Amino acid dipepetide frequency for Zavarzinia aquatilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.871AlaAla: 20.871 ± 0.25	1.12AlaCys: 1.12 ± 0.032	7.789AlaAsp: 7.789 ± 0.092	8.352AlaGlu: 8.352 ± 0.106	4.565AlaPhe: 4.565 ± 0.058	13.637AlaGly: 13.637 ± 0.165	2.168AlaHis: 2.168 ± 0.042	6.496AlaIle: 6.496 ± 0.074	3.849AlaLys: 3.849 ± 0.074	14.949AlaLeu: 14.949 ± 0.13	3.348AlaMet: 3.348 ± 0.06	2.646AlaAsn: 2.646 ± 0.053	6.556AlaPro: 6.556 ± 0.093	3.503AlaGln: 3.503 ± 0.057	10.122AlaArg: 10.122 ± 0.125	5.914AlaSer: 5.914 ± 0.076	6.449AlaThr: 6.449 ± 0.074	9.488AlaVal: 9.488 ± 0.096	1.468AlaTrp: 1.468 ± 0.034	2.577AlaTyr: 2.577 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.988CysAla: 0.988 ± 0.028	0.104CysCys: 0.104 ± 0.01	0.492CysAsp: 0.492 ± 0.019	0.368CysGlu: 0.368 ± 0.018	0.335CysPhe: 0.335 ± 0.016	0.912CysGly: 0.912 ± 0.028	0.228CysHis: 0.228 ± 0.015	0.359CysIle: 0.359 ± 0.017	0.196CysLys: 0.196 ± 0.012	0.809CysLeu: 0.809 ± 0.026	0.127CysMet: 0.127 ± 0.01	0.176CysAsn: 0.176 ± 0.011	0.5CysPro: 0.5 ± 0.023	0.201CysGln: 0.201 ± 0.013	0.718CysArg: 0.718 ± 0.025	0.393CysSer: 0.393 ± 0.017	0.389CysThr: 0.389 ± 0.02	0.541CysVal: 0.541 ± 0.023	0.129CysTrp: 0.129 ± 0.01	0.171CysTyr: 0.171 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.079AspAla: 7.079 ± 0.086	0.446AspCys: 0.446 ± 0.017	3.578AspAsp: 3.578 ± 0.088	3.478AspGlu: 3.478 ± 0.06	2.368AspPhe: 2.368 ± 0.047	6.178AspGly: 6.178 ± 0.108	1.312AspHis: 1.312 ± 0.039	3.323AspIle: 3.323 ± 0.056	1.649AspLys: 1.649 ± 0.041	6.538AspLeu: 6.538 ± 0.079	1.294AspMet: 1.294 ± 0.026	1.262AspAsn: 1.262 ± 0.039	3.537AspPro: 3.537 ± 0.049	1.624AspGln: 1.624 ± 0.035	4.602AspArg: 4.602 ± 0.055	2.164AspSer: 2.164 ± 0.05	2.744AspThr: 2.744 ± 0.091	4.269AspVal: 4.269 ± 0.062	1.036AspTrp: 1.036 ± 0.03	1.609AspTyr: 1.609 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.469GluAla: 8.469 ± 0.101	0.326GluCys: 0.326 ± 0.019	2.753GluAsp: 2.753 ± 0.05	2.714GluGlu: 2.714 ± 0.052	1.613GluPhe: 1.613 ± 0.035	4.792GluGly: 4.792 ± 0.058	1.006GluHis: 1.006 ± 0.033	3.262GluIle: 3.262 ± 0.064	1.956GluLys: 1.956 ± 0.042	4.797GluLeu: 4.797 ± 0.069	1.354GluMet: 1.354 ± 0.032	1.302GluAsn: 1.302 ± 0.037	2.251GluPro: 2.251 ± 0.045	1.709GluGln: 1.709 ± 0.038	4.435GluArg: 4.435 ± 0.074	2.134GluSer: 2.134 ± 0.045	3.416GluThr: 3.416 ± 0.058	4.019GluVal: 4.019 ± 0.061	0.574GluTrp: 0.574 ± 0.02	0.874GluTyr: 0.874 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.783PheAla: 4.783 ± 0.068	0.402PheCys: 0.402 ± 0.016	2.731PheAsp: 2.731 ± 0.047	2.051PheGlu: 2.051 ± 0.042	1.3PhePhe: 1.3 ± 0.038	3.965PheGly: 3.965 ± 0.06	0.736PheHis: 0.736 ± 0.025	1.553PheIle: 1.553 ± 0.036	0.843PheLys: 0.843 ± 0.026	3.332PheLeu: 3.332 ± 0.055	0.788PheMet: 0.788 ± 0.025	0.923PheAsn: 0.923 ± 0.026	1.545PhePro: 1.545 ± 0.037	0.882PheGln: 0.882 ± 0.028	2.321PheArg: 2.321 ± 0.044	1.874PheSer: 1.874 ± 0.04	2.02PheThr: 2.02 ± 0.043	2.805PheVal: 2.805 ± 0.048	0.492PheTrp: 0.492 ± 0.02	0.826PheTyr: 0.826 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.332GlyAla: 11.332 ± 0.146	0.869GlyCys: 0.869 ± 0.03	5.7GlyAsp: 5.7 ± 0.13	4.996GlyGlu: 4.996 ± 0.069	3.946GlyPhe: 3.946 ± 0.071	9.458GlyGly: 9.458 ± 0.2	2.019GlyHis: 2.019 ± 0.043	4.972GlyIle: 4.972 ± 0.065	3.145GlyLys: 3.145 ± 0.054	10.396GlyLeu: 10.396 ± 0.129	2.069GlyMet: 2.069 ± 0.039	2.511GlyAsn: 2.511 ± 0.087	4.01GlyPro: 4.01 ± 0.056	2.928GlyGln: 2.928 ± 0.048	7.299GlyArg: 7.299 ± 0.096	4.508GlySer: 4.508 ± 0.083	5.06GlyThr: 5.06 ± 0.097	6.441GlyVal: 6.441 ± 0.078	1.375GlyTrp: 1.375 ± 0.032	2.188GlyTyr: 2.188 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.184HisAla: 2.184 ± 0.047	0.226HisCys: 0.226 ± 0.012	1.237HisAsp: 1.237 ± 0.032	0.907HisGlu: 0.907 ± 0.029	0.873HisPhe: 0.873 ± 0.026	1.927HisGly: 1.927 ± 0.037	0.59HisHis: 0.59 ± 0.029	0.798HisIle: 0.798 ± 0.026	0.459HisLys: 0.459 ± 0.02	2.126HisLeu: 2.126 ± 0.037	0.484HisMet: 0.484 ± 0.02	0.372HisAsn: 0.372 ± 0.016	1.234HisPro: 1.234 ± 0.033	0.51HisGln: 0.51 ± 0.02	1.502HisArg: 1.502 ± 0.039	0.754HisSer: 0.754 ± 0.025	0.692HisThr: 0.692 ± 0.024	1.566HisVal: 1.566 ± 0.037	0.328HisTrp: 0.328 ± 0.017	0.545HisTyr: 0.545 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.787IleAla: 7.787 ± 0.076	0.417IleCys: 0.417 ± 0.02	3.724IleAsp: 3.724 ± 0.06	3.8IleGlu: 3.8 ± 0.063	1.515IlePhe: 1.515 ± 0.033	5.195IleGly: 5.195 ± 0.066	0.887IleHis: 0.887 ± 0.026	1.706IleIle: 1.706 ± 0.036	1.15IleLys: 1.15 ± 0.036	4.297IleLeu: 4.297 ± 0.063	0.896IleMet: 0.896 ± 0.028	1.169IleAsn: 1.169 ± 0.036	2.072IlePro: 2.072 ± 0.041	1.043IleGln: 1.043 ± 0.031	3.269IleArg: 3.269 ± 0.048	2.423IleSer: 2.423 ± 0.046	2.539IleThr: 2.539 ± 0.05	4.13IleVal: 4.13 ± 0.064	0.505IleTrp: 0.505 ± 0.02	0.951IleTyr: 0.951 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.38LysAla: 4.38 ± 0.066	0.155LysCys: 0.155 ± 0.011	1.534LysAsp: 1.534 ± 0.036	1.199LysGlu: 1.199 ± 0.034	0.776LysPhe: 0.776 ± 0.024	2.702LysGly: 2.702 ± 0.043	0.45LysHis: 0.45 ± 0.019	1.455LysIle: 1.455 ± 0.04	0.981LysLys: 0.981 ± 0.034	2.888LysLeu: 2.888 ± 0.057	0.636LysMet: 0.636 ± 0.021	0.587LysAsn: 0.587 ± 0.024	1.96LysPro: 1.96 ± 0.05	0.784LysGln: 0.784 ± 0.027	2.062LysArg: 2.062 ± 0.047	1.407LysSer: 1.407 ± 0.03	1.662LysThr: 1.662 ± 0.04	2.47LysVal: 2.47 ± 0.054	0.297LysTrp: 0.297 ± 0.013	0.522LysTyr: 0.522 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.049LeuAla: 15.049 ± 0.152	0.86LeuCys: 0.86 ± 0.028	6.847LeuAsp: 6.847 ± 0.079	4.639LeuGlu: 4.639 ± 0.068	3.61LeuPhe: 3.61 ± 0.061	9.377LeuGly: 9.377 ± 0.097	1.871LeuHis: 1.871 ± 0.044	4.93LeuIle: 4.93 ± 0.072	3.205LeuLys: 3.205 ± 0.053	9.613LeuLeu: 9.613 ± 0.138	2.314LeuMet: 2.314 ± 0.043	2.337LeuAsn: 2.337 ± 0.047	6.217LeuPro: 6.217 ± 0.081	2.406LeuGln: 2.406 ± 0.046	7.484LeuArg: 7.484 ± 0.087	6.352LeuSer: 6.352 ± 0.071	5.712LeuThr: 5.712 ± 0.077	7.901LeuVal: 7.901 ± 0.088	1.285LeuTrp: 1.285 ± 0.038	2.109LeuTyr: 2.109 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.353MetAla: 3.353 ± 0.055	0.133MetCys: 0.133 ± 0.011	1.034MetAsp: 1.034 ± 0.026	0.98MetGlu: 0.98 ± 0.029	0.625MetPhe: 0.625 ± 0.021	1.749MetGly: 1.749 ± 0.041	0.356MetHis: 0.356 ± 0.015	1.245MetIle: 1.245 ± 0.033	0.822MetLys: 0.822 ± 0.027	2.096MetLeu: 2.096 ± 0.041	0.616MetMet: 0.616 ± 0.024	0.66MetAsn: 0.66 ± 0.021	1.437MetPro: 1.437 ± 0.033	0.627MetGln: 0.627 ± 0.025	1.627MetArg: 1.627 ± 0.035	1.459MetSer: 1.459 ± 0.036	1.79MetThr: 1.79 ± 0.034	1.638MetVal: 1.638 ± 0.034	0.184MetTrp: 0.184 ± 0.012	0.259MetTyr: 0.259 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.811AsnAla: 2.811 ± 0.053	0.199AsnCys: 0.199 ± 0.011	1.456AsnAsp: 1.456 ± 0.06	1.012AsnGlu: 1.012 ± 0.029	0.876AsnPhe: 0.876 ± 0.024	2.244AsnGly: 2.244 ± 0.058	0.429AsnHis: 0.429 ± 0.017	1.186AsnIle: 1.186 ± 0.032	0.568AsnLys: 0.568 ± 0.021	2.421AsnLeu: 2.421 ± 0.043	0.487AsnMet: 0.487 ± 0.02	0.586AsnAsn: 0.586 ± 0.023	1.638AsnPro: 1.638 ± 0.034	0.606AsnGln: 0.606 ± 0.021	1.603AsnArg: 1.603 ± 0.036	0.986AsnSer: 0.986 ± 0.031	1.133AsnThr: 1.133 ± 0.033	1.711AsnVal: 1.711 ± 0.037	0.335AsnTrp: 0.335 ± 0.015	0.588AsnTyr: 0.588 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.702ProAla: 7.702 ± 0.107	0.375ProCys: 0.375 ± 0.02	3.554ProAsp: 3.554 ± 0.057	3.407ProGlu: 3.407 ± 0.059	1.96ProPhe: 1.96 ± 0.037	5.269ProGly: 5.269 ± 0.075	0.999ProHis: 0.999 ± 0.029	2.042ProIle: 2.042 ± 0.042	1.447ProLys: 1.447 ± 0.033	5.335ProLeu: 5.335 ± 0.073	1.213ProMet: 1.213 ± 0.031	1.056ProAsn: 1.056 ± 0.026	3.22ProPro: 3.22 ± 0.083	1.321ProGln: 1.321 ± 0.033	3.302ProArg: 3.302 ± 0.055	2.549ProSer: 2.549 ± 0.049	2.364ProThr: 2.364 ± 0.042	4.58ProVal: 4.58 ± 0.07	0.751ProTrp: 0.751 ± 0.024	1.12ProTyr: 1.12 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.834GlnAla: 3.834 ± 0.053	0.18GlnCys: 0.18 ± 0.011	1.341GlnAsp: 1.341 ± 0.03	1.13GlnGlu: 1.13 ± 0.033	0.915GlnPhe: 0.915 ± 0.026	2.497GlnGly: 2.497 ± 0.05	0.49GlnHis: 0.49 ± 0.018	1.624GlnIle: 1.624 ± 0.033	0.847GlnLys: 0.847 ± 0.028	2.494GlnLeu: 2.494 ± 0.051	0.69GlnMet: 0.69 ± 0.022	0.63GlnAsn: 0.63 ± 0.021	1.472GlnPro: 1.472 ± 0.033	0.937GlnGln: 0.937 ± 0.03	2.016GlnArg: 2.016 ± 0.043	1.408GlnSer: 1.408 ± 0.034	1.301GlnThr: 1.301 ± 0.033	2.153GlnVal: 2.153 ± 0.04	0.362GlnTrp: 0.362 ± 0.019	0.525GlnTyr: 0.525 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.719ArgAla: 8.719 ± 0.099	0.541ArgCys: 0.541 ± 0.024	4.226ArgAsp: 4.226 ± 0.054	3.746ArgGlu: 3.746 ± 0.068	3.009ArgPhe: 3.009 ± 0.054	5.402ArgGly: 5.402 ± 0.063	1.922ArgHis: 1.922 ± 0.04	3.852ArgIle: 3.852 ± 0.06	2.072ArgLys: 2.072 ± 0.043	9.523ArgLeu: 9.523 ± 0.116	1.674ArgMet: 1.674 ± 0.034	1.627ArgAsn: 1.627 ± 0.033	4.138ArgPro: 4.138 ± 0.065	2.518ArgGln: 2.518 ± 0.046	6.774ArgArg: 6.774 ± 0.103	3.16ArgSer: 3.16 ± 0.05	2.81ArgThr: 2.81 ± 0.044	4.93ArgVal: 4.93 ± 0.054	1.007ArgTrp: 1.007 ± 0.028	1.641ArgTyr: 1.641 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.945SerAla: 5.945 ± 0.082	0.411SerCys: 0.411 ± 0.019	2.627SerAsp: 2.627 ± 0.048	2.147SerGlu: 2.147 ± 0.044	2.077SerPhe: 2.077 ± 0.04	5.231SerGly: 5.231 ± 0.09	0.939SerHis: 0.939 ± 0.023	2.436SerIle: 2.436 ± 0.05	1.201SerLys: 1.201 ± 0.033	5.366SerLeu: 5.366 ± 0.07	1.09SerMet: 1.09 ± 0.03	1.052SerAsn: 1.052 ± 0.027	2.709SerPro: 2.709 ± 0.048	1.175SerGln: 1.175 ± 0.027	3.469SerArg: 3.469 ± 0.053	2.42SerSer: 2.42 ± 0.057	2.408SerThr: 2.408 ± 0.054	3.632SerVal: 3.632 ± 0.059	0.647SerTrp: 0.647 ± 0.022	1.244SerTyr: 1.244 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	6.671ThrAla: 6.671 ± 0.084	0.422ThrCys: 0.422 ± 0.018	2.809ThrAsp: 2.809 ± 0.049	2.566ThrGlu: 2.566 ± 0.047	1.771ThrPhe: 1.771 ± 0.043	5.605ThrGly: 5.605 ± 0.093	0.811ThrHis: 0.811 ± 0.027	2.76ThrIle: 2.76 ± 0.057	1.326ThrLys: 1.326 ± 0.039	5.854ThrLeu: 5.854 ± 0.091	1.1ThrMet: 1.1 ± 0.027	1.101ThrAsn: 1.101 ± 0.033	3.185ThrPro: 3.185 ± 0.051	1.039ThrGln: 1.039 ± 0.031	3.249ThrArg: 3.249 ± 0.057	2.48ThrSer: 2.48 ± 0.054	2.701ThrThr: 2.701 ± 0.054	4.564ThrVal: 4.564 ± 0.075	0.647ThrTrp: 0.647 ± 0.021	1.305ThrTyr: 1.305 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	10.088ValAla: 10.088 ± 0.097	0.588ValCys: 0.588 ± 0.024	4.535ValAsp: 4.535 ± 0.062	4.691ValGlu: 4.691 ± 0.058	2.676ValPhe: 2.676 ± 0.049	6.011ValGly: 6.011 ± 0.086	1.314ValHis: 1.314 ± 0.034	4.063ValIle: 4.063 ± 0.058	2.272ValLys: 2.272 ± 0.05	7.53ValLeu: 7.53 ± 0.083	1.817ValMet: 1.817 ± 0.037	1.944ValAsn: 1.944 ± 0.044	4.15ValPro: 4.15 ± 0.059	1.821ValGln: 1.821 ± 0.036	4.411ValArg: 4.411 ± 0.063	4.052ValSer: 4.052 ± 0.064	5.005ValThr: 5.005 ± 0.082	6.145ValVal: 6.145 ± 0.076	0.8ValTrp: 0.8 ± 0.023	1.407ValTyr: 1.407 ± 0.032	0.001ValXaa: 0.001 ± 0.001
Trp	1.232TrpAla: 1.232 ± 0.037	0.155TrpCys: 0.155 ± 0.011	0.606TrpAsp: 0.606 ± 0.022	0.478TrpGlu: 0.478 ± 0.02	0.481TrpPhe: 0.481 ± 0.017	0.958TrpGly: 0.958 ± 0.031	0.323TrpHis: 0.323 ± 0.015	0.581TrpIle: 0.581 ± 0.02	0.375TrpLys: 0.375 ± 0.015	1.568TrpLeu: 1.568 ± 0.041	0.282TrpMet: 0.282 ± 0.015	0.383TrpAsn: 0.383 ± 0.018	0.701TrpPro: 0.701 ± 0.024	0.56TrpGln: 0.56 ± 0.021	1.258TrpArg: 1.258 ± 0.035	0.813TrpSer: 0.813 ± 0.024	0.714TrpThr: 0.714 ± 0.024	0.776TrpVal: 0.776 ± 0.023	0.248TrpTrp: 0.248 ± 0.013	0.316TrpTyr: 0.316 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.592TyrAla: 2.592 ± 0.052	0.205TyrCys: 0.205 ± 0.014	1.517TyrAsp: 1.517 ± 0.046	1.094TyrGlu: 1.094 ± 0.032	0.879TyrPhe: 0.879 ± 0.029	2.115TyrGly: 2.115 ± 0.044	0.461TyrHis: 0.461 ± 0.018	0.832TyrIle: 0.832 ± 0.027	0.544TyrLys: 0.544 ± 0.022	2.184TyrLeu: 2.184 ± 0.04	0.408TyrMet: 0.408 ± 0.018	0.553TyrAsn: 0.553 ± 0.022	1.035TyrPro: 1.035 ± 0.029	0.65TyrGln: 0.65 ± 0.023	1.768TyrArg: 1.768 ± 0.038	0.978TyrSer: 0.978 ± 0.034	1.062TyrThr: 1.062 ± 0.033	1.563TyrVal: 1.563 ± 0.039	0.338TyrTrp: 0.338 ± 0.014	0.581TyrTyr: 0.581 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4178 proteins (1369053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---