Amino acid dipepetide frequency for Psychroflexus salarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.717AlaAla: 3.717 ± 0.095
0.546AlaCys: 0.546 ± 0.033
3.117AlaAsp: 3.117 ± 0.071
4.635AlaGlu: 4.635 ± 0.091
3.471AlaPhe: 3.471 ± 0.065
3.645AlaGly: 3.645 ± 0.1
1.173AlaHis: 1.173 ± 0.043
5.402AlaIle: 5.402 ± 0.08
5.202AlaLys: 5.202 ± 0.102
6.216AlaLeu: 6.216 ± 0.1
1.39AlaMet: 1.39 ± 0.046
3.725AlaAsn: 3.725 ± 0.075
1.648AlaPro: 1.648 ± 0.048
2.805AlaGln: 2.805 ± 0.062
1.841AlaArg: 1.841 ± 0.049
4.405AlaSer: 4.405 ± 0.082
3.285AlaThr: 3.285 ± 0.074
3.887AlaVal: 3.887 ± 0.073
0.554AlaTrp: 0.554 ± 0.025
2.673AlaTyr: 2.673 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.402CysAla: 0.402 ± 0.027
0.098CysCys: 0.098 ± 0.013
0.42CysAsp: 0.42 ± 0.026
0.441CysGlu: 0.441 ± 0.028
0.405CysPhe: 0.405 ± 0.023
0.576CysGly: 0.576 ± 0.031
0.167CysHis: 0.167 ± 0.017
0.573CysIle: 0.573 ± 0.029
0.39CysLys: 0.39 ± 0.024
0.671CysLeu: 0.671 ± 0.032
0.126CysMet: 0.126 ± 0.013
0.354CysAsn: 0.354 ± 0.024
0.289CysPro: 0.289 ± 0.025
0.316CysGln: 0.316 ± 0.022
0.183CysArg: 0.183 ± 0.016
0.517CysSer: 0.517 ± 0.031
0.372CysThr: 0.372 ± 0.025
0.453CysVal: 0.453 ± 0.027
0.062CysTrp: 0.062 ± 0.008
0.266CysTyr: 0.266 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.737AspAla: 3.737 ± 0.093
0.446AspCys: 0.446 ± 0.03
3.077AspAsp: 3.077 ± 0.075
3.988AspGlu: 3.988 ± 0.085
3.912AspPhe: 3.912 ± 0.08
3.235AspGly: 3.235 ± 0.09
1.002AspHis: 1.002 ± 0.036
4.252AspIle: 4.252 ± 0.087
3.626AspLys: 3.626 ± 0.078
5.852AspLeu: 5.852 ± 0.079
0.946AspMet: 0.946 ± 0.03
2.962AspAsn: 2.962 ± 0.093
1.509AspPro: 1.509 ± 0.052
2.433AspGln: 2.433 ± 0.063
1.751AspArg: 1.751 ± 0.048
3.086AspSer: 3.086 ± 0.074
2.507AspThr: 2.507 ± 0.062
3.712AspVal: 3.712 ± 0.083
0.689AspTrp: 0.689 ± 0.035
2.92AspTyr: 2.92 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
5.031GluAla: 5.031 ± 0.096
0.289GluCys: 0.289 ± 0.021
3.82GluAsp: 3.82 ± 0.079
4.149GluGlu: 4.149 ± 0.084
3.255GluPhe: 3.255 ± 0.073
3.344GluGly: 3.344 ± 0.089
1.205GluHis: 1.205 ± 0.049
5.482GluIle: 5.482 ± 0.093
4.743GluLys: 4.743 ± 0.093
6.371GluLeu: 6.371 ± 0.096
1.333GluMet: 1.333 ± 0.043
4.491GluAsn: 4.491 ± 0.079
1.606GluPro: 1.606 ± 0.045
2.782GluGln: 2.782 ± 0.069
2.268GluArg: 2.268 ± 0.06
3.515GluSer: 3.515 ± 0.072
3.784GluThr: 3.784 ± 0.073
4.965GluVal: 4.965 ± 0.097
0.526GluTrp: 0.526 ± 0.027
2.006GluTyr: 2.006 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.888PheAla: 2.888 ± 0.068
0.431PheCys: 0.431 ± 0.024
3.336PheAsp: 3.336 ± 0.074
3.725PheGlu: 3.725 ± 0.062
2.628PhePhe: 2.628 ± 0.076
3.637PheGly: 3.637 ± 0.075
0.784PheHis: 0.784 ± 0.033
4.13PheIle: 4.13 ± 0.09
4.644PheLys: 4.644 ± 0.086
4.555PheLeu: 4.555 ± 0.086
1.065PheMet: 1.065 ± 0.035
3.95PheAsn: 3.95 ± 0.086
1.572PhePro: 1.572 ± 0.048
1.74PheGln: 1.74 ± 0.051
1.592PheArg: 1.592 ± 0.047
4.248PheSer: 4.248 ± 0.089
3.164PheThr: 3.164 ± 0.065
2.907PheVal: 2.907 ± 0.061
0.594PheTrp: 0.594 ± 0.028
2.202PheTyr: 2.202 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
3.665GlyAla: 3.665 ± 0.08
0.473GlyCys: 0.473 ± 0.028
3.191GlyAsp: 3.191 ± 0.091
3.637GlyGlu: 3.637 ± 0.082
3.673GlyPhe: 3.673 ± 0.081
4.153GlyGly: 4.153 ± 0.14
1.146GlyHis: 1.146 ± 0.045
4.824GlyIle: 4.824 ± 0.08
4.144GlyLys: 4.144 ± 0.086
5.783GlyLeu: 5.783 ± 0.093
1.302GlyMet: 1.302 ± 0.046
3.253GlyAsn: 3.253 ± 0.093
1.211GlyPro: 1.211 ± 0.04
2.357GlyGln: 2.357 ± 0.059
1.875GlyArg: 1.875 ± 0.058
3.658GlySer: 3.658 ± 0.089
3.33GlyThr: 3.33 ± 0.084
3.869GlyVal: 3.869 ± 0.089
0.613GlyTrp: 0.613 ± 0.027
2.287GlyTyr: 2.287 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
0.939HisAla: 0.939 ± 0.044
0.174HisCys: 0.174 ± 0.018
0.896HisAsp: 0.896 ± 0.038
1.02HisGlu: 1.02 ± 0.045
1.225HisPhe: 1.225 ± 0.041
0.973HisGly: 0.973 ± 0.034
0.544HisHis: 0.544 ± 0.028
1.517HisIle: 1.517 ± 0.052
1.355HisLys: 1.355 ± 0.047
2.056HisLeu: 2.056 ± 0.064
0.303HisMet: 0.303 ± 0.02
0.977HisAsn: 0.977 ± 0.037
0.86HisPro: 0.86 ± 0.034
1.189HisGln: 1.189 ± 0.043
0.631HisArg: 0.631 ± 0.03
1.035HisSer: 1.035 ± 0.04
0.879HisThr: 0.879 ± 0.033
1.026HisVal: 1.026 ± 0.04
0.22HisTrp: 0.22 ± 0.016
0.872HisTyr: 0.872 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.235IleAla: 5.235 ± 0.087
0.591IleCys: 0.591 ± 0.03
4.97IleAsp: 4.97 ± 0.078
5.491IleGlu: 5.491 ± 0.08
3.518IlePhe: 3.518 ± 0.073
4.873IleGly: 4.873 ± 0.083
1.266IleHis: 1.266 ± 0.051
6.05IleIle: 6.05 ± 0.123
6.345IleLys: 6.345 ± 0.103
7.049IleLeu: 7.049 ± 0.111
1.245IleMet: 1.245 ± 0.039
5.527IleAsn: 5.527 ± 0.104
2.97IlePro: 2.97 ± 0.058
2.618IleGln: 2.618 ± 0.056
2.29IleArg: 2.29 ± 0.057
6.259IleSer: 6.259 ± 0.109
4.589IleThr: 4.589 ± 0.105
4.164IleVal: 4.164 ± 0.082
0.635IleTrp: 0.635 ± 0.029
2.892IleTyr: 2.892 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
5.645LysAla: 5.645 ± 0.098
0.336LysCys: 0.336 ± 0.022
4.25LysAsp: 4.25 ± 0.088
4.675LysGlu: 4.675 ± 0.089
3.372LysPhe: 3.372 ± 0.082
3.671LysGly: 3.671 ± 0.074
1.899LysHis: 1.899 ± 0.063
5.913LysIle: 5.913 ± 0.094
6.076LysLys: 6.076 ± 0.126
7.587LysLeu: 7.587 ± 0.113
1.683LysMet: 1.683 ± 0.051
5.039LysAsn: 5.039 ± 0.1
2.735LysPro: 2.735 ± 0.068
3.647LysGln: 3.647 ± 0.08
3.192LysArg: 3.192 ± 0.077
5.504LysSer: 5.504 ± 0.081
4.86LysThr: 4.86 ± 0.08
4.31LysVal: 4.31 ± 0.079
0.631LysTrp: 0.631 ± 0.032
2.695LysTyr: 2.695 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
6.067LeuAla: 6.067 ± 0.106
0.63LeuCys: 0.63 ± 0.03
5.447LeuAsp: 5.447 ± 0.1
6.269LeuGlu: 6.269 ± 0.097
4.76LeuPhe: 4.76 ± 0.103
5.711LeuGly: 5.711 ± 0.087
1.592LeuHis: 1.592 ± 0.049
7.826LeuIle: 7.826 ± 0.135
8.873LeuLys: 8.873 ± 0.125
8.41LeuLeu: 8.41 ± 0.152
1.999LeuMet: 1.999 ± 0.05
6.89LeuAsn: 6.89 ± 0.117
3.431LeuPro: 3.431 ± 0.059
3.699LeuGln: 3.699 ± 0.078
3.127LeuArg: 3.127 ± 0.069
7.435LeuSer: 7.435 ± 0.108
5.123LeuThr: 5.123 ± 0.095
5.737LeuVal: 5.737 ± 0.094
0.723LeuTrp: 0.723 ± 0.031
3.006LeuTyr: 3.006 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.441MetAla: 1.441 ± 0.044
0.144MetCys: 0.144 ± 0.013
0.774MetAsp: 0.774 ± 0.032
0.868MetGlu: 0.868 ± 0.031
0.886MetPhe: 0.886 ± 0.048
1.178MetGly: 1.178 ± 0.045
0.415MetHis: 0.415 ± 0.024
1.412MetIle: 1.412 ± 0.048
1.993MetLys: 1.993 ± 0.047
1.968MetLeu: 1.968 ± 0.056
0.526MetMet: 0.526 ± 0.027
1.155MetAsn: 1.155 ± 0.032
0.847MetPro: 0.847 ± 0.035
0.87MetGln: 0.87 ± 0.035
0.885MetArg: 0.885 ± 0.036
1.291MetSer: 1.291 ± 0.043
1.066MetThr: 1.066 ± 0.038
1.017MetVal: 1.017 ± 0.035
0.121MetTrp: 0.121 ± 0.012
0.629MetTyr: 0.629 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
4.027AsnAla: 4.027 ± 0.092
0.496AsnCys: 0.496 ± 0.031
3.16AsnAsp: 3.16 ± 0.061
3.779AsnGlu: 3.779 ± 0.059
3.755AsnPhe: 3.755 ± 0.089
3.68AsnGly: 3.68 ± 0.11
1.272AsnHis: 1.272 ± 0.045
4.675AsnIle: 4.675 ± 0.097
4.298AsnLys: 4.298 ± 0.084
6.493AsnLeu: 6.493 ± 0.106
1.229AsnMet: 1.229 ± 0.042
4.085AsnAsn: 4.085 ± 0.111
2.695AsnPro: 2.695 ± 0.073
3.451AsnGln: 3.451 ± 0.073
2.29AsnArg: 2.29 ± 0.054
4.335AsnSer: 4.335 ± 0.096
3.641AsnThr: 3.641 ± 0.084
3.129AsnVal: 3.129 ± 0.075
0.843AsnTrp: 0.843 ± 0.039
3.387AsnTyr: 3.387 ± 0.078
0.0AsnXaa: 0.0 ± 0.0
Pro
1.664ProAla: 1.664 ± 0.042
0.188ProCys: 0.188 ± 0.017
1.966ProAsp: 1.966 ± 0.051
2.809ProGlu: 2.809 ± 0.067
1.713ProPhe: 1.713 ± 0.05
1.752ProGly: 1.752 ± 0.053
0.6ProHis: 0.6 ± 0.03
2.654ProIle: 2.654 ± 0.059
2.858ProLys: 2.858 ± 0.069
2.685ProLeu: 2.685 ± 0.064
0.629ProMet: 0.629 ± 0.025
2.381ProAsn: 2.381 ± 0.068
0.768ProPro: 0.768 ± 0.032
1.436ProGln: 1.436 ± 0.039
0.915ProArg: 0.915 ± 0.041
2.156ProSer: 2.156 ± 0.051
1.837ProThr: 1.837 ± 0.052
2.101ProVal: 2.101 ± 0.055
0.311ProTrp: 0.311 ± 0.023
1.218ProTyr: 1.218 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.658GlnAla: 2.658 ± 0.068
0.193GlnCys: 0.193 ± 0.016
2.389GlnAsp: 2.389 ± 0.068
2.289GlnGlu: 2.289 ± 0.053
2.218GlnPhe: 2.218 ± 0.054
1.801GlnGly: 1.801 ± 0.055
0.933GlnHis: 0.933 ± 0.041
3.263GlnIle: 3.263 ± 0.065
3.169GlnLys: 3.169 ± 0.068
5.208GlnLeu: 5.208 ± 0.105
0.81GlnMet: 0.81 ± 0.033
3.006GlnAsn: 3.006 ± 0.066
1.575GlnPro: 1.575 ± 0.047
2.271GlnGln: 2.271 ± 0.066
1.314GlnArg: 1.314 ± 0.041
2.547GlnSer: 2.547 ± 0.061
2.434GlnThr: 2.434 ± 0.067
2.562GlnVal: 2.562 ± 0.059
0.382GlnTrp: 0.382 ± 0.021
1.327GlnTyr: 1.327 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
1.909ArgAla: 1.909 ± 0.046
0.194ArgCys: 0.194 ± 0.016
1.794ArgAsp: 1.794 ± 0.051
2.031ArgGlu: 2.031 ± 0.055
2.011ArgPhe: 2.011 ± 0.051
1.77ArgGly: 1.77 ± 0.051
0.626ArgHis: 0.626 ± 0.025
2.62ArgIle: 2.62 ± 0.062
2.547ArgLys: 2.547 ± 0.067
3.644ArgLeu: 3.644 ± 0.077
0.769ArgMet: 0.769 ± 0.036
1.959ArgAsn: 1.959 ± 0.057
1.036ArgPro: 1.036 ± 0.033
1.495ArgGln: 1.495 ± 0.05
1.254ArgArg: 1.254 ± 0.043
1.918ArgSer: 1.918 ± 0.055
1.596ArgThr: 1.596 ± 0.047
1.875ArgVal: 1.875 ± 0.051
0.303ArgTrp: 0.303 ± 0.018
1.463ArgTyr: 1.463 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
4.191SerAla: 4.191 ± 0.074
0.629SerCys: 0.629 ± 0.03
3.398SerAsp: 3.398 ± 0.074
3.983SerGlu: 3.983 ± 0.063
4.002SerPhe: 4.002 ± 0.089
4.414SerGly: 4.414 ± 0.098
1.131SerHis: 1.131 ± 0.037
5.84SerIle: 5.84 ± 0.097
5.179SerLys: 5.179 ± 0.099
6.635SerLeu: 6.635 ± 0.108
1.149SerMet: 1.149 ± 0.039
4.162SerAsn: 4.162 ± 0.093
2.141SerPro: 2.141 ± 0.049
2.708SerGln: 2.708 ± 0.061
2.17SerArg: 2.17 ± 0.055
4.619SerSer: 4.619 ± 0.107
4.2SerThr: 4.2 ± 0.094
4.238SerVal: 4.238 ± 0.089
0.649SerTrp: 0.649 ± 0.029
2.715SerTyr: 2.715 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
3.659ThrAla: 3.659 ± 0.077
0.397ThrCys: 0.397 ± 0.025
3.282ThrAsp: 3.282 ± 0.097
3.854ThrGlu: 3.854 ± 0.072
2.588ThrPhe: 2.588 ± 0.064
3.559ThrGly: 3.559 ± 0.083
1.014ThrHis: 1.014 ± 0.038
4.207ThrIle: 4.207 ± 0.088
4.023ThrLys: 4.023 ± 0.08
4.981ThrLeu: 4.981 ± 0.078
0.822ThrMet: 0.822 ± 0.035
3.489ThrAsn: 3.489 ± 0.083
2.272ThrPro: 2.272 ± 0.066
2.305ThrGln: 2.305 ± 0.052
1.572ThrArg: 1.572 ± 0.042
4.312ThrSer: 4.312 ± 0.087
3.354ThrThr: 3.354 ± 0.09
3.236ThrVal: 3.236 ± 0.115
0.507ThrTrp: 0.507 ± 0.025
2.544ThrTyr: 2.544 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
3.533ValAla: 3.533 ± 0.084
0.472ValCys: 0.472 ± 0.025
3.65ValAsp: 3.65 ± 0.072
4.547ValGlu: 4.547 ± 0.093
3.358ValPhe: 3.358 ± 0.073
3.551ValGly: 3.551 ± 0.076
0.891ValHis: 0.891 ± 0.033
4.771ValIle: 4.771 ± 0.1
4.432ValLys: 4.432 ± 0.074
5.649ValLeu: 5.649 ± 0.093
1.212ValMet: 1.212 ± 0.037
4.059ValAsn: 4.059 ± 0.069
1.839ValPro: 1.839 ± 0.058
1.773ValGln: 1.773 ± 0.045
1.797ValArg: 1.797 ± 0.041
4.16ValSer: 4.16 ± 0.073
3.339ValThr: 3.339 ± 0.109
4.031ValVal: 4.031 ± 0.09
0.532ValTrp: 0.532 ± 0.029
2.304ValTyr: 2.304 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.532TrpAla: 0.532 ± 0.03
0.09TrpCys: 0.09 ± 0.011
0.572TrpAsp: 0.572 ± 0.032
0.534TrpGlu: 0.534 ± 0.028
0.634TrpPhe: 0.634 ± 0.029
0.532TrpGly: 0.532 ± 0.027
0.228TrpHis: 0.228 ± 0.017
0.579TrpIle: 0.579 ± 0.03
0.597TrpLys: 0.597 ± 0.032
1.061TrpLeu: 1.061 ± 0.035
0.276TrpMet: 0.276 ± 0.018
0.559TrpAsn: 0.559 ± 0.026
0.265TrpPro: 0.265 ± 0.021
0.477TrpGln: 0.477 ± 0.027
0.4TrpArg: 0.4 ± 0.021
0.617TrpSer: 0.617 ± 0.034
0.454TrpThr: 0.454 ± 0.027
0.566TrpVal: 0.566 ± 0.027
0.132TrpTrp: 0.132 ± 0.017
0.383TrpTyr: 0.383 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.397TyrAla: 2.397 ± 0.055
0.264TyrCys: 0.264 ± 0.019
2.132TyrAsp: 2.132 ± 0.057
2.241TyrGlu: 2.241 ± 0.053
2.406TyrPhe: 2.406 ± 0.065
2.389TyrGly: 2.389 ± 0.064
0.804TyrHis: 0.804 ± 0.031
2.588TyrIle: 2.588 ± 0.057
3.228TyrLys: 3.228 ± 0.078
3.88TyrLeu: 3.88 ± 0.089
0.669TyrMet: 0.669 ± 0.03
2.697TyrAsn: 2.697 ± 0.064
1.371TyrPro: 1.371 ± 0.044
1.976TyrGln: 1.976 ± 0.053
1.468TyrArg: 1.468 ± 0.048
2.537TyrSer: 2.537 ± 0.067
2.165TyrThr: 2.165 ± 0.055
2.119TyrVal: 2.119 ± 0.056
0.459TyrTrp: 0.459 ± 0.021
1.684TyrTyr: 1.684 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2311 proteins (777795 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski