Amino acid dipepetide frequency for Oribacterium parvum ACB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.087AlaAla: 5.087 ± 0.125
0.932AlaCys: 0.932 ± 0.041
3.305AlaAsp: 3.305 ± 0.075
5.853AlaGlu: 5.853 ± 0.107
3.529AlaPhe: 3.529 ± 0.077
5.224AlaGly: 5.224 ± 0.095
1.03AlaHis: 1.03 ± 0.04
4.975AlaIle: 4.975 ± 0.085
5.613AlaLys: 5.613 ± 0.103
7.896AlaLeu: 7.896 ± 0.124
2.372AlaMet: 2.372 ± 0.056
2.412AlaAsn: 2.412 ± 0.069
1.73AlaPro: 1.73 ± 0.051
1.669AlaGln: 1.669 ± 0.052
2.708AlaArg: 2.708 ± 0.062
4.036AlaSer: 4.036 ± 0.08
2.89AlaThr: 2.89 ± 0.077
5.478AlaVal: 5.478 ± 0.092
0.543AlaTrp: 0.543 ± 0.03
2.613AlaTyr: 2.613 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.763CysAla: 0.763 ± 0.04
0.189CysCys: 0.189 ± 0.018
0.613CysAsp: 0.613 ± 0.031
0.669CysGlu: 0.669 ± 0.036
0.716CysPhe: 0.716 ± 0.035
1.036CysGly: 1.036 ± 0.046
0.29CysHis: 0.29 ± 0.02
1.104CysIle: 1.104 ± 0.041
0.875CysLys: 0.875 ± 0.042
1.167CysLeu: 1.167 ± 0.045
0.347CysMet: 0.347 ± 0.019
0.441CysAsn: 0.441 ± 0.025
0.549CysPro: 0.549 ± 0.03
0.227CysGln: 0.227 ± 0.017
0.424CysArg: 0.424 ± 0.027
0.718CysSer: 0.718 ± 0.032
0.588CysThr: 0.588 ± 0.029
0.651CysVal: 0.651 ± 0.033
0.077CysTrp: 0.077 ± 0.009
0.452CysTyr: 0.452 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.813AspAla: 3.813 ± 0.073
0.725AspCys: 0.725 ± 0.033
2.166AspAsp: 2.166 ± 0.061
4.04AspGlu: 4.04 ± 0.076
3.193AspPhe: 3.193 ± 0.064
3.826AspGly: 3.826 ± 0.097
0.775AspHis: 0.775 ± 0.038
3.973AspIle: 3.973 ± 0.08
3.731AspLys: 3.731 ± 0.082
4.991AspLeu: 4.991 ± 0.082
1.465AspMet: 1.465 ± 0.046
1.788AspAsn: 1.788 ± 0.056
1.696AspPro: 1.696 ± 0.051
1.079AspGln: 1.079 ± 0.039
2.184AspArg: 2.184 ± 0.059
3.377AspSer: 3.377 ± 0.071
2.463AspThr: 2.463 ± 0.061
3.053AspVal: 3.053 ± 0.072
0.516AspTrp: 0.516 ± 0.028
2.464AspTyr: 2.464 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.886GluAla: 5.886 ± 0.107
0.758GluCys: 0.758 ± 0.036
4.833GluAsp: 4.833 ± 0.086
11.266GluGlu: 11.266 ± 0.215
2.492GluPhe: 2.492 ± 0.062
5.613GluGly: 5.613 ± 0.084
1.322GluHis: 1.322 ± 0.043
5.944GluIle: 5.944 ± 0.095
9.877GluLys: 9.877 ± 0.141
7.225GluLeu: 7.225 ± 0.109
2.432GluMet: 2.432 ± 0.062
4.881GluAsn: 4.881 ± 0.095
1.609GluPro: 1.609 ± 0.053
2.543GluGln: 2.543 ± 0.062
4.104GluArg: 4.104 ± 0.087
4.621GluSer: 4.621 ± 0.091
3.267GluThr: 3.267 ± 0.082
4.723GluVal: 4.723 ± 0.09
0.697GluTrp: 0.697 ± 0.033
2.874GluTyr: 2.874 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.182PheAla: 3.182 ± 0.075
0.645PheCys: 0.645 ± 0.034
2.242PheAsp: 2.242 ± 0.057
2.281PheGlu: 2.281 ± 0.05
2.866PhePhe: 2.866 ± 0.09
3.041PheGly: 3.041 ± 0.076
1.044PheHis: 1.044 ± 0.036
3.084PheIle: 3.084 ± 0.076
2.273PheLys: 2.273 ± 0.062
5.653PheLeu: 5.653 ± 0.132
1.23PheMet: 1.23 ± 0.037
1.5PheAsn: 1.5 ± 0.046
1.952PhePro: 1.952 ± 0.058
1.741PheGln: 1.741 ± 0.052
2.051PheArg: 2.051 ± 0.059
4.66PheSer: 4.66 ± 0.097
2.494PheThr: 2.494 ± 0.064
2.895PheVal: 2.895 ± 0.071
0.424PheTrp: 0.424 ± 0.023
2.098PheTyr: 2.098 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.751GlyAla: 4.751 ± 0.103
0.771GlyCys: 0.771 ± 0.034
3.277GlyAsp: 3.277 ± 0.069
6.219GlyGlu: 6.219 ± 0.107
3.357GlyPhe: 3.357 ± 0.065
4.801GlyGly: 4.801 ± 0.103
1.068GlyHis: 1.068 ± 0.043
6.171GlyIle: 6.171 ± 0.111
6.694GlyLys: 6.694 ± 0.101
5.807GlyLeu: 5.807 ± 0.086
2.252GlyMet: 2.252 ± 0.054
3.309GlyAsn: 3.309 ± 0.07
1.229GlyPro: 1.229 ± 0.043
1.879GlyGln: 1.879 ± 0.052
3.244GlyArg: 3.244 ± 0.074
4.062GlySer: 4.062 ± 0.081
3.584GlyThr: 3.584 ± 0.081
4.569GlyVal: 4.569 ± 0.084
0.577GlyTrp: 0.577 ± 0.033
2.815GlyTyr: 2.815 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.066HisAla: 1.066 ± 0.04
0.322HisCys: 0.322 ± 0.023
0.834HisAsp: 0.834 ± 0.034
1.077HisGlu: 1.077 ± 0.041
1.254HisPhe: 1.254 ± 0.045
1.287HisGly: 1.287 ± 0.046
0.417HisHis: 0.417 ± 0.044
1.329HisIle: 1.329 ± 0.048
1.043HisLys: 1.043 ± 0.037
1.597HisLeu: 1.597 ± 0.052
0.351HisMet: 0.351 ± 0.023
0.672HisAsn: 0.672 ± 0.028
0.814HisPro: 0.814 ± 0.03
0.444HisGln: 0.444 ± 0.023
0.782HisArg: 0.782 ± 0.036
1.273HisSer: 1.273 ± 0.048
0.73HisThr: 0.73 ± 0.037
0.891HisVal: 0.891 ± 0.041
0.147HisTrp: 0.147 ± 0.015
0.823HisTyr: 0.823 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.373IleAla: 5.373 ± 0.105
0.985IleCys: 0.985 ± 0.041
3.477IleAsp: 3.477 ± 0.072
4.99IleGlu: 4.99 ± 0.084
3.44IlePhe: 3.44 ± 0.084
4.726IleGly: 4.726 ± 0.08
1.373IleHis: 1.373 ± 0.046
4.44IleIle: 4.44 ± 0.095
3.95IleLys: 3.95 ± 0.084
8.309IleLeu: 8.309 ± 0.14
1.815IleMet: 1.815 ± 0.056
2.433IleAsn: 2.433 ± 0.07
3.378IlePro: 3.378 ± 0.075
2.327IleGln: 2.327 ± 0.05
3.545IleArg: 3.545 ± 0.07
5.429IleSer: 5.429 ± 0.095
3.421IleThr: 3.421 ± 0.079
4.467IleVal: 4.467 ± 0.096
0.486IleTrp: 0.486 ± 0.027
2.594IleTyr: 2.594 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
5.811LysAla: 5.811 ± 0.106
0.508LysCys: 0.508 ± 0.029
4.768LysAsp: 4.768 ± 0.091
9.488LysGlu: 9.488 ± 0.113
1.912LysPhe: 1.912 ± 0.048
5.067LysGly: 5.067 ± 0.098
1.108LysHis: 1.108 ± 0.043
4.991LysIle: 4.991 ± 0.086
7.941LysLys: 7.941 ± 0.135
6.217LysLeu: 6.217 ± 0.084
2.315LysMet: 2.315 ± 0.057
4.316LysAsn: 4.316 ± 0.078
1.965LysPro: 1.965 ± 0.063
2.301LysGln: 2.301 ± 0.057
3.663LysArg: 3.663 ± 0.078
4.051LysSer: 4.051 ± 0.076
3.822LysThr: 3.822 ± 0.081
4.314LysVal: 4.314 ± 0.087
0.599LysTrp: 0.599 ± 0.029
2.529LysTyr: 2.529 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
6.581LeuAla: 6.581 ± 0.103
1.556LeuCys: 1.556 ± 0.052
4.754LeuAsp: 4.754 ± 0.087
7.33LeuGlu: 7.33 ± 0.128
5.417LeuPhe: 5.417 ± 0.139
6.517LeuGly: 6.517 ± 0.114
1.872LeuHis: 1.872 ± 0.057
6.031LeuIle: 6.031 ± 0.109
6.806LeuLys: 6.806 ± 0.101
10.723LeuLeu: 10.723 ± 0.196
2.555LeuMet: 2.555 ± 0.067
3.775LeuAsn: 3.775 ± 0.086
4.03LeuPro: 4.03 ± 0.077
3.319LeuGln: 3.319 ± 0.068
4.432LeuArg: 4.432 ± 0.09
9.66LeuSer: 9.66 ± 0.14
4.262LeuThr: 4.262 ± 0.069
5.196LeuVal: 5.196 ± 0.09
0.729LeuTrp: 0.729 ± 0.033
3.803LeuTyr: 3.803 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.236MetAla: 2.236 ± 0.062
0.221MetCys: 0.221 ± 0.016
1.76MetAsp: 1.76 ± 0.05
2.852MetGlu: 2.852 ± 0.059
0.796MetPhe: 0.796 ± 0.035
2.113MetGly: 2.113 ± 0.062
0.477MetHis: 0.477 ± 0.025
1.798MetIle: 1.798 ± 0.059
2.386MetLys: 2.386 ± 0.055
2.464MetLeu: 2.464 ± 0.06
0.87MetMet: 0.87 ± 0.035
1.476MetAsn: 1.476 ± 0.052
0.91MetPro: 0.91 ± 0.035
1.187MetGln: 1.187 ± 0.04
1.227MetArg: 1.227 ± 0.043
1.612MetSer: 1.612 ± 0.05
1.212MetThr: 1.212 ± 0.046
1.679MetVal: 1.679 ± 0.053
0.158MetTrp: 0.158 ± 0.015
0.631MetTyr: 0.631 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.252AsnAla: 3.252 ± 0.09
0.518AsnCys: 0.518 ± 0.029
1.739AsnAsp: 1.739 ± 0.053
2.783AsnGlu: 2.783 ± 0.067
1.853AsnPhe: 1.853 ± 0.048
3.347AsnGly: 3.347 ± 0.081
0.77AsnHis: 0.77 ± 0.031
3.246AsnIle: 3.246 ± 0.071
2.757AsnLys: 2.757 ± 0.064
4.124AsnLeu: 4.124 ± 0.084
1.146AsnMet: 1.146 ± 0.043
1.599AsnAsn: 1.599 ± 0.057
2.222AsnPro: 2.222 ± 0.064
1.369AsnGln: 1.369 ± 0.046
2.04AsnArg: 2.04 ± 0.054
2.324AsnSer: 2.324 ± 0.055
2.296AsnThr: 2.296 ± 0.068
2.529AsnVal: 2.529 ± 0.064
0.41AsnTrp: 0.41 ± 0.023
1.713AsnTyr: 1.713 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
2.065ProAla: 2.065 ± 0.062
0.358ProCys: 0.358 ± 0.022
1.91ProAsp: 1.91 ± 0.05
3.253ProGlu: 3.253 ± 0.076
1.755ProPhe: 1.755 ± 0.056
2.278ProGly: 2.278 ± 0.064
0.542ProHis: 0.542 ± 0.031
2.278ProIle: 2.278 ± 0.065
2.394ProLys: 2.394 ± 0.056
3.14ProLeu: 3.14 ± 0.075
0.884ProMet: 0.884 ± 0.039
1.338ProAsn: 1.338 ± 0.047
0.652ProPro: 0.652 ± 0.035
0.722ProGln: 0.722 ± 0.032
0.968ProArg: 0.968 ± 0.041
2.049ProSer: 2.049 ± 0.062
1.451ProThr: 1.451 ± 0.05
2.484ProVal: 2.484 ± 0.061
0.262ProTrp: 0.262 ± 0.02
1.545ProTyr: 1.545 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.04GlnAla: 2.04 ± 0.059
0.288GlnCys: 0.288 ± 0.022
1.654GlnAsp: 1.654 ± 0.05
2.804GlnGlu: 2.804 ± 0.074
1.175GlnPhe: 1.175 ± 0.039
2.177GlnGly: 2.177 ± 0.053
0.434GlnHis: 0.434 ± 0.023
2.183GlnIle: 2.183 ± 0.063
2.754GlnLys: 2.754 ± 0.062
2.306GlnLeu: 2.306 ± 0.058
0.761GlnMet: 0.761 ± 0.036
1.699GlnAsn: 1.699 ± 0.051
0.61GlnPro: 0.61 ± 0.03
0.744GlnGln: 0.744 ± 0.035
1.32GlnArg: 1.32 ± 0.046
1.912GlnSer: 1.912 ± 0.052
1.143GlnThr: 1.143 ± 0.039
1.69GlnVal: 1.69 ± 0.05
0.294GlnTrp: 0.294 ± 0.021
1.286GlnTyr: 1.286 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.761ArgAla: 2.761 ± 0.063
0.451ArgCys: 0.451 ± 0.027
2.294ArgAsp: 2.294 ± 0.063
4.497ArgGlu: 4.497 ± 0.091
2.158ArgPhe: 2.158 ± 0.057
2.715ArgGly: 2.715 ± 0.071
0.645ArgHis: 0.645 ± 0.031
3.7ArgIle: 3.7 ± 0.079
3.788ArgLys: 3.788 ± 0.081
4.08ArgLeu: 4.08 ± 0.084
1.271ArgMet: 1.271 ± 0.039
2.075ArgAsn: 2.075 ± 0.061
1.219ArgPro: 1.219 ± 0.047
1.318ArgGln: 1.318 ± 0.047
2.177ArgArg: 2.177 ± 0.062
2.273ArgSer: 2.273 ± 0.059
1.847ArgThr: 1.847 ± 0.051
2.711ArgVal: 2.711 ± 0.065
0.311ArgTrp: 0.311 ± 0.02
1.832ArgTyr: 1.832 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
4.56SerAla: 4.56 ± 0.095
0.789SerCys: 0.789 ± 0.036
3.091SerAsp: 3.091 ± 0.078
4.723SerGlu: 4.723 ± 0.099
4.15SerPhe: 4.15 ± 0.085
5.554SerGly: 5.554 ± 0.1
1.164SerHis: 1.164 ± 0.045
5.017SerIle: 5.017 ± 0.095
3.82SerLys: 3.82 ± 0.08
7.589SerLeu: 7.589 ± 0.131
1.927SerMet: 1.927 ± 0.051
2.123SerAsn: 2.123 ± 0.058
2.127SerPro: 2.127 ± 0.061
1.641SerGln: 1.641 ± 0.056
2.67SerArg: 2.67 ± 0.072
4.509SerSer: 4.509 ± 0.095
3.13SerThr: 3.13 ± 0.069
4.397SerVal: 4.397 ± 0.068
0.511SerTrp: 0.511 ± 0.027
2.982SerTyr: 2.982 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
3.724ThrAla: 3.724 ± 0.077
0.41ThrCys: 0.41 ± 0.026
2.634ThrAsp: 2.634 ± 0.069
4.31ThrGlu: 4.31 ± 0.097
1.664ThrPhe: 1.664 ± 0.05
3.791ThrGly: 3.791 ± 0.076
0.781ThrHis: 0.781 ± 0.038
3.305ThrIle: 3.305 ± 0.076
3.255ThrLys: 3.255 ± 0.078
4.39ThrLeu: 4.39 ± 0.083
1.247ThrMet: 1.247 ± 0.04
1.604ThrAsn: 1.604 ± 0.046
1.69ThrPro: 1.69 ± 0.064
1.076ThrGln: 1.076 ± 0.04
1.648ThrArg: 1.648 ± 0.043
2.31ThrSer: 2.31 ± 0.062
2.18ThrThr: 2.18 ± 0.065
4.025ThrVal: 4.025 ± 0.076
0.379ThrTrp: 0.379 ± 0.024
1.345ThrTyr: 1.345 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
3.935ValAla: 3.935 ± 0.078
0.814ValCys: 0.814 ± 0.034
3.333ValAsp: 3.333 ± 0.077
5.308ValGlu: 5.308 ± 0.102
3.069ValPhe: 3.069 ± 0.073
4.057ValGly: 4.057 ± 0.079
1.075ValHis: 1.075 ± 0.042
4.082ValIle: 4.082 ± 0.08
4.513ValLys: 4.513 ± 0.082
7.05ValLeu: 7.05 ± 0.122
1.622ValMet: 1.622 ± 0.055
2.594ValAsn: 2.594 ± 0.065
2.27ValPro: 2.27 ± 0.067
1.945ValGln: 1.945 ± 0.06
2.569ValArg: 2.569 ± 0.063
4.545ValSer: 4.545 ± 0.082
2.683ValThr: 2.683 ± 0.072
3.936ValVal: 3.936 ± 0.094
0.41ValTrp: 0.41 ± 0.025
2.308ValTyr: 2.308 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.421TrpAla: 0.421 ± 0.025
0.101TrpCys: 0.101 ± 0.013
0.448TrpAsp: 0.448 ± 0.026
0.641TrpGlu: 0.641 ± 0.034
0.341TrpPhe: 0.341 ± 0.023
0.469TrpGly: 0.469 ± 0.028
0.132TrpHis: 0.132 ± 0.013
0.655TrpIle: 0.655 ± 0.032
0.858TrpLys: 0.858 ± 0.041
0.666TrpLeu: 0.666 ± 0.032
0.263TrpMet: 0.263 ± 0.019
0.452TrpAsn: 0.452 ± 0.026
0.143TrpPro: 0.143 ± 0.015
0.341TrpGln: 0.341 ± 0.023
0.334TrpArg: 0.334 ± 0.023
0.404TrpSer: 0.404 ± 0.025
0.361TrpThr: 0.361 ± 0.024
0.414TrpVal: 0.414 ± 0.026
0.102TrpTrp: 0.102 ± 0.013
0.372TrpTyr: 0.372 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.586TyrAla: 2.586 ± 0.066
0.551TyrCys: 0.551 ± 0.028
2.187TyrAsp: 2.187 ± 0.057
2.583TyrGlu: 2.583 ± 0.059
2.218TyrPhe: 2.218 ± 0.059
2.799TyrGly: 2.799 ± 0.065
0.837TyrHis: 0.837 ± 0.034
2.652TyrIle: 2.652 ± 0.068
2.358TyrLys: 2.358 ± 0.056
3.955TyrLeu: 3.955 ± 0.087
0.94TyrMet: 0.94 ± 0.039
1.549TyrAsn: 1.549 ± 0.048
1.535TyrPro: 1.535 ± 0.045
1.404TyrGln: 1.404 ± 0.048
2.029TyrArg: 2.029 ± 0.049
2.65TyrSer: 2.65 ± 0.064
1.942TyrThr: 1.942 ± 0.053
2.015TyrVal: 2.015 ± 0.056
0.288TyrTrp: 0.288 ± 0.022
1.801TyrTyr: 1.801 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2127 proteins (714622 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski