Amino acid dipepetide frequency for Fluviicola taffensis (strain DSM 16823 / NCIMB 13979 / RW262)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.971AlaAla: 3.971 ± 0.081	0.76AlaCys: 0.76 ± 0.028	3.159AlaAsp: 3.159 ± 0.052	3.548AlaGlu: 3.548 ± 0.059	3.186AlaPhe: 3.186 ± 0.053	4.609AlaGly: 4.609 ± 0.092	1.022AlaHis: 1.022 ± 0.028	4.911AlaIle: 4.911 ± 0.077	4.091AlaLys: 4.091 ± 0.067	5.724AlaLeu: 5.724 ± 0.072	1.377AlaMet: 1.377 ± 0.038	3.483AlaAsn: 3.483 ± 0.061	2.071AlaPro: 2.071 ± 0.045	2.47AlaGln: 2.47 ± 0.045	1.952AlaArg: 1.952 ± 0.041	4.342AlaSer: 4.342 ± 0.07	4.036AlaThr: 4.036 ± 0.09	3.738AlaVal: 3.738 ± 0.058	0.627AlaTrp: 0.627 ± 0.02	2.321AlaTyr: 2.321 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.684CysAla: 0.684 ± 0.029	0.123CysCys: 0.123 ± 0.009	0.575CysAsp: 0.575 ± 0.035	0.546CysGlu: 0.546 ± 0.022	0.604CysPhe: 0.604 ± 0.024	0.806CysGly: 0.806 ± 0.026	0.186CysHis: 0.186 ± 0.012	0.736CysIle: 0.736 ± 0.024	0.536CysLys: 0.536 ± 0.018	0.841CysLeu: 0.841 ± 0.022	0.18CysMet: 0.18 ± 0.011	0.562CysAsn: 0.562 ± 0.023	0.438CysPro: 0.438 ± 0.023	0.311CysGln: 0.311 ± 0.016	0.238CysArg: 0.238 ± 0.014	0.895CysSer: 0.895 ± 0.033	0.7CysThr: 0.7 ± 0.031	0.598CysVal: 0.598 ± 0.023	0.095CysTrp: 0.095 ± 0.009	0.398CysTyr: 0.398 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.31AspAla: 3.31 ± 0.056	0.523AspCys: 0.523 ± 0.024	2.388AspAsp: 2.388 ± 0.047	3.408AspGlu: 3.408 ± 0.054	3.285AspPhe: 3.285 ± 0.055	3.829AspGly: 3.829 ± 0.082	0.848AspHis: 0.848 ± 0.025	3.486AspIle: 3.486 ± 0.05	3.359AspLys: 3.359 ± 0.061	5.135AspLeu: 5.135 ± 0.07	1.021AspMet: 1.021 ± 0.029	2.553AspAsn: 2.553 ± 0.046	1.944AspPro: 1.944 ± 0.048	1.899AspGln: 1.899 ± 0.039	1.814AspArg: 1.814 ± 0.039	3.862AspSer: 3.862 ± 0.071	2.704AspThr: 2.704 ± 0.062	3.076AspVal: 3.076 ± 0.058	0.694AspTrp: 0.694 ± 0.023	2.452AspTyr: 2.452 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	3.722GluAla: 3.722 ± 0.071	0.451GluCys: 0.451 ± 0.019	2.837GluAsp: 2.837 ± 0.047	4.301GluGlu: 4.301 ± 0.07	2.948GluPhe: 2.948 ± 0.048	3.348GluGly: 3.348 ± 0.052	1.079GluHis: 1.079 ± 0.029	5.394GluIle: 5.394 ± 0.068	5.332GluLys: 5.332 ± 0.081	6.635GluLeu: 6.635 ± 0.088	1.645GluMet: 1.645 ± 0.032	3.922GluAsn: 3.922 ± 0.065	1.507GluPro: 1.507 ± 0.035	2.383GluGln: 2.383 ± 0.046	2.491GluArg: 2.491 ± 0.046	3.605GluSer: 3.605 ± 0.058	3.376GluThr: 3.376 ± 0.054	3.877GluVal: 3.877 ± 0.056	0.718GluTrp: 0.718 ± 0.023	2.294GluTyr: 2.294 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.02PheAla: 3.02 ± 0.045	0.587PheCys: 0.587 ± 0.031	3.101PheAsp: 3.101 ± 0.046	3.424PheGlu: 3.424 ± 0.054	2.709PhePhe: 2.709 ± 0.062	3.805PheGly: 3.805 ± 0.064	0.974PheHis: 0.974 ± 0.028	3.877PheIle: 3.877 ± 0.063	3.328PheLys: 3.328 ± 0.053	4.633PheLeu: 4.633 ± 0.067	1.048PheMet: 1.048 ± 0.03	3.039PheAsn: 3.039 ± 0.059	1.914PhePro: 1.914 ± 0.038	1.976PheGln: 1.976 ± 0.035	1.793PheArg: 1.793 ± 0.045	4.366PheSer: 4.366 ± 0.064	3.354PheThr: 3.354 ± 0.064	3.258PheVal: 3.258 ± 0.051	0.603PheTrp: 0.603 ± 0.022	2.209PheTyr: 2.209 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.195GlyAla: 4.195 ± 0.076	0.91GlyCys: 0.91 ± 0.047	3.087GlyAsp: 3.087 ± 0.062	3.434GlyGlu: 3.434 ± 0.051	3.615GlyPhe: 3.615 ± 0.051	4.989GlyGly: 4.989 ± 0.121	1.1GlyHis: 1.1 ± 0.028	5.573GlyIle: 5.573 ± 0.061	4.979GlyLys: 4.979 ± 0.089	5.776GlyLeu: 5.776 ± 0.078	1.658GlyMet: 1.658 ± 0.036	4.08GlyAsn: 4.08 ± 0.071	1.553GlyPro: 1.553 ± 0.046	2.169GlyGln: 2.169 ± 0.047	1.974GlyArg: 1.974 ± 0.041	4.857GlySer: 4.857 ± 0.083	5.057GlyThr: 5.057 ± 0.127	4.345GlyVal: 4.345 ± 0.062	0.762GlyTrp: 0.762 ± 0.027	2.698GlyTyr: 2.698 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.059HisAla: 1.059 ± 0.029	0.196HisCys: 0.196 ± 0.011	0.759HisAsp: 0.759 ± 0.025	1.024HisGlu: 1.024 ± 0.031	1.331HisPhe: 1.331 ± 0.03	1.101HisGly: 1.101 ± 0.031	0.456HisHis: 0.456 ± 0.021	1.276HisIle: 1.276 ± 0.03	0.926HisLys: 0.926 ± 0.025	1.849HisLeu: 1.849 ± 0.042	0.352HisMet: 0.352 ± 0.016	0.779HisAsn: 0.779 ± 0.025	0.907HisPro: 0.907 ± 0.024	0.76HisGln: 0.76 ± 0.027	0.676HisArg: 0.676 ± 0.022	1.224HisSer: 1.224 ± 0.028	0.929HisThr: 0.929 ± 0.031	1.129HisVal: 1.129 ± 0.032	0.256HisTrp: 0.256 ± 0.013	0.803HisTyr: 0.803 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.104IleAla: 5.104 ± 0.076	0.873IleCys: 0.873 ± 0.031	4.636IleAsp: 4.636 ± 0.063	5.116IleGlu: 5.116 ± 0.078	3.422IlePhe: 3.422 ± 0.058	5.111IleGly: 5.111 ± 0.062	1.725IleHis: 1.725 ± 0.038	5.365IleIle: 5.365 ± 0.068	4.335IleLys: 4.335 ± 0.071	6.933IleLeu: 6.933 ± 0.094	1.287IleMet: 1.287 ± 0.03	4.066IleAsn: 4.066 ± 0.065	3.47IlePro: 3.47 ± 0.053	3.432IleGln: 3.432 ± 0.053	2.933IleArg: 2.933 ± 0.042	6.023IleSer: 6.023 ± 0.061	4.869IleThr: 4.869 ± 0.076	4.813IleVal: 4.813 ± 0.065	0.793IleTrp: 0.793 ± 0.023	2.891IleTyr: 2.891 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.108LysAla: 4.108 ± 0.068	0.425LysCys: 0.425 ± 0.019	3.665LysAsp: 3.665 ± 0.067	5.358LysGlu: 5.358 ± 0.076	2.717LysPhe: 2.717 ± 0.049	4.124LysGly: 4.124 ± 0.065	1.361LysHis: 1.361 ± 0.037	5.355LysIle: 5.355 ± 0.08	6.03LysLys: 6.03 ± 0.11	6.122LysLeu: 6.122 ± 0.076	2.068LysMet: 2.068 ± 0.04	4.325LysAsn: 4.325 ± 0.076	2.252LysPro: 2.252 ± 0.051	2.8LysGln: 2.8 ± 0.052	2.906LysArg: 2.906 ± 0.049	4.509LysSer: 4.509 ± 0.074	4.164LysThr: 4.164 ± 0.07	4.068LysVal: 4.068 ± 0.067	0.848LysTrp: 0.848 ± 0.028	2.699LysTyr: 2.699 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.607LeuAla: 5.607 ± 0.075	0.811LeuCys: 0.811 ± 0.026	4.848LeuAsp: 4.848 ± 0.069	5.73LeuGlu: 5.73 ± 0.085	5.223LeuPhe: 5.223 ± 0.076	5.671LeuGly: 5.671 ± 0.073	1.529LeuHis: 1.529 ± 0.034	7.422LeuIle: 7.422 ± 0.094	7.186LeuLys: 7.186 ± 0.104	8.709LeuLeu: 8.709 ± 0.118	2.09LeuMet: 2.09 ± 0.043	5.71LeuAsn: 5.71 ± 0.073	3.434LeuPro: 3.434 ± 0.053	3.096LeuGln: 3.096 ± 0.052	3.229LeuArg: 3.229 ± 0.056	6.942LeuSer: 6.942 ± 0.075	5.678LeuThr: 5.678 ± 0.082	5.82LeuVal: 5.82 ± 0.062	0.836LeuTrp: 0.836 ± 0.025	2.834LeuTyr: 2.834 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.385MetAla: 1.385 ± 0.041	0.16MetCys: 0.16 ± 0.01	1.227MetAsp: 1.227 ± 0.029	1.492MetGlu: 1.492 ± 0.034	0.804MetPhe: 0.804 ± 0.023	1.378MetGly: 1.378 ± 0.036	0.419MetHis: 0.419 ± 0.02	1.545MetIle: 1.545 ± 0.042	2.308MetLys: 2.308 ± 0.042	1.754MetLeu: 1.754 ± 0.041	0.55MetMet: 0.55 ± 0.024	1.553MetAsn: 1.553 ± 0.034	0.775MetPro: 0.775 ± 0.021	0.781MetGln: 0.781 ± 0.028	1.001MetArg: 1.001 ± 0.025	1.39MetSer: 1.39 ± 0.036	1.306MetThr: 1.306 ± 0.033	1.231MetVal: 1.231 ± 0.03	0.2MetTrp: 0.2 ± 0.012	0.712MetTyr: 0.712 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.712AsnAla: 3.712 ± 0.062	0.676AsnCys: 0.676 ± 0.03	2.892AsnAsp: 2.892 ± 0.045	3.527AsnGlu: 3.527 ± 0.062	2.845AsnPhe: 2.845 ± 0.049	5.031AsnGly: 5.031 ± 0.11	1.115AsnHis: 1.115 ± 0.031	3.656AsnIle: 3.656 ± 0.058	3.507AsnLys: 3.507 ± 0.051	5.274AsnLeu: 5.274 ± 0.073	1.208AsnMet: 1.208 ± 0.027	3.487AsnAsn: 3.487 ± 0.069	3.168AsnPro: 3.168 ± 0.066	2.72AsnGln: 2.72 ± 0.046	2.214AsnArg: 2.214 ± 0.043	4.292AsnSer: 4.292 ± 0.065	3.554AsnThr: 3.554 ± 0.07	3.198AsnVal: 3.198 ± 0.063	0.896AsnTrp: 0.896 ± 0.027	2.777AsnTyr: 2.777 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	2.312ProAla: 2.312 ± 0.053	0.344ProCys: 0.344 ± 0.017	1.931ProAsp: 1.931 ± 0.039	2.471ProGlu: 2.471 ± 0.044	1.987ProPhe: 1.987 ± 0.037	2.195ProGly: 2.195 ± 0.056	0.581ProHis: 0.581 ± 0.02	2.94ProIle: 2.94 ± 0.052	2.343ProLys: 2.343 ± 0.047	2.912ProLeu: 2.912 ± 0.05	0.721ProMet: 0.721 ± 0.023	2.536ProAsn: 2.536 ± 0.051	0.878ProPro: 0.878 ± 0.034	1.141ProGln: 1.141 ± 0.032	0.949ProArg: 0.949 ± 0.029	2.476ProSer: 2.476 ± 0.048	2.572ProThr: 2.572 ± 0.082	2.582ProVal: 2.582 ± 0.051	0.329ProTrp: 0.329 ± 0.016	1.394ProTyr: 1.394 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.207GlnAla: 2.207 ± 0.039	0.259GlnCys: 0.259 ± 0.018	1.637GlnAsp: 1.637 ± 0.04	2.386GlnGlu: 2.386 ± 0.052	2.145GlnPhe: 2.145 ± 0.042	2.022GlnGly: 2.022 ± 0.036	0.598GlnHis: 0.598 ± 0.019	2.992GlnIle: 2.992 ± 0.05	2.79GlnLys: 2.79 ± 0.055	4.156GlnLeu: 4.156 ± 0.074	0.826GlnMet: 0.826 ± 0.027	2.276GlnAsn: 2.276 ± 0.055	1.113GlnPro: 1.113 ± 0.033	1.513GlnGln: 1.513 ± 0.042	1.379GlnArg: 1.379 ± 0.032	2.258GlnSer: 2.258 ± 0.041	2.477GlnThr: 2.477 ± 0.054	2.425GlnVal: 2.425 ± 0.044	0.435GlnTrp: 0.435 ± 0.018	1.335GlnTyr: 1.335 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.91ArgAla: 1.91 ± 0.041	0.247ArgCys: 0.247 ± 0.015	1.678ArgAsp: 1.678 ± 0.034	2.157ArgGlu: 2.157 ± 0.047	2.135ArgPhe: 2.135 ± 0.041	1.718ArgGly: 1.718 ± 0.038	0.536ArgHis: 0.536 ± 0.02	3.293ArgIle: 3.293 ± 0.058	2.9ArgLys: 2.9 ± 0.052	3.52ArgLeu: 3.52 ± 0.061	1.084ArgMet: 1.084 ± 0.026	2.123ArgAsn: 2.123 ± 0.045	1.037ArgPro: 1.037 ± 0.029	1.113ArgGln: 1.113 ± 0.03	1.276ArgArg: 1.276 ± 0.036	2.055ArgSer: 2.055 ± 0.041	1.964ArgThr: 1.964 ± 0.036	2.19ArgVal: 2.19 ± 0.041	0.415ArgTrp: 0.415 ± 0.016	1.46ArgTyr: 1.46 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.241SerAla: 4.241 ± 0.08	0.909SerCys: 0.909 ± 0.031	3.666SerAsp: 3.666 ± 0.049	4.158SerGlu: 4.158 ± 0.061	4.223SerPhe: 4.223 ± 0.057	5.35SerGly: 5.35 ± 0.097	1.136SerHis: 1.136 ± 0.026	5.849SerIle: 5.849 ± 0.067	4.97SerLys: 4.97 ± 0.074	6.498SerLeu: 6.498 ± 0.073	1.463SerMet: 1.463 ± 0.034	4.38SerAsn: 4.38 ± 0.069	2.415SerPro: 2.415 ± 0.052	2.374SerGln: 2.374 ± 0.044	2.101SerArg: 2.101 ± 0.045	5.413SerSer: 5.413 ± 0.095	4.512SerThr: 4.512 ± 0.088	4.461SerVal: 4.461 ± 0.076	0.913SerTrp: 0.913 ± 0.029	3.003SerTyr: 3.003 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	4.19ThrAla: 4.19 ± 0.102	0.581ThrCys: 0.581 ± 0.023	3.279ThrAsp: 3.279 ± 0.058	3.263ThrGlu: 3.263 ± 0.049	3.211ThrPhe: 3.211 ± 0.058	4.765ThrGly: 4.765 ± 0.102	1.047ThrHis: 1.047 ± 0.029	5.316ThrIle: 5.316 ± 0.082	3.536ThrLys: 3.536 ± 0.058	5.497ThrLeu: 5.497 ± 0.071	1.099ThrMet: 1.099 ± 0.026	3.913ThrAsn: 3.913 ± 0.075	2.745ThrPro: 2.745 ± 0.077	2.029ThrGln: 2.029 ± 0.047	1.708ThrArg: 1.708 ± 0.031	4.523ThrSer: 4.523 ± 0.085	4.351ThrThr: 4.351 ± 0.128	4.378ThrVal: 4.378 ± 0.111	0.762ThrTrp: 0.762 ± 0.032	2.697ThrTyr: 2.697 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	3.875ValAla: 3.875 ± 0.063	0.682ValCys: 0.682 ± 0.023	3.296ValAsp: 3.296 ± 0.057	3.649ValGlu: 3.649 ± 0.053	3.45ValPhe: 3.45 ± 0.057	3.816ValGly: 3.816 ± 0.051	1.058ValHis: 1.058 ± 0.027	4.802ValIle: 4.802 ± 0.062	4.088ValLys: 4.088 ± 0.06	5.642ValLeu: 5.642 ± 0.06	1.238ValMet: 1.238 ± 0.029	3.759ValAsn: 3.759 ± 0.072	2.236ValPro: 2.236 ± 0.046	2.18ValGln: 2.18 ± 0.037	2.17ValArg: 2.17 ± 0.046	4.835ValSer: 4.835 ± 0.07	4.0ValThr: 4.0 ± 0.121	4.239ValVal: 4.239 ± 0.082	0.671ValTrp: 0.671 ± 0.026	2.5ValTyr: 2.5 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.573TrpAla: 0.573 ± 0.028	0.123TrpCys: 0.123 ± 0.009	0.675TrpAsp: 0.675 ± 0.026	0.635TrpGlu: 0.635 ± 0.023	0.622TrpPhe: 0.622 ± 0.021	0.719TrpGly: 0.719 ± 0.027	0.209TrpHis: 0.209 ± 0.013	0.98TrpIle: 0.98 ± 0.028	0.975TrpLys: 0.975 ± 0.027	1.008TrpLeu: 1.008 ± 0.027	0.334TrpMet: 0.334 ± 0.015	0.877TrpAsn: 0.877 ± 0.03	0.218TrpPro: 0.218 ± 0.013	0.351TrpGln: 0.351 ± 0.016	0.372TrpArg: 0.372 ± 0.019	0.86TrpSer: 0.86 ± 0.038	0.721TrpThr: 0.721 ± 0.028	0.661TrpVal: 0.661 ± 0.023	0.157TrpTrp: 0.157 ± 0.01	0.461TrpTyr: 0.461 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.214TyrAla: 2.214 ± 0.045	0.414TyrCys: 0.414 ± 0.017	2.252TyrAsp: 2.252 ± 0.048	2.237TyrGlu: 2.237 ± 0.036	2.554TyrPhe: 2.554 ± 0.046	2.422TyrGly: 2.422 ± 0.044	0.817TyrHis: 0.817 ± 0.02	2.432TyrIle: 2.432 ± 0.044	2.384TyrLys: 2.384 ± 0.049	3.787TyrLeu: 3.787 ± 0.071	0.723TyrMet: 0.723 ± 0.021	2.323TyrAsn: 2.323 ± 0.047	1.521TyrPro: 1.521 ± 0.038	1.731TyrGln: 1.731 ± 0.037	1.636TyrArg: 1.636 ± 0.038	3.304TyrSer: 3.304 ± 0.045	2.567TyrThr: 2.567 ± 0.059	2.1TyrVal: 2.1 ± 0.037	0.521TyrTrp: 0.521 ± 0.023	2.029TyrTyr: 2.029 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4016 proteins (1385128 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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