Amino acid dipepetide frequency for Caulobacter virus Rogue

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.148AlaAla: 13.148 ± 0.649
0.967AlaCys: 0.967 ± 0.119
6.812AlaAsp: 6.812 ± 0.399
6.705AlaGlu: 6.705 ± 0.415
4.05AlaPhe: 4.05 ± 0.292
9.589AlaGly: 9.589 ± 0.697
1.994AlaHis: 1.994 ± 0.199
5.37AlaIle: 5.37 ± 0.327
5.477AlaLys: 5.477 ± 0.463
10.203AlaLeu: 10.203 ± 0.499
3.621AlaMet: 3.621 ± 0.275
3.038AlaAsn: 3.038 ± 0.237
5.6AlaPro: 5.6 ± 0.318
4.511AlaGln: 4.511 ± 0.333
6.965AlaArg: 6.965 ± 0.382
5.738AlaSer: 5.738 ± 0.319
5.492AlaThr: 5.492 ± 0.495
6.72AlaVal: 6.72 ± 0.334
2.01AlaTrp: 2.01 ± 0.226
3.391AlaTyr: 3.391 ± 0.249
0.0AlaXaa: 0.0 ± 0.0
Cys
0.706CysAla: 0.706 ± 0.105
0.184CysCys: 0.184 ± 0.061
0.598CysAsp: 0.598 ± 0.095
0.721CysGlu: 0.721 ± 0.106
0.307CysPhe: 0.307 ± 0.065
0.813CysGly: 0.813 ± 0.105
0.276CysHis: 0.276 ± 0.071
0.338CysIle: 0.338 ± 0.075
0.338CysLys: 0.338 ± 0.07
0.706CysLeu: 0.706 ± 0.116
0.169CysMet: 0.169 ± 0.056
0.261CysAsn: 0.261 ± 0.066
0.476CysPro: 0.476 ± 0.094
0.307CysGln: 0.307 ± 0.064
0.936CysArg: 0.936 ± 0.133
0.583CysSer: 0.583 ± 0.103
0.522CysThr: 0.522 ± 0.092
0.568CysVal: 0.568 ± 0.088
0.184CysTrp: 0.184 ± 0.053
0.368CysTyr: 0.368 ± 0.069
0.0CysXaa: 0.0 ± 0.0
Asp
7.073AspAla: 7.073 ± 0.449
0.675AspCys: 0.675 ± 0.112
4.449AspAsp: 4.449 ± 0.389
4.695AspGlu: 4.695 ± 0.346
2.301AspPhe: 2.301 ± 0.199
6.459AspGly: 6.459 ± 0.291
1.596AspHis: 1.596 ± 0.182
3.145AspIle: 3.145 ± 0.251
2.593AspLys: 2.593 ± 0.212
6.551AspLeu: 6.551 ± 0.35
1.611AspMet: 1.611 ± 0.196
1.642AspAsn: 1.642 ± 0.164
4.05AspPro: 4.05 ± 0.249
1.642AspGln: 1.642 ± 0.158
4.173AspArg: 4.173 ± 0.315
1.994AspSer: 1.994 ± 0.17
3.513AspThr: 3.513 ± 0.252
5.048AspVal: 5.048 ± 0.383
1.273AspTrp: 1.273 ± 0.148
2.439AspTyr: 2.439 ± 0.205
0.0AspXaa: 0.0 ± 0.0
Glu
8.3GluAla: 8.3 ± 0.471
0.414GluCys: 0.414 ± 0.091
4.142GluAsp: 4.142 ± 0.361
4.096GluGlu: 4.096 ± 0.317
2.501GluPhe: 2.501 ± 0.189
3.912GluGly: 3.912 ± 0.245
1.504GluHis: 1.504 ± 0.15
3.237GluIle: 3.237 ± 0.235
2.67GluLys: 2.67 ± 0.236
3.759GluLeu: 3.759 ± 0.267
1.642GluMet: 1.642 ± 0.15
1.764GluAsn: 1.764 ± 0.195
2.777GluPro: 2.777 ± 0.184
2.378GluGln: 2.378 ± 0.216
4.771GluArg: 4.771 ± 0.361
2.378GluSer: 2.378 ± 0.179
4.004GluThr: 4.004 ± 0.301
4.741GluVal: 4.741 ± 0.315
0.936GluTrp: 0.936 ± 0.11
1.442GluTyr: 1.442 ± 0.171
0.0GluXaa: 0.0 ± 0.0
Phe
3.59PheAla: 3.59 ± 0.232
0.43PheCys: 0.43 ± 0.08
3.038PheAsp: 3.038 ± 0.257
2.531PheGlu: 2.531 ± 0.213
1.58PhePhe: 1.58 ± 0.157
3.068PheGly: 3.068 ± 0.221
0.982PheHis: 0.982 ± 0.16
1.473PheIle: 1.473 ± 0.154
1.887PheLys: 1.887 ± 0.18
3.068PheLeu: 3.068 ± 0.216
0.859PheMet: 0.859 ± 0.109
1.151PheAsn: 1.151 ± 0.148
1.534PhePro: 1.534 ± 0.172
1.197PheGln: 1.197 ± 0.124
2.041PheArg: 2.041 ± 0.169
2.102PheSer: 2.102 ± 0.202
2.347PheThr: 2.347 ± 0.226
2.639PheVal: 2.639 ± 0.197
0.721PheTrp: 0.721 ± 0.097
1.319PheTyr: 1.319 ± 0.158
0.0PheXaa: 0.0 ± 0.0
Gly
8.116GlyAla: 8.116 ± 0.606
0.813GlyCys: 0.813 ± 0.109
5.4GlyAsp: 5.4 ± 0.347
4.48GlyGlu: 4.48 ± 0.266
3.329GlyPhe: 3.329 ± 0.262
10.018GlyGly: 10.018 ± 2.692
1.473GlyHis: 1.473 ± 0.149
2.577GlyIle: 2.577 ± 0.195
4.357GlyLys: 4.357 ± 0.253
6.214GlyLeu: 6.214 ± 0.466
2.347GlyMet: 2.347 ± 0.217
2.179GlyAsn: 2.179 ± 0.322
3.283GlyPro: 3.283 ± 0.254
2.9GlyGln: 2.9 ± 0.279
5.247GlyArg: 5.247 ± 0.309
5.216GlySer: 5.216 ± 0.77
4.787GlyThr: 4.787 ± 0.842
6.382GlyVal: 6.382 ± 0.33
1.948GlyTrp: 1.948 ± 0.227
2.93GlyTyr: 2.93 ± 0.298
0.0GlyXaa: 0.0 ± 0.0
His
2.424HisAla: 2.424 ± 0.198
0.322HisCys: 0.322 ± 0.071
1.703HisAsp: 1.703 ± 0.173
1.273HisGlu: 1.273 ± 0.151
0.721HisPhe: 0.721 ± 0.129
1.902HisGly: 1.902 ± 0.177
0.629HisHis: 0.629 ± 0.116
0.859HisIle: 0.859 ± 0.137
0.798HisLys: 0.798 ± 0.129
1.657HisLeu: 1.657 ± 0.164
0.583HisMet: 0.583 ± 0.083
0.598HisAsn: 0.598 ± 0.112
1.289HisPro: 1.289 ± 0.14
0.66HisGln: 0.66 ± 0.102
1.258HisArg: 1.258 ± 0.157
0.89HisSer: 0.89 ± 0.124
0.844HisThr: 0.844 ± 0.107
1.519HisVal: 1.519 ± 0.148
0.399HisTrp: 0.399 ± 0.077
0.736HisTyr: 0.736 ± 0.104
0.0HisXaa: 0.0 ± 0.0
Ile
5.492IleAla: 5.492 ± 0.311
0.522IleCys: 0.522 ± 0.089
3.866IleAsp: 3.866 ± 0.241
3.421IleGlu: 3.421 ± 0.281
1.335IlePhe: 1.335 ± 0.125
3.759IleGly: 3.759 ± 0.303
1.043IleHis: 1.043 ± 0.145
1.902IleIle: 1.902 ± 0.186
2.424IleLys: 2.424 ± 0.2
3.283IleLeu: 3.283 ± 0.206
0.982IleMet: 0.982 ± 0.127
1.596IleAsn: 1.596 ± 0.229
2.071IlePro: 2.071 ± 0.164
1.58IleGln: 1.58 ± 0.165
2.777IleArg: 2.777 ± 0.257
2.332IleSer: 2.332 ± 0.245
3.176IleThr: 3.176 ± 0.39
3.605IleVal: 3.605 ± 0.208
0.614IleTrp: 0.614 ± 0.095
1.135IleTyr: 1.135 ± 0.118
0.0IleXaa: 0.0 ± 0.0
