Amino acid dipepetide frequency for Prevotella sp. oral taxon 473 str. F0040

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.645AlaAla: 7.645 ± 0.158
0.865AlaCys: 0.865 ± 0.034
4.487AlaAsp: 4.487 ± 0.091
5.656AlaGlu: 5.656 ± 0.116
3.439AlaPhe: 3.439 ± 0.075
5.081AlaGly: 5.081 ± 0.096
1.941AlaHis: 1.941 ± 0.063
4.528AlaIle: 4.528 ± 0.089
4.485AlaLys: 4.485 ± 0.091
8.491AlaLeu: 8.491 ± 0.14
2.103AlaMet: 2.103 ± 0.063
3.357AlaAsn: 3.357 ± 0.074
3.214AlaPro: 3.214 ± 0.073
4.565AlaGln: 4.565 ± 0.103
4.016AlaArg: 4.016 ± 0.076
4.566AlaSer: 4.566 ± 0.083
4.938AlaThr: 4.938 ± 0.101
5.172AlaVal: 5.172 ± 0.099
0.917AlaTrp: 0.917 ± 0.034
3.01AlaTyr: 3.01 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.853CysAla: 0.853 ± 0.034
0.202CysCys: 0.202 ± 0.016
0.592CysAsp: 0.592 ± 0.028
0.624CysGlu: 0.624 ± 0.034
0.545CysPhe: 0.545 ± 0.027
0.944CysGly: 0.944 ± 0.043
0.331CysHis: 0.331 ± 0.022
0.663CysIle: 0.663 ± 0.034
0.488CysLys: 0.488 ± 0.026
1.02CysLeu: 1.02 ± 0.041
0.234CysMet: 0.234 ± 0.02
0.531CysAsn: 0.531 ± 0.03
0.522CysPro: 0.522 ± 0.031
0.379CysGln: 0.379 ± 0.022
0.588CysArg: 0.588 ± 0.032
0.757CysSer: 0.757 ± 0.037
0.633CysThr: 0.633 ± 0.032
0.719CysVal: 0.719 ± 0.034
0.142CysTrp: 0.142 ± 0.013
0.429CysTyr: 0.429 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
4.542AspAla: 4.542 ± 0.086
0.602AspCys: 0.602 ± 0.029
2.445AspAsp: 2.445 ± 0.062
3.465AspGlu: 3.465 ± 0.072
3.243AspPhe: 3.243 ± 0.072
3.774AspGly: 3.774 ± 0.087
1.024AspHis: 1.024 ± 0.039
3.377AspIle: 3.377 ± 0.073
2.927AspLys: 2.927 ± 0.074
4.716AspLeu: 4.716 ± 0.082
1.237AspMet: 1.237 ± 0.043
2.507AspAsn: 2.507 ± 0.062
1.731AspPro: 1.731 ± 0.053
1.516AspGln: 1.516 ± 0.041
2.63AspArg: 2.63 ± 0.064
2.909AspSer: 2.909 ± 0.071
2.714AspThr: 2.714 ± 0.07
3.61AspVal: 3.61 ± 0.079
0.748AspTrp: 0.748 ± 0.031
2.702AspTyr: 2.702 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
5.366GluAla: 5.366 ± 0.103
0.542GluCys: 0.542 ± 0.029
2.962GluAsp: 2.962 ± 0.069
4.637GluGlu: 4.637 ± 0.11
2.278GluPhe: 2.278 ± 0.046
4.363GluGly: 4.363 ± 0.07
1.588GluHis: 1.588 ± 0.051
3.887GluIle: 3.887 ± 0.074
4.117GluLys: 4.117 ± 0.09
5.626GluLeu: 5.626 ± 0.094
1.849GluMet: 1.849 ± 0.062
2.845GluAsn: 2.845 ± 0.065
1.536GluPro: 1.536 ± 0.048
2.952GluGln: 2.952 ± 0.07
3.904GluArg: 3.904 ± 0.082
3.098GluSer: 3.098 ± 0.066
2.939GluThr: 2.939 ± 0.063
4.735GluVal: 4.735 ± 0.088
0.793GluTrp: 0.793 ± 0.032
1.904GluTyr: 1.904 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.583PheAla: 3.583 ± 0.071
0.665PheCys: 0.665 ± 0.034
2.803PheAsp: 2.803 ± 0.062
2.382PheGlu: 2.382 ± 0.057
2.378PhePhe: 2.378 ± 0.068
3.101PheGly: 3.101 ± 0.073
1.016PheHis: 1.016 ± 0.035
2.476PheIle: 2.476 ± 0.073
1.969PheLys: 1.969 ± 0.062
4.403PheLeu: 4.403 ± 0.096
1.11PheMet: 1.11 ± 0.039
2.09PheAsn: 2.09 ± 0.064
1.825PhePro: 1.825 ± 0.046
1.48PheGln: 1.48 ± 0.048
2.363PheArg: 2.363 ± 0.065
3.804PheSer: 3.804 ± 0.078
2.792PheThr: 2.792 ± 0.065
3.211PheVal: 3.211 ± 0.077
0.538PheTrp: 0.538 ± 0.027
1.774PheTyr: 1.774 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
5.152GlyAla: 5.152 ± 0.097
0.859GlyCys: 0.859 ± 0.039
3.335GlyAsp: 3.335 ± 0.074
4.185GlyGlu: 4.185 ± 0.065
3.164GlyPhe: 3.164 ± 0.079
4.788GlyGly: 4.788 ± 0.104
1.491GlyHis: 1.491 ± 0.044
4.252GlyIle: 4.252 ± 0.085
4.664GlyLys: 4.664 ± 0.082
5.996GlyLeu: 5.996 ± 0.103
1.739GlyMet: 1.739 ± 0.06
3.108GlyAsn: 3.108 ± 0.084
1.065GlyPro: 1.065 ± 0.041
2.513GlyGln: 2.513 ± 0.07
3.496GlyArg: 3.496 ± 0.066
3.648GlySer: 3.648 ± 0.082
3.94GlyThr: 3.94 ± 0.072
5.013GlyVal: 5.013 ± 0.088
1.006GlyTrp: 1.006 ± 0.039
2.875GlyTyr: 2.875 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.671HisAla: 1.671 ± 0.05
0.324HisCys: 0.324 ± 0.02
1.183HisAsp: 1.183 ± 0.041
1.209HisGlu: 1.209 ± 0.039
1.322HisPhe: 1.322 ± 0.04
1.444HisGly: 1.444 ± 0.05
0.764HisHis: 0.764 ± 0.033
1.46HisIle: 1.46 ± 0.049
1.114HisLys: 1.114 ± 0.037
2.592HisLeu: 2.592 ± 0.066
0.375HisMet: 0.375 ± 0.023
1.139HisAsn: 1.139 ± 0.04
1.331HisPro: 1.331 ± 0.046
1.008HisGln: 1.008 ± 0.039
1.377HisArg: 1.377 ± 0.043
1.335HisSer: 1.335 ± 0.041
1.32HisThr: 1.32 ± 0.044
1.317HisVal: 1.317 ± 0.046
0.316HisTrp: 0.316 ± 0.022
1.144HisTyr: 1.144 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
5.266IleAla: 5.266 ± 0.095
0.768IleCys: 0.768 ± 0.034
3.787IleAsp: 3.787 ± 0.072
3.816IleGlu: 3.816 ± 0.077
2.445IlePhe: 2.445 ± 0.064
3.851IleGly: 3.851 ± 0.094
1.247IleHis: 1.247 ± 0.043
3.402IleIle: 3.402 ± 0.093
2.916IleLys: 2.916 ± 0.067
5.058IleLeu: 5.058 ± 0.111
1.178IleMet: 1.178 ± 0.041
2.646IleAsn: 2.646 ± 0.062
2.677IlePro: 2.677 ± 0.065
1.807IleGln: 1.807 ± 0.054
2.842IleArg: 2.842 ± 0.068
3.922IleSer: 3.922 ± 0.081
3.473IleThr: 3.473 ± 0.063
4.286IleVal: 4.286 ± 0.085
0.474IleTrp: 0.474 ± 0.029
2.085IleTyr: 2.085 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.805LysAla: 4.805 ± 0.109
0.443LysCys: 0.443 ± 0.028
3.139LysAsp: 3.139 ± 0.075
3.94LysGlu: 3.94 ± 0.088
2.016LysPhe: 2.016 ± 0.058
3.911LysGly: 3.911 ± 0.083
1.276LysHis: 1.276 ± 0.039
3.18LysIle: 3.18 ± 0.071
3.672LysLys: 3.672 ± 0.099
4.658LysLeu: 4.658 ± 0.094
1.636LysMet: 1.636 ± 0.055
2.75LysAsn: 2.75 ± 0.069
1.935LysPro: 1.935 ± 0.06
2.325LysGln: 2.325 ± 0.063
2.882LysArg: 2.882 ± 0.064
3.296LysSer: 3.296 ± 0.076
3.238LysThr: 3.238 ± 0.074
4.015LysVal: 4.015 ± 0.077
0.671LysTrp: 0.671 ± 0.03
2.013LysTyr: 2.013 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
7.493LeuAla: 7.493 ± 0.12
1.306LeuCys: 1.306 ± 0.044
4.933LeuAsp: 4.933 ± 0.094
5.122LeuGlu: 5.122 ± 0.093
4.51LeuPhe: 4.51 ± 0.093
6.087LeuGly: 6.087 ± 0.112
2.499LeuHis: 2.499 ± 0.068
4.747LeuIle: 4.747 ± 0.097
5.078LeuLys: 5.078 ± 0.094
10.046LeuLeu: 10.046 ± 0.176
2.344LeuMet: 2.344 ± 0.062
4.204LeuAsn: 4.204 ± 0.086
4.934LeuPro: 4.934 ± 0.083
4.44LeuGln: 4.44 ± 0.087
6.134LeuArg: 6.134 ± 0.091
7.776LeuSer: 7.776 ± 0.102
5.671LeuThr: 5.671 ± 0.094
5.774LeuVal: 5.774 ± 0.097
1.257LeuTrp: 1.257 ± 0.045
3.23LeuTyr: 3.23 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.146MetAla: 2.146 ± 0.062
0.197MetCys: 0.197 ± 0.018
1.16MetAsp: 1.16 ± 0.038
1.37MetGlu: 1.37 ± 0.047
0.892MetPhe: 0.892 ± 0.045
1.841MetGly: 1.841 ± 0.06
0.523MetHis: 0.523 ± 0.029
1.294MetIle: 1.294 ± 0.043
1.71MetLys: 1.71 ± 0.054
2.476MetLeu: 2.476 ± 0.063
0.787MetMet: 0.787 ± 0.033
1.238MetAsn: 1.238 ± 0.038
1.174MetPro: 1.174 ± 0.049
1.133MetGln: 1.133 ± 0.035
1.446MetArg: 1.446 ± 0.043
1.641MetSer: 1.641 ± 0.05
1.38MetThr: 1.38 ± 0.044
1.637MetVal: 1.637 ± 0.043
0.234MetTrp: 0.234 ± 0.02
0.592MetTyr: 0.592 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.691AsnAla: 3.691 ± 0.076
0.428AsnCys: 0.428 ± 0.028
2.338AsnAsp: 2.338 ± 0.063
2.692AsnGlu: 2.692 ± 0.068
2.179AsnPhe: 2.179 ± 0.06
3.392AsnGly: 3.392 ± 0.092
1.057AsnHis: 1.057 ± 0.037
2.88AsnIle: 2.88 ± 0.068
2.412AsnLys: 2.412 ± 0.065
4.211AsnLeu: 4.211 ± 0.091
1.006AsnMet: 1.006 ± 0.038
2.314AsnAsn: 2.314 ± 0.077
2.334AsnPro: 2.334 ± 0.055
1.607AsnGln: 1.607 ± 0.055
2.265AsnArg: 2.265 ± 0.066
2.571AsnSer: 2.571 ± 0.066
2.53AsnThr: 2.53 ± 0.071
3.187AsnVal: 3.187 ± 0.076
0.547AsnTrp: 0.547 ± 0.027
1.98AsnTyr: 1.98 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
3.109ProAla: 3.109 ± 0.069
0.361ProCys: 0.361 ± 0.023
2.114ProAsp: 2.114 ± 0.059
3.053ProGlu: 3.053 ± 0.074
1.832ProPhe: 1.832 ± 0.053
2.139ProGly: 2.139 ± 0.057
1.023ProHis: 1.023 ± 0.041
2.386ProIle: 2.386 ± 0.061
2.247ProLys: 2.247 ± 0.057
3.9ProLeu: 3.9 ± 0.076
1.027ProMet: 1.027 ± 0.036
1.893ProAsn: 1.893 ± 0.051
1.046ProPro: 1.046 ± 0.04
1.975ProGln: 1.975 ± 0.054
1.664ProArg: 1.664 ± 0.046
2.748ProSer: 2.748 ± 0.066
2.778ProThr: 2.778 ± 0.068
2.421ProVal: 2.421 ± 0.065
0.503ProTrp: 0.503 ± 0.029
1.585ProTyr: 1.585 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
3.117GlnAla: 3.117 ± 0.069
0.411GlnCys: 0.411 ± 0.026
1.721GlnAsp: 1.721 ± 0.049
2.504GlnGlu: 2.504 ± 0.063
1.666GlnPhe: 1.666 ± 0.05
2.583GlnGly: 2.583 ± 0.056
1.228GlnHis: 1.228 ± 0.048
2.333GlnIle: 2.333 ± 0.059
2.43GlnLys: 2.43 ± 0.054
4.717GlnLeu: 4.717 ± 0.105
1.134GlnMet: 1.134 ± 0.041
1.753GlnAsn: 1.753 ± 0.05
1.754GlnPro: 1.754 ± 0.05
2.714GlnGln: 2.714 ± 0.079
2.829GlnArg: 2.829 ± 0.06
2.451GlnSer: 2.451 ± 0.068
2.299GlnThr: 2.299 ± 0.069
2.415GlnVal: 2.415 ± 0.056
0.643GlnTrp: 0.643 ± 0.035
1.518GlnTyr: 1.518 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
3.978ArgAla: 3.978 ± 0.077
0.598ArgCys: 0.598 ± 0.03
2.479ArgAsp: 2.479 ± 0.059
3.401ArgGlu: 3.401 ± 0.07
2.631ArgPhe: 2.631 ± 0.074
3.136ArgGly: 3.136 ± 0.077
1.292ArgHis: 1.292 ± 0.046
3.524ArgIle: 3.524 ± 0.075
3.236ArgLys: 3.236 ± 0.071
5.31ArgLeu: 5.31 ± 0.094
1.543ArgMet: 1.543 ± 0.039
2.573ArgAsn: 2.573 ± 0.066
2.1ArgPro: 2.1 ± 0.053
2.334ArgGln: 2.334 ± 0.061
2.916ArgArg: 2.916 ± 0.084
2.85ArgSer: 2.85 ± 0.072
2.978ArgThr: 2.978 ± 0.064
3.508ArgVal: 3.508 ± 0.061
0.791ArgTrp: 0.791 ± 0.034
2.4ArgTyr: 2.4 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
5.036SerAla: 5.036 ± 0.084
0.78SerCys: 0.78 ± 0.033
3.17SerAsp: 3.17 ± 0.067
3.481SerGlu: 3.481 ± 0.069
3.222SerPhe: 3.222 ± 0.073
4.167SerGly: 4.167 ± 0.085
1.461SerHis: 1.461 ± 0.051
3.839SerIle: 3.839 ± 0.073
3.056SerLys: 3.056 ± 0.067
7.041SerLeu: 7.041 ± 0.114
1.454SerMet: 1.454 ± 0.046
2.574SerAsn: 2.574 ± 0.064
2.752SerPro: 2.752 ± 0.066
2.556SerGln: 2.556 ± 0.055
3.067SerArg: 3.067 ± 0.067
4.331SerSer: 4.331 ± 0.084
3.847SerThr: 3.847 ± 0.077
4.002SerVal: 4.002 ± 0.064
0.748SerTrp: 0.748 ± 0.034
2.483SerTyr: 2.483 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
5.042ThrAla: 5.042 ± 0.088
