Amino acid dipepetide frequency for Paraburkholderia sacchari

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.108AlaAla: 18.108 ± 0.157	1.421AlaCys: 1.421 ± 0.032	6.472AlaAsp: 6.472 ± 0.064	5.99AlaGlu: 5.99 ± 0.07	4.458AlaPhe: 4.458 ± 0.053	10.646AlaGly: 10.646 ± 0.089	3.028AlaHis: 3.028 ± 0.043	5.778AlaIle: 5.778 ± 0.069	3.861AlaLys: 3.861 ± 0.064	14.66AlaLeu: 14.66 ± 0.115	3.459AlaMet: 3.459 ± 0.037	3.561AlaAsn: 3.561 ± 0.048	6.196AlaPro: 6.196 ± 0.077	5.998AlaGln: 5.998 ± 0.069	9.43AlaArg: 9.43 ± 0.086	7.497AlaSer: 7.497 ± 0.074	6.287AlaThr: 6.287 ± 0.068	8.867AlaVal: 8.867 ± 0.08	1.866AlaTrp: 1.866 ± 0.038	2.642AlaTyr: 2.642 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.372CysAla: 1.372 ± 0.032	0.123CysCys: 0.123 ± 0.009	0.534CysAsp: 0.534 ± 0.018	0.569CysGlu: 0.569 ± 0.018	0.344CysPhe: 0.344 ± 0.014	1.06CysGly: 1.06 ± 0.026	0.252CysHis: 0.252 ± 0.012	0.401CysIle: 0.401 ± 0.017	0.23CysLys: 0.23 ± 0.011	0.803CysLeu: 0.803 ± 0.021	0.231CysMet: 0.231 ± 0.012	0.257CysAsn: 0.257 ± 0.012	0.46CysPro: 0.46 ± 0.016	0.229CysGln: 0.229 ± 0.011	0.605CysArg: 0.605 ± 0.018	0.524CysSer: 0.524 ± 0.015	0.491CysThr: 0.491 ± 0.018	0.846CysVal: 0.846 ± 0.023	0.121CysTrp: 0.121 ± 0.008	0.228CysTyr: 0.228 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.722AspAla: 7.722 ± 0.081	0.473AspCys: 0.473 ± 0.019	2.927AspAsp: 2.927 ± 0.044	3.369AspGlu: 3.369 ± 0.052	1.969AspPhe: 1.969 ± 0.035	4.427AspGly: 4.427 ± 0.054	1.16AspHis: 1.16 ± 0.028	2.485AspIle: 2.485 ± 0.039	1.477AspLys: 1.477 ± 0.032	5.131AspLeu: 5.131 ± 0.055	1.165AspMet: 1.165 ± 0.028	1.248AspAsn: 1.248 ± 0.032	2.866AspPro: 2.866 ± 0.043	1.533AspGln: 1.533 ± 0.028	3.108AspArg: 3.108 ± 0.04	2.331AspSer: 2.331 ± 0.034	2.734AspThr: 2.734 ± 0.04	4.188AspVal: 4.188 ± 0.054	0.88AspTrp: 0.88 ± 0.024	1.589AspTyr: 1.589 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.012GluAla: 7.012 ± 0.076	0.414GluCys: 0.414 ± 0.017	2.182GluAsp: 2.182 ± 0.041	2.476GluGlu: 2.476 ± 0.048	1.793GluPhe: 1.793 ± 0.035	3.658GluGly: 3.658 ± 0.042	1.515GluHis: 1.515 ± 0.031	2.87GluIle: 2.87 ± 0.043	1.851GluLys: 1.851 ± 0.035	5.255GluLeu: 5.255 ± 0.061	1.288GluMet: 1.288 ± 0.026	1.474GluAsn: 1.474 ± 0.032	2.514GluPro: 2.514 ± 0.035	2.423GluGln: 2.423 ± 0.045	5.023GluArg: 5.023 ± 0.063	2.663GluSer: 2.663 ± 0.037	2.839GluThr: 2.839 ± 0.046	3.648GluVal: 3.648 ± 0.049	0.704GluTrp: 0.704 ± 0.021	1.218GluTyr: 1.218 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.918PheAla: 4.918 ± 0.06	0.445PheCys: 0.445 ± 0.016	2.574PheAsp: 2.574 ± 0.041	2.208PheGlu: 2.208 ± 0.038	1.405PhePhe: 1.405 ± 0.031	3.769PheGly: 3.769 ± 0.053	0.755PheHis: 0.755 ± 0.024	1.625PheIle: 1.625 ± 0.035	0.999PheLys: 0.999 ± 0.027	2.915PheLeu: 2.915 ± 0.043	0.869PheMet: 0.869 ± 0.023	1.173PheAsn: 1.173 ± 0.029	1.568PhePro: 1.568 ± 0.033	0.975PheGln: 0.975 ± 0.024	1.995PheArg: 1.995 ± 0.033	2.256PheSer: 2.256 ± 0.04	2.002PheThr: 2.002 ± 0.036	3.18PheVal: 3.18 ± 0.042	0.519PheTrp: 0.519 ± 0.02	0.984PheTyr: 0.984 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.169GlyAla: 10.169 ± 0.093	0.837GlyCys: 0.837 ± 0.02	3.885GlyAsp: 3.885 ± 0.053	4.494GlyGlu: 4.494 ± 0.053	3.518GlyPhe: 3.518 ± 0.043	7.026GlyGly: 7.026 ± 0.09	1.933GlyHis: 1.933 ± 0.035	4.265GlyIle: 4.265 ± 0.051	3.388GlyLys: 3.388 ± 0.049	7.944GlyLeu: 7.944 ± 0.069	2.319GlyMet: 2.319 ± 0.042	2.46GlyAsn: 2.46 ± 0.052	2.991GlyPro: 2.991 ± 0.038	2.779GlyGln: 2.779 ± 0.045	5.085GlyArg: 5.085 ± 0.055	4.51GlySer: 4.51 ± 0.061	4.647GlyThr: 4.647 ± 0.062	7.018GlyVal: 7.018 ± 0.064	1.359GlyTrp: 1.359 ± 0.029	2.477GlyTyr: 2.477 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	3.278HisAla: 3.278 ± 0.043	0.29HisCys: 0.29 ± 0.013	1.353HisAsp: 1.353 ± 0.027	1.294HisGlu: 1.294 ± 0.026	0.974HisPhe: 0.974 ± 0.021	2.252HisGly: 2.252 ± 0.038	0.627HisHis: 0.627 ± 0.019	0.954HisIle: 0.954 ± 0.022	0.555HisLys: 0.555 ± 0.02	2.148HisLeu: 2.148 ± 0.039	0.533HisMet: 0.533 ± 0.018	0.573HisAsn: 0.573 ± 0.017	1.43HisPro: 1.43 ± 0.028	0.618HisGln: 0.618 ± 0.02	1.485HisArg: 1.485 ± 0.027	1.071HisSer: 1.071 ± 0.025	1.12HisThr: 1.12 ± 0.029	1.73HisVal: 1.73 ± 0.03	0.419HisTrp: 0.419 ± 0.015	0.701HisTyr: 0.701 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.992IleAla: 6.992 ± 0.066	0.469IleCys: 0.469 ± 0.016	3.46IleAsp: 3.46 ± 0.042	3.341IleGlu: 3.341 ± 0.044	1.475IlePhe: 1.475 ± 0.029	4.727IleGly: 4.727 ± 0.058	0.93IleHis: 0.93 ± 0.022	1.598IleIle: 1.598 ± 0.034	1.346IleLys: 1.346 ± 0.033	3.297IleLeu: 3.297 ± 0.049	0.822IleMet: 0.822 ± 0.021	1.412IleAsn: 1.412 ± 0.031	2.025IlePro: 2.025 ± 0.034	1.244IleGln: 1.244 ± 0.025	2.694IleArg: 2.694 ± 0.041	2.507IleSer: 2.507 ± 0.036	2.383IleThr: 2.383 ± 0.039	4.496IleVal: 4.496 ± 0.054	0.5IleTrp: 0.5 ± 0.017	1.089IleTyr: 1.089 