Amino acid dipepetide frequency for Streptococcus phage Javan484

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.021AlaAla: 4.021 ± 1.184
0.503AlaCys: 0.503 ± 0.194
3.949AlaAsp: 3.949 ± 0.587
4.739AlaGlu: 4.739 ± 0.55
3.231AlaPhe: 3.231 ± 0.662
4.81AlaGly: 4.81 ± 1.098
0.359AlaHis: 0.359 ± 0.145
5.457AlaIle: 5.457 ± 0.906
6.605AlaLys: 6.605 ± 0.933
6.031AlaLeu: 6.031 ± 0.668
2.657AlaMet: 2.657 ± 0.493
3.446AlaAsn: 3.446 ± 0.5
1.149AlaPro: 1.149 ± 0.289
2.298AlaGln: 2.298 ± 0.509
2.657AlaArg: 2.657 ± 0.36
4.092AlaSer: 4.092 ± 1.062
4.38AlaThr: 4.38 ± 0.864
4.595AlaVal: 4.595 ± 1.14
0.718AlaTrp: 0.718 ± 0.195
1.651AlaTyr: 1.651 ± 0.283
0.0AlaXaa: 0.0 ± 0.0
Cys
0.144CysAla: 0.144 ± 0.101
0.0CysCys: 0.0 ± 0.0
0.431CysAsp: 0.431 ± 0.172
0.503CysGlu: 0.503 ± 0.207
0.0CysPhe: 0.0 ± 0.0
0.215CysGly: 0.215 ± 0.121
0.072CysHis: 0.072 ± 0.074
0.503CysIle: 0.503 ± 0.202
0.431CysLys: 0.431 ± 0.199
0.503CysLeu: 0.503 ± 0.174
0.144CysMet: 0.144 ± 0.1
0.359CysAsn: 0.359 ± 0.187
0.0CysPro: 0.0 ± 0.0
0.072CysGln: 0.072 ± 0.075
0.359CysArg: 0.359 ± 0.148
0.215CysSer: 0.215 ± 0.159
0.144CysThr: 0.144 ± 0.094
0.359CysVal: 0.359 ± 0.158
0.287CysTrp: 0.287 ± 0.135
0.359CysTyr: 0.359 ± 0.171
0.0CysXaa: 0.0 ± 0.0
Asp
3.446AspAla: 3.446 ± 0.508
0.431AspCys: 0.431 ± 0.177
4.308AspAsp: 4.308 ± 0.514
4.451AspGlu: 4.451 ± 0.785
3.231AspPhe: 3.231 ± 0.547
5.098AspGly: 5.098 ± 0.625
0.862AspHis: 0.862 ± 0.252
5.457AspIle: 5.457 ± 0.698
6.462AspLys: 6.462 ± 0.818
6.749AspLeu: 6.749 ± 0.725
1.795AspMet: 1.795 ± 0.281
3.159AspAsn: 3.159 ± 0.47
1.005AspPro: 1.005 ± 0.276
1.436AspGln: 1.436 ± 0.298
1.795AspArg: 1.795 ± 0.296
3.59AspSer: 3.59 ± 0.557
3.662AspThr: 3.662 ± 0.492
5.026AspVal: 5.026 ± 0.515
0.503AspTrp: 0.503 ± 0.194
3.446AspTyr: 3.446 ± 0.613
0.0AspXaa: 0.0 ± 0.0
Glu
4.739GluAla: 4.739 ± 0.65
0.215GluCys: 0.215 ± 0.122
3.446GluAsp: 3.446 ± 0.669
6.175GluGlu: 6.175 ± 1.074
3.518GluPhe: 3.518 ± 0.539
3.446GluGly: 3.446 ± 0.44
1.58GluHis: 1.58 ± 0.376
5.672GluIle: 5.672 ± 0.781
5.887GluLys: 5.887 ± 0.72
8.257GluLeu: 8.257 ± 0.872
2.441GluMet: 2.441 ± 0.368
3.303GluAsn: 3.303 ± 0.614
1.364GluPro: 1.364 ± 0.344
3.374GluGln: 3.374 ± 0.599
2.513GluArg: 2.513 ± 0.437
4.308GluSer: 4.308 ± 0.472
3.59GluThr: 3.59 ± 0.71
4.451GluVal: 4.451 ± 0.743
0.933GluTrp: 0.933 ± 0.279
3.087GluTyr: 3.087 ± 0.575
0.0GluXaa: 0.0 ± 0.0
Phe
2.441PheAla: 2.441 ± 0.592
0.287PheCys: 0.287 ± 0.147
3.805PheAsp: 3.805 ± 0.568
3.159PheGlu: 3.159 ± 0.416
1.58PhePhe: 1.58 ± 0.311
3.231PheGly: 3.231 ± 0.662
0.503PheHis: 0.503 ± 0.203
1.939PheIle: 1.939 ± 0.446
4.882PheLys: 4.882 ± 0.608
2.8PheLeu: 2.8 ± 0.444
1.077PheMet: 1.077 ± 0.275
2.872PheAsn: 2.872 ± 0.483
0.862PhePro: 0.862 ± 0.225
1.221PheGln: 1.221 ± 0.28
2.441PheArg: 2.441 ± 0.389
3.446PheSer: 3.446 ± 0.425
2.585PheThr: 2.585 ± 0.37
2.8PheVal: 2.8 ± 0.418
0.144PheTrp: 0.144 ± 0.095
1.651PheTyr: 1.651 ± 0.333
0.0PheXaa: 0.0 ± 0.0
Gly
4.164GlyAla: 4.164 ± 1.196
0.287GlyCys: 0.287 ± 0.133
3.446GlyAsp: 3.446 ± 0.573
3.159GlyGlu: 3.159 ± 0.531
3.303GlyPhe: 3.303 ± 0.557
3.374GlyGly: 3.374 ± 0.531
1.149GlyHis: 1.149 ± 0.234
4.81GlyIle: 4.81 ± 0.752
6.605GlyLys: 6.605 ± 0.789
6.462GlyLeu: 6.462 ± 1.145
1.58GlyMet: 1.58 ± 0.305
3.231GlyAsn: 3.231 ± 0.43
0.718GlyPro: 0.718 ± 0.226
1.867GlyGln: 1.867 ± 0.403
2.657GlyArg: 2.657 ± 0.471
2.513GlySer: 2.513 ± 0.619
4.451GlyThr: 4.451 ± 0.714
4.308GlyVal: 4.308 ± 0.712
0.718GlyTrp: 0.718 ± 0.371
3.159GlyTyr: 3.159 ± 0.607
0.0GlyXaa: 0.0 ± 0.0
His
1.149HisAla: 1.149 ± 0.346
0.072HisCys: 0.072 ± 0.08
0.933HisAsp: 0.933 ± 0.305
1.292HisGlu: 1.292 ± 0.341
0.79HisPhe: 0.79 ± 0.219
1.149HisGly: 1.149 ± 0.325
0.215HisHis: 0.215 ± 0.161
1.221HisIle: 1.221 ± 0.321
1.077HisLys: 1.077 ± 0.297
0.862HisLeu: 0.862 ± 0.237
0.215HisMet: 0.215 ± 0.123
1.077HisAsn: 1.077 ± 0.262
0.574HisPro: 0.574 ± 0.211
0.646HisGln: 0.646 ± 0.219
0.646HisArg: 0.646 ± 0.203
1.005HisSer: 1.005 ± 0.341
0.933HisThr: 0.933 ± 0.242
0.862HisVal: 0.862 ± 0.242
0.287HisTrp: 0.287 ± 0.15
0.574HisTyr: 0.574 ± 0.194
0.0HisXaa: 0.0 ± 0.0
Ile
4.882IleAla: 4.882 ± 0.763
0.431IleCys: 0.431 ± 0.213
6.677IleAsp: 6.677 ± 0.86
5.241IleGlu: 5.241 ± 0.688
2.441IlePhe: 2.441 ± 0.503
4.523IleGly: 4.523 ± 0.668
1.58IleHis: 1.58 ± 0.357
4.739IleIle: 4.739 ± 0.595
7.18IleLys: 7.18 ± 0.709
5.744IleLeu: 5.744 ± 0.686
1.292IleMet: 1.292 ± 0.287
4.667IleAsn: 4.667 ± 0.659
1.723IlePro: 1.723 ± 0.341
2.01IleGln: 2.01 ± 0.339
3.016IleArg: 3.016 ± 0.524
5.169IleSer: 5.169 ± 0.682
5.528IleThr: 5.528 ± 0.622
3.662IleVal: 3.662 ± 0.471
0.503IleTrp: 0.503 ± 0.209
2.944IleTyr: 2.944 ± 0.557
0.0IleXaa: 0.0 ± 0.0
Lys
6.605LysAla: 6.605 ± 0.674
0.144LysCys: 0.144 ± 0.098
5.241LysAsp: 5.241 ± 0.64
6.605LysGlu: 6.605 ± 0.99
3.59LysPhe: 3.59 ± 0.471
4.81LysGly: 4.81 ± 0.58
0.933LysHis: 0.933 ± 0.223
6.534LysIle: 6.534 ± 0.627
7.108LysLys: 7.108 ± 1.006
7.898LysLeu: 7.898 ± 0.895
2.872LysMet: 2.872 ± 0.424
5.457LysAsn: 5.457 ± 0.63
2.082LysPro: 2.082 ± 0.386
4.667LysGln: 4.667 ± 0.554
3.877LysArg: 3.877 ± 0.526
5.241LysSer: 5.241 ± 0.685
6.031LysThr: 6.031 ± 0.914
5.959LysVal: 5.959 ± 0.837
1.077LysTrp: 1.077 ± 0.287
3.446LysTyr: 3.446 ± 0.567
0.0LysXaa: 0.0 ± 0.0
Leu
6.031LeuAla: 6.031 ± 0.823
0.503LeuCys: 0.503 ± 0.255
6.246LeuAsp: 6.246 ± 0.625
7.252LeuGlu: 7.252 ± 0.736
3.805LeuPhe: 3.805 ± 0.462
4.954LeuGly: 4.954 ± 0.855
0.933LeuHis: 0.933 ± 0.278
7.108LeuIle: 7.108 ± 0.823
8.113LeuLys: 8.113 ± 1.071
7.252LeuLeu: 7.252 ± 1.042
2.369LeuMet: 2.369 ± 0.427
4.81LeuAsn: 4.81 ± 0.565
2.298LeuPro: 2.298 ± 0.418
3.877LeuGln: 3.877 ± 0.576
2.8LeuArg: 2.8 ± 0.551
6.246LeuSer: 6.246 ± 0.6
5.528LeuThr: 5.528 ± 0.566
4.308LeuVal: 4.308 ± 0.518
0.503LeuTrp: 0.503 ± 0.184
2.585LeuTyr: 2.585 ± 0.44
0.0LeuXaa: 0.0 ± 0.0
Met
2.657MetAla: 2.657 ± 0.577
0.0MetCys: 0.0 ± 0.0
1.58MetAsp: 1.58 ± 0.298
2.226MetGlu: 2.226 ± 0.492
1.292MetPhe: 1.292 ± 0.292
0.933MetGly: 0.933 ± 0.286
0.359MetHis: 0.359 ± 0.163
2.01MetIle: 2.01 ± 0.33
1.508MetLys: 1.508 ± 0.361
1.723MetLeu: 1.723 ± 0.373
0.144MetMet: 0.144 ± 0.098
1.436MetAsn: 1.436 ± 0.296
0.646MetPro: 0.646 ± 0.232
1.508MetGln: 1.508 ± 0.341
1.939MetArg: 1.939 ± 0.349
1.508MetSer: 1.508 ± 0.367
1.939MetThr: 1.939 ± 0.385
1.077MetVal: 1.077 ± 0.284
0.144MetTrp: 0.144 ± 0.099
0.79MetTyr: 0.79 ± 0.2
0.0MetXaa: 0.0 ± 0.0
Asn
4.021AsnAla: 4.021 ± 0.556
0.503AsnCys: 0.503 ± 0.185
2.944AsnAsp: 2.944 ± 0.436
3.446AsnGlu: 3.446 ± 0.527
2.585AsnPhe: 2.585 ± 0.456
4.523AsnGly: 4.523 ± 0.606
0.718AsnHis: 0.718 ± 0.208
3.805AsnIle: 3.805 ± 0.656
3.877AsnLys: 3.877 ± 0.619
4.595AsnLeu: 4.595 ± 0.482
1.077AsnMet: 1.077 ± 0.301
2.585AsnAsn: 2.585 ± 0.462
1.58AsnPro: 1.58 ± 0.374
2.226AsnGln: 2.226 ± 0.393
2.369AsnArg: 2.369 ± 0.423
2.872AsnSer: 2.872 ± 0.556
2.872AsnThr: 2.872 ± 0.447
2.872AsnVal: 2.872 ± 0.405
1.005AsnTrp: 1.005 ± 0.238
2.298AsnTyr: 2.298 ± 0.341
0.0AsnXaa: 0.0 ± 0.0
Pro
1.364ProAla: 1.364 ± 0.28
0.072ProCys: 0.072 ± 0.074
1.723ProAsp: 1.723 ± 0.46
1.723ProGlu: 1.723 ± 0.371
1.292ProPhe: 1.292 ± 0.318
0.718ProGly: 0.718 ± 0.193
0.646ProHis: 0.646 ± 0.221
1.508ProIle: 1.508 ± 0.343
2.8ProLys: 2.8 ± 0.46
1.795ProLeu: 1.795 ± 0.469
0.503ProMet: 0.503 ± 0.222
1.364ProAsn: 1.364 ± 0.339
0.862ProPro: 0.862 ± 0.246
0.718ProGln: 0.718 ± 0.282
1.077ProArg: 1.077 ± 0.308
1.436ProSer: 1.436 ± 0.278
1.939ProThr: 1.939 ± 0.363
1.221ProVal: 1.221 ± 0.263
0.359ProTrp: 0.359 ± 0.185
1.077ProTyr: 1.077 ± 0.3
0.0ProXaa: 0.0 ± 0.0
Gln
3.805GlnAla: 3.805 ± 0.833
0.215GlnCys: 0.215 ± 0.165
1.58GlnAsp: 1.58 ± 0.305
2.657GlnGlu: 2.657 ± 0.457
1.221GlnPhe: 1.221 ± 0.295
2.728GlnGly: 2.728 ± 0.411
0.359GlnHis: 0.359 ± 0.143
3.374GlnIle: 3.374 ± 0.545
3.805GlnLys: 3.805 ± 0.497
3.087GlnLeu: 3.087 ± 0.433
0.862GlnMet: 0.862 ± 0.306
2.154GlnAsn: 2.154 ± 0.431
1.221GlnPro: 1.221 ± 0.285
1.867GlnGln: 1.867 ± 0.484
1.364GlnArg: 1.364 ± 0.244
3.805GlnSer: 3.805 ± 0.538
2.513GlnThr: 2.513 ± 0.512
1.723GlnVal: 1.723 ± 0.383
0.359GlnTrp: 0.359 ± 0.161
1.436GlnTyr: 1.436 ± 0.335
0.0GlnXaa: 0.0 ± 0.0
Arg
2.01ArgAla: 2.01 ± 0.364
0.144ArgCys: 0.144 ± 0.095
2.154ArgAsp: 2.154 ± 0.431
2.944ArgGlu: 2.944 ± 0.507
2.01ArgPhe: 2.01 ± 0.408
2.585ArgGly: 2.585 ± 0.476
0.646ArgHis: 0.646 ± 0.292
2.944ArgIle: 2.944 ± 0.43
4.523ArgLys: 4.523 ± 0.65
4.092ArgLeu: 4.092 ± 0.505
1.292ArgMet: 1.292 ± 0.36
1.867ArgAsn: 1.867 ± 0.402
1.077ArgPro: 1.077 ± 0.321
1.436ArgGln: 1.436 ± 0.327
2.154ArgArg: 2.154 ± 0.396
1.867ArgSer: 1.867 ± 0.381
2.082ArgThr: 2.082 ± 0.355
2.298ArgVal: 2.298 ± 0.439
0.359ArgTrp: 0.359 ± 0.163
1.723ArgTyr: 1.723 ± 0.385
0.0ArgXaa: 0.0 ± 0.0
Ser
4.882SerAla: 4.882 ± 1.318
0.215SerCys: 0.215 ± 0.119
4.164SerAsp: 4.164 ± 0.605
4.739SerGlu: 4.739 ± 0.655
2.441SerPhe: 2.441 ± 0.368
3.59SerGly: 3.59 ± 0.671
1.077SerHis: 1.077 ± 0.293
4.667SerIle: 4.667 ± 0.562
5.313SerLys: 5.313 ± 0.62
4.81SerLeu: 4.81 ± 0.585
2.082SerMet: 2.082 ± 0.56
2.728SerAsn: 2.728 ± 0.524
1.508SerPro: 1.508 ± 0.358
3.662SerGln: 3.662 ± 0.714
2.082SerArg: 2.082 ± 0.351
4.38SerSer: 4.38 ± 0.887
3.446SerThr: 3.446 ± 0.519
4.523SerVal: 4.523 ± 0.574
0.574SerTrp: 0.574 ± 0.215
2.01SerTyr: 2.01 ± 0.381
0.0SerXaa: 0.0 ± 0.0
Thr
4.236ThrAla: 4.236 ± 0.904
0.144ThrCys: 0.144 ± 0.175
5.098ThrAsp: 5.098 ± 0.682
3.949ThrGlu: 3.949 ± 0.614
3.231ThrPhe: 3.231 ± 0.5
4.882ThrGly: 4.882 ± 0.786
1.364ThrHis: 1.364 ± 0.306
4.451ThrIle: 4.451 ± 0.494
4.595ThrLys: 4.595 ± 0.649
6.462ThrLeu: 6.462 ± 0.677
0.862ThrMet: 0.862 ± 0.258
3.303ThrAsn: 3.303 ± 0.488
2.082ThrPro: 2.082 ± 0.39
2.657ThrGln: 2.657 ± 0.336
2.082ThrArg: 2.082 ± 0.357
3.59ThrSer: 3.59 ± 0.476
4.451ThrThr: 4.451 ± 0.725
3.877ThrVal: 3.877 ± 0.623
0.359ThrTrp: 0.359 ± 0.182
1.723ThrTyr: 1.723 ± 0.326
0.0ThrXaa: 0.0 ± 0.0
Val
4.021ValAla: 4.021 ± 0.985
0.431ValCys: 0.431 ± 0.168
4.021ValAsp: 4.021 ± 0.457
4.451ValGlu: 4.451 ± 0.696
2.441ValPhe: 2.441 ± 0.486
3.877ValGly: 3.877 ± 0.557
1.005ValHis: 1.005 ± 0.239
4.38ValIle: 4.38 ± 0.548
5.385ValLys: 5.385 ± 0.681
4.595ValLeu: 4.595 ± 0.635
1.149ValMet: 1.149 ± 0.221
2.728ValAsn: 2.728 ± 0.406
1.939ValPro: 1.939 ± 0.36
1.939ValGln: 1.939 ± 0.296
2.369ValArg: 2.369 ± 0.415
4.308ValSer: 4.308 ± 0.641
4.523ValThr: 4.523 ± 0.486
4.092ValVal: 4.092 ± 0.496
0.503ValTrp: 0.503 ± 0.143
1.795ValTyr: 1.795 ± 0.372
0.0ValXaa: 0.0 ± 0.0
Trp
0.574TrpAla: 0.574 ± 0.251
0.144TrpCys: 0.144 ± 0.097
0.79TrpAsp: 0.79 ± 0.183
0.646TrpGlu: 0.646 ± 0.199
0.503TrpPhe: 0.503 ± 0.219
0.933TrpGly: 0.933 ± 0.28
0.072TrpHis: 0.072 ± 0.087
0.574TrpIle: 0.574 ± 0.208
1.149TrpLys: 1.149 ± 0.268
1.221TrpLeu: 1.221 ± 0.369
0.215TrpMet: 0.215 ± 0.114
0.144TrpAsn: 0.144 ± 0.091
0.215TrpPro: 0.215 ± 0.112
0.359TrpGln: 0.359 ± 0.144
0.79TrpArg: 0.79 ± 0.25
0.646TrpSer: 0.646 ± 0.223
0.359TrpThr: 0.359 ± 0.244
0.287TrpVal: 0.287 ± 0.167
0.0TrpTrp: 0.0 ± 0.0
0.215TrpTyr: 0.215 ± 0.121
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.154TyrAla: 2.154 ± 0.441
0.359TyrCys: 0.359 ± 0.175
3.374TyrAsp: 3.374 ± 0.526
2.944TyrGlu: 2.944 ± 0.508
1.292TyrPhe: 1.292 ± 0.394
1.58TyrGly: 1.58 ± 0.314
1.149TyrHis: 1.149 ± 0.351
2.8TyrIle: 2.8 ± 0.357
2.872TyrLys: 2.872 ± 0.579
2.585TyrLeu: 2.585 ± 0.463
0.718TyrMet: 0.718 ± 0.218
2.082TyrAsn: 2.082 ± 0.386
1.292TyrPro: 1.292 ± 0.362
2.298TyrGln: 2.298 ± 0.44
1.221TyrArg: 1.221 ± 0.356
2.657TyrSer: 2.657 ± 0.44
2.441TyrThr: 2.441 ± 0.41
1.651TyrVal: 1.651 ± 0.318
0.503TyrTrp: 0.503 ± 0.178
1.651TyrTyr: 1.651 ± 0.389
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (13929 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski