Amino acid dipepetide frequency for Agarivorans albus MKT 106

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.831AlaAla: 8.831 ± 0.115
1.088AlaCys: 1.088 ± 0.03
4.778AlaAsp: 4.778 ± 0.066
6.456AlaGlu: 6.456 ± 0.085
3.537AlaPhe: 3.537 ± 0.056
6.436AlaGly: 6.436 ± 0.081
1.609AlaHis: 1.609 ± 0.036
5.975AlaIle: 5.975 ± 0.073
5.611AlaLys: 5.611 ± 0.08
10.411AlaLeu: 10.411 ± 0.099
2.711AlaMet: 2.711 ± 0.049
4.16AlaAsn: 4.16 ± 0.061
2.984AlaPro: 2.984 ± 0.048
4.308AlaGln: 4.308 ± 0.071
3.474AlaArg: 3.474 ± 0.051
6.293AlaSer: 6.293 ± 0.074
4.344AlaThr: 4.344 ± 0.06
6.162AlaVal: 6.162 ± 0.086
1.217AlaTrp: 1.217 ± 0.03
2.691AlaTyr: 2.691 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.806CysAla: 0.806 ± 0.029
0.19CysCys: 0.19 ± 0.013
0.592CysAsp: 0.592 ± 0.024
0.617CysGlu: 0.617 ± 0.02
0.482CysPhe: 0.482 ± 0.017
0.857CysGly: 0.857 ± 0.024
0.321CysHis: 0.321 ± 0.02
0.594CysIle: 0.594 ± 0.02
0.408CysLys: 0.408 ± 0.018
1.164CysLeu: 1.164 ± 0.038
0.22CysMet: 0.22 ± 0.013
0.379CysAsn: 0.379 ± 0.016
0.442CysPro: 0.442 ± 0.019
0.52CysGln: 0.52 ± 0.021
0.431CysArg: 0.431 ± 0.019
0.796CysSer: 0.796 ± 0.028
0.402CysThr: 0.402 ± 0.017
0.622CysVal: 0.622 ± 0.022
0.147CysTrp: 0.147 ± 0.012
0.362CysTyr: 0.362 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.57AspAla: 4.57 ± 0.059
0.529AspCys: 0.529 ± 0.02
2.815AspAsp: 2.815 ± 0.049
3.554AspGlu: 3.554 ± 0.049
2.403AspPhe: 2.403 ± 0.046
3.699AspGly: 3.699 ± 0.072
0.981AspHis: 0.981 ± 0.034
3.612AspIle: 3.612 ± 0.05
3.05AspLys: 3.05 ± 0.045
5.319AspLeu: 5.319 ± 0.075
1.313AspMet: 1.313 ± 0.029
2.471AspAsn: 2.471 ± 0.048
2.139AspPro: 2.139 ± 0.046
2.212AspGln: 2.212 ± 0.039
1.829AspArg: 1.829 ± 0.041
3.594AspSer: 3.594 ± 0.062
2.526AspThr: 2.526 ± 0.047
3.514AspVal: 3.514 ± 0.055
0.931AspTrp: 0.931 ± 0.029
2.193AspTyr: 2.193 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.357GluAla: 5.357 ± 0.07
0.464GluCys: 0.464 ± 0.02
2.891GluAsp: 2.891 ± 0.051
3.486GluGlu: 3.486 ± 0.065
2.458GluPhe: 2.458 ± 0.044
3.359GluGly: 3.359 ± 0.048
1.64GluHis: 1.64 ± 0.037
3.252GluIle: 3.252 ± 0.054
2.91GluLys: 2.91 ± 0.054
7.761GluLeu: 7.761 ± 0.088
1.484GluMet: 1.484 ± 0.031
2.384GluAsn: 2.384 ± 0.043
2.159GluPro: 2.159 ± 0.04
5.778GluGln: 5.778 ± 0.087
3.094GluArg: 3.094 ± 0.055
3.291GluSer: 3.291 ± 0.055
2.639GluThr: 2.639 ± 0.049
4.286GluVal: 4.286 ± 0.064
0.693GluTrp: 0.693 ± 0.024
1.711GluTyr: 1.711 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.979PheAla: 3.979 ± 0.059
0.5PheCys: 0.5 ± 0.021
2.686PheAsp: 2.686 ± 0.051
2.631PheGlu: 2.631 ± 0.041
1.626PhePhe: 1.626 ± 0.041
3.044PheGly: 3.044 ± 0.05
0.774PheHis: 0.774 ± 0.021
2.513PheIle: 2.513 ± 0.047
2.047PheLys: 2.047 ± 0.04
3.194PheLeu: 3.194 ± 0.059
0.972PheMet: 0.972 ± 0.027
2.075PheAsn: 2.075 ± 0.037
1.326PhePro: 1.326 ± 0.03
1.245PheGln: 1.245 ± 0.031
1.42PheArg: 1.42 ± 0.032
3.723PheSer: 3.723 ± 0.052
2.234PheThr: 2.234 ± 0.048
2.972PheVal: 2.972 ± 0.05
0.589PheTrp: 0.589 ± 0.025
1.405PheTyr: 1.405 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.28GlyAla: 5.28 ± 0.074
0.864GlyCys: 0.864 ± 0.03
3.772GlyAsp: 3.772 ± 0.072
4.684GlyGlu: 4.684 ± 0.058
3.322GlyPhe: 3.322 ± 0.055
4.66GlyGly: 4.66 ± 0.072
1.447GlyHis: 1.447 ± 0.041
4.364GlyIle: 4.364 ± 0.06
3.733GlyLys: 3.733 ± 0.062
7.447GlyLeu: 7.447 ± 0.088
1.778GlyMet: 1.778 ± 0.042
2.536GlyAsn: 2.536 ± 0.052
1.689GlyPro: 1.689 ± 0.04
3.05GlyGln: 3.05 ± 0.054
2.857GlyArg: 2.857 ± 0.05
4.407GlySer: 4.407 ± 0.074
2.961GlyThr: 2.961 ± 0.061
4.864GlyVal: 4.864 ± 0.066
0.974GlyTrp: 0.974 ± 0.03
2.491GlyTyr: 2.491 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.657HisAla: 1.657 ± 0.029
0.349HisCys: 0.349 ± 0.02
1.01HisAsp: 1.01 ± 0.034
0.928HisGlu: 0.928 ± 0.029
1.072HisPhe: 1.072 ± 0.03
1.536HisGly: 1.536 ± 0.041
0.658HisHis: 0.658 ± 0.024
1.242HisIle: 1.242 ± 0.027
0.976HisLys: 0.976 ± 0.028
2.39HisLeu: 2.39 ± 0.046
0.431HisMet: 0.431 ± 0.017
0.873HisAsn: 0.873 ± 0.024
1.177HisPro: 1.177 ± 0.027
1.495HisGln: 1.495 ± 0.035
0.998HisArg: 0.998 ± 0.031
1.534HisSer: 1.534 ± 0.036
0.949HisThr: 0.949 ± 0.026
1.141HisVal: 1.141 ± 0.029
0.444HisTrp: 0.444 ± 0.019
0.95HisTyr: 0.95 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.375IleAla: 6.375 ± 0.077
0.648IleCys: 0.648 ± 0.022
3.987IleAsp: 3.987 ± 0.059
4.405IleGlu: 4.405 ± 0.062
2.004IlePhe: 2.004 ± 0.042
4.27IleGly: 4.27 ± 0.06
1.125IleHis: 1.125 ± 0.031
3.165IleIle: 3.165 ± 0.062
3.012IleLys: 3.012 ± 0.052
4.473IleLeu: 4.473 ± 0.068
1.157IleMet: 1.157 ± 0.035
2.983IleAsn: 2.983 ± 0.052
2.349IlePro: 2.349 ± 0.043
2.109IleGln: 2.109 ± 0.038
2.438IleArg: 2.438 ± 0.047
4.561IleSer: 4.561 ± 0.068
3.162IleThr: 3.162 ± 0.055
3.94IleVal: 3.94 ± 0.054
0.614IleTrp: 0.614 ± 0.023
1.603IleTyr: 1.603 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.871LysAla: 4.871 ± 0.074
0.268LysCys: 0.268 ± 0.016
2.463LysAsp: 2.463 ± 0.045
2.583LysGlu: 2.583 ± 0.047
1.415LysPhe: 1.415 ± 0.032
3.114LysGly: 3.114 ± 0.048
1.392LysHis: 1.392 ± 0.036
2.557LysIle: 2.557 ± 0.046
2.267LysLys: 2.267 ± 0.048
5.593LysLeu: 5.593 ± 0.079
1.209LysMet: 1.209 ± 0.027
1.805LysAsn: 1.805 ± 0.04
2.345LysPro: 2.345 ± 0.049
4.035LysGln: 4.035 ± 0.072
2.583LysArg: 2.583 ± 0.048
2.789LysSer: 2.789 ± 0.049
2.449LysThr: 2.449 ± 0.044
3.89LysVal: 3.89 ± 0.059
0.531LysTrp: 0.531 ± 0.02
1.209LysTyr: 1.209 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
11.872LeuAla: 11.872 ± 0.114
1.133LeuCys: 1.133 ± 0.035
5.87LeuAsp: 5.87 ± 0.076
6.485LeuGlu: 6.485 ± 0.074
4.218LeuPhe: 4.218 ± 0.062
7.129LeuGly: 7.129 ± 0.082
2.052LeuHis: 2.052 ± 0.042
5.907LeuIle: 5.907 ± 0.074
5.394LeuLys: 5.394 ± 0.074
11.73LeuLeu: 11.73 ± 0.138
2.528LeuMet: 2.528 ± 0.052
5.036LeuAsn: 5.036 ± 0.064
4.836LeuPro: 4.836 ± 0.065
4.594LeuGln: 4.594 ± 0.056
4.552LeuArg: 4.552 ± 0.059
9.187LeuSer: 9.187 ± 0.096
5.027LeuThr: 5.027 ± 0.065
7.645LeuVal: 7.645 ± 0.091
1.196LeuTrp: 1.196 ± 0.033
2.745LeuTyr: 2.745 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.479MetAla: 2.479 ± 0.046
0.179MetCys: 0.179 ± 0.011
1.135MetAsp: 1.135 ± 0.032
1.132MetGlu: 1.132 ± 0.028
0.97MetPhe: 0.97 ± 0.027
1.623MetGly: 1.623 ± 0.034
0.475MetHis: 0.475 ± 0.02
1.234MetIle: 1.234 ± 0.028
1.121MetLys: 1.121 ± 0.029
2.906MetLeu: 2.906 ± 0.051
0.616MetMet: 0.616 ± 0.022
0.949MetAsn: 0.949 ± 0.027
1.148MetPro: 1.148 ± 0.031
1.363MetGln: 1.363 ± 0.029
1.158MetArg: 1.158 ± 0.03
1.869MetSer: 1.869 ± 0.037
1.156MetThr: 1.156 ± 0.031
1.773MetVal: 1.773 ± 0.037
0.211MetTrp: 0.211 ± 0.013
0.51MetTyr: 0.51 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.592AsnAla: 3.592 ± 0.053
0.449AsnCys: 0.449 ± 0.02
2.335AsnAsp: 2.335 ± 0.042
2.24AsnGlu: 2.24 ± 0.046
1.604AsnPhe: 1.604 ± 0.03
3.068AsnGly: 3.068 ± 0.061
0.959AsnHis: 0.959 ± 0.03
2.626AsnIle: 2.626 ± 0.046
2.29AsnLys: 2.29 ± 0.037
4.14AsnLeu: 4.14 ± 0.062
1.036AsnMet: 1.036 ± 0.029
2.175AsnAsn: 2.175 ± 0.055
2.044AsnPro: 2.044 ± 0.043
2.83AsnGln: 2.83 ± 0.047
1.745AsnArg: 1.745 ± 0.041
2.885AsnSer: 2.885 ± 0.05
2.177AsnThr: 2.177 ± 0.044
2.476AsnVal: 2.476 ± 0.052
0.714AsnTrp: 0.714 ± 0.028
1.531AsnTyr: 1.531 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
3.364ProAla: 3.364 ± 0.057
0.321ProCys: 0.321 ± 0.014
2.078ProAsp: 2.078 ± 0.042
3.272ProGlu: 3.272 ± 0.058
1.567ProPhe: 1.567 ± 0.034
2.34ProGly: 2.34 ± 0.047
0.816ProHis: 0.816 ± 0.024
2.268ProIle: 2.268 ± 0.04
2.003ProLys: 2.003 ± 0.042
4.255ProLeu: 4.255 ± 0.062
0.96ProMet: 0.96 ± 0.027
1.824ProAsn: 1.824 ± 0.037
1.18ProPro: 1.18 ± 0.034
1.902ProGln: 1.902 ± 0.043
1.296ProArg: 1.296 ± 0.033
2.872ProSer: 2.872 ± 0.059
1.808ProThr: 1.808 ± 0.041
2.829ProVal: 2.829 ± 0.044
0.533ProTrp: 0.533 ± 0.024
1.242ProTyr: 1.242 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
5.983GlnAla: 5.983 ± 0.087
0.452GlnCys: 0.452 ± 0.019
2.282GlnAsp: 2.282 ± 0.044
2.503GlnGlu: 2.503 ± 0.048
2.164GlnPhe: 2.164 ± 0.038
3.442GlnGly: 3.442 ± 0.051
1.685GlnHis: 1.685 ± 0.037
2.813GlnIle: 2.813 ± 0.057
1.889GlnLys: 1.889 ± 0.049
7.246GlnLeu: 7.246 ± 0.109
1.104GlnMet: 1.104 ± 0.024
1.781GlnAsn: 1.781 ± 0.037
1.836GlnPro: 1.836 ± 0.035
6.0GlnGln: 6.0 ± 0.118
3.047GlnArg: 3.047 ± 0.056
3.12GlnSer: 3.12 ± 0.05
2.494GlnThr: 2.494 ± 0.049
3.885GlnVal: 3.885 ± 0.056
0.861GlnTrp: 0.861 ± 0.026
1.482GlnTyr: 1.482 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.314ArgAla: 3.314 ± 0.045
0.508ArgCys: 0.508 ± 0.02
2.14ArgAsp: 2.14 ± 0.043
2.683ArgGlu: 2.683 ± 0.056
2.302ArgPhe: 2.302 ± 0.038
2.417ArgGly: 2.417 ± 0.046
1.059ArgHis: 1.059 ± 0.031
2.626ArgIle: 2.626 ± 0.052
2.046ArgLys: 2.046 ± 0.038
4.912ArgLeu: 4.912 ± 0.068
1.046ArgMet: 1.046 ± 0.027
1.742ArgAsn: 1.742 ± 0.033
1.593ArgPro: 1.593 ± 0.036
2.24ArgGln: 2.24 ± 0.041
2.117ArgArg: 2.117 ± 0.048
2.738ArgSer: 2.738 ± 0.048
1.733ArgThr: 1.733 ± 0.034
3.039ArgVal: 3.039 ± 0.048
0.689ArgTrp: 0.689 ± 0.02
1.8ArgTyr: 1.8 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.165SerAla: 6.165 ± 0.074
0.723SerCys: 0.723 ± 0.023
3.806SerAsp: 3.806 ± 0.065
4.242SerGlu: 4.242 ± 0.054
3.085SerPhe: 3.085 ± 0.048
5.073SerGly: 5.073 ± 0.071
1.508SerHis: 1.508 ± 0.036
4.197SerIle: 4.197 ± 0.059
3.293SerLys: 3.293 ± 0.049
8.11SerLeu: 8.11 ± 0.099
1.67SerMet: 1.67 ± 0.036
2.938SerAsn: 2.938 ± 0.057
2.67SerPro: 2.67 ± 0.045
3.86SerGln: 3.86 ± 0.059
2.776SerArg: 2.776 ± 0.045
5.039SerSer: 5.039 ± 0.081
3.059SerThr: 3.059 ± 0.053
4.53SerVal: 4.53 ± 0.07
0.999SerTrp: 0.999 ± 0.027
2.357SerTyr: 2.357 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.305ThrAla: 4.305 ± 0.06
0.415ThrCys: 0.415 ± 0.018
2.343ThrAsp: 2.343 ± 0.047
2.827ThrGlu: 2.827 ± 0.046
1.725ThrPhe: 1.725 ± 0.039
3.583ThrGly: 3.583 ± 0.055
0.989ThrHis: 0.989 ± 0.028
3.004ThrIle: 3.004 ± 0.056
2.168ThrLys: 2.168 ± 0.038
5.401ThrLeu: 5.401 ± 0.066
1.038ThrMet: 1.038 ± 0.029
1.944ThrAsn: 1.944 ± 0.041
2.306ThrPro: 2.306 ± 0.043
2.289ThrGln: 2.289 ± 0.042
1.942ThrArg: 1.942 ± 0.035
3.108ThrSer: 3.108 ± 0.054
2.499ThrThr: 2.499 ± 0.044
3.434ThrVal: 3.434 ± 0.061
0.656ThrTrp: 0.656 ± 0.02
1.248ThrTyr: 1.248 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
6.909ValAla: 6.909 ± 0.077
0.723ValCys: 0.723 ± 0.021
4.103ValAsp: 4.103 ± 0.06
4.533ValGlu: 4.533 ± 0.071
2.936ValPhe: 2.936 ± 0.05
4.589ValGly: 4.589 ± 0.064
1.18ValHis: 1.18 ± 0.03
4.267ValIle: 4.267 ± 0.061
3.389ValLys: 3.389 ± 0.049
6.973ValLeu: 6.973 ± 0.09
1.756ValMet: 1.756 ± 0.035
3.178ValAsn: 3.178 ± 0.046
2.482ValPro: 2.482 ± 0.044
2.304ValGln: 2.304 ± 0.04
2.597ValArg: 2.597 ± 0.048
5.291ValSer: 5.291 ± 0.065
3.652ValThr: 3.652 ± 0.064
5.452ValVal: 5.452 ± 0.073
0.766ValTrp: 0.766 ± 0.026
1.976ValTyr: 1.976 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.942TrpAla: 0.942 ± 0.029
0.153TrpCys: 0.153 ± 0.01
0.641TrpAsp: 0.641 ± 0.026
0.515TrpGlu: 0.515 ± 0.018
0.625TrpPhe: 0.625 ± 0.023
0.839TrpGly: 0.839 ± 0.028
0.349TrpHis: 0.349 ± 0.015
0.643TrpIle: 0.643 ± 0.023
0.5TrpLys: 0.5 ± 0.018
2.062TrpLeu: 2.062 ± 0.041
0.351TrpMet: 0.351 ± 0.016
0.516TrpAsn: 0.516 ± 0.023
0.558TrpPro: 0.558 ± 0.025
1.34TrpGln: 1.34 ± 0.037
0.713TrpArg: 0.713 ± 0.023
0.794TrpSer: 0.794 ± 0.027
0.524TrpThr: 0.524 ± 0.021
0.842TrpVal: 0.842 ± 0.022
0.235TrpTrp: 0.235 ± 0.013
0.404TrpTyr: 0.404 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.424TyrAla: 2.424 ± 0.042
0.395TyrCys: 0.395 ± 0.017
1.528TyrAsp: 1.528 ± 0.036
1.324TyrGlu: 1.324 ± 0.033
1.439TyrPhe: 1.439 ± 0.037
2.104TyrGly: 2.104 ± 0.041
0.795TyrHis: 0.795 ± 0.029
1.52TyrIle: 1.52 ± 0.034
1.262TyrLys: 1.262 ± 0.036
3.647TyrLeu: 3.647 ± 0.05
0.625TyrMet: 0.625 ± 0.02
1.165TyrAsn: 1.165 ± 0.031
1.465TyrPro: 1.465 ± 0.034
2.594TyrGln: 2.594 ± 0.05
1.68TyrArg: 1.68 ± 0.038
2.209TyrSer: 2.209 ± 0.044
1.431TyrThr: 1.431 ± 0.039
1.759TyrVal: 1.759 ± 0.037
0.545TyrTrp: 0.545 ± 0.023
1.089TyrTyr: 1.089 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4397 proteins (1381857 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski