Amino acid dipepetide frequency for Caenorhabditis latens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.992AlaAla: 4.992 ± 0.038	1.047AlaCys: 1.047 ± 0.013	3.034AlaAsp: 3.034 ± 0.024	4.151AlaGlu: 4.151 ± 0.03	2.544AlaPhe: 2.544 ± 0.02	3.111AlaGly: 3.111 ± 0.026	1.322AlaHis: 1.322 ± 0.013	3.634AlaIle: 3.634 ± 0.023	3.7AlaLys: 3.7 ± 0.029	5.071AlaLeu: 5.071 ± 0.027	1.592AlaMet: 1.592 ± 0.014	2.614AlaAsn: 2.614 ± 0.017	3.568AlaPro: 3.568 ± 0.045	2.429AlaGln: 2.429 ± 0.027	3.045AlaArg: 3.045 ± 0.021	4.533AlaSer: 4.533 ± 0.028	3.772AlaThr: 3.772 ± 0.026	4.151AlaVal: 4.151 ± 0.024	0.558AlaTrp: 0.558 ± 0.009	1.674AlaTyr: 1.674 ± 0.015	0.015AlaXaa: 0.015 ± 0.001
Cys	1.112CysAla: 1.112 ± 0.013	0.543CysCys: 0.543 ± 0.013	1.081CysAsp: 1.081 ± 0.015	1.203CysGlu: 1.203 ± 0.016	0.952CysPhe: 0.952 ± 0.012	1.265CysGly: 1.265 ± 0.017	0.504CysHis: 0.504 ± 0.008	1.101CysIle: 1.101 ± 0.014	1.021CysLys: 1.021 ± 0.013	1.703CysLeu: 1.703 ± 0.015	0.43CysMet: 0.43 ± 0.007	0.86CysAsn: 0.86 ± 0.013	1.021CysPro: 1.021 ± 0.018	0.839CysGln: 0.839 ± 0.016	1.07CysArg: 1.07 ± 0.013	1.645CysSer: 1.645 ± 0.016	1.045CysThr: 1.045 ± 0.014	1.213CysVal: 1.213 ± 0.015	0.221CysTrp: 0.221 ± 0.005	0.627CysTyr: 0.627 ± 0.011	0.004CysXaa: 0.004 ± 0.001
Asp	3.177AspAla: 3.177 ± 0.024	0.997AspCys: 0.997 ± 0.013	4.064AspAsp: 4.064 ± 0.032	4.8AspGlu: 4.8 ± 0.032	2.515AspPhe: 2.515 ± 0.018	3.423AspGly: 3.423 ± 0.043	1.183AspHis: 1.183 ± 0.014	3.069AspIle: 3.069 ± 0.017	2.901AspLys: 2.901 ± 0.022	4.404AspLeu: 4.404 ± 0.026	1.343AspMet: 1.343 ± 0.012	2.295AspAsn: 2.295 ± 0.017	2.376AspPro: 2.376 ± 0.019	1.965AspGln: 1.965 ± 0.015	2.652AspArg: 2.652 ± 0.022	4.175AspSer: 4.175 ± 0.029	2.609AspThr: 2.609 ± 0.019	3.723AspVal: 3.723 ± 0.024	0.667AspTrp: 0.667 ± 0.01	1.853AspTyr: 1.853 ± 0.015	0.014AspXaa: 0.014 ± 0.001
Glu	3.979GluAla: 3.979 ± 0.029	1.148GluCys: 1.148 ± 0.015	4.299GluAsp: 4.299 ± 0.03	7.189GluGlu: 7.189 ± 0.06	2.701GluPhe: 2.701 ± 0.018	2.82GluGly: 2.82 ± 0.024	1.526GluHis: 1.526 ± 0.013	4.264GluIle: 4.264 ± 0.023	6.372GluLys: 6.372 ± 0.04	5.544GluLeu: 5.544 ± 0.032	2.184GluMet: 2.184 ± 0.014	3.975GluAsn: 3.975 ± 0.024	2.646GluPro: 2.646 ± 0.028	2.781GluGln: 2.781 ± 0.024	3.621GluArg: 3.621 ± 0.029	4.668GluSer: 4.668 ± 0.026	4.067GluThr: 4.067 ± 0.027	3.929GluVal: 3.929 ± 0.025	0.773GluTrp: 0.773 ± 0.01	2.1GluTyr: 2.1 ± 0.019	0.025GluXaa: 0.025 ± 0.002
Phe	2.56PheAla: 2.56 ± 0.021	1.009PheCys: 1.009 ± 0.013	2.722PheAsp: 2.722 ± 0.017	2.94PheGlu: 2.94 ± 0.021	2.449PhePhe: 2.449 ± 0.024	2.854PheGly: 2.854 ± 0.022	1.144PheHis: 1.144 ± 0.013	2.684PheIle: 2.684 ± 0.022	2.341PheLys: 2.341 ± 0.018	4.317PheLeu: 4.317 ± 0.03	1.121PheMet: 1.121 ± 0.014	2.152PheAsn: 2.152 ± 0.017	1.942PhePro: 1.942 ± 0.017	1.746PheGln: 1.746 ± 0.016	2.159PheArg: 2.159 ± 0.017	3.578PheSer: 3.578 ± 0.023	2.336PheThr: 2.336 ± 0.018	3.042PheVal: 3.042 ± 0.023	0.587PheTrp: 0.587 ± 0.009	1.661PheTyr: 1.661 ± 0.017	0.009PheXaa: 0.009 ± 0.001
Gly	3.265GlyAla: 3.265 ± 0.028	1.064GlyCys: 1.064 ± 0.015	2.787GlyAsp: 2.787 ± 0.023	3.219GlyGlu: 3.219 ± 0.028	2.526GlyPhe: 2.526 ± 0.023	4.144GlyGly: 4.144 ± 0.052	1.232GlyHis: 1.232 ± 0.014	3.088GlyIle: 3.088 ± 0.022	3.36GlyLys: 3.36 ± 0.023	3.895GlyLeu: 3.895 ± 0.025	1.331GlyMet: 1.331 ± 0.013	2.704GlyAsn: 2.704 ± 0.024	2.141GlyPro: 2.141 ± 0.026	1.935GlyGln: 1.935 ± 0.021	2.748GlyArg: 2.748 ± 0.021	4.203GlySer: 4.203 ± 0.027	3.103GlyThr: 3.103 ± 0.024	3.326GlyVal: 3.326 ± 0.022	0.631GlyTrp: 0.631 ± 0.01	1.946GlyTyr: 1.946 ± 0.017	0.013GlyXaa: 0.013 ± 0.001
His	1.196HisAla: 1.196 ± 0.011	0.517HisCys: 0.517 ± 0.008	1.095HisAsp: 1.095 ± 0.012	1.339HisGlu: 1.339 ± 0.012	1.248HisPhe: 1.248 ± 0.012	1.286HisGly: 1.286 ± 0.014	0.921HisHis: 0.921 ± 0.014	1.3HisIle: 1.3 ± 0.013	1.137HisLys: 1.137 ± 0.012	2.198HisLeu: 2.198 ± 0.018	0.582HisMet: 0.582 ± 0.008	1.011HisAsn: 1.011 ± 0.011	1.246HisPro: 1.246 ± 0.015	1.127HisGln: 1.127 ± 0.013	1.426HisArg: 1.426 ± 0.013	1.792HisSer: 1.792 ± 0.014	1.093HisThr: 1.093 ± 0.011	1.52HisVal: 1.52 ± 0.013	0.298HisTrp: 0.298 ± 0.006	0.824HisTyr: 0.824 ± 0.012	0.007HisXaa: 0.007 ± 0.001
Ile	3.675IleAla: 3.675 ± 0.021	1.281IleCys: 1.281 ± 0.016	3.522IleAsp: 3.522 ± 0.022	4.086IleGlu: 4.086 ± 0.022	2.929IlePhe: 2.929 ± 0.027	3.332IleGly: 3.332 ± 0.024	1.486IleHis: 1.486 ± 0.014	3.53IleIle: 3.53 ± 0.025	3.095IleLys: 3.095 ± 0.022	5.406IleLeu: 5.406 ± 0.032	1.353IleMet: 1.353 ± 0.013	2.611IleAsn: 2.611 ± 0.017	3.248IlePro: 3.248 ± 0.021	2.495IleGln: 2.495 ± 0.02	3.343IleArg: 3.343 ± 0.02	4.7IleSer: 4.7 ± 0.026	3.203IleThr: 3.203 ± 0.021	3.969IleVal: 3.969 ± 0.025	0.68IleTrp: 0.68 ± 0.008	1.893IleTyr: 1.893 ± 0.02	0.014IleXaa: 0.014 ± 0.001
Lys	3.396LysAla: 3.396 ± 0.028	1.318LysCys: 1.318 ± 0.017	3.176LysAsp: 3.176 ± 0.026	5.073LysGlu: 5.073 ± 0.031	2.551LysPhe: 2.551 ± 0.018	2.434LysGly: 2.434 ± 0.024	1.344LysHis: 1.344 ± 0.012	3.947LysIle: 3.947 ± 0.024	6.411LysLys: 6.411 ± 0.051	5.504LysLeu: 5.504 ± 0.026	2.067LysMet: 2.067 ± 0.016	3.544LysAsn: 3.544 ± 0.022	2.787LysPro: 2.787 ± 0.028	2.43LysGln: 2.43 ± 0.018	3.866LysArg: 3.866 ± 0.026	4.702LysSer: 4.702 ± 0.029	4.078LysThr: 4.078 ± 0.024	3.539LysVal: 3.539 ± 0.021	0.8LysTrp: 0.8 ± 0.01	2.093LysTyr: 2.093 ± 0.017	0.021LysXaa: 0.021 ± 0.002
Leu	5.416LeuAla: 5.416 ± 0.028	1.599LeuCys: 1.599 ± 0.016	4.407LeuAsp: 4.407 ± 0.025	5.912LeuGlu: 5.912 ± 0.034	4.084LeuPhe: 4.084 ± 0.028	3.834LeuGly: 3.834 ± 0.025	2.013LeuHis: 2.013 ± 0.017	5.244LeuIle: 5.244 ± 0.032	5.867LeuLys: 5.867 ± 0.033	8.032LeuLeu: 8.032 ± 0.041	2.172LeuMet: 2.172 ± 0.018	4.172LeuAsn: 4.172 ± 0.021	4.301LeuPro: 4.301 ± 0.031	3.456LeuGln: 3.456 ± 0.025	4.615LeuArg: 4.615 ± 0.027	6.446LeuSer: 6.446 ± 0.031	4.774LeuThr: 4.774 ± 0.028	5.105LeuVal: 5.105 ± 0.025	0.833LeuTrp: 0.833 ± 0.01	2.385LeuTyr: 2.385 ± 0.02	0.021LeuXaa: 0.021 ± 0.002
Met	1.719MetAla: 1.719 ± 0.015	0.495MetCys: 0.495 ± 0.008	1.485MetAsp: 1.485 ± 0.013	1.976MetGlu: 1.976 ± 0.016	1.185MetPhe: 1.185 ± 0.013	1.194MetGly: 1.194 ± 0.012	0.537MetHis: 0.537 ± 0.008	1.611MetIle: 1.611 ± 0.016	2.014MetLys: 2.014 ± 0.017	2.084MetLeu: 2.084 ± 0.017	0.892MetMet: 0.892 ± 0.01	1.458MetAsn: 1.458 ± 0.014	1.141MetPro: 1.141 ± 0.012	0.947MetGln: 0.947 ± 0.012	1.439MetArg: 1.439 ± 0.014	2.237MetSer: 2.237 ± 0.017	1.674MetThr: 1.674 ± 0.015	1.423MetVal: 1.423 ± 0.013	0.27MetTrp: 0.27 ± 0.006	0.737MetTyr: 0.737 ± 0.009	0.008MetXaa: 0.008 ± 0.001
Asn	2.803AsnAla: 2.803 ± 0.021	1.002AsnCys: 1.002 ± 0.013	2.57AsnAsp: 2.57 ± 0.019	3.312AsnGlu: 3.312 ± 0.02	2.187AsnPhe: 2.187 ± 0.018	3.396AsnGly: 3.396 ± 0.027	1.155AsnHis: 1.155 ± 0.012	2.782AsnIle: 2.782 ± 0.018	2.614AsnLys: 2.614 ± 0.019	4.139AsnLeu: 4.139 ± 0.023	1.308AsnMet: 1.308 ± 0.013	2.556AsnAsn: 2.556 ± 0.021	2.381AsnPro: 2.381 ± 0.017	2.186AsnGln: 2.186 ± 0.021	2.599AsnArg: 2.599 ± 0.018	3.915AsnSer: 3.915 ± 0.022	2.532AsnThr: 2.532 ± 0.018	3.133AsnVal: 3.133 ± 0.021	0.595AsnTrp: 0.595 ± 0.009	1.688AsnTyr: 1.688 ± 0.017	0.013AsnXaa: 0.013 ± 0.001
Pro	3.242ProAla: 3.242 ± 0.036	0.676ProCys: 0.676 ± 0.01	2.45ProAsp: 2.45 ± 0.029	3.378ProGlu: 3.378 ± 0.027	1.976ProPhe: 1.976 ± 0.015	2.432ProGly: 2.432 ± 0.031	1.019ProHis: 1.019 ± 0.012	3.024ProIle: 3.024 ± 0.019	2.927ProLys: 2.927 ± 0.028	3.769ProLeu: 3.769 ± 0.03	1.199ProMet: 1.199 ± 0.012	2.294ProAsn: 2.294 ± 0.017	4.194ProPro: 4.194 ± 0.054	2.048ProGln: 2.048 ± 0.021	2.439ProArg: 2.439 ± 0.02	4.422ProSer: 4.422 ± 0.036	3.533ProThr: 3.533 ± 0.038	3.317ProVal: 3