Lys
6.198LysAla: 6.198 ± 0.429
0.245LysCys: 0.245 ± 0.064
2.746LysAsp: 2.746 ± 0.281
2.056LysGlu: 2.056 ± 0.231
1.626LysPhe: 1.626 ± 0.174
3.391LysGly: 3.391 ± 0.277
0.782LysHis: 0.782 ± 0.139
2.24LysIle: 2.24 ± 0.172
2.424LysLys: 2.424 ± 0.277
4.342LysLeu: 4.342 ± 0.311
0.967LysMet: 0.967 ± 0.112
1.089LysAsn: 1.089 ± 0.133
2.7LysPro: 2.7 ± 0.215
1.289LysGln: 1.289 ± 0.174
3.59LysArg: 3.59 ± 0.285
2.117LysSer: 2.117 ± 0.175
3.421LysThr: 3.421 ± 0.26
3.912LysVal: 3.912 ± 0.264
0.69LysTrp: 0.69 ± 0.11
1.089LysTyr: 1.089 ± 0.122
0.0LysXaa: 0.0 ± 0.0
Leu
9.221LeuAla: 9.221 ± 0.384
0.782LeuCys: 0.782 ± 0.111
5.615LeuAsp: 5.615 ± 0.313
5.14LeuGlu: 5.14 ± 0.38
2.363LeuPhe: 2.363 ± 0.202
6.122LeuGly: 6.122 ± 0.356
1.887LeuHis: 1.887 ± 0.2
3.912LeuIle: 3.912 ± 0.244
4.066LeuLys: 4.066 ± 0.301
6.075LeuLeu: 6.075 ± 0.351
1.841LeuMet: 1.841 ± 0.188
2.685LeuAsn: 2.685 ± 0.216
4.388LeuPro: 4.388 ± 0.257
2.194LeuGln: 2.194 ± 0.209
5.523LeuArg: 5.523 ± 0.359
5.293LeuSer: 5.293 ± 0.372
5.615LeuThr: 5.615 ± 0.319
4.817LeuVal: 4.817 ± 0.34
1.227LeuTrp: 1.227 ± 0.115
2.117LeuTyr: 2.117 ± 0.205
0.0LeuXaa: 0.0 ± 0.0
Met
2.777MetAla: 2.777 ± 0.203
0.184MetCys: 0.184 ± 0.049
1.151MetAsp: 1.151 ± 0.156
1.059MetGlu: 1.059 ± 0.137
0.736MetPhe: 0.736 ± 0.12
1.534MetGly: 1.534 ± 0.236
0.384MetHis: 0.384 ± 0.07
1.35MetIle: 1.35 ± 0.156
1.289MetLys: 1.289 ± 0.125
1.688MetLeu: 1.688 ± 0.175
0.614MetMet: 0.614 ± 0.105
0.875MetAsn: 0.875 ± 0.13
1.488MetPro: 1.488 ± 0.171
0.782MetGln: 0.782 ± 0.121
1.764MetArg: 1.764 ± 0.187
1.856MetSer: 1.856 ± 0.167
2.363MetThr: 2.363 ± 0.189
1.273MetVal: 1.273 ± 0.164
0.384MetTrp: 0.384 ± 0.088
0.414MetTyr: 0.414 ± 0.095
0.0MetXaa: 0.0 ± 0.0
Asn
3.406AsnAla: 3.406 ± 0.262
0.338AsnCys: 0.338 ± 0.077
1.688AsnAsp: 1.688 ± 0.173
1.856AsnGlu: 1.856 ± 0.178
0.997AsnPhe: 0.997 ± 0.137
3.145AsnGly: 3.145 ± 0.368
0.568AsnHis: 0.568 ± 0.105
1.396AsnIle: 1.396 ± 0.174
1.151AsnLys: 1.151 ± 0.121
2.762AsnLeu: 2.762 ± 0.2
0.552AsnMet: 0.552 ± 0.122
1.197AsnAsn: 1.197 ± 0.163
1.948AsnPro: 1.948 ± 0.185
0.798AsnGln: 0.798 ± 0.104
1.764AsnArg: 1.764 ± 0.167
1.365AsnSer: 1.365 ± 0.161
1.749AsnThr: 1.749 ± 0.191
1.826AsnVal: 1.826 ± 0.192
0.338AsnTrp: 0.338 ± 0.072
0.982AsnTyr: 0.982 ± 0.127
0.0AsnXaa: 0.0 ± 0.0
Pro
5.753ProAla: 5.753 ± 0.336
0.384ProCys: 0.384 ± 0.078
3.897ProAsp: 3.897 ± 0.241
3.636ProGlu: 3.636 ± 0.259
1.887ProPhe: 1.887 ± 0.179
4.311ProGly: 4.311 ± 0.324
1.135ProHis: 1.135 ± 0.142
2.792ProIle: 2.792 ± 0.199
2.102ProLys: 2.102 ± 0.17
3.728ProLeu: 3.728 ± 0.254
1.013ProMet: 1.013 ± 0.14
1.657ProAsn: 1.657 ± 0.158
3.084ProPro: 3.084 ± 0.359
1.688ProGln: 1.688 ± 0.156
2.67ProArg: 2.67 ± 0.221
2.792ProSer: 2.792 ± 0.222
3.452ProThr: 3.452 ± 0.312
3.375ProVal: 3.375 ± 0.244
0.644ProTrp: 0.644 ± 0.098
1.519ProTyr: 1.519 ± 0.154
0.0ProXaa: 0.0 ± 0.0
Gln
4.679GlnAla: 4.679 ± 0.344
0.184GlnCys: 0.184 ± 0.057
1.902GlnAsp: 1.902 ± 0.203
1.933GlnGlu: 1.933 ± 0.172
1.135GlnPhe: 1.135 ± 0.133
2.639GlnGly: 2.639 ± 0.199
0.782GlnHis: 0.782 ± 0.125
1.718GlnIle: 1.718 ± 0.163
1.703GlnLys: 1.703 ± 0.216
1.672GlnLeu: 1.672 ± 0.209
0.675GlnMet: 0.675 ± 0.118
0.828GlnAsn: 0.828 ± 0.113
1.58GlnPro: 1.58 ± 0.132
1.212GlnGln: 1.212 ± 0.149
2.439GlnArg: 2.439 ± 0.241
1.626GlnSer: 1.626 ± 0.147
1.872GlnThr: 1.872 ± 0.156
2.501GlnVal: 2.501 ± 0.192
0.537GlnTrp: 0.537 ± 0.087
0.859GlnTyr: 0.859 ± 0.116
0.0GlnXaa: 0.0 ± 0.0
Arg
6.781ArgAla: 6.781 ± 0.443
0.552ArgCys: 0.552 ± 0.093
4.649ArgAsp: 4.649 ± 0.334
4.265ArgGlu: 4.265 ± 0.365
3.038ArgPhe: 3.038 ± 0.215
4.357ArgGly: 4.357 ± 0.235
1.365ArgHis: 1.365 ± 0.179
3.176ArgIle: 3.176 ± 0.247
3.068ArgLys: 3.068 ± 0.254
6.168ArgLeu: 6.168 ± 0.367
1.902ArgMet: 1.902 ± 0.183
1.856ArgAsn: 1.856 ± 0.158
2.9ArgPro: 2.9 ± 0.251
2.439ArgGln: 2.439 ± 0.207
5.354ArgArg: 5.354 ± 0.465
3.068ArgSer: 3.068 ± 0.265
2.992ArgThr: 2.992 ± 0.239
3.943ArgVal: 3.943 ± 0.239
1.335ArgTrp: 1.335 ± 0.127
2.854ArgTyr: 2.854 ± 0.261
0.0ArgXaa: 0.0 ± 0.0
Ser
4.725SerAla: 4.725 ± 0.344
0.537SerCys: 0.537 ± 0.119
3.222SerAsp: 3.222 ± 0.228
2.731SerGlu: 2.731 ± 0.192
2.562SerPhe: 2.562 ± 0.203
5.354SerGly: 5.354 ± 0.748
1.013SerHis: 1.013 ± 0.137
2.547SerIle: 2.547 ± 0.205
2.255SerLys: 2.255 ± 0.218
3.958SerLeu: 3.958 ± 0.248
1.105SerMet: 1.105 ± 0.147
1.672SerAsn: 1.672 ± 0.174
2.593SerPro: 2.593 ± 0.214
1.596SerGln: 1.596 ± 0.194
3.207SerArg: 3.207 ± 0.243
3.038SerSer: 3.038 ± 0.244
3.759SerThr: 3.759 ± 0.395
3.513SerVal: 3.513 ± 0.294
0.905SerTrp: 0.905 ± 0.115
1.626SerTyr: 1.626 ± 0.15
0.0SerXaa: 0.0 ± 0.0
Thr
6.797ThrAla: 6.797 ± 0.407
0.644ThrCys: 0.644 ± 0.116
3.836ThrAsp: 3.836 ± 0.261
3.176ThrGlu: 3.176 ± 0.242
2.854ThrPhe: 2.854 ± 0.193
5.462ThrGly: 5.462 ± 0.654
1.166ThrHis: 1.166 ± 0.141
3.421ThrIle: 3.421 ± 0.46
2.455ThrLys: 2.455 ± 0.171
5.753ThrLeu: 5.753 ± 0.418
1.243ThrMet: 1.243 ± 0.148
1.979ThrAsn: 1.979 ± 0.221
4.127ThrPro: 4.127 ± 0.397
1.672ThrGln: 1.672 ± 0.169
3.299ThrArg: 3.299 ± 0.239
3.053ThrSer: 3.053 ± 0.317
3.345ThrThr: 3.345 ± 0.407
4.495ThrVal: 4.495 ± 0.446
0.844ThrTrp: 0.844 ± 0.116
1.948ThrTyr: 1.948 ± 0.195
0.0ThrXaa: 0.0 ± 0.0
Val
7.027ValAla: 7.027 ± 0.441
0.614ValCys: 0.614 ± 0.106
4.679ValAsp: 4.679 ± 0.311
4.572ValGlu: 4.572 ± 0.302
2.439ValPhe: 2.439 ± 0.204
4.603ValGly: 4.603 ± 0.322
1.442ValHis: 1.442 ± 0.16
3.621ValIle: 3.621 ± 0.246
3.621ValLys: 3.621 ± 0.243
5.615ValLeu: 5.615 ± 0.332
1.35ValMet: 1.35 ± 0.142
2.025ValAsn: 2.025 ± 0.224
3.498ValPro: 3.498 ± 0.253
2.347ValGln: 2.347 ± 0.165
4.741ValArg: 4.741 ± 0.324
4.035ValSer: 4.035 ± 0.278
5.032ValThr: 5.032 ± 0.36
4.725ValVal: 4.725 ± 0.291
1.151ValTrp: 1.151 ± 0.119
2.041ValTyr: 2.041 ± 0.164
0.0ValXaa: 0.0 ± 0.0
Trp
1.642TrpAla: 1.642 ± 0.165
0.138TrpCys: 0.138 ± 0.038
1.181TrpAsp: 1.181 ± 0.142
0.936TrpGlu: 0.936 ± 0.109
0.813TrpPhe: 0.813 ± 0.114
1.181TrpGly: 1.181 ± 0.136
0.261TrpHis: 0.261 ± 0.068
0.629TrpIle: 0.629 ± 0.095
0.951TrpLys: 0.951 ± 0.124
1.381TrpLeu: 1.381 ± 0.14
0.384TrpMet: 0.384 ± 0.073
0.828TrpAsn: 0.828 ± 0.115
0.782TrpPro: 0.782 ± 0.118
0.414TrpGln: 0.414 ± 0.088
1.289TrpArg: 1.289 ± 0.16
1.12TrpSer: 1.12 ± 0.129
1.197TrpThr: 1.197 ± 0.16
1.243TrpVal: 1.243 ± 0.16
0.245TrpTrp: 0.245 ± 0.062
0.215TrpTyr: 0.215 ± 0.054
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.544TyrAla: 3.544 ± 0.242
0.43TyrCys: 0.43 ± 0.074
2.347TyrAsp: 2.347 ± 0.194
2.087TyrGlu: 2.087 ± 0.198
0.982TyrPhe: 0.982 ± 0.126
2.378TyrGly: 2.378 ± 0.205
0.782TyrHis: 0.782 ± 0.116
1.212TyrIle: 1.212 ± 0.134
1.289TyrLys: 1.289 ± 0.154
2.301TyrLeu: 2.301 ± 0.224
0.491TyrMet: 0.491 ± 0.097
0.905TyrAsn: 0.905 ± 0.116
1.35TyrPro: 1.35 ± 0.141
0.875TyrGln: 0.875 ± 0.115
2.271TyrArg: 2.271 ± 0.171
1.319TyrSer: 1.319 ± 0.141
2.087TyrThr: 2.087 ± 0.2
2.332TyrVal: 2.332 ± 0.181
0.445TyrTrp: 0.445 ± 0.078
0.844TyrTyr: 0.844 ± 0.117
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 331 proteins (65181 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski