Amino acid dipepetide frequency for Corynebacterium sp. 2039

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.53AlaAla: 15.53 ± 0.174
0.744AlaCys: 0.744 ± 0.026
6.316AlaAsp: 6.316 ± 0.101
9.134AlaGlu: 9.134 ± 0.136
3.196AlaPhe: 3.196 ± 0.057
10.172AlaGly: 10.172 ± 0.111
2.196AlaHis: 2.196 ± 0.048
5.054AlaIle: 5.054 ± 0.088
3.082AlaLys: 3.082 ± 0.072
11.539AlaLeu: 11.539 ± 0.141
2.621AlaMet: 2.621 ± 0.053
2.511AlaAsn: 2.511 ± 0.054
5.21AlaPro: 5.21 ± 0.103
4.0AlaGln: 4.0 ± 0.075
6.799AlaArg: 6.799 ± 0.101
5.257AlaSer: 5.257 ± 0.081
6.66AlaThr: 6.66 ± 0.095
9.162AlaVal: 9.162 ± 0.119
1.488AlaTrp: 1.488 ± 0.043
1.957AlaTyr: 1.957 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.686CysAla: 0.686 ± 0.028
0.053CysCys: 0.053 ± 0.009
0.399CysAsp: 0.399 ± 0.023
0.368CysGlu: 0.368 ± 0.02
0.212CysPhe: 0.212 ± 0.015
0.695CysGly: 0.695 ± 0.028
0.175CysHis: 0.175 ± 0.013
0.279CysIle: 0.279 ± 0.018
0.091CysLys: 0.091 ± 0.009
0.605CysLeu: 0.605 ± 0.027
0.109CysMet: 0.109 ± 0.012
0.148CysAsn: 0.148 ± 0.012
0.377CysPro: 0.377 ± 0.024
0.2CysGln: 0.2 ± 0.018
0.392CysArg: 0.392 ± 0.021
0.426CysSer: 0.426 ± 0.024
0.428CysThr: 0.428 ± 0.022
0.471CysVal: 0.471 ± 0.025
0.111CysTrp: 0.111 ± 0.013
0.14CysTyr: 0.14 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
5.886AspAla: 5.886 ± 0.093
0.353AspCys: 0.353 ± 0.02
2.867AspAsp: 2.867 ± 0.077
3.975AspGlu: 3.975 ± 0.074
2.053AspPhe: 2.053 ± 0.051
4.255AspGly: 4.255 ± 0.087
1.313AspHis: 1.313 ± 0.039
2.929AspIle: 2.929 ± 0.062
1.383AspLys: 1.383 ± 0.043
5.935AspLeu: 5.935 ± 0.092
1.054AspMet: 1.054 ± 0.036
1.479AspAsn: 1.479 ± 0.046
4.01AspPro: 4.01 ± 0.069
1.846AspGln: 1.846 ± 0.048
3.473AspArg: 3.473 ± 0.065
3.044AspSer: 3.044 ± 0.058
3.381AspThr: 3.381 ± 0.062
3.811AspVal: 3.811 ± 0.07
0.842AspTrp: 0.842 ± 0.033
1.414AspTyr: 1.414 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.069GluAla: 7.069 ± 0.125
0.327GluCys: 0.327 ± 0.021
3.746GluAsp: 3.746 ± 0.07
5.138GluGlu: 5.138 ± 0.102
2.149GluPhe: 2.149 ± 0.05
5.227GluGly: 5.227 ± 0.083
1.68GluHis: 1.68 ± 0.045
3.874GluIle: 3.874 ± 0.072
2.564GluLys: 2.564 ± 0.064
7.928GluLeu: 7.928 ± 0.106
1.37GluMet: 1.37 ± 0.036
2.184GluAsn: 2.184 ± 0.053
3.018GluPro: 3.018 ± 0.08
3.018GluGln: 3.018 ± 0.061
4.314GluArg: 4.314 ± 0.085
3.477GluSer: 3.477 ± 0.06
3.43GluThr: 3.43 ± 0.066
5.733GluVal: 5.733 ± 0.102
0.928GluTrp: 0.928 ± 0.032
1.377GluTyr: 1.377 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.526PheAla: 3.526 ± 0.064
0.23PheCys: 0.23 ± 0.016
2.08PheAsp: 2.08 ± 0.047
1.911PheGlu: 1.911 ± 0.05
1.23PhePhe: 1.23 ± 0.044
3.388PheGly: 3.388 ± 0.067
0.806PheHis: 0.806 ± 0.034
1.736PheIle: 1.736 ± 0.043
0.707PheLys: 0.707 ± 0.027
3.385PheLeu: 3.385 ± 0.073
0.639PheMet: 0.639 ± 0.026
1.091PheAsn: 1.091 ± 0.033
1.546PhePro: 1.546 ± 0.042
1.033PheGln: 1.033 ± 0.037
1.951PheArg: 1.951 ± 0.049
2.254PheSer: 2.254 ± 0.059
2.21PheThr: 2.21 ± 0.055
1.97PheVal: 1.97 ± 0.046
0.541PheTrp: 0.541 ± 0.029
0.773PheTyr: 0.773 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
8.595GlyAla: 8.595 ± 0.113
0.608GlyCys: 0.608 ± 0.031
4.299GlyAsp: 4.299 ± 0.072
6.012GlyGlu: 6.012 ± 0.083
3.138GlyPhe: 3.138 ± 0.056
7.209GlyGly: 7.209 ± 0.126
1.964GlyHis: 1.964 ± 0.048
4.749GlyIle: 4.749 ± 0.083
2.731GlyLys: 2.731 ± 0.056
8.536GlyLeu: 8.536 ± 0.101
2.305GlyMet: 2.305 ± 0.06
2.272GlyAsn: 2.272 ± 0.053
3.623GlyPro: 3.623 ± 0.058
3.051GlyGln: 3.051 ± 0.057
5.26GlyArg: 5.26 ± 0.091
5.268GlySer: 5.268 ± 0.089
5.214GlyThr: 5.214 ± 0.09
7.231GlyVal: 7.231 ± 0.099
1.464GlyTrp: 1.464 ± 0.039
2.185GlyTyr: 2.185 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.01HisAla: 2.01 ± 0.049
0.176HisCys: 0.176 ± 0.014
1.237HisAsp: 1.237 ± 0.036
1.296HisGlu: 1.296 ± 0.038
0.772HisPhe: 0.772 ± 0.025
1.914HisGly: 1.914 ± 0.041
0.728HisHis: 0.728 ± 0.03
0.945HisIle: 0.945 ± 0.034
0.413HisLys: 0.413 ± 0.022
2.492HisLeu: 2.492 ± 0.055
0.428HisMet: 0.428 ± 0.024
0.693HisAsn: 0.693 ± 0.026
1.78HisPro: 1.78 ± 0.041
0.867HisGln: 0.867 ± 0.029
1.756HisArg: 1.756 ± 0.05
1.233HisSer: 1.233 ± 0.037
1.256HisThr: 1.256 ± 0.039
1.392HisVal: 1.392 ± 0.038
0.282HisTrp: 0.282 ± 0.017
0.525HisTyr: 0.525 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.12IleAla: 6.12 ± 0.085
0.384IleCys: 0.384 ± 0.02
3.352IleAsp: 3.352 ± 0.058
3.137IleGlu: 3.137 ± 0.061
1.85IlePhe: 1.85 ± 0.05
4.632IleGly: 4.632 ± 0.091
1.111IleHis: 1.111 ± 0.034
2.933IleIle: 2.933 ± 0.069
1.296IleLys: 1.296 ± 0.037
4.602IleLeu: 4.602 ± 0.081
1.043IleMet: 1.043 ± 0.038
1.687IleAsn: 1.687 ± 0.043
2.932IlePro: 2.932 ± 0.058
1.391IleGln: 1.391 ± 0.043
3.042IleArg: 3.042 ± 0.059
3.458IleSer: 3.458 ± 0.056
3.343IleThr: 3.343 ± 0.057
3.287IleVal: 3.287 ± 0.066
0.652IleTrp: 0.652 ± 0.027
1.049IleTyr: 1.049 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
2.867LysAla: 2.867 ± 0.068
0.105LysCys: 0.105 ± 0.011
1.446LysAsp: 1.446 ± 0.045
1.794LysGlu: 1.794 ± 0.047
0.87LysPhe: 0.87 ± 0.029
1.922LysGly: 1.922 ± 0.048
0.579LysHis: 0.579 ± 0.026
1.568LysIle: 1.568 ± 0.043
1.354LysLys: 1.354 ± 0.047
2.839LysLeu: 2.839 ± 0.069
0.682LysMet: 0.682 ± 0.029
0.934LysAsn: 0.934 ± 0.033
1.418LysPro: 1.418 ± 0.049
1.065LysGln: 1.065 ± 0.035
1.798LysArg: 1.798 ± 0.045
1.451LysSer: 1.451 ± 0.038
1.582LysThr: 1.582 ± 0.039
2.519LysVal: 2.519 ± 0.051
0.39LysTrp: 0.39 ± 0.023
0.593LysTyr: 0.593 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
12.745LeuAla: 12.745 ± 0.129
0.663LeuCys: 0.663 ± 0.027
5.949LeuAsp: 5.949 ± 0.08
5.724LeuGlu: 5.724 ± 0.087
3.033LeuPhe: 3.033 ± 0.068
9.465LeuGly: 9.465 ± 0.116
2.185LeuHis: 2.185 ± 0.049
5.647LeuIle: 5.647 ± 0.096
2.8LeuLys: 2.8 ± 0.053
10.961LeuLeu: 10.961 ± 0.169
2.091LeuMet: 2.091 ± 0.047
3.047LeuAsn: 3.047 ± 0.059
5.857LeuPro: 5.857 ± 0.09
3.072LeuGln: 3.072 ± 0.068
6.893LeuArg: 6.893 ± 0.088
6.95LeuSer: 6.95 ± 0.104
5.369LeuThr: 5.369 ± 0.078
7.978LeuVal: 7.978 ± 0.098
1.194LeuTrp: 1.194 ± 0.039
1.743LeuTyr: 1.743 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.555MetAla: 2.555 ± 0.056
0.147MetCys: 0.147 ± 0.013
1.108MetAsp: 1.108 ± 0.035
1.105MetGlu: 1.105 ± 0.033
0.7MetPhe: 0.7 ± 0.033
1.675MetGly: 1.675 ± 0.05
0.384MetHis: 0.384 ± 0.02
1.255MetIle: 1.255 ± 0.041
0.744MetLys: 0.744 ± 0.029
2.228MetLeu: 2.228 ± 0.055
0.538MetMet: 0.538 ± 0.025
0.774MetAsn: 0.774 ± 0.028
1.108MetPro: 1.108 ± 0.035
0.622MetGln: 0.622 ± 0.025
1.252MetArg: 1.252 ± 0.033
1.911MetSer: 1.911 ± 0.046
1.516MetThr: 1.516 ± 0.041
1.8MetVal: 1.8 ± 0.053
0.266MetTrp: 0.266 ± 0.017
0.347MetTyr: 0.347 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.774AsnAla: 2.774 ± 0.058
0.199AsnCys: 0.199 ± 0.018
1.352AsnAsp: 1.352 ± 0.034
1.569AsnGlu: 1.569 ± 0.04
1.039AsnPhe: 1.039 ± 0.037
2.136AsnGly: 2.136 ± 0.054
0.667AsnHis: 0.667 ± 0.026
1.458AsnIle: 1.458 ± 0.044
0.712AsnLys: 0.712 ± 0.029
2.902AsnLeu: 2.902 ± 0.061
0.641AsnMet: 0.641 ± 0.026
0.837AsnAsn: 0.837 ± 0.035
2.241AsnPro: 2.241 ± 0.048
1.041AsnGln: 1.041 ± 0.031
1.774AsnArg: 1.774 ± 0.049
1.693AsnSer: 1.693 ± 0.045
1.667AsnThr: 1.667 ± 0.046
1.793AsnVal: 1.793 ± 0.052
0.458AsnTrp: 0.458 ± 0.024
0.747AsnTyr: 0.747 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.308ProAla: 6.308 ± 0.12
0.238ProCys: 0.238 ± 0.016
3.288ProAsp: 3.288 ± 0.058
5.29ProGlu: 5.29 ± 0.088
1.546ProPhe: 1.546 ± 0.044
5.326ProGly: 5.326 ± 0.091
1.142ProHis: 1.142 ± 0.039
2.007ProIle: 2.007 ± 0.043
1.507ProLys: 1.507 ± 0.055
4.744ProLeu: 4.744 ± 0.078
1.137ProMet: 1.137 ± 0.031
1.398ProAsn: 1.398 ± 0.046
2.068ProPro: 2.068 ± 0.07
1.972ProGln: 1.972 ± 0.051
3.048ProArg: 3.048 ± 0.06
2.732ProSer: 2.732 ± 0.065
3.35ProThr: 3.35 ± 0.066
4.664ProVal: 4.664 ± 0.083
0.806ProTrp: 0.806 ± 0.034
1.068ProTyr: 1.068 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.017GlnAla: 4.017 ± 0.074
0.159GlnCys: 0.159 ± 0.014
1.629GlnAsp: 1.629 ± 0.048
2.189GlnGlu: 2.189 ± 0.047
0.97GlnPhe: 0.97 ± 0.032
2.665GlnGly: 2.665 ± 0.05
0.728GlnHis: 0.728 ± 0.027
1.954GlnIle: 1.954 ± 0.045
0.924GlnLys: 0.924 ± 0.031
4.124GlnLeu: 4.124 ± 0.068
0.81GlnMet: 0.81 ± 0.03
0.931GlnAsn: 0.931 ± 0.034
1.857GlnPro: 1.857 ± 0.054
1.632GlnGln: 1.632 ± 0.053
2.573GlnArg: 2.573 ± 0.063
1.681GlnSer: 1.681 ± 0.045
1.562GlnThr: 1.562 ± 0.042
3.138GlnVal: 3.138 ± 0.057
0.535GlnTrp: 0.535 ± 0.024
0.601GlnTyr: 0.601 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
6.267ArgAla: 6.267 ± 0.091
0.389ArgCys: 0.389 ± 0.02
3.489ArgAsp: 3.489 ± 0.067
5.146ArgGlu: 5.146 ± 0.094
2.152ArgPhe: 2.152 ± 0.045
4.891ArgGly: 4.891 ± 0.079
1.574ArgHis: 1.574 ± 0.04
3.429ArgIle: 3.429 ± 0.06
1.995ArgLys: 1.995 ± 0.044
5.926ArgLeu: 5.926 ± 0.086
1.686ArgMet: 1.686 ± 0.048
1.862ArgAsn: 1.862 ± 0.047
3.046ArgPro: 3.046 ± 0.056
2.468ArgGln: 2.468 ± 0.051
5.222ArgArg: 5.222 ± 0.102
3.892ArgSer: 3.892 ± 0.071
3.538ArgThr: 3.538 ± 0.065
4.622ArgVal: 4.622 ± 0.072
1.027ArgTrp: 1.027 ± 0.034
1.573ArgTyr: 1.573 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.457SerAla: 6.457 ± 0.086
0.373SerCys: 0.373 ± 0.021
2.901SerAsp: 2.901 ± 0.06
3.424SerGlu: 3.424 ± 0.06
2.174SerPhe: 2.174 ± 0.048
5.876SerGly: 5.876 ± 0.083
1.236SerHis: 1.236 ± 0.04
2.722SerIle: 2.722 ± 0.054
1.313SerLys: 1.313 ± 0.034
5.926SerLeu: 5.926 ± 0.087
1.371SerMet: 1.371 ± 0.043
1.474SerAsn: 1.474 ± 0.037
3.351SerPro: 3.351 ± 0.06
2.014SerGln: 2.014 ± 0.052
3.855SerArg: 3.855 ± 0.074
3.748SerSer: 3.748 ± 0.072
3.844SerThr: 3.844 ± 0.069
4.303SerVal: 4.303 ± 0.074
1.009SerTrp: 1.009 ± 0.034
1.372SerTyr: 1.372 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
6.64ThrAla: 6.64 ± 0.085
0.384ThrCys: 0.384 ± 0.022
3.0ThrAsp: 3.0 ± 0.054
3.703ThrGlu: 3.703 ± 0.066
1.934ThrPhe: 1.934 ± 0.046
5.233ThrGly: 5.233 ± 0.071
1.248ThrHis: 1.248 ± 0.04
2.754ThrIle: 2.754 ± 0.049
1.339ThrLys: 1.339 ± 0.041
6.132ThrLeu: 6.132 ± 0.086
1.159ThrMet: 1.159 ± 0.034
1.229ThrAsn: 1.229 ± 0.035
4.237ThrPro: 4.237 ± 0.072
1.857ThrGln: 1.857 ± 0.045
3.612ThrArg: 3.612 ± 0.068
3.433ThrSer: 3.433 ± 0.067
4.009ThrThr: 4.009 ± 0.084
4.825ThrVal: 4.825 ± 0.078
1.032ThrTrp: 1.032 ± 0.033
1.28ThrTyr: 1.28 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
9.045ValAla: 9.045 ± 0.087
0.552ValCys: 0.552 ± 0.025
5.027ValAsp: 5.027 ± 0.08
5.383ValGlu: 5.383 ± 0.086
2.558ValPhe: 2.558 ± 0.055
6.067ValGly: 6.067 ± 0.083
1.642ValHis: 1.642 ± 0.046
4.411ValIle: 4.411 ± 0.076
1.97ValLys: 1.97 ± 0.048
8.357ValLeu: 8.357 ± 0.11
1.649ValMet: 1.649 ± 0.048
2.121ValAsn: 2.121 ± 0.056
4.072ValPro: 4.072 ± 0.074
2.106ValGln: 2.106 ± 0.045
4.519ValArg: 4.519 ± 0.078
4.627ValSer: 4.627 ± 0.062
4.714ValThr: 4.714 ± 0.075
6.716ValVal: 6.716 ± 0.104
1.007ValTrp: 1.007 ± 0.039
1.494ValTyr: 1.494 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.452TrpAla: 1.452 ± 0.042
0.129TrpCys: 0.129 ± 0.011
0.71TrpAsp: 0.71 ± 0.027
0.942TrpGlu: 0.942 ± 0.037
0.613TrpPhe: 0.613 ± 0.026
1.037TrpGly: 1.037 ± 0.037
0.341TrpHis: 0.341 ± 0.018
0.761TrpIle: 0.761 ± 0.033
0.416TrpLys: 0.416 ± 0.021
1.741TrpLeu: 1.741 ± 0.05
0.36TrpMet: 0.36 ± 0.023
0.458TrpAsn: 0.458 ± 0.024
0.659TrpPro: 0.659 ± 0.026
0.629TrpGln: 0.629 ± 0.025
0.997TrpArg: 0.997 ± 0.034
0.845TrpSer: 0.845 ± 0.03
0.767TrpThr: 0.767 ± 0.031
1.205TrpVal: 1.205 ± 0.04
0.368TrpTrp: 0.368 ± 0.026
0.296TrpTyr: 0.296 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.079TyrAla: 2.079 ± 0.05
0.152TyrCys: 0.152 ± 0.013
1.109TyrAsp: 1.109 ± 0.034
1.311TyrGlu: 1.311 ± 0.039
0.818TyrPhe: 0.818 ± 0.032
1.931TyrGly: 1.931 ± 0.05
0.492TyrHis: 0.492 ± 0.023
0.835TyrIle: 0.835 ± 0.03
0.435TyrLys: 0.435 ± 0.022
2.463TyrLeu: 2.463 ± 0.057
0.343TyrMet: 0.343 ± 0.021
0.569TyrAsn: 0.569 ± 0.025
1.23TyrPro: 1.23 ± 0.033
0.797TyrGln: 0.797 ± 0.028
1.661TyrArg: 1.661 ± 0.045
1.364TyrSer: 1.364 ± 0.039
1.2TyrThr: 1.2 ± 0.029
1.42TyrVal: 1.42 ± 0.042
0.326TyrTrp: 0.326 ± 0.02
0.469TyrTyr: 0.469 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2838 proteins (925458 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski