Amino acid dipepetide frequency for Puniceispirillum marinum (strain IMCC1322)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.043AlaAla: 12.043 ± 0.186	1.111AlaCys: 1.111 ± 0.042	7.539AlaAsp: 7.539 ± 0.143	6.047AlaGlu: 6.047 ± 0.097	3.927AlaPhe: 3.927 ± 0.081	9.197AlaGly: 9.197 ± 0.137	2.615AlaHis: 2.615 ± 0.071	6.765AlaIle: 6.765 ± 0.102	4.602AlaLys: 4.602 ± 0.079	10.88AlaLeu: 10.88 ± 0.152	3.435AlaMet: 3.435 ± 0.069	3.482AlaAsn: 3.482 ± 0.08	4.391AlaPro: 4.391 ± 0.102	3.344AlaGln: 3.344 ± 0.065	6.044AlaArg: 6.044 ± 0.108	6.913AlaSer: 6.913 ± 0.11	5.594AlaThr: 5.594 ± 0.111	7.264AlaVal: 7.264 ± 0.105	1.147AlaTrp: 1.147 ± 0.04	2.424AlaTyr: 2.424 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.994CysAla: 0.994 ± 0.041	0.124CysCys: 0.124 ± 0.011	0.719CysAsp: 0.719 ± 0.033	0.442CysGlu: 0.442 ± 0.02	0.447CysPhe: 0.447 ± 0.025	1.015CysGly: 1.015 ± 0.041	0.329CysHis: 0.329 ± 0.02	0.514CysIle: 0.514 ± 0.027	0.336CysLys: 0.336 ± 0.022	0.992CysLeu: 0.992 ± 0.038	0.249CysMet: 0.249 ± 0.018	0.328CysAsn: 0.328 ± 0.021	0.485CysPro: 0.485 ± 0.026	0.333CysGln: 0.333 ± 0.021	0.581CysArg: 0.581 ± 0.023	0.531CysSer: 0.531 ± 0.028	0.442CysThr: 0.442 ± 0.025	0.653CysVal: 0.653 ± 0.03	0.138CysTrp: 0.138 ± 0.013	0.277CysTyr: 0.277 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	7.475AspAla: 7.475 ± 0.143	0.621AspCys: 0.621 ± 0.029	4.758AspAsp: 4.758 ± 0.118	3.823AspGlu: 3.823 ± 0.077	2.563AspPhe: 2.563 ± 0.059	5.5AspGly: 5.5 ± 0.138	1.458AspHis: 1.458 ± 0.041	5.025AspIle: 5.025 ± 0.085	2.709AspLys: 2.709 ± 0.054	5.655AspLeu: 5.655 ± 0.086	2.196AspMet: 2.196 ± 0.055	2.395AspAsn: 2.395 ± 0.072	2.784AspPro: 2.784 ± 0.057	2.013AspGln: 2.013 ± 0.053	3.353AspArg: 3.353 ± 0.071	3.183AspSer: 3.183 ± 0.069	3.098AspThr: 3.098 ± 0.081	4.72AspVal: 4.72 ± 0.087	0.927AspTrp: 0.927 ± 0.036	1.832AspTyr: 1.832 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.782GluAla: 5.782 ± 0.105	0.385GluCys: 0.385 ± 0.024	2.979GluAsp: 2.979 ± 0.065	2.412GluGlu: 2.412 ± 0.066	1.865GluPhe: 1.865 ± 0.054	3.138GluGly: 3.138 ± 0.067	1.151GluHis: 1.151 ± 0.04	3.787GluIle: 3.787 ± 0.078	2.472GluLys: 2.472 ± 0.055	4.485GluLeu: 4.485 ± 0.081	1.783GluMet: 1.783 ± 0.053	2.228GluAsn: 2.228 ± 0.055	1.784GluPro: 1.784 ± 0.051	1.927GluGln: 1.927 ± 0.053	3.026GluArg: 3.026 ± 0.069	2.677GluSer: 2.677 ± 0.063	3.644GluThr: 3.644 ± 0.063	3.214GluVal: 3.214 ± 0.058	0.617GluTrp: 0.617 ± 0.031	1.009GluTyr: 1.009 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.268PheAla: 4.268 ± 0.076	0.479PheCys: 0.479 ± 0.027	3.042PheAsp: 3.042 ± 0.068	2.138PheGlu: 2.138 ± 0.052	1.713PhePhe: 1.713 ± 0.054	3.602PheGly: 3.602 ± 0.072	0.782PheHis: 0.782 ± 0.03	2.5PheIle: 2.5 ± 0.064	1.364PheLys: 1.364 ± 0.037	3.449PheLeu: 3.449 ± 0.072	1.171PheMet: 1.171 ± 0.042	1.337PheAsn: 1.337 ± 0.04	1.536PhePro: 1.536 ± 0.05	1.148PheGln: 1.148 ± 0.042	1.817PheArg: 1.817 ± 0.048	2.59PheSer: 2.59 ± 0.059	2.404PheThr: 2.404 ± 0.098	2.909PheVal: 2.909 ± 0.067	0.57PheTrp: 0.57 ± 0.03	1.108PheTyr: 1.108 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	7.75GlyAla: 7.75 ± 0.102	0.897GlyCys: 0.897 ± 0.038	4.628GlyAsp: 4.628 ± 0.084	3.597GlyGlu: 3.597 ± 0.071	3.571GlyPhe: 3.571 ± 0.073	6.384GlyGly: 6.384 ± 0.154	1.983GlyHis: 1.983 ± 0.057	5.135GlyIle: 5.135 ± 0.09	3.76GlyLys: 3.76 ± 0.067	7.802GlyLeu: 7.802 ± 0.112	2.614GlyMet: 2.614 ± 0.073	2.639GlyAsn: 2.639 ± 0.073	2.214GlyPro: 2.214 ± 0.051	2.965GlyGln: 2.965 ± 0.061	4.373GlyArg: 4.373 ± 0.08	4.467GlySer: 4.467 ± 0.074	4.464GlyThr: 4.464 ± 0.162	5.646GlyVal: 5.646 ± 0.086	1.208GlyTrp: 1.208 ± 0.044	2.306GlyTyr: 2.306 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.378HisAla: 2.378 ± 0.061	0.291HisCys: 0.291 ± 0.021	1.712HisAsp: 1.712 ± 0.051	1.115HisGlu: 1.115 ± 0.037	0.987HisPhe: 0.987 ± 0.038	1.815HisGly: 1.815 ± 0.047	0.732HisHis: 0.732 ± 0.036	1.705HisIle: 1.705 ± 0.054	0.899HisLys: 0.899 ± 0.032	2.077HisLeu: 2.077 ± 0.054	0.726HisMet: 0.726 ± 0.034	0.88HisAsn: 0.88 ± 0.035	1.257HisPro: 1.257 ± 0.039	0.808HisGln: 0.808 ± 0.03	1.127HisArg: 1.127 ± 0.041	1.251HisSer: 1.251 ± 0.042	0.924HisThr: 0.924 ± 0.032	1.569HisVal: 1.569 ± 0.048	0.282HisTrp: 0.282 ± 0.019	0.748HisTyr: 0.748 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	7.559IleAla: 7.559 ± 0.096	0.844IleCys: 0.844 ± 0.032	4.873IleAsp: 4.873 ± 0.083	3.823IleGlu: 3.823 ± 0.076	2.45IlePhe: 2.45 ± 0.053	5.494IleGly: 5.494 ± 0.099	1.209IleHis: 1.209 ± 0.036	4.243IleIle: 4.243 ± 0.077	2.613IleLys: 2.613 ± 0.059	5.651IleLeu: 5.651 ± 0.107	1.794IleMet: 1.794 ± 0.051	2.45IleAsn: 2.45 ± 0.048	2.676IlePro: 2.676 ± 0.056	1.651IleGln: 1.651 ± 0.043	3.108IleArg: 3.108 ± 0.06	4.627IleSer: 4.627 ± 0.092	4.088IleThr: 4.088 ± 0.085	4.29IleVal: 4.29 ± 0.071	0.837IleTrp: 0.837 ± 0.039	1.694IleTyr: 1.694 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.777LysAla: 4.777 ± 0.086	0.262LysCys: 0.262 ± 0.017	2.351LysAsp: 2.351 ± 0.059	1.574LysGlu: 1.574 ± 0.051	1.298LysPhe: 1.298 ± 0.037	2.812LysGly: 2.812 ± 0.058	0.929LysHis: 0.929 ± 0.037	2.788LysIle: 2.788 ± 0.065	1.985LysLys: 1.985 ± 0.069	3.942LysLeu: 3.942 ± 0.073	1.359LysMet: 1.359 ± 0.04	1.602LysAsn: 1.602 ± 0.045	2.161LysPro: 2.161 ± 0.059	1.59LysGln: 1.59 ± 0.049	2.464LysArg: 2.464 ± 0.064	2.921LysSer: 2.921 ± 0.061	2.76LysThr: 2.76 ± 0.06	2.533LysVal: 2.533 ± 0.058	0.508LysTrp: 0.508 ± 0.026	0.911LysTyr: 0.911 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.653LeuAla: 11.653 ± 0.163	1.065LeuCys: 1.065 ± 0.034	6.28LeuAsp: 6.28 ± 0.096	4.526LeuGlu: 4.526 ± 0.09	3.936LeuPhe: 3.936 ± 0.084	7.462LeuGly: 7.462 ± 0.127	1.931LeuHis: 1.931 ± 0.051	5.654LeuIle: 5.654 ± 0.092	3.587LeuLys: 3.587 ± 0.07	8.143LeuLeu: 8.143 ± 0.146	2.753LeuMet: 2.753 ± 0.068	3.208LeuAsn: 3.208 ± 0.067	4.621LeuPro: 4.621 ± 0.078	2.877LeuGln: 2.877 ± 0.059	5.133LeuArg: 5.133 ± 0.091	6.59LeuSer: 6.59 ± 0.107	5.386LeuThr: 5.386 ± 0.096	6.469LeuVal: 6.469 ± 0.095	1.039LeuTrp: 1.039 ± 0.04	2.139LeuTyr: 2.139 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	3.742MetAla: 3.742 ± 0.076	0.191MetCys: 0.191 ± 0.016	1.496MetAsp: 1.496 ± 0.042	1.208MetGlu: 1.208 ± 0.038	0.94MetPhe: 0.94 ± 0.038	2.13MetGly: 2.13 ± 0.057	0.575MetHis: 0.575 ± 0.029	1.923MetIle: 1.923 ± 0.061	1.21MetLys: 1.21 ± 0.043	3.096MetLeu: 3.096 ± 0.073	1.054MetMet: 1.054 ± 0.042	1.144MetAsn: 1.144 ± 0.041	1.836MetPro: 1.836 ± 0.056	1.295MetGln: 1.295 ± 0.039	1.992MetArg: 1.992 ± 0.049	2.1MetSer: 2.1 ± 0.057	2.168MetThr: 2.168 ± 0.049	2.137MetVal: 2.137 ± 0.057	0.237MetTrp: 0.237 ± 0.018	0.424MetTyr: 0.424 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.782AsnAla: 3.782 ± 0.081	0.34AsnCys: 0.34 ± 0.019	2.348AsnAsp: 2.348 ± 0.081	1.829AsnGlu: 1.829 ± 0.055	1.383AsnPhe: 1.383 ± 0.037	2.841AsnGly: 2.841 ± 0.08	0.706AsnHis: 0.706 ± 0.034	2.531AsnIle: 2.531 ± 0.063	1.46AsnLys: 1.46 ± 0.041	3.356AsnLeu: 3.356 ± 0.076	1.124AsnMet: 1.124 ± 0.036	1.471AsnAsn: 1.471 ± 0.063	2.031AsnPro: 2.031 ± 0.055	1.187AsnGln: 1.187 ± 0.039	1.968AsnArg: 1.968 ± 0.044	1.947AsnSer: 1.947 ± 0.056	1.71AsnThr: 1.71 ± 0.054	2.419AsnVal: 2.419 ± 0.063	0.509AsnTrp: 0.509 ± 0.025	0.963AsnTyr: 0.963 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.612ProAla: 4.612 ± 0.083	0.331ProCys: 0.331 ± 0.021	3.77ProAsp: 3.77 ± 0.072	2.874ProGlu: 2.874 ± 0.057	1.916ProPhe: 1.916 ± 0.047	2.862ProGly: 2.862 ± 0.067	1.229ProHis: 1.229 ± 0.038	2.522ProIle: 2.522 ± 0.062	1.845ProLys: 1.845 ± 0.054	4.029ProLeu: 4.029 ± 0.079	1.195ProMet: 1.195 ± 0.044	1.473ProAsn: 1.473 ± 0.043	1.784ProPro: 1.784 ± 0.054	1.408ProGln: 1.408 ± 0.051	1.992ProArg: 1.992 ± 0.048	2.605ProSer: 2.605 ± 0.061	2.33ProThr: 2.33 ± 0.057	3.647ProVal: 3.647 ± 0.062	0.509ProTrp: 0.509 ± 0.026	1.087ProTyr: 1.087 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.62GlnAla: 3.62 ± 0.078	0.275GlnCys: 0.275 ± 0.021	1.897GlnAsp: 1.897 ± 0.048	1.345GlnGlu: 1.345 ± 0.039	1.245GlnPhe: 1.245 ± 0.042	2.167GlnGly: 2.167 ± 0.056	0.834GlnHis: 0.834 ± 0.036	2.521GlnIle: 2.521 ± 0.054	1.603GlnLys: 1.603 ± 0.042	3.227GlnLeu: 3.227 ± 0.063	1.089GlnMet: 1.089 ± 0.036	1.512GlnAsn: 1.512 ± 0.044	1.544GlnPro: 1.544 ± 0.042	1.394GlnGln: 1.394 ± 0.048	1.927GlnArg: 1.927 ± 0.058	2.225GlnSer: 2.225 ± 0.052	2.185GlnThr: 2.185 ± 0.057	1.965GlnVal: 1.965 ± 0.053	0.379GlnTrp: 0.379 ± 0.026	0.674GlnTyr: 0.674 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.177ArgAla: 5.177 ± 0.093	0.527ArgCys: 0.527 ± 0.025	3.685ArgAsp: 3.685 ± 0.068	2.65ArgGlu: 2.65 ± 0.068	2.417ArgPhe: 2.417 ± 0.049	3.482ArgGly: 3.482 ± 0.068	1.574ArgHis: 1.574 ± 0.048	3.572ArgIle: 3.572 ± 0.086	2.183ArgLys: 2.183 ± 0.048	5.959ArgLeu: 5.959 ± 0.099	1.624ArgMet: 1.624 ± 0.045	2.039ArgAsn: 2.039 ± 0.053	2.384ArgPro: 2.384 ± 0.048	2.338ArgGln: 2.338 ± 0.063	3.466ArgArg: 3.466 ± 0.086	2.839ArgSer: 2.839 ± 0.064	2.538ArgThr: 2.538 ± 0.06	3.464ArgVal: 3.464 ± 0.066	0.68ArgTrp: 0.68 ± 0.027	1.536ArgTyr: 1.536 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.292SerAla: 6.292 ± 0.096	0.575SerCys: 0.575 ± 0.028	4.084SerAsp: 4.084 ± 0.07	2.925SerGlu: 2.925 ± 0.061	2.825SerPhe: 2.825 ± 0.056	5.607SerGly: 5.607 ± 0.09	1.456SerHis: 1.456 ± 0.043	3.896SerIle: 3.896 ± 0.071	2.55SerLys: 2.55 ± 0.057	6.062SerLeu: 6.062 ± 0.105	1.795SerMet: 1.795 ± 0.051	2.162SerAsn: 2.162 ± 0.059	2.591SerPro: 2.591 ± 0.057	2.149SerGln: 2.149 ± 0.047	3.021SerArg: 3.021 ± 0.066	3.907SerSer: 3.907 ± 0.084	3.023SerThr: 3.023 ± 0.062	4.284SerVal: 4.284 ± 0.076	0.848SerTrp: 0.848 ± 0.036	1.615SerTyr: 1.615 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.103ThrAla: 6.103 ± 0.131	0.493ThrCys: 0.493 ± 0.024	3.38ThrAsp: 3.38 ± 0.103	2.563ThrGlu: 2.563 ± 0.06	1.98ThrPhe: 1.98 ± 0.062	5.062ThrGly: 5.062 ± 0.114	1.393ThrHis: 1.393 ± 0.045	3.801ThrIle: 3.801 ± 0.083	2.191ThrLys: 2.191 ± 0.054	5.499ThrLeu: 5.499 ± 0.102	1.546ThrMet: 1.546 ± 0.038	1.914ThrAsn: 1.914 ± 0.072	3.2ThrPro: 3.2 ± 0.074	1.668ThrGln: 1.668 ± 0.05	2.815ThrArg: 2.815 ± 0.059	3.663ThrSer: 3.663 ± 0.081	3.053ThrThr: 3.053 ± 0.076	3.951ThrVal: 3.951 ± 0.104	0.496ThrTrp: 0.496 ± 0.026	1.389ThrTyr: 1.389 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	7.443ValAla: 7.443 ± 0.105	0.653ValCys: 0.653 ± 0.034	4.032ValAsp: 4.032 ± 0.082	3.668ValGlu: 3.668 ± 0.069	2.751ValPhe: 2.751 ± 0.064	4.891ValGly: 4.891 ± 0.073	1.322ValHis: 1.322 ± 0.04	4.993ValIle: 4.993 ± 0.085	2.761ValLys: 2.761 ± 0.063	6.284ValLeu: 6.284 ± 0.11	2.353ValMet: 2.353 ± 0.057	2.376ValAsn: 2.376 ± 0.077	3.179ValPro: 3.179 ± 0.058	1.944ValGln: 1.944 ± 0.041	3.568ValArg: 3.568 ± 0.072	4.539ValSer: 4.539 ± 0.079	4.696ValThr: 4.696 ± 0.12	4.6ValVal: 4.6 ± 0.088	0.734ValTrp: 0.734 ± 0.03	1.413ValTyr: 1.413 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.917TrpAla: 0.917 ± 0.037	0.163TrpCys: 0.163 ± 0.013	0.7TrpAsp: 0.7 ± 0.03	0.453TrpGlu: 0.453 ± 0.022	0.537TrpPhe: 0.537 ± 0.028	0.795TrpGly: 0.795 ± 0.032	0.442TrpHis: 0.442 ± 0.022	0.71TrpIle: 0.71 ± 0.029	0.435TrpLys: 0.435 ± 0.023	1.431TrpLeu: 1.431 ± 0.046	0.383TrpMet: 0.383 ± 0.02	0.439TrpAsn: 0.439 ± 0.023	0.587TrpPro: 0.587 ± 0.028	0.74TrpGln: 0.74 ± 0.033	0.896TrpArg: 0.896 ± 0.032	0.698TrpSer: 0.698 ± 0.032	0.606TrpThr: 0.606 ± 0.025	0.795TrpVal: 0.795 ± 0.03	0.158TrpTrp: 0.158 ± 0.016	0.286TrpTyr: 0.286 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.394TyrAla: 2.394 ± 0.062	0.3TyrCys: 0.3 ± 0.019	1.813TyrAsp: 1.813 ± 0.047	1.354TyrGlu: 1.354 ± 0.042	1.177TyrPhe: 1.177 ± 0.042	2.149TyrGly: 2.149 ± 0.059	0.635TyrHis: 0.635 ± 0.027	1.392TyrIle: 1.392 ± 0.046	0.96TyrLys: 0.96 ± 0.034	2.432TyrLeu: 2.432 ± 0.052	0.656TyrMet: 0.656 ± 0.029	0.825TyrAsn: 0.825 ± 0.038	0.977TyrPro: 0.977 ± 0.036	0.85TyrGln: 0.85 ± 0.033	1.462TyrArg: 1.462 ± 0.042	1.393TyrSer: 1.393 ± 0.047	1.047TyrThr: 1.047 ± 0.046	1.67TyrVal: 1.67 ± 0.05	0.348TyrTrp: 0.348 ± 0.021	0.68TyrTyr: 0.68 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2545 proteins (832913 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---