Amino acid dipepetide frequency for Thiothrix eikelboomii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.244AlaAla: 11.244 ± 0.132	1.199AlaCys: 1.199 ± 0.035	5.258AlaAsp: 5.258 ± 0.066	6.662AlaGlu: 6.662 ± 0.084	3.441AlaPhe: 3.441 ± 0.058	7.47AlaGly: 7.47 ± 0.092	2.072AlaHis: 2.072 ± 0.039	5.517AlaIle: 5.517 ± 0.067	4.604AlaLys: 4.604 ± 0.072	11.452AlaLeu: 11.452 ± 0.125	2.576AlaMet: 2.576 ± 0.049	3.687AlaAsn: 3.687 ± 0.064	3.581AlaPro: 3.581 ± 0.067	5.199AlaGln: 5.199 ± 0.093	4.797AlaArg: 4.797 ± 0.07	5.94AlaSer: 5.94 ± 0.073	5.163AlaThr: 5.163 ± 0.077	6.678AlaVal: 6.678 ± 0.072	1.62AlaTrp: 1.62 ± 0.04	2.97AlaTyr: 2.97 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.83CysAla: 0.83 ± 0.026	0.126CysCys: 0.126 ± 0.011	0.457CysAsp: 0.457 ± 0.02	0.548CysGlu: 0.548 ± 0.024	0.358CysPhe: 0.358 ± 0.016	0.849CysGly: 0.849 ± 0.031	0.306CysHis: 0.306 ± 0.015	0.496CysIle: 0.496 ± 0.022	0.37CysLys: 0.37 ± 0.019	1.135CysLeu: 1.135 ± 0.031	0.204CysMet: 0.204 ± 0.014	0.28CysAsn: 0.28 ± 0.015	0.507CysPro: 0.507 ± 0.023	0.463CysGln: 0.463 ± 0.018	0.481CysArg: 0.481 ± 0.018	0.615CysSer: 0.615 ± 0.023	0.523CysThr: 0.523 ± 0.024	0.561CysVal: 0.561 ± 0.022	0.133CysTrp: 0.133 ± 0.011	0.293CysTyr: 0.293 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.428AspAla: 4.428 ± 0.076	0.492AspCys: 0.492 ± 0.021	2.221AspAsp: 2.221 ± 0.055	3.145AspGlu: 3.145 ± 0.055	2.112AspPhe: 2.112 ± 0.045	3.433AspGly: 3.433 ± 0.088	1.04AspHis: 1.04 ± 0.028	2.605AspIle: 2.605 ± 0.052	2.281AspLys: 2.281 ± 0.045	5.854AspLeu: 5.854 ± 0.072	1.177AspMet: 1.177 ± 0.033	1.758AspAsn: 1.758 ± 0.044	2.533AspPro: 2.533 ± 0.048	2.478AspGln: 2.478 ± 0.05	2.295AspArg: 2.295 ± 0.044	2.655AspSer: 2.655 ± 0.052	2.663AspThr: 2.663 ± 0.06	2.823AspVal: 2.823 ± 0.052	0.889AspTrp: 0.889 ± 0.028	2.032AspTyr: 2.032 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.195GluAla: 6.195 ± 0.079	0.381GluCys: 0.381 ± 0.018	2.388GluAsp: 2.388 ± 0.049	2.89GluGlu: 2.89 ± 0.058	2.131GluPhe: 2.131 ± 0.044	3.511GluGly: 3.511 ± 0.047	1.573GluHis: 1.573 ± 0.035	3.221GluIle: 3.221 ± 0.059	2.614GluLys: 2.614 ± 0.055	7.043GluLeu: 7.043 ± 0.098	1.346GluMet: 1.346 ± 0.038	1.911GluAsn: 1.911 ± 0.047	2.45GluPro: 2.45 ± 0.05	4.213GluGln: 4.213 ± 0.07	4.081GluArg: 4.081 ± 0.074	2.676GluSer: 2.676 ± 0.057	3.215GluThr: 3.215 ± 0.046	4.02GluVal: 4.02 ± 0.062	0.769GluTrp: 0.769 ± 0.026	1.622GluTyr: 1.622 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.681PheAla: 3.681 ± 0.051	0.436PheCys: 0.436 ± 0.022	2.113PheAsp: 2.113 ± 0.046	2.131PheGlu: 2.131 ± 0.045	1.619PhePhe: 1.619 ± 0.044	2.863PheGly: 2.863 ± 0.048	0.753PheHis: 0.753 ± 0.024	2.325PheIle: 2.325 ± 0.044	1.847PheLys: 1.847 ± 0.041	3.585PheLeu: 3.585 ± 0.064	0.985PheMet: 0.985 ± 0.033	1.666PheAsn: 1.666 ± 0.041	1.525PhePro: 1.525 ± 0.037	1.478PheGln: 1.478 ± 0.029	1.764PheArg: 1.764 ± 0.041	2.65PheSer: 2.65 ± 0.05	2.199PheThr: 2.199 ± 0.044	2.342PheVal: 2.342 ± 0.043	0.581PheTrp: 0.581 ± 0.024	1.266PheTyr: 1.266 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.761GlyAla: 5.761 ± 0.091	0.842GlyCys: 0.842 ± 0.029	3.225GlyAsp: 3.225 ± 0.069	4.09GlyGlu: 4.09 ± 0.062	3.113GlyPhe: 3.113 ± 0.045	5.106GlyGly: 5.106 ± 0.105	1.537GlyHis: 1.537 ± 0.04	4.395GlyIle: 4.395 ± 0.065	3.916GlyLys: 3.916 ± 0.062	8.183GlyLeu: 8.183 ± 0.098	1.97GlyMet: 1.97 ± 0.041	2.419GlyAsn: 2.419 ± 0.058	1.452GlyPro: 1.452 ± 0.038	3.559GlyGln: 3.559 ± 0.059	3.561GlyArg: 3.561 ± 0.054	4.391GlySer: 4.391 ± 0.078	3.455GlyThr: 3.455 ± 0.093	5.159GlyVal: 5.159 ± 0.076	1.148GlyTrp: 1.148 ± 0.031	2.418GlyTyr: 2.418 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.091HisAla: 2.091 ± 0.04	0.318HisCys: 0.318 ± 0.015	1.098HisAsp: 1.098 ± 0.031	1.284HisGlu: 1.284 ± 0.032	0.971HisPhe: 0.971 ± 0.027	1.537HisGly: 1.537 ± 0.037	0.667HisHis: 0.667 ± 0.026	1.142HisIle: 1.142 ± 0.035	0.859HisLys: 0.859 ± 0.027	2.824HisLeu: 2.824 ± 0.054	0.454HisMet: 0.454 ± 0.021	0.752HisAsn: 0.752 ± 0.023	1.469HisPro: 1.469 ± 0.037	1.312HisGln: 1.312 ± 0.035	1.136HisArg: 1.136 ± 0.033	1.304HisSer: 1.304 ± 0.03	1.227HisThr: 1.227 ± 0.037	1.108HisVal: 1.108 ± 0.03	0.445HisTrp: 0.445 ± 0.022	1.007HisTyr: 1.007 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.721IleAla: 5.721 ± 0.077	0.555IleCys: 0.555 ± 0.021	2.994IleAsp: 2.994 ± 0.052	3.591IleGlu: 3.591 ± 0.063	1.963IlePhe: 1.963 ± 0.045	4.057IleGly: 4.057 ± 0.069	1.3IleHis: 1.3 ± 0.034	2.992IleIle: 2.992 ± 0.058	2.542IleLys: 2.542 ± 0.051	5.677IleLeu: 5.677 ± 0.083	1.149IleMet: 1.149 ± 0.029	2.248IleAsn: 2.248 ± 0.047	2.85IlePro: 2.85 ± 0.046	2.606IleGln: 2.606 ± 0.055	3.093IleArg: 3.093 ± 0.046	3.543IleSer: 3.543 ± 0.061	3.098IleThr: 3.098 ± 0.057	3.374IleVal: 3.374 ± 0.059	0.643IleTrp: 0.643 ± 0.023	1.668IleTyr: 1.668 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.604LysAla: 4.604 ± 0.07	0.224LysCys: 0.224 ± 0.016	2.144LysAsp: 2.144 ± 0.048	2.216LysGlu: 2.216 ± 0.049	1.191LysPhe: 1.191 ± 0.032	2.759LysGly: 2.759 ± 0.056	1.054LysHis: 1.054 ± 0.034	2.549LysIle: 2.549 ± 0.045	2.076LysLys: 2.076 ± 0.045	4.986LysLeu: 4.986 ± 0.062	1.015LysMet: 1.015 ± 0.03	1.752LysAsn: 1.752 ± 0.043	2.674LysPro: 2.674 ± 0.055	2.706LysGln: 2.706 ± 0.046	2.542LysArg: 2.542 ± 0.052	2.227LysSer: 2.227 ± 0.044	2.962LysThr: 2.962 ± 0.056	3.025LysVal: 3.025 ± 0.06	0.4LysTrp: 0.4 ± 0.018	1.127LysTyr: 1.127 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	13.028LeuAla: 13.028 ± 0.139	1.004LeuCys: 1.004 ± 0.031	5.804LeuAsp: 5.804 ± 0.082	6.883LeuGlu: 6.883 ± 0.077	4.066LeuPhe: 4.066 ± 0.067	8.018LeuGly: 8.018 ± 0.101	2.434LeuHis: 2.434 ± 0.053	6.348LeuIle: 6.348 ± 0.085	5.441LeuLys: 5.441 ± 0.085	12.263LeuLeu: 12.263 ± 0.171	2.697LeuMet: 2.697 ± 0.05	4.305LeuAsn: 4.305 ± 0.058	5.954LeuPro: 5.954 ± 0.087	5.488LeuGln: 5.488 ± 0.096	5.8LeuArg: 5.8 ± 0.09	7.514LeuSer: 7.514 ± 0.088	6.253LeuThr: 6.253 ± 0.084	7.384LeuVal: 7.384 ± 0.082	1.308LeuTrp: 1.308 ± 0.036	2.817LeuTyr: 2.817 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.333MetAla: 2.333 ± 0.045	0.152MetCys: 0.152 ± 0.011	1.171MetAsp: 1.171 ± 0.034	1.139MetGlu: 1.139 ± 0.03	0.674MetPhe: 0.674 ± 0.025	1.723MetGly: 1.723 ± 0.043	0.547MetHis: 0.547 ± 0.023	1.289MetIle: 1.289 ± 0.032	1.182MetLys: 1.182 ± 0.027	2.579MetLeu: 2.579 ± 0.047	0.641MetMet: 0.641 ± 0.026	0.988MetAsn: 0.988 ± 0.027	1.215MetPro: 1.215 ± 0.037	1.445MetGln: 1.445 ± 0.036	1.34MetArg: 1.34 ± 0.032	1.635MetSer: 1.635 ± 0.037	1.485MetThr: 1.485 ± 0.034	1.494MetVal: 1.494 ± 0.035	0.2MetTrp: 0.2 ± 0.013	0.458MetTyr: 0.458 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.093AsnAla: 3.093 ± 0.058	0.332AsnCys: 0.332 ± 0.016	1.596AsnAsp: 1.596 ± 0.042	1.795AsnGlu: 1.795 ± 0.042	1.382AsnPhe: 1.382 ± 0.032	2.579AsnGly: 2.579 ± 0.076	0.896AsnHis: 0.896 ± 0.031	1.951AsnIle: 1.951 ± 0.043	1.569AsnLys: 1.569 ± 0.039	4.182AsnLeu: 4.182 ± 0.059	0.776AsnMet: 0.776 ± 0.028	1.495AsnAsn: 1.495 ± 0.048	2.458AsnPro: 2.458 ± 0.051	2.076AsnGln: 2.076 ± 0.047	1.914AsnArg: 1.914 ± 0.044	2.105AsnSer: 2.105 ± 0.047	2.302AsnThr: 2.302 ± 0.049	1.726AsnVal: 1.726 ± 0.041	0.54AsnTrp: 0.54 ± 0.024	1.324AsnTyr: 1.324 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	5.004ProAla: 5.004 ± 0.075	0.34ProCys: 0.34 ± 0.017	2.571ProAsp: 2.571 ± 0.045	3.519ProGlu: 3.519 ± 0.056	1.694ProPhe: 1.694 ± 0.038	2.381ProGly: 2.381 ± 0.048	1.009ProHis: 1.009 ± 0.027	2.608ProIle: 2.608 ± 0.045	2.046ProLys: 2.046 ± 0.043	4.994ProLeu: 4.994 ± 0.066	1.031ProMet: 1.031 ± 0.027	1.867ProAsn: 1.867 ± 0.039	2.002ProPro: 2.002 ± 0.049	2.086ProGln: 2.086 ± 0.042	1.843ProArg: 1.843 ± 0.041	2.89ProSer: 2.89 ± 0.054	2.733ProThr: 2.733 ± 0.059	3.398ProVal: 3.398 ± 0.061	0.644ProTrp: 0.644 ± 0.023	1.389ProTyr: 1.389 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	7.391GlnAla: 7.391 ± 0.111	0.376GlnCys: 0.376 ± 0.018	2.135GlnAsp: 2.135 ± 0.043	2.466GlnGlu: 2.466 ± 0.045	1.753GlnPhe: 1.753 ± 0.036	3.876GlnGly: 3.876 ± 0.066	1.4GlnHis: 1.4 ± 0.039	2.754GlnIle: 2.754 ± 0.05	1.723GlnLys: 1.723 ± 0.038	6.043GlnLeu: 6.043 ± 0.103	1.119GlnMet: 1.119 ± 0.028	1.405GlnAsn: 1.405 ± 0.034	2.535GlnPro: 2.535 ± 0.048	4.055GlnGln: 4.055 ± 0.113	3.391GlnArg: 3.391 ± 0.068	2.303GlnSer: 2.303 ± 0.045	3.13GlnThr: 3.13 ± 0.057	3.809GlnVal: 3.809 ± 0.058	0.759GlnTrp: 0.759 ± 0.026	1.304GlnTyr: 1.304 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.364ArgAla: 4.364 ± 0.069	0.512ArgCys: 0.512 ± 0.019	2.652ArgAsp: 2.652 ± 0.073	3.365ArgGlu: 3.365 ± 0.056	2.433ArgPhe: 2.433 ± 0.041	2.983ArgGly: 2.983 ± 0.055	1.338ArgHis: 1.338 ± 0.04	3.201ArgIle: 3.201 ± 0.062	2.234ArgLys: 2.234 ± 0.047	6.567ArgLeu: 6.567 ± 0.082	1.377ArgMet: 1.377 ± 0.037	1.743ArgAsn: 1.743 ± 0.04	2.282ArgPro: 2.282 ± 0.046	2.943ArgGln: 2.943 ± 0.063	2.873ArgArg: 2.873 ± 0.057	2.924ArgSer: 2.924 ± 0.046	2.401ArgThr: 2.401 ± 0.045	3.474ArgVal: 3.474 ± 0.053	0.791ArgTrp: 0.791 ± 0.027	2.048ArgTyr: 2.048 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.403SerAla: 5.403 ± 0.072	0.552SerCys: 0.552 ± 0.022	2.532SerAsp: 2.532 ± 0.05	3.037SerGlu: 3.037 ± 0.048	2.659SerPhe: 2.659 ± 0.048	4.532SerGly: 4.532 ± 0.063	1.298SerHis: 1.298 ± 0.033	3.356SerIle: 3.356 ± 0.057	2.363SerLys: 2.363 ± 0.047	7.644SerLeu: 7.644 ± 0.1	1.501SerMet: 1.501 ± 0.033	2.014SerAsn: 2.014 ± 0.048	2.692SerPro: 2.692 ± 0.051	2.635SerGln: 2.635 ± 0.05	2.892SerArg: 2.892 ± 0.053	3.949SerSer: 3.949 ± 0.073	3.476SerThr: 3.476 ± 0.064	3.893SerVal: 3.893 ± 0.06	0.828SerTrp: 0.828 ± 0.027	1.823SerTyr: 1.823 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.862ThrAla: 5.862 ± 0.081	0.532ThrCys: 0.532 ± 0.024	2.932ThrAsp: 2.932 ± 0.077	3.366ThrGlu: 3.366 ± 0.06	1.635ThrPhe: 1.635 ± 0.037	4.439ThrGly: 4.439 ± 0.075	1.382ThrHis: 1.382 ± 0.035	2.84ThrIle: 2.84 ± 0.053	1.939ThrLys: 1.939 ± 0.042	6.286ThrLeu: 6.286 ± 0.085	1.021ThrMet: 1.021 ± 0.03	1.842ThrAsn: 1.842 ± 0.042	3.166ThrPro: 3.166 ± 0.055	2.958ThrGln: 2.958 ± 0.056	2.636ThrArg: 2.636 ± 0.047	3.111ThrSer: 3.111 ± 0.061	3.523ThrThr: 3.523 ± 0.068	3.948ThrVal: 3.948 ± 0.067	0.834ThrTrp: 0.834 ± 0.026	1.465ThrTyr: 1.465 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.312ValAla: 6.312 ± 0.081	0.686ValCys: 0.686 ± 0.024	3.541ValAsp: 3.541 ± 0.054	3.88ValGlu: 3.88 ± 0.061	2.67ValPhe: 2.67 ± 0.048	4.515ValGly: 4.515 ± 0.065	1.287ValHis: 1.287 ± 0.035	4.005ValIle: 4.005 ± 0.061	2.99ValLys: 2.99 ± 0.06	7.54ValLeu: 7.54 ± 0.085	1.737ValMet: 1.737 ± 0.036	2.526ValAsn: 2.526 ± 0.047	2.575ValPro: 2.575 ± 0.045	2.899ValGln: 2.899 ± 0.052	3.35ValArg: 3.35 ± 0.056	4.081ValSer: 4.081 ± 0.064	3.615ValThr: 3.615 ± 0.056	4.596ValVal: 4.596 ± 0.07	0.906ValTrp: 0.906 ± 0.025	1.848ValTyr: 1.848 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.011TrpAla: 1.011 ± 0.032	0.135TrpCys: 0.135 ± 0.01	0.625TrpAsp: 0.625 ± 0.025	0.7TrpGlu: 0.7 ± 0.024	0.622TrpPhe: 0.622 ± 0.025	0.866TrpGly: 0.866 ± 0.03	0.327TrpHis: 0.327 ± 0.015	0.701TrpIle: 0.701 ± 0.029	0.575TrpLys: 0.575 ± 0.023	2.182TrpLeu: 2.182 ± 0.051	0.366TrpMet: 0.366 ± 0.016	0.492TrpAsn: 0.492 ± 0.019	0.517TrpPro: 0.517 ± 0.02	1.153TrpGln: 1.153 ± 0.039	0.861TrpArg: 0.861 ± 0.027	0.785TrpSer: 0.785 ± 0.028	0.594TrpThr: 0.594 ± 0.021	0.994TrpVal: 0.994 ± 0.03	0.247TrpTrp: 0.247 ± 0.015	0.436TrpTyr: 0.436 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.772TyrAla: 2.772 ± 0.044	0.343TyrCys: 0.343 ± 0.017	1.456TyrAsp: 1.456 ± 0.045	1.545TyrGlu: 1.545 ± 0.035	1.322TyrPhe: 1.322 ± 0.034	2.204TyrGly: 2.204 ± 0.044	0.784TyrHis: 0.784 ± 0.025	1.37TyrIle: 1.37 ± 0.035	1.058TyrLys: 1.058 ± 0.028	3.788TyrLeu: 3.788 ± 0.055	0.551TyrMet: 0.551 ± 0.019	0.941TyrAsn: 0.941 ± 0.028	1.611TyrPro: 1.611 ± 0.037	1.979TyrGln: 1.979 ± 0.048	1.854TyrArg: 1.854 ± 0.039	1.78TyrSer: 1.78 ± 0.038	1.697TyrThr: 1.697 ± 0.041	1.754TyrVal: 1.754 ± 0.035	0.505TyrTrp: 0.505 ± 0.023	1.031TyrTyr: 1.031 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3906 proteins (1248811 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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