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.622LysAla: 3.622 ± 0.06	0.169LysCys: 0.169 ± 0.01	1.468LysAsp: 1.468 ± 0.031	1.436LysGlu: 1.436 ± 0.029	0.92LysPhe: 0.92 ± 0.022	2.204LysGly: 2.204 ± 0.037	0.733LysHis: 0.733 ± 0.02	1.633LysIle: 1.633 ± 0.031	1.259LysLys: 1.259 ± 0.042	3.441LysLeu: 3.441 ± 0.048	0.775LysMet: 0.775 ± 0.023	0.889LysAsn: 0.889 ± 0.025	1.996LysPro: 1.996 ± 0.031	1.227LysGln: 1.227 ± 0.03	2.395LysArg: 2.395 ± 0.041	1.707LysSer: 1.707 ± 0.031	1.822LysThr: 1.822 ± 0.038	2.33LysVal: 2.33 ± 0.043	0.401LysTrp: 0.401 ± 0.013	0.714LysTyr: 0.714 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.383LeuAla: 14.383 ± 0.109	1.066LeuCys: 1.066 ± 0.027	5.906LeuAsp: 5.906 ± 0.069	5.188LeuGlu: 5.188 ± 0.062	3.614LeuPhe: 3.614 ± 0.055	8.088LeuGly: 8.088 ± 0.077	2.31LeuHis: 2.31 ± 0.037	4.539LeuIle: 4.539 ± 0.054	3.311LeuLys: 3.311 ± 0.047	9.656LeuLeu: 9.656 ± 0.094	2.352LeuMet: 2.352 ± 0.034	2.785LeuAsn: 2.785 ± 0.042	5.657LeuPro: 5.657 ± 0.053	3.113LeuGln: 3.113 ± 0.039	6.988LeuArg: 6.988 ± 0.084	5.847LeuSer: 5.847 ± 0.06	5.346LeuThr: 5.346 ± 0.055	7.476LeuVal: 7.476 ± 0.07	1.116LeuTrp: 1.116 ± 0.028	2.239LeuTyr: 2.239 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.649MetAla: 2.649 ± 0.042	0.204MetCys: 0.204 ± 0.01	0.961MetAsp: 0.961 ± 0.024	0.98MetGlu: 0.98 ± 0.023	0.786MetPhe: 0.786 ± 0.022	1.727MetGly: 1.727 ± 0.031	0.587MetHis: 0.587 ± 0.017	1.18MetIle: 1.18 ± 0.024	1.046MetLys: 1.046 ± 0.025	2.742MetLeu: 2.742 ± 0.036	0.603MetMet: 0.603 ± 0.019	0.952MetAsn: 0.952 ± 0.022	1.496MetPro: 1.496 ± 0.03	1.048MetGln: 1.048 ± 0.024	1.854MetArg: 1.854 ± 0.032	1.743MetSer: 1.743 ± 0.03	1.582MetThr: 1.582 ± 0.027	1.569MetVal: 1.569 ± 0.032	0.214MetTrp: 0.214 ± 0.011	0.41MetTyr: 0.41 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.809AsnAla: 3.809 ± 0.055	0.267AsnCys: 0.267 ± 0.012	1.451AsnAsp: 1.451 ± 0.025	1.413AsnGlu: 1.413 ± 0.027	1.035AsnPhe: 1.035 ± 0.024	2.783AsnGly: 2.783 ± 0.057	0.547AsnHis: 0.547 ± 0.015	1.275AsnIle: 1.275 ± 0.033	0.709AsnLys: 0.709 ± 0.022	2.744AsnLeu: 2.744 ± 0.04	0.63AsnMet: 0.63 ± 0.019	0.86AsnAsn: 0.86 ± 0.03	1.834AsnPro: 1.834 ± 0.032	0.962AsnGln: 0.962 ± 0.027	1.775AsnArg: 1.775 ± 0.033	1.344AsnSer: 1.344 ± 0.035	1.519AsnThr: 1.519 ± 0.033	2.371AsnVal: 2.371 ± 0.043	0.447AsnTrp: 0.447 ± 0.014	0.798AsnTyr: 0.798 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.672ProAla: 6.672 ± 0.075	0.367ProCys: 0.367 ± 0.014	3.079ProAsp: 3.079 ± 0.044	3.157ProGlu: 3.157 ± 0.042	1.949ProPhe: 1.949 ± 0.032	4.425ProGly: 4.425 ± 0.046	1.267ProHis: 1.267 ± 0.029	2.031ProIle: 2.031 ± 0.032	1.407ProLys: 1.407 ± 0.031	5.14ProLeu: 5.14 ± 0.066	1.104ProMet: 1.104 ± 0.025	1.466ProAsn: 1.466 ± 0.03	2.366ProPro: 2.366 ± 0.042	1.943ProGln: 1.943 ± 0.04	2.893ProArg: 2.893 ± 0.043	2.612ProSer: 2.612 ± 0.039	2.386ProThr: 2.386 ± 0.036	4.241ProVal: 4.241 ± 0.05	0.698ProTrp: 0.698 ± 0.021	1.239ProTyr: 1.239 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.473GlnAla: 4.473 ± 0.059	0.302GlnCys: 0.302 ± 0.011	1.371GlnAsp: 1.371 ± 0.026	1.356GlnGlu: 1.356 ± 0.031	1.318GlnPhe: 1.318 ± 0.023	2.601GlnGly: 2.601 ± 0.038	0.973GlnHis: 0.973 ± 0.021	2.02GlnIle: 2.02 ± 0.032	1.128GlnLys: 1.128 ± 0.029	3.725GlnLeu: 3.725 ± 0.055	1.051GlnMet: 1.051 ± 0.023	0.993GlnAsn: 0.993 ± 0.028	2.027GlnPro: 2.027 ± 0.044	1.903GlnGln: 1.903 ± 0.039	2.973GlnArg: 2.973 ± 0.047	1.996GlnSer: 1.996 ± 0.035	1.965GlnThr: 1.965 ± 0.03	2.437GlnVal: 2.437 ± 0.041	0.565GlnTrp: 0.565 ± 0.021	0.997GlnTyr: 0.997 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.53ArgAla: 8.53 ± 0.089	0.629ArgCys: 0.629 ± 0.019	3.74ArgAsp: 3.74 ± 0.047	4.628ArgGlu: 4.628 ± 0.061	2.939ArgPhe: 2.939 ± 0.041	4.658ArgGly: 4.658 ± 0.054	1.856ArgHis: 1.856 ± 0.033	3.577ArgIle: 3.577 ± 0.048	2.08ArgLys: 2.08 ± 0.035	6.969ArgLeu: 6.969 ± 0.075	1.843ArgMet: 1.843 ± 0.036	1.924ArgAsn: 1.924 ± 0.035	2.861ArgPro: 2.861 ± 0.041	2.374ArgGln: 2.374 ± 0.037	5.13ArgArg: 5.13 ± 0.062	3.307ArgSer: 3.307 ± 0.045	3.393ArgThr: 3.393 ± 0.047	5.348ArgVal: 5.348 ± 0.056	1.024ArgTrp: 1.024 ± 0.023	2.073ArgTyr: 2.073 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.845SerAla: 6.845 ± 0.073	0.474SerCys: 0.474 ± 0.017	2.668SerAsp: 2.668 ± 0.04	2.521SerGlu: 2.521 ± 0.037	2.107SerPhe: 2.107 ± 0.036	5.444SerGly: 5.444 ± 0.067	1.229SerHis: 1.229 ± 0.026	2.693SerIle: 2.693 ± 0.037	1.538SerLys: 1.538 ± 0.033	5.459SerLeu: 5.459 ± 0.056	1.366SerMet: 1.366 ± 0.026	1.707SerAsn: 1.707 ± 0.033	2.765SerPro: 2.765 ± 0.041	1.793SerGln: 1.793 ± 0.033	3.545SerArg: 3.545 ± 0.047	3.119SerSer: 3.119 ± 0.05	3.061SerThr: 3.061 ± 0.054	4.277SerVal: 4.277 ± 0.057	0.713SerTrp: 0.713 ± 0.023	1.267SerTyr: 1.267 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.794ThrAla: 5.794 ± 0.067	0.457ThrCys: 0.457 ± 0.017	2.557ThrAsp: 2.557 ± 0.036	2.275ThrGlu: 2.275 ± 0.036	1.966ThrPhe: 1.966 ± 0.033	4.732ThrGly: 4.732 ± 0.061	1.203ThrHis: 1.203 ± 0.023	2.573ThrIle: 2.573 ± 0.041	1.274ThrLys: 1.274 ± 0.026	6.511ThrLeu: 6.511 ± 0.072	1.209ThrMet: 1.209 ± 0.024	1.421ThrAsn: 1.421 ± 0.032	3.477ThrPro: 3.477 ± 0.045	1.971ThrGln: 1.971 ± 0.039	3.547ThrArg: 3.547 ± 0.04	2.891ThrSer: 2.891 ± 0.042	2.838ThrThr: 2.838 ± 0.052	4.284ThrVal: 4.284 ± 0.05	0.699ThrTrp: 0.699 ± 0.02	1.209ThrTyr: 1.209 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.75ValAla: 9.75 ± 0.086	0.85ValCys: 0.85 ± 0.02	4.183ValAsp: 4.183 ± 0.047	4.299ValGlu: 4.299 ± 0.061	2.889ValPhe: 2.889 ± 0.046	5.666ValGly: 5.666 ± 0.061	1.592ValHis: 1.592 ± 0.033	3.714ValIle: 3.714 ± 0.048	2.574ValLys: 2.574 ± 0.041	8.039ValLeu: 8.039 ± 0.074	1.86ValMet: 1.86 ± 0.035	2.3ValAsn: 2.3 ± 0.042	4.002ValPro: 4.002 ± 0.046	2.547ValGln: 2.547 ± 0.037	5.207ValArg: 5.207 ± 0.055	4.556ValSer: 4.556 ± 0.054	4.481ValThr: 4.481 ± 0.055	6.346ValVal: 6.346 ± 0.066	0.975ValTrp: 0.975 ± 0.026	1.732ValTyr: 1.732 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.167TrpAla: 1.167 ± 0.027	0.155TrpCys: 0.155 ± 0.01	0.609TrpAsp: 0.609 ± 0.019	0.51TrpGlu: 0.51 ± 0.016	0.581TrpPhe: 0.581 ± 0.019	0.93TrpGly: 0.93 ± 0.026	0.395TrpHis: 0.395 ± 0.016	0.728TrpIle: 0.728 ± 0.021	0.436TrpLys: 0.436 ± 0.016	1.938TrpLeu: 1.938 ± 0.036	0.368TrpMet: 0.368 ± 0.017	0.466TrpAsn: 0.466 ± 0.015	0.69TrpPro: 0.69 ± 0.022	0.646TrpGln: 0.646 ± 0.018	1.253TrpArg: 1.253 ± 0.029	0.791TrpSer: 0.791 ± 0.022	0.682TrpThr: 0.682 ± 0.021	0.951TrpVal: 0.951 ± 0.023	0.224TrpTrp: 0.224 ± 0.013	0.326TrpTyr: 0.326 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.96TyrAla: 2.96 ± 0.043	0.267TyrCys: 0.267 ± 0.012	1.403TyrAsp: 1.403 ± 0.031	1.316TyrGlu: 1.316 ± 0.028	1.099TyrPhe: 1.099 ± 0.026	2.28TyrGly: 2.28 ± 0.035	0.513TyrHis: 0.513 ± 0.017	0.864TyrIle: 0.864 ± 0.023	0.672TyrLys: 0.672 ± 0.021	2.462TyrLeu: 2.462 ± 0.041	0.485TyrMet: 0.485 ± 0.016	0.655TyrAsn: 0.655 ± 0.02	1.222TyrPro: 1.222 ± 0.03	0.846TyrGln: 0.846 ± 0.023	1.899TyrArg: 1.899 ± 0.031	1.318TyrSer: 1.318 ± 0.028	1.31TyrThr: 1.31 ± 0.027	1.957TyrVal: 1.957 ± 0.036	0.402TyrTrp: 0.402 ± 0.016	0.697TyrTyr: 0.697 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5729 proteins (1829930 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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