Amino acid dipepetide frequency for Bdellovibrio sp. NC01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.093AlaAla: 8.093 ± 0.127	0.887AlaCys: 0.887 ± 0.026	4.259AlaAsp: 4.259 ± 0.064	5.052AlaGlu: 5.052 ± 0.082	3.611AlaPhe: 3.611 ± 0.056	6.095AlaGly: 6.095 ± 0.102	1.678AlaHis: 1.678 ± 0.04	4.894AlaIle: 4.894 ± 0.067	5.939AlaLys: 5.939 ± 0.079	8.621AlaLeu: 8.621 ± 0.106	2.233AlaMet: 2.233 ± 0.046	3.681AlaAsn: 3.681 ± 0.073	3.327AlaPro: 3.327 ± 0.061	3.927AlaGln: 3.927 ± 0.058	3.577AlaArg: 3.577 ± 0.056	5.858AlaSer: 5.858 ± 0.109	4.875AlaThr: 4.875 ± 0.092	5.653AlaVal: 5.653 ± 0.072	0.888AlaTrp: 0.888 ± 0.028	2.383AlaTyr: 2.383 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.838CysAla: 0.838 ± 0.032	0.073CysCys: 0.073 ± 0.008	0.531CysAsp: 0.531 ± 0.021	0.567CysGlu: 0.567 ± 0.022	0.391CysPhe: 0.391 ± 0.017	0.758CysGly: 0.758 ± 0.026	0.229CysHis: 0.229 ± 0.016	0.425CysIle: 0.425 ± 0.02	0.465CysLys: 0.465 ± 0.02	0.858CysLeu: 0.858 ± 0.028	0.217CysMet: 0.217 ± 0.013	0.34CysAsn: 0.34 ± 0.018	0.481CysPro: 0.481 ± 0.022	0.367CysGln: 0.367 ± 0.019	0.425CysArg: 0.425 ± 0.021	0.783CysSer: 0.783 ± 0.031	0.511CysThr: 0.511 ± 0.024	0.637CysVal: 0.637 ± 0.024	0.123CysTrp: 0.123 ± 0.016	0.288CysTyr: 0.288 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.907AspAla: 3.907 ± 0.061	0.482AspCys: 0.482 ± 0.021	2.443AspAsp: 2.443 ± 0.045	3.19AspGlu: 3.19 ± 0.054	2.779AspPhe: 2.779 ± 0.052	3.575AspGly: 3.575 ± 0.061	1.006AspHis: 1.006 ± 0.032	3.317AspIle: 3.317 ± 0.053	3.316AspLys: 3.316 ± 0.046	5.74AspLeu: 5.74 ± 0.085	1.281AspMet: 1.281 ± 0.035	1.911AspAsn: 1.911 ± 0.036	2.358AspPro: 2.358 ± 0.051	2.113AspGln: 2.113 ± 0.044	2.389AspArg: 2.389 ± 0.043	3.366AspSer: 3.366 ± 0.059	2.283AspThr: 2.283 ± 0.045	3.698AspVal: 3.698 ± 0.05	0.71AspTrp: 0.71 ± 0.025	1.83AspTyr: 1.83 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.332GluAla: 5.332 ± 0.08	0.455GluCys: 0.455 ± 0.02	2.944GluAsp: 2.944 ± 0.051	4.175GluGlu: 4.175 ± 0.068	2.732GluPhe: 2.732 ± 0.049	3.631GluGly: 3.631 ± 0.066	1.168GluHis: 1.168 ± 0.032	4.353GluIle: 4.353 ± 0.062	5.228GluLys: 5.228 ± 0.066	5.909GluLeu: 5.909 ± 0.084	1.768GluMet: 1.768 ± 0.041	2.87GluAsn: 2.87 ± 0.045	1.725GluPro: 1.725 ± 0.037	2.483GluGln: 2.483 ± 0.044	2.889GluArg: 2.889 ± 0.054	3.563GluSer: 3.563 ± 0.061	3.171GluThr: 3.171 ± 0.048	4.529GluVal: 4.529 ± 0.07	0.708GluTrp: 0.708 ± 0.026	1.792GluTyr: 1.792 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.128PheAla: 4.128 ± 0.067	0.509PheCys: 0.509 ± 0.022	2.72PheAsp: 2.72 ± 0.049	2.733PheGlu: 2.733 ± 0.055	2.363PhePhe: 2.363 ± 0.054	3.087PheGly: 3.087 ± 0.052	0.863PheHis: 0.863 ± 0.027	2.632PheIle: 2.632 ± 0.05	3.13PheLys: 3.13 ± 0.056	4.286PheLeu: 4.286 ± 0.075	1.226PheMet: 1.226 ± 0.03	2.06PheAsn: 2.06 ± 0.045	1.736PhePro: 1.736 ± 0.036	1.614PheGln: 1.614 ± 0.039	1.743PheArg: 1.743 ± 0.039	3.237PheSer: 3.237 ± 0.051	2.572PheThr: 2.572 ± 0.042	3.336PheVal: 3.336 ± 0.064	0.57PheTrp: 0.57 ± 0.025	1.486PheTyr: 1.486 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.569GlyAla: 5.569 ± 0.086	0.699GlyCys: 0.699 ± 0.028	3.494GlyAsp: 3.494 ± 0.052	3.76GlyGlu: 3.76 ± 0.067	3.454GlyPhe: 3.454 ± 0.056	5.51GlyGly: 5.51 ± 0.121	1.438GlyHis: 1.438 ± 0.038	4.261GlyIle: 4.261 ± 0.066	4.654GlyLys: 4.654 ± 0.065	6.503GlyLeu: 6.503 ± 0.07	1.839GlyMet: 1.839 ± 0.045	2.787GlyAsn: 2.787 ± 0.075	2.191GlyPro: 2.191 ± 0.041	2.672GlyGln: 2.672 ± 0.047	2.941GlyArg: 2.941 ± 0.046	5.177GlySer: 5.177 ± 0.102	4.748GlyThr: 4.748 ± 0.129	5.075GlyVal: 5.075 ± 0.081	0.905GlyTrp: 0.905 ± 0.026	2.444GlyTyr: 2.444 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.37HisAla: 1.37 ± 0.035	0.242HisCys: 0.242 ± 0.014	0.949HisAsp: 0.949 ± 0.028	1.133HisGlu: 1.133 ± 0.032	1.079HisPhe: 1.079 ± 0.033	1.349HisGly: 1.349 ± 0.039	0.486HisHis: 0.486 ± 0.02	1.055HisIle: 1.055 ± 0.028	1.068HisLys: 1.068 ± 0.033	2.03HisLeu: 2.03 ± 0.04	0.527HisMet: 0.527 ± 0.023	0.664HisAsn: 0.664 ± 0.023	1.07HisPro: 1.07 ± 0.031	0.681HisGln: 0.681 ± 0.023	0.878HisArg: 0.878 ± 0.026	1.24HisSer: 1.24 ± 0.031	0.831HisThr: 0.831 ± 0.023	1.156HisVal: 1.156 ± 0.033	0.272HisTrp: 0.272 ± 0.015	0.713HisTyr: 0.713 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.374IleAla: 5.374 ± 0.074	0.61IleCys: 0.61 ± 0.02	3.26IleAsp: 3.26 ± 0.049	4.031IleGlu: 4.031 ± 0.066	2.708IlePhe: 2.708 ± 0.06	4.045IleGly: 4.045 ± 0.065	1.169IleHis: 1.169 ± 0.031	3.112IleIle: 3.112 ± 0.06	3.602IleLys: 3.602 ± 0.053	5.554IleLeu: 5.554 ± 0.072	1.217IleMet: 1.217 ± 0.036	2.533IleAsn: 2.533 ± 0.047	2.821IlePro: 2.821 ± 0.045	2.361IleGln: 2.361 ± 0.046	2.743IleArg: 2.743 ± 0.047	4.551IleSer: 4.551 ± 0.061	3.43IleThr: 3.43 ± 0.063	3.97IleVal: 3.97 ± 0.063	0.565IleTrp: 0.565 ± 0.024	1.822IleTyr: 1.822 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	6.023LysAla: 6.023 ± 0.094	0.416LysCys: 0.416 ± 0.025	4.234LysAsp: 4.234 ± 0.055	4.826LysGlu: 4.826 ± 0.08	2.681LysPhe: 2.681 ± 0.054	4.113LysGly: 4.113 ± 0.067	1.136LysHis: 1.136 ± 0.035	4.724LysIle: 4.724 ± 0.058	5.826LysLys: 5.826 ± 0.093	5.718LysLeu: 5.718 ± 0.072	2.153LysMet: 2.153 ± 0.043	3.568LysAsn: 3.568 ± 0.059	2.506LysPro: 2.506 ± 0.049	2.22LysGln: 2.22 ± 0.041	2.654LysArg: 2.654 ± 0.047	4.364LysSer: 4.364 ± 0.056	4.118LysThr: 4.118 ± 0.059	4.866LysVal: 4.866 ± 0.072	0.75LysTrp: 0.75 ± 0.025	2.075LysTyr: 2.075 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	8.183LeuAla: 8.183 ± 0.081	0.846LeuCys: 0.846 ± 0.029	4.599LeuAsp: 4.599 ± 0.059	5.734LeuGlu: 5.734 ± 0.087	4.166LeuPhe: 4.166 ± 0.08	6.569LeuGly: 6.569 ± 0.076	1.734LeuHis: 1.734 ± 0.036	5.639LeuIle: 5.639 ± 0.075	7.302LeuLys: 7.302 ± 0.093	8.737LeuLeu: 8.737 ± 0.119	2.432LeuMet: 2.432 ± 0.051	4.431LeuAsn: 4.431 ± 0.065	4.047LeuPro: 4.047 ± 0.063	3.814LeuGln: 3.814 ± 0.064	4.646LeuArg: 4.646 ± 0.066	7.213LeuSer: 7.213 ± 0.08	5.453LeuThr: 5.453 ± 0.074	6.207LeuVal: 6.207 ± 0.077	0.993LeuTrp: 0.993 ± 0.031	2.465LeuTyr: 2.465 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.373MetAla: 2.373 ± 0.052	0.213MetCys: 0.213 ± 0.012	1.292MetAsp: 1.292 ± 0.033	1.437MetGlu: 1.437 ± 0.036	0.896MetPhe: 0.896 ± 0.031	1.979MetGly: 1.979 ± 0.053	0.41MetHis: 0.41 ± 0.02	1.61MetIle: 1.61 ± 0.041	2.582MetLys: 2.582 ± 0.05	1.998MetLeu: 1.998 ± 0.04	0.809MetMet: 0.809 ± 0.034	1.405MetAsn: 1.405 ± 0.036	1.042MetPro: 1.042 ± 0.036	1.01MetGln: 1.01 ± 0.028	1.171MetArg: 1.171 ± 0.037	1.876MetSer: 1.876 ± 0.045	1.682MetThr: 1.682 ± 0.037	1.542MetVal: 1.542 ± 0.042	0.231MetTrp: 0.231 ± 0.014	0.584MetTyr: 0.584 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.334AsnAla: 3.334 ± 0.06	0.459AsnCys: 0.459 ± 0.02	2.134AsnAsp: 2.134 ± 0.05	2.453AsnGlu: 2.453 ± 0.052	2.186AsnPhe: 2.186 ± 0.045	3.293AsnGly: 3.293 ± 0.1	0.776AsnHis: 0.776 ± 0.023	2.6AsnIle: 2.6 ± 0.043	2.71AsnLys: 2.71 ± 0.053	4.379AsnLeu: 4.379 ± 0.06	1.074AsnMet: 1.074 ± 0.032	1.943AsnAsn: 1.943 ± 0.051	2.457AsnPro: 2.457 ± 0.051	1.735AsnGln: 1.735 ± 0.044	1.782AsnArg: 1.782 ± 0.04	3.18AsnSer: 3.18 ± 0.055	2.367AsnThr: 2.367 ± 0.054	2.871AsnVal: 2.871 ± 0.056	0.627AsnTrp: 0.627 ± 0.023	1.607AsnTyr: 1.607 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.666ProAla: 3.666 ± 0.065	0.281ProCys: 0.281 ± 0.015	2.142ProAsp: 2.142 ± 0.048	3.184ProGlu: 3.184 ± 0.058	1.844ProPhe: 1.844 ± 0.034	2.67ProGly: 2.67 ± 0.049	0.802ProHis: 0.802 ± 0.026	2.038ProIle: 2.038 ± 0.05	2.446ProLys: 2.446 ± 0.054	3.713ProLeu: 3.713 ± 0.065	1.052ProMet: 1.052 ± 0.032	1.702ProAsn: 1.702 ± 0.039	1.401ProPro: 1.401 ± 0.049	1.772ProGln: 1.772 ± 0.046	1.527ProArg: 1.527 ± 0.035	2.741ProSer: 2.741 ± 0.053	2.55ProThr: 2.55 ± 0.051	3.004ProVal: 3.004 ± 0.058	0.513ProTrp: 0.513 ± 0.022	1.309ProTyr: 1.309 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.638GlnAla: 3.638 ± 0.063	0.272GlnCys: 0.272 ± 0.015	1.968GlnAsp: 1.968 ± 0.038	2.412GlnGlu: 2.412 ± 0.045	1.69GlnPhe: 1.69 ± 0.039	2.661GlnGly: 2.661 ± 0.055	0.64GlnHis: 0.64 ± 0.023	2.589GlnIle: 2.589 ± 0.043	3.105GlnLys: 3.105 ± 0.052	3.277GlnLeu: 3.277 ± 0.054	1.266GlnMet: 1.266 ± 0.038	1.925GlnAsn: 1.925 ± 0.043	1.28GlnPro: 1.28 ± 0.035	1.675GlnGln: 1.675 ± 0.049	1.795GlnArg: 1.795 ± 0.04	2.534GlnSer: 2.534 ± 0.049	2.256GlnThr: 2.256 ± 0.045	2.855GlnVal: 2.855 ± 0.044	0.525GlnTrp: 0.525 ± 0.025	1.188GlnTyr: 1.188 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.386ArgAla: 3.386 ± 0.062	0.371ArgCys: 0.371 ± 0.02	2.358ArgAsp: 2.358 ± 0.046	2.956ArgGlu: 2.956 ± 0.052	2.063ArgPhe: 2.063 ± 0.046	2.742ArgGly: 2.742 ± 0.048	0.8ArgHis: 0.8 ± 0.03	2.932ArgIle: 2.932 ± 0.055	3.008ArgLys: 3.008 ± 0.05	4.227ArgLeu: 4.227 ± 0.066	1.323ArgMet: 1.323 ± 0.029	1.838ArgAsn: 1.838 ± 0.039	1.665ArgPro: 1.665 ± 0.038	1.691ArgGln: 1.691 ± 0.034	2.117ArgArg: 2.117 ± 0.048	2.808ArgSer: 2.808 ± 0.044	2.244ArgThr: 2.244 ± 0.04	3.057ArgVal: 3.057 ± 0.053	0.605ArgTrp: 0.605 ± 0.025	1.513ArgTyr: 1.513 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.074SerAla: 6.074 ± 0.094	0.774SerCys: 0.774 ± 0.03	3.432SerAsp: 3.432 ± 0.059	4.068SerGlu: 4.068 ± 0.069	3.622SerPhe: 3.622 ± 0.057	5.615SerGly: 5.615 ± 0.13	1.284SerHis: 1.284 ± 0.034	3.767SerIle: 3.767 ± 0.066	4.099SerLys: 4.099 ± 0.059	7.323SerLeu: 7.323 ± 0.072	1.646SerMet: 1.646 ± 0.043	2.652SerAsn: 2.652 ± 0.059	2.792SerPro: 2.792 ± 0.054	2.782SerGln: 2.782 ± 0.052	2.876SerArg: 2.876 ± 0.059	5.579SerSer: 5.579 ± 0.118	3.915SerThr: 3.915 ± 0.082	4.705SerVal: 4.705 ± 0.066	0.898SerTrp: 0.898 ± 0.028	2.375SerTyr: 2.375 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.076ThrAla: 5.076 ± 0.094	0.613ThrCys: 0.613 ± 0.031	2.82ThrAsp: 2.82 ± 0.054	3.174ThrGlu: 3.174 ± 0.054	2.503ThrPhe: 2.503 ± 0.051	4.44ThrGly: 4.44 ± 0.084	1.078ThrHis: 1.078 ± 0.027	3.032ThrIle: 3.032 ± 0.05	3.297ThrLys: 3.297 ± 0.057	5.531ThrLeu: 5.531 ± 0.078	1.237ThrMet: 1.237 ± 0.032	2.487ThrAsn: 2.487 ± 0.071	2.969ThrPro: 2.969 ± 0.05	2.099ThrGln: 2.099 ± 0.047	2.221ThrArg: 2.221 ± 0.043	4.213ThrSer: 4.213 ± 0.084	3.633ThrThr: 3.633 ± 0.094	4.205ThrVal: 4.205 ± 0.066	0.698ThrTrp: 0.698 ± 0.026	1.924ThrTyr: 1.924 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.986ValAla: 5.986 ± 0.081	0.656ValCys: 0.656 ± 0.025	3.714ValAsp: 3.714 ± 0.056	4.207ValGlu: 4.207 ± 0.066	3.052ValPhe: 3.052 ± 0.054	4.944ValGly: 4.944 ± 0.07	1.259ValHis: 1.259 ± 0.032	4.177ValIle: 4.177 ± 0.071	4.42ValLys: 4.42 ± 0.067	6.592ValLeu: 6.592 ± 0.081	1.748ValMet: 1.748 ± 0.039	3.052ValAsn: 3.052 ± 0.053	2.783ValPro: 2.783 ± 0.048	2.683ValGln: 2.683 ± 0.04	3.166ValArg: 3.166 ± 0.057	4.834ValSer: 4.834 ± 0.068	4.33ValThr: 4.33 ± 0.082	5.022ValVal: 5.022 ± 0.068	0.654ValTrp: 0.654 ± 0.027	1.883ValTyr: 1.883 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.942TrpAla: 0.942 ± 0.029	0.102TrpCys: 0.102 ± 0.009	0.627TrpAsp: 0.627 ± 0.024	0.593TrpGlu: 0.593 ± 0.025	0.471TrpPhe: 0.471 ± 0.021	0.907TrpGly: 0.907 ± 0.027	0.212TrpHis: 0.212 ± 0.012	0.745TrpIle: 0.745 ± 0.024	0.858TrpLys: 0.858 ± 0.025	1.097TrpLeu: 1.097 ± 0.035	0.371TrpMet: 0.371 ± 0.018	0.669TrpAsn: 0.669 ± 0.027	0.423TrpPro: 0.423 ± 0.021	0.456TrpGln: 0.456 ± 0.02	0.523TrpArg: 0.523 ± 0.021	0.846TrpSer: 0.846 ± 0.03	0.688TrpThr: 0.688 ± 0.025	0.828TrpVal: 0.828 ± 0.027	0.167TrpTrp: 0.167 ± 0.013	0.337TrpTyr: 0.337 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.24TyrAla: 2.24 ± 0.049	0.347TyrCys: 0.347 ± 0.021	1.772TyrAsp: 1.772 ± 0.041	1.742TyrGlu: 1.742 ± 0.039	1.74TyrPhe: 1.74 ± 0.043	2.138TyrGly: 2.138 ± 0.046	0.622TyrHis: 0.622 ± 0.024	1.575TyrIle: 1.575 ± 0.037	1.917TyrLys: 1.917 ± 0.037	3.119TyrLeu: 3.119 ± 0.05	0.719TyrMet: 0.719 ± 0.026	1.45TyrAsn: 1.45 ± 0.037	1.285TyrPro: 1.285 ± 0.034	1.395TyrGln: 1.395 ± 0.035	1.642TyrArg: 1.642 ± 0.039	2.316TyrSer: 2.316 ± 0.042	1.594TyrThr: 1.594 ± 0.042	1.947TyrVal: 1.947 ± 0.049	0.459TyrTrp: 0.459 ± 0.019	1.143TyrTyr: 1.143 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3773 proteins (1203359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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