0.496ThrCys: 0.496 ± 0.029
3.189ThrAsp: 3.189 ± 0.065
3.157ThrGlu: 3.157 ± 0.074
2.878ThrPhe: 2.878 ± 0.073
3.545ThrGly: 3.545 ± 0.083
1.316ThrHis: 1.316 ± 0.04
3.554ThrIle: 3.554 ± 0.074
2.739ThrLys: 2.739 ± 0.062
6.323ThrLeu: 6.323 ± 0.102
1.267ThrMet: 1.267 ± 0.04
2.481ThrAsn: 2.481 ± 0.069
3.207ThrPro: 3.207 ± 0.065
2.262ThrGln: 2.262 ± 0.062
2.477ThrArg: 2.477 ± 0.056
3.727ThrSer: 3.727 ± 0.077
4.053ThrThr: 4.053 ± 0.094
3.297ThrVal: 3.297 ± 0.072
0.707ThrTrp: 0.707 ± 0.033
2.205ThrTyr: 2.205 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
5.991ValAla: 5.991 ± 0.088
0.806ValCys: 0.806 ± 0.037
3.617ValAsp: 3.617 ± 0.077
4.332ValGlu: 4.332 ± 0.089
2.744ValPhe: 2.744 ± 0.075
4.633ValGly: 4.633 ± 0.098
1.343ValHis: 1.343 ± 0.046
3.58ValIle: 3.58 ± 0.078
3.774ValLys: 3.774 ± 0.089
6.014ValLeu: 6.014 ± 0.101
1.689ValMet: 1.689 ± 0.053
3.002ValAsn: 3.002 ± 0.067
2.767ValPro: 2.767 ± 0.063
2.547ValGln: 2.547 ± 0.053
3.557ValArg: 3.557 ± 0.078
4.527ValSer: 4.527 ± 0.075
3.537ValThr: 3.537 ± 0.078
5.268ValVal: 5.268 ± 0.101
0.726ValTrp: 0.726 ± 0.031
2.364ValTyr: 2.364 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.847TrpAla: 0.847 ± 0.033
0.154TrpCys: 0.154 ± 0.015
0.61TrpAsp: 0.61 ± 0.028
0.794TrpGlu: 0.794 ± 0.034
0.523TrpPhe: 0.523 ± 0.032
0.937TrpGly: 0.937 ± 0.037
0.35TrpHis: 0.35 ± 0.021
0.61TrpIle: 0.61 ± 0.031
0.794TrpLys: 0.794 ± 0.034
1.205TrpLeu: 1.205 ± 0.041
0.396TrpMet: 0.396 ± 0.023
0.656TrpAsn: 0.656 ± 0.029
0.287TrpPro: 0.287 ± 0.021
0.659TrpGln: 0.659 ± 0.034
0.744TrpArg: 0.744 ± 0.039
0.812TrpSer: 0.812 ± 0.04
0.671TrpThr: 0.671 ± 0.032
0.798TrpVal: 0.798 ± 0.035
0.199TrpTrp: 0.199 ± 0.017
0.396TrpTyr: 0.396 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.143TyrAla: 3.143 ± 0.065
0.388TyrCys: 0.388 ± 0.025
2.351TyrAsp: 2.351 ± 0.057
2.104TyrGlu: 2.104 ± 0.054
1.858TyrPhe: 1.858 ± 0.057
2.57TyrGly: 2.57 ± 0.077
0.972TyrHis: 0.972 ± 0.034
1.973TyrIle: 1.973 ± 0.053
1.972TyrLys: 1.972 ± 0.055
3.783TyrLeu: 3.783 ± 0.073
0.764TyrMet: 0.764 ± 0.033
1.962TyrAsn: 1.962 ± 0.067
1.612TyrPro: 1.612 ± 0.049
1.45TyrGln: 1.45 ± 0.039
2.382TyrArg: 2.382 ± 0.053
2.299TyrSer: 2.299 ± 0.062
2.19TyrThr: 2.19 ± 0.068
2.431TyrVal: 2.431 ± 0.06
0.485TyrTrp: 0.485 ± 0.029
1.828TyrTyr: 1.828 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2316 proteins (734294 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski