 0.595 ± 0.035
0.48TrpThr: 0.48 ± 0.033
0.526TrpVal: 0.526 ± 0.035
0.131TrpTrp: 0.131 ± 0.018
0.429TrpTyr: 0.429 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.47TyrAla: 2.47 ± 0.072
0.23TyrCys: 0.23 ± 0.022
2.309TyrAsp: 2.309 ± 0.069
2.426TyrGlu: 2.426 ± 0.064
1.93TyrPhe: 1.93 ± 0.053
2.413TyrGly: 2.413 ± 0.074
0.868TyrHis: 0.868 ± 0.045
2.328TyrIle: 2.328 ± 0.07
2.277TyrLys: 2.277 ± 0.07
4.219TyrLeu: 4.219 ± 0.098
0.78TyrMet: 0.78 ± 0.039
1.639TyrAsn: 1.639 ± 0.055
1.425TyrPro: 1.425 ± 0.049
2.188TyrGln: 2.188 ± 0.062
1.706TyrArg: 1.706 ± 0.057
2.172TyrSer: 2.172 ± 0.057
2.047TyrThr: 2.047 ± 0.084
2.165TyrVal: 2.165 ± 0.057
0.369TyrTrp: 0.369 ± 0.024
1.713TyrTyr: 1.713 ± 0.084
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2144 proteins (564361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski