Amino acid dipepetide frequency for Serpentinomonas raichei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.636AlaAla: 20.636 ± 0.275	1.388AlaCys: 1.388 ± 0.043	6.349AlaAsp: 6.349 ± 0.101	7.129AlaGlu: 7.129 ± 0.111	3.851AlaPhe: 3.851 ± 0.075	9.888AlaGly: 9.888 ± 0.129	3.439AlaHis: 3.439 ± 0.066	4.718AlaIle: 4.718 ± 0.083	2.881AlaLys: 2.881 ± 0.083	18.71AlaLeu: 18.71 ± 0.245	2.947AlaMet: 2.947 ± 0.061	2.467AlaAsn: 2.467 ± 0.064	7.191AlaPro: 7.191 ± 0.129	8.195AlaGln: 8.195 ± 0.142	9.17AlaArg: 9.17 ± 0.114	6.49AlaSer: 6.49 ± 0.107	5.761AlaThr: 5.761 ± 0.103	8.639AlaVal: 8.639 ± 0.132	2.014AlaTrp: 2.014 ± 0.068	2.334AlaTyr: 2.334 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.365CysAla: 1.365 ± 0.045	0.108CysCys: 0.108 ± 0.011	0.559CysAsp: 0.559 ± 0.028	0.554CysGlu: 0.554 ± 0.028	0.295CysPhe: 0.295 ± 0.02	1.034CysGly: 1.034 ± 0.044	0.34CysHis: 0.34 ± 0.02	0.407CysIle: 0.407 ± 0.021	0.234CysLys: 0.234 ± 0.018	1.017CysLeu: 1.017 ± 0.039	0.18CysMet: 0.18 ± 0.016	0.255CysAsn: 0.255 ± 0.019	0.648CysPro: 0.648 ± 0.036	0.435CysGln: 0.435 ± 0.024	0.612CysArg: 0.612 ± 0.029	0.545CysSer: 0.545 ± 0.03	0.502CysThr: 0.502 ± 0.024	0.695CysVal: 0.695 ± 0.034	0.148CysTrp: 0.148 ± 0.014	0.223CysTyr: 0.223 ± 0.018	0.003CysXaa: 0.003 ± 0.002
Asp	6.539AspAla: 6.539 ± 0.109	0.554AspCys: 0.554 ± 0.027	2.256AspAsp: 2.256 ± 0.062	3.025AspGlu: 3.025 ± 0.07	1.976AspPhe: 1.976 ± 0.047	3.954AspGly: 3.954 ± 0.096	1.007AspHis: 1.007 ± 0.038	1.949AspIle: 1.949 ± 0.056	1.254AspLys: 1.254 ± 0.046	5.625AspLeu: 5.625 ± 0.09	0.997AspMet: 0.997 ± 0.037	0.955AspAsn: 0.955 ± 0.044	3.025AspPro: 3.025 ± 0.071	1.659AspGln: 1.659 ± 0.047	2.727AspArg: 2.727 ± 0.059	2.008AspSer: 2.008 ± 0.048	2.08AspThr: 2.08 ± 0.059	3.124AspVal: 3.124 ± 0.065	1.197AspTrp: 1.197 ± 0.039	1.212AspTyr: 1.212 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.189GluAla: 7.189 ± 0.121	0.415GluCys: 0.415 ± 0.023	1.7GluAsp: 1.7 ± 0.054	2.055GluGlu: 2.055 ± 0.064	1.789GluPhe: 1.789 ± 0.05	3.78GluGly: 3.78 ± 0.07	1.516GluHis: 1.516 ± 0.047	2.596GluIle: 2.596 ± 0.059	1.3GluLys: 1.3 ± 0.049	6.876GluLeu: 6.876 ± 0.109	1.06GluMet: 1.06 ± 0.04	0.974GluAsn: 0.974 ± 0.035	2.969GluPro: 2.969 ± 0.062	3.677GluGln: 3.677 ± 0.083	5.627GluArg: 5.627 ± 0.09	2.26GluSer: 2.26 ± 0.055	2.169GluThr: 2.169 ± 0.054	4.084GluVal: 4.084 ± 0.083	0.694GluTrp: 0.694 ± 0.033	0.896GluTyr: 0.896 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.91PheAla: 3.91 ± 0.073	0.388PheCys: 0.388 ± 0.025	2.4PheAsp: 2.4 ± 0.054	2.447PheGlu: 2.447 ± 0.056	1.243PhePhe: 1.243 ± 0.05	3.159PheGly: 3.159 ± 0.07	0.675PheHis: 0.675 ± 0.028	1.411PheIle: 1.411 ± 0.047	1.067PheLys: 1.067 ± 0.036	2.889PheLeu: 2.889 ± 0.066	0.768PheMet: 0.768 ± 0.036	1.053PheAsn: 1.053 ± 0.041	1.338PhePro: 1.338 ± 0.045	1.099PheGln: 1.099 ± 0.037	1.65PheArg: 1.65 ± 0.043	1.735PheSer: 1.735 ± 0.049	1.554PheThr: 1.554 ± 0.058	2.553PheVal: 2.553 ± 0.065	0.507PheTrp: 0.507 ± 0.024	0.794PheTyr: 0.794 ± 0.036	0.003PheXaa: 0.003 ± 0.002
Gly	9.371GlyAla: 9.371 ± 0.127	1.071GlyCys: 1.071 ± 0.037	3.23GlyAsp: 3.23 ± 0.07	3.786GlyGlu: 3.786 ± 0.071	3.08GlyPhe: 3.08 ± 0.065	6.327GlyGly: 6.327 ± 0.115	2.196GlyHis: 2.196 ± 0.055	3.448GlyIle: 3.448 ± 0.081	2.508GlyLys: 2.508 ± 0.062	9.985GlyLeu: 9.985 ± 0.142	2.026GlyMet: 2.026 ± 0.053	1.86GlyAsn: 1.86 ± 0.074	3.428GlyPro: 3.428 ± 0.061	4.472GlyGln: 4.472 ± 0.078	5.786GlyArg: 5.786 ± 0.091	4.559GlySer: 4.559 ± 0.084	3.681GlyThr: 3.681 ± 0.094	6.293GlyVal: 6.293 ± 0.103	1.502GlyTrp: 1.502 ± 0.053	1.931GlyTyr: 1.931 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	3.263HisAla: 3.263 ± 0.068	0.369HisCys: 0.369 ± 0.022	1.241HisAsp: 1.241 ± 0.04	1.329HisGlu: 1.329 ± 0.041	0.898HisPhe: 0.898 ± 0.037	2.435HisGly: 2.435 ± 0.061	0.663HisHis: 0.663 ± 0.029	1.086HisIle: 1.086 ± 0.041	0.609HisLys: 0.609 ± 0.028	2.806HisLeu: 2.806 ± 0.07	0.46HisMet: 0.46 ± 0.025	0.603HisAsn: 0.603 ± 0.027	1.915HisPro: 1.915 ± 0.062	1.117HisGln: 1.117 ± 0.038	1.524HisArg: 1.524 ± 0.043	1.349HisSer: 1.349 ± 0.043	1.286HisThr: 1.286 ± 0.047	1.325HisVal: 1.325 ± 0.037	0.619HisTrp: 0.619 ± 0.031	0.733HisTyr: 0.733 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.134IleAla: 5.134 ± 0.092	0.401IleCys: 0.401 ± 0.022	2.907IleAsp: 2.907 ± 0.049	3.642IleGlu: 3.642 ± 0.075	1.146IlePhe: 1.146 ± 0.04	4.048IleGly: 4.048 ± 0.065	0.858IleHis: 0.858 ± 0.036	1.357IleIle: 1.357 ± 0.049	1.292IleLys: 1.292 ± 0.048	3.09IleLeu: 3.09 ± 0.07	0.747IleMet: 0.747 ± 0.032	1.313IleAsn: 1.313 ± 0.044	1.759IlePro: 1.759 ± 0.052	1.267IleGln: 1.267 ± 0.048	2.416IleArg: 2.416 ± 0.06	2.064IleSer: 2.064 ± 0.053	2.06IleThr: 2.06 ± 0.066	3.055IleVal: 3.055 ± 0.073	0.497IleTrp: 0.497 ± 0.029	0.913IleTyr: 0.913 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.146LysAla: 3.146 ± 0.075	0.145LysCys: 0.145 ± 0.015	1.069LysAsp: 1.069 ± 0.042	1.108LysGlu: 1.108 ± 0.044	0.726LysPhe: 0.726 ± 0.033	2.017LysGly: 2.017 ± 0.054	0.53LysHis: 0.53 ± 0.028	1.184LysIle: 1.184 ± 0.045	1.036LysLys: 1.036 ± 0.044	2.912LysLeu: 2.912 ± 0.06	0.556LysMet: 0.556 ± 0.031	0.696LysAsn: 0.696 ± 0.031	1.709LysPro: 1.709 ± 0.06	1.021LysGln: 1.021 ± 0.039	1.934LysArg: 1.934 ± 0.061	1.393LysSer: 1.393 ± 0.049	1.388LysThr: 1.388 ± 0.047	1.917LysVal: 1.917 ± 0.059	0.266LysTrp: 0.266 ± 0.02	0.523LysTyr: 0.523 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	16.824LeuAla: 16.824 ± 0.22	1.283LeuCys: 1.283 ± 0.039	6.297LeuAsp: 6.297 ± 0.097	6.225LeuGlu: 6.225 ± 0.101	3.18LeuPhe: 3.18 ± 0.069	9.798LeuGly: 9.798 ± 0.138	3.23LeuHis: 3.23 ± 0.066	4.675LeuIle: 4.675 ± 0.075	3.092LeuLys: 3.092 ± 0.072	15.329LeuLeu: 15.329 ± 0.247	2.438LeuMet: 2.438 ± 0.064	2.816LeuAsn: 2.816 ± 0.061	7.203LeuPro: 7.203 ± 0.101	7.07LeuGln: 7.07 ± 0.123	9.664LeuArg: 9.664 ± 0.13	6.241LeuSer: 6.241 ± 0.107	5.059LeuThr: 5.059 ± 0.087	7.64LeuVal: 7.64 ± 0.108	1.695LeuTrp: 1.695 ± 0.054	2.07LeuTyr: 2.07 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.656MetAla: 2.656 ± 0.061	0.182MetCys: 0.182 ± 0.017	0.852MetAsp: 0.852 ± 0.031	0.905MetGlu: 0.905 ± 0.033	0.568MetPhe: 0.568 ± 0.03	1.784MetGly: 1.784 ± 0.053	0.504MetHis: 0.504 ± 0.024	0.782MetIle: 0.782 ± 0.036	0.723MetLys: 0.723 ± 0.035	2.437MetLeu: 2.437 ± 0.063	0.461MetMet: 0.461 ± 0.026	0.866MetAsn: 0.866 ± 0.038	1.306MetPro: 1.306 ± 0.04	1.223MetGln: 1.223 ± 0.04	1.542MetArg: 1.542 ± 0.045	1.406MetSer: 1.406 ± 0.041	1.057MetThr: 1.057 ± 0.04	1.538MetVal: 1.538 ± 0.046	0.2MetTrp: 0.2 ± 0.016	0.283MetTyr: 0.283 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.9AsnAla: 2.9 ± 0.062	0.22AsnCys: 0.22 ± 0.017	1.046AsnAsp: 1.046 ± 0.041	1.148AsnGlu: 1.148 ± 0.034	0.808AsnPhe: 0.808 ± 0.032	1.799AsnGly: 1.799 ± 0.069	0.563AsnHis: 0.563 ± 0.026	1.01AsnIle: 1.01 ± 0.038	0.612AsnLys: 0.612 ± 0.033	2.7AsnLeu: 2.7 ± 0.061	0.484AsnMet: 0.484 ± 0.025	0.567AsnAsn: 0.567 ± 0.03	2.098AsnPro: 2.098 ± 0.062	1.043AsnGln: 1.043 ± 0.043	1.698AsnArg: 1.698 ± 0.044	0.942AsnSer: 0.942 ± 0.036	1.18AsnThr: 1.18 ± 0.042	1.567AsnVal: 1.567 ± 0.052	0.442AsnTrp: 0.442 ± 0.026	0.472AsnTyr: 0.472 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.308ProAla: 8.308 ± 0.143	0.48ProCys: 0.48 ± 0.024	3.32ProAsp: 3.32 ± 0.062	3.874ProGlu: 3.874 ± 0.074	1.768ProPhe: 1.768 ± 0.054	4.826ProGly: 4.826 ± 0.084	1.479ProHis: 1.479 ± 0.046	1.958ProIle: 1.958 ± 0.048	1.324ProLys: 1.324 ± 0.044	6.364ProLeu: 6.364 ± 0.105	1.304ProMet: 1.304 ± 0.039	1.399ProAsn: 1.399 ± 0.045	3.249ProPro: 3.249 ± 0.08	2.663ProGln: 2.663 ± 0.066	2.991ProArg: 2.991 ± 0.061	2.964ProSer: 2.964 ± 0.07	2.882ProThr: 2.882 ± 0.06	4.048ProVal: 4.048 ± 0.085	0.887ProTrp: 0.887 ± 0.034	1.063ProTyr: 1.063 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	8.544GlnAla: 8.544 ± 0.149	0.391GlnCys: 0.391 ± 0.024	1.668GlnAsp: 1.668 ± 0.04	2.0GlnGlu: 2.0 ± 0.052	1.371GlnPhe: 1.371 ± 0.039	3.854GlnGly: 3.854 ± 0.073	1.56GlnHis: 1.56 ± 0.05	2.16GlnIle: 2.16 ± 0.056	0.931GlnLys: 0.931 ± 0.036	5.136GlnLeu: 5.136 ± 0.094	1.134GlnMet: 1.134 ± 0.033	0.914GlnAsn: 0.914 ± 0.033	3.497GlnPro: 3.497 ± 0.078	3.635GlnGln: 3.635 ± 0.098	5.66GlnArg: 5.66 ± 0.107	2.302GlnSer: 2.302 ± 0.063	2.556GlnThr: 2.556 ± 0.059	3.649GlnVal: 3.649 ± 0.071	0.887GlnTrp: 0.887 ± 0.036	0.705GlnTyr: 0.705 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.718ArgAla: 8.718 ± 0.13	0.735ArgCys: 0.735 ± 0.032	3.094ArgAsp: 3.094 ± 0.064	4.004ArgGlu: 4.004 ± 0.076	2.803ArgPhe: 2.803 ± 0.055	4.541ArgGly: 4.541 ± 0.081	2.178ArgHis: 2.178 ± 0.06	3.52ArgIle: 3.52 ± 0.066	1.739ArgLys: 1.739 ± 0.048	9.819ArgLeu: 9.819 ± 0.166	1.677ArgMet: 1.677 ± 0.043	1.74ArgAsn: 1.74 ± 0.047	3.719ArgPro: 3.719 ± 0.068	3.865ArgGln: 3.865 ± 0.075	5.039ArgArg: 5.039 ± 0.091	3.935ArgSer: 3.935 ± 0.067	3.181ArgThr: 3.181 ± 0.067	5.227ArgVal: 5.227 ± 0.1	1.389ArgTrp: 1.389 ± 0.041	1.668ArgTyr: 1.668 ± 0.036	0.003ArgXaa: 0.003 ± 0.002
Ser	7.05SerAla: 7.05 ± 0.105	0.418SerCys: 0.418 ± 0.024	2.357SerAsp: 2.357 ± 0.056	2.668SerGlu: 2.668 ± 0.064	1.752SerPhe: 1.752 ± 0.049	5.31SerGly: 5.31 ± 0.082	1.211SerHis: 1.211 ± 0.038	1.927SerIle: 1.927 ± 0.055	1.296SerLys: 1.296 ± 0.048	5.306SerLeu: 5.306 ± 0.084	1.057SerMet: 1.057 ± 0.038	1.3SerAsn: 1.3 ± 0.044	2.857SerPro: 2.857 ± 0.068	2.003SerGln: 2.003 ± 0.055	3.215SerArg: 3.215 ± 0.066	2.709SerSer: 2.709 ± 0.078	2.61SerThr: 2.61 ± 0.067	3.527SerVal: 3.527 ± 0.077	0.634SerTrp: 0.634 ± 0.025	1.049SerTyr: 1.049 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.399ThrAla: 5.399 ± 0.113	0.382ThrCys: 0.382 ± 0.023	2.176ThrAsp: 2.176 ± 0.067	2.455ThrGlu: 2.455 ± 0.059	1.486ThrPhe: 1.486 ± 0.055	4.022ThrGly: 4.022 ± 0.095	1.173ThrHis: 1.173 ± 0.039	1.586ThrIle: 1.586 ± 0.055	0.842ThrLys: 0.842 ± 0.035	6.655ThrLeu: 6.655 ± 0.112	0.812ThrMet: 0.812 ± 0.035	0.905ThrAsn: 0.905 ± 0.044	3.519ThrPro: 3.519 ± 0.075	2.194ThrGln: 2.194 ± 0.052	3.019ThrArg: 3.019 ± 0.064	2.064ThrSer: 2.064 ± 0.063	2.008ThrThr: 2.008 ± 0.058	3.667ThrVal: 3.667 ± 0.099	0.579ThrTrp: 0.579 ± 0.025	0.792ThrTyr: 0.792 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.081ValAla: 9.081 ± 0.122	0.792ValCys: 0.792 ± 0.032	3.077ValAsp: 3.077 ± 0.072	3.687ValGlu: 3.687 ± 0.071	2.581ValPhe: 2.581 ± 0.063	5.221ValGly: 5.221 ± 0.094	1.566ValHis: 1.566 ± 0.05	2.9ValIle: 2.9 ± 0.071	1.698ValLys: 1.698 ± 0.056	9.216ValLeu: 9.216 ± 0.126	1.464ValMet: 1.464 ± 0.044	1.737ValAsn: 1.737 ± 0.05	3.745ValPro: 3.745 ± 0.064	3.934ValGln: 3.934 ± 0.077	5.397ValArg: 5.397 ± 0.079	3.45ValSer: 3.45 ± 0.083	3.108ValThr: 3.108 ± 0.089	5.343ValVal: 5.343 ± 0.098	1.078ValTrp: 1.078 ± 0.038	1.413ValTyr: 1.413 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.703TrpAla: 1.703 ± 0.045	0.21TrpCys: 0.21 ± 0.017	0.589TrpAsp: 0.589 ± 0.028	0.573TrpGlu: 0.573 ± 0.027	0.533TrpPhe: 0.533 ± 0.025	1.052TrpGly: 1.052 ± 0.035	0.415TrpHis: 0.415 ± 0.024	0.588TrpIle: 0.588 ± 0.031	0.322TrpLys: 0.322 ± 0.022	2.565TrpLeu: 2.565 ± 0.079	0.4TrpMet: 0.4 ± 0.022	0.363TrpAsn: 0.363 ± 0.02	0.947TrpPro: 0.947 ± 0.038	1.055TrpGln: 1.055 ± 0.039	1.369TrpArg: 1.369 ± 0.05	0.838TrpSer: 0.838 ± 0.03	0.558TrpThr: 0.558 ± 0.024	1.234TrpVal: 1.234 ± 0.044	0.281TrpTrp: 0.281 ± 0.02	0.261TrpTyr: 0.261 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.457TyrAla: 2.457 ± 0.053	0.227TyrCys: 0.227 ± 0.017	0.936TyrAsp: 0.936 ± 0.034	1.011TyrGlu: 1.011 ± 0.041	0.787TyrPhe: 0.787 ± 0.031	1.689TyrGly: 1.689 ± 0.046	0.528TyrHis: 0.528 ± 0.03	0.704TyrIle: 0.704 ± 0.028	0.514TyrLys: 0.514 ± 0.025	2.395TyrLeu: 2.395 ± 0.063	0.3TyrMet: 0.3 ± 0.021	0.518TyrAsn: 0.518 ± 0.025	1.031TyrPro: 1.031 ± 0.034	0.928TyrGln: 0.928 ± 0.038	1.556TyrArg: 1.556 ± 0.051	1.002TyrSer: 1.002 ± 0.035	1.052TyrThr: 1.052 ± 0.036	1.36TyrVal: 1.36 ± 0.039	0.341TyrTrp: 0.341 ± 0.02	0.466TyrTyr: 0.466 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.003XaaGly: 0.003 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.003XaaVal: 0.003 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2363 proteins (785481 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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