Amino acid dipepetide frequency for Winogradskyella sp. J14-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.838AlaAla: 3.838 ± 0.075	0.582AlaCys: 0.582 ± 0.041	3.585AlaAsp: 3.585 ± 0.106	4.084AlaGlu: 4.084 ± 0.068	3.337AlaPhe: 3.337 ± 0.052	3.919AlaGly: 3.919 ± 0.109	1.082AlaHis: 1.082 ± 0.031	5.356AlaIle: 5.356 ± 0.082	4.75AlaLys: 4.75 ± 0.102	6.239AlaLeu: 6.239 ± 0.09	1.501AlaMet: 1.501 ± 0.037	3.759AlaAsn: 3.759 ± 0.079	1.757AlaPro: 1.757 ± 0.061	2.286AlaGln: 2.286 ± 0.049	1.868AlaArg: 1.868 ± 0.051	4.21AlaSer: 4.21 ± 0.063	3.854AlaThr: 3.854 ± 0.1	4.032AlaVal: 4.032 ± 0.083	0.588AlaTrp: 0.588 ± 0.022	2.477AlaTyr: 2.477 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.481CysAla: 0.481 ± 0.025	0.093CysCys: 0.093 ± 0.011	0.482CysAsp: 0.482 ± 0.035	0.507CysGlu: 0.507 ± 0.024	0.471CysPhe: 0.471 ± 0.023	0.681CysGly: 0.681 ± 0.085	0.178CysHis: 0.178 ± 0.016	0.628CysIle: 0.628 ± 0.028	0.503CysLys: 0.503 ± 0.025	0.594CysLeu: 0.594 ± 0.027	0.123CysMet: 0.123 ± 0.012	0.464CysAsn: 0.464 ± 0.02	0.321CysPro: 0.321 ± 0.023	0.201CysGln: 0.201 ± 0.013	0.181CysArg: 0.181 ± 0.014	0.54CysSer: 0.54 ± 0.031	0.408CysThr: 0.408 ± 0.035	0.462CysVal: 0.462 ± 0.022	0.062CysTrp: 0.062 ± 0.008	0.313CysTyr: 0.313 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.191AspAla: 4.191 ± 0.103	0.506AspCys: 0.506 ± 0.03	3.683AspAsp: 3.683 ± 0.114	3.937AspGlu: 3.937 ± 0.074	3.672AspPhe: 3.672 ± 0.063	4.11AspGly: 4.11 ± 0.145	0.847AspHis: 0.847 ± 0.033	5.016AspIle: 5.016 ± 0.076	4.096AspLys: 4.096 ± 0.089	5.555AspLeu: 5.555 ± 0.084	1.12AspMet: 1.12 ± 0.032	3.832AspAsn: 3.832 ± 0.067	1.776AspPro: 1.776 ± 0.067	1.469AspGln: 1.469 ± 0.045	1.811AspArg: 1.811 ± 0.042	3.314AspSer: 3.314 ± 0.073	3.263AspThr: 3.263 ± 0.118	3.925AspVal: 3.925 ± 0.067	0.742AspTrp: 0.742 ± 0.026	3.15AspTyr: 3.15 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.604GluAla: 4.604 ± 0.085	0.421GluCys: 0.421 ± 0.047	4.256GluAsp: 4.256 ± 0.077	4.671GluGlu: 4.671 ± 0.103	3.031GluPhe: 3.031 ± 0.06	3.687GluGly: 3.687 ± 0.07	1.175GluHis: 1.175 ± 0.036	5.258GluIle: 5.258 ± 0.088	5.113GluLys: 5.113 ± 0.096	6.04GluLeu: 6.04 ± 0.083	1.339GluMet: 1.339 ± 0.041	4.632GluAsn: 4.632 ± 0.081	1.608GluPro: 1.608 ± 0.053	2.321GluGln: 2.321 ± 0.051	2.556GluArg: 2.556 ± 0.072	3.406GluSer: 3.406 ± 0.064	3.941GluThr: 3.941 ± 0.072	4.38GluVal: 4.38 ± 0.083	0.589GluTrp: 0.589 ± 0.026	2.317GluTyr: 2.317 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	2.883PheAla: 2.883 ± 0.055	0.395PheCys: 0.395 ± 0.02	3.398PheAsp: 3.398 ± 0.064	3.526PheGlu: 3.526 ± 0.058	2.651PhePhe: 2.651 ± 0.059	3.764PheGly: 3.764 ± 0.077	0.734PheHis: 0.734 ± 0.026	3.964PheIle: 3.964 ± 0.076	3.981PheLys: 3.981 ± 0.079	4.358PheLeu: 4.358 ± 0.083	1.018PheMet: 1.018 ± 0.033	3.805PheAsn: 3.805 ± 0.066	1.656PhePro: 1.656 ± 0.042	1.512PheGln: 1.512 ± 0.044	1.651PheArg: 1.651 ± 0.047	3.95PheSer: 3.95 ± 0.076	3.274PheThr: 3.274 ± 0.075	2.95PheVal: 2.95 ± 0.046	0.555PheTrp: 0.555 ± 0.027	2.155PheTyr: 2.155 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	3.906GlyAla: 3.906 ± 0.096	0.608GlyCys: 0.608 ± 0.039	3.671GlyAsp: 3.671 ± 0.12	3.665GlyGlu: 3.665 ± 0.063	3.725GlyPhe: 3.725 ± 0.071	4.592GlyGly: 4.592 ± 0.206	1.116GlyHis: 1.116 ± 0.036	5.165GlyIle: 5.165 ± 0.09	4.662GlyLys: 4.662 ± 0.078	5.571GlyLeu: 5.571 ± 0.084	1.476GlyMet: 1.476 ± 0.045	4.022GlyAsn: 4.022 ± 0.099	1.374GlyPro: 1.374 ± 0.048	1.89GlyGln: 1.89 ± 0.045	1.987GlyArg: 1.987 ± 0.053	3.925GlySer: 3.925 ± 0.097	4.181GlyThr: 4.181 ± 0.129	4.129GlyVal: 4.129 ± 0.076	0.732GlyTrp: 0.732 ± 0.038	2.771GlyTyr: 2.771 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	0.9HisAla: 0.9 ± 0.031	0.179HisCys: 0.179 ± 0.015	0.811HisAsp: 0.811 ± 0.027	0.802HisGlu: 0.802 ± 0.032	1.07HisPhe: 1.07 ± 0.035	0.978HisGly: 0.978 ± 0.028	0.498HisHis: 0.498 ± 0.028	1.44HisIle: 1.44 ± 0.034	1.287HisLys: 1.287 ± 0.042	1.744HisLeu: 1.744 ± 0.046	0.323HisMet: 0.323 ± 0.017	1.085HisAsn: 1.085 ± 0.042	0.837HisPro: 0.837 ± 0.032	0.676HisGln: 0.676 ± 0.028	0.618HisArg: 0.618 ± 0.025	1.004HisSer: 1.004 ± 0.035	0.886HisThr: 0.886 ± 0.03	0.908HisVal: 0.908 ± 0.031	0.191HisTrp: 0.191 ± 0.015	0.819HisTyr: 0.819 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.403IleAla: 5.403 ± 0.086	0.598IleCys: 0.598 ± 0.027	5.151IleAsp: 5.151 ± 0.077	5.781IleGlu: 5.781 ± 0.093	3.605IlePhe: 3.605 ± 0.075	4.912IleGly: 4.912 ± 0.079	1.218IleHis: 1.218 ± 0.036	6.205IleIle: 6.205 ± 0.104	5.899IleLys: 5.899 ± 0.1	6.949IleLeu: 6.949 ± 0.116	1.343IleMet: 1.343 ± 0.035	5.107IleAsn: 5.107 ± 0.082	3.144IlePro: 3.144 ± 0.052	2.252IleGln: 2.252 ± 0.042	2.365IleArg: 2.365 ± 0.047	5.667IleSer: 5.667 ± 0.093	5.11IleThr: 5.11 ± 0.124	4.976IleVal: 4.976 ± 0.077	0.68IleTrp: 0.68 ± 0.026	2.973IleTyr: 2.973 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.146LysAla: 5.146 ± 0.102	0.308LysCys: 0.308 ± 0.02	4.841LysAsp: 4.841 ± 0.095	5.432LysGlu: 5.432 ± 0.118	2.931LysPhe: 2.931 ± 0.067	4.293LysGly: 4.293 ± 0.093	1.539LysHis: 1.539 ± 0.046	5.683LysIle: 5.683 ± 0.095	6.249LysLys: 6.249 ± 0.126	6.6LysLeu: 6.6 ± 0.12	1.699LysMet: 1.699 ± 0.041	4.959LysAsn: 4.959 ± 0.087	2.482LysPro: 2.482 ± 0.058	2.78LysGln: 2.78 ± 0.062	3.042LysArg: 3.042 ± 0.069	4.767LysSer: 4.767 ± 0.102	4.965LysThr: 4.965 ± 0.091	4.552LysVal: 4.552 ± 0.091	0.748LysTrp: 0.748 ± 0.031	2.928LysTyr: 2.928 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	5.525LeuAla: 5.525 ± 0.079	0.669LeuCys: 0.669 ± 0.033	5.379LeuAsp: 5.379 ± 0.086	6.087LeuGlu: 6.087 ± 0.103	4.639LeuPhe: 4.639 ± 0.094	5.69LeuGly: 5.69 ± 0.084	1.491LeuHis: 1.491 ± 0.04	6.809LeuIle: 6.809 ± 0.118	7.942LeuLys: 7.942 ± 0.138	8.153LeuLeu: 8.153 ± 0.126	2.001LeuMet: 2.001 ± 0.049	6.094LeuAsn: 6.094 ± 0.103	3.304LeuPro: 3.304 ± 0.061	3.046LeuGln: 3.046 ± 0.064	3.184LeuArg: 3.184 ± 0.074	6.431LeuSer: 6.431 ± 0.084	5.197LeuThr: 5.197 ± 0.09	5.49LeuVal: 5.49 ± 0.081	0.782LeuTrp: 0.782 ± 0.03	3.263LeuTyr: 3.263 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.541MetAla: 1.541 ± 0.042	0.116MetCys: 0.116 ± 0.012	1.06MetAsp: 1.06 ± 0.033	1.133MetGlu: 1.133 ± 0.037	0.819MetPhe: 0.819 ± 0.03	1.155MetGly: 1.155 ± 0.036	0.429MetHis: 0.429 ± 0.017	1.422MetIle: 1.422 ± 0.037	1.949MetLys: 1.949 ± 0.047	1.857MetLeu: 1.857 ± 0.052	0.51MetMet: 0.51 ± 0.027	1.177MetAsn: 1.177 ± 0.038	0.807MetPro: 0.807 ± 0.027	0.803MetGln: 0.803 ± 0.025	0.855MetArg: 0.855 ± 0.033	1.42MetSer: 1.42 ± 0.04	1.146MetThr: 1.146 ± 0.033	1.314MetVal: 1.314 ± 0.039	0.151MetTrp: 0.151 ± 0.013	0.719MetTyr: 0.719 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	4.255AsnAla: 4.255 ± 0.078	0.555AsnCys: 0.555 ± 0.033	3.895AsnAsp: 3.895 ± 0.075	3.871AsnGlu: 3.871 ± 0.071	3.276AsnPhe: 3.276 ± 0.069	4.417AsnGly: 4.417 ± 0.111	1.046AsnHis: 1.046 ± 0.035	5.168AsnIle: 5.168 ± 0.076	4.365AsnLys: 4.365 ± 0.093	5.766AsnLeu: 5.766 ± 0.11	1.275AsnMet: 1.275 ± 0.04	4.696AsnAsn: 4.696 ± 0.119	2.95AsnPro: 2.95 ± 0.055	2.256AsnGln: 2.256 ± 0.048	2.265AsnArg: 2.265 ± 0.055	4.101AsnSer: 4.101 ± 0.077	4.35AsnThr: 4.35 ± 0.101	3.852AsnVal: 3.852 ± 0.088	0.792AsnTrp: 0.792 ± 0.029	3.067AsnTyr: 3.067 ± 0.077	0.0AsnXaa: 0.0 ± 0.0
Pro	1.72ProAla: 1.72 ± 0.066	0.21ProCys: 0.21 ± 0.015	1.984ProAsp: 1.984 ± 0.051	2.632ProGlu: 2.632 ± 0.054	1.859ProPhe: 1.859 ± 0.04	1.73ProGly: 1.73 ± 0.055	0.548ProHis: 0.548 ± 0.025	2.62ProIle: 2.62 ± 0.051	2.578ProLys: 2.578 ± 0.065	2.82ProLeu: 2.82 ± 0.061	0.72ProMet: 0.72 ± 0.027	2.579ProAsn: 2.579 ± 0.07	0.827ProPro: 0.827 ± 0.035	1.128ProGln: 1.128 ± 0.035	0.911ProArg: 0.911 ± 0.03	2.139ProSer: 2.139 ± 0.056	2.049ProThr: 2.049 ± 0.076	2.136ProVal: 2.136 ± 0.048	0.325ProTrp: 0.325 ± 0.015	1.476ProTyr: 1.476 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.86GlnAla: 1.86 ± 0.047	0.188GlnCys: 0.188 ± 0.014	1.74GlnAsp: 1.74 ± 0.04	1.966GlnGlu: 1.966 ± 0.048	1.714GlnPhe: 1.714 ± 0.046	1.764GlnGly: 1.764 ± 0.045	0.58GlnHis: 0.58 ± 0.025	2.584GlnIle: 2.584 ± 0.058	2.499GlnLys: 2.499 ± 0.062	3.551GlnLeu: 3.551 ± 0.071	0.756GlnMet: 0.756 ± 0.029	2.199GlnAsn: 2.199 ± 0.052	1.183GlnPro: 1.183 ± 0.038	1.469GlnGln: 1.469 ± 0.046	1.264GlnArg: 1.264 ± 0.039	1.891GlnSer: 1.891 ± 0.042	1.996GlnThr: 1.996 ± 0.053	1.739GlnVal: 1.739 ± 0.043	0.354GlnTrp: 0.354 ± 0.018	1.307GlnTyr: 1.307 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.129ArgAla: 2.129 ± 0.049	0.2ArgCys: 0.2 ± 0.015	1.805ArgAsp: 1.805 ± 0.047	2.051ArgGlu: 2.051 ± 0.061	1.949ArgPhe: 1.949 ± 0.05	1.863ArgGly: 1.863 ± 0.051	0.622ArgHis: 0.622 ± 0.028	2.805ArgIle: 2.805 ± 0.062	2.533ArgLys: 2.533 ± 0.066	3.387ArgLeu: 3.387 ± 0.066	0.772ArgMet: 0.772 ± 0.032	1.995ArgAsn: 1.995 ± 0.047	1.096ArgPro: 1.096 ± 0.035	1.214ArgGln: 1.214 ± 0.04	1.314ArgArg: 1.314 ± 0.043	1.837ArgSer: 1.837 ± 0.05	1.841ArgThr: 1.841 ± 0.052	2.045ArgVal: 2.045 ± 0.05	0.373ArgTrp: 0.373 ± 0.02	1.563ArgTyr: 1.563 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.813SerAla: 3.813 ± 0.081	0.638SerCys: 0.638 ± 0.028	3.749SerAsp: 3.749 ± 0.074	4.178SerGlu: 4.178 ± 0.081	3.735SerPhe: 3.735 ± 0.068	4.532SerGly: 4.532 ± 0.104	1.012SerHis: 1.012 ± 0.036	5.245SerIle: 5.245 ± 0.079	5.105SerLys: 5.105 ± 0.109	5.654SerLeu: 5.654 ± 0.092	1.17SerMet: 1.17 ± 0.037	4.279SerAsn: 4.279 ± 0.092	1.997SerPro: 1.997 ± 0.05	2.036SerGln: 2.036 ± 0.045	2.002SerArg: 2.002 ± 0.048	4.07SerSer: 4.07 ± 0.075	3.695SerThr: 3.695 ± 0.08	3.992SerVal: 3.992 ± 0.066	0.666SerTrp: 0.666 ± 0.028	2.683SerTyr: 2.683 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.776ThrAla: 3.776 ± 0.102	0.432ThrCys: 0.432 ± 0.038	3.578ThrAsp: 3.578 ± 0.096	3.814ThrGlu: 3.814 ± 0.071	3.311ThrPhe: 3.311 ± 0.075	4.068ThrGly: 4.068 ± 0.132	0.981ThrHis: 0.981 ± 0.032	5.502ThrIle: 5.502 ± 0.136	4.002ThrLys: 4.002 ± 0.09	5.636ThrLeu: 5.636 ± 0.087	0.938ThrMet: 0.938 ± 0.033	3.824ThrAsn: 3.824 ± 0.107	2.245ThrPro: 2.245 ± 0.062	1.856ThrGln: 1.856 ± 0.043	1.609ThrArg: 1.609 ± 0.045	4.098ThrSer: 4.098 ± 0.075	3.866ThrThr: 3.866 ± 0.102	4.205ThrVal: 4.205 ± 0.134	0.608ThrTrp: 0.608 ± 0.042	2.728ThrTyr: 2.728 ± 0.079	0.0ThrXaa: 0.0 ± 0.0
Val	4.155ValAla: 4.155 ± 0.076	0.53ValCys: 0.53 ± 0.026	3.891ValAsp: 3.891 ± 0.081	4.2ValGlu: 4.2 ± 0.083	3.407ValPhe: 3.407 ± 0.067	3.816ValGly: 3.816 ± 0.087	0.92ValHis: 0.92 ± 0.028	4.95ValIle: 4.95 ± 0.076	4.332ValLys: 4.332 ± 0.077	5.906ValLeu: 5.906 ± 0.082	1.26ValMet: 1.26 ± 0.041	3.877ValAsn: 3.877 ± 0.073	2.017ValPro: 2.017 ± 0.054	1.557ValGln: 1.557 ± 0.04	1.986ValArg: 1.986 ± 0.054	4.306ValSer: 4.306 ± 0.071	3.929ValThr: 3.929 ± 0.118	4.36ValVal: 4.36 ± 0.077	0.58ValTrp: 0.58 ± 0.025	2.403ValTyr: 2.403 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.55TrpAla: 0.55 ± 0.028	0.096TrpCys: 0.096 ± 0.01	0.6TrpAsp: 0.6 ± 0.026	0.638TrpGlu: 0.638 ± 0.024	0.571TrpPhe: 0.571 ± 0.025	0.564TrpGly: 0.564 ± 0.036	0.213TrpHis: 0.213 ± 0.016	0.697TrpIle: 0.697 ± 0.027	0.733TrpLys: 0.733 ± 0.025	0.996TrpLeu: 0.996 ± 0.034	0.284TrpMet: 0.284 ± 0.018	0.784TrpAsn: 0.784 ± 0.035	0.201TrpPro: 0.201 ± 0.016	0.441TrpGln: 0.441 ± 0.021	0.343TrpArg: 0.343 ± 0.022	0.652TrpSer: 0.652 ± 0.029	0.601TrpThr: 0.601 ± 0.033	0.599TrpVal: 0.599 ± 0.025	0.145TrpTrp: 0.145 ± 0.014	0.45TrpTyr: 0.45 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.431TyrAla: 2.431 ± 0.055	0.369TyrCys: 0.369 ± 0.024	2.458TyrAsp: 2.458 ± 0.05	2.369TyrGlu: 2.369 ± 0.046	2.407TyrPhe: 2.407 ± 0.056	2.63TyrGly: 2.63 ± 0.062	0.828TyrHis: 0.828 ± 0.033	2.82TyrIle: 2.82 ± 0.055	3.367TyrLys: 3.367 ± 0.072	3.801TyrLeu: 3.801 ± 0.082	0.758TyrMet: 0.758 ± 0.033	3.049TyrAsn: 3.049 ± 0.074	1.405TyrPro: 1.405 ± 0.036	1.41TyrGln: 1.41 ± 0.047	1.578TyrArg: 1.578 ± 0.046	2.525TyrSer: 2.525 ± 0.055	2.527TyrThr: 2.527 ± 0.077	2.337TyrVal: 2.337 ± 0.051	0.494TyrTrp: 0.494 ± 0.026	1.951TyrTyr: 1.951 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2928 proteins (1008313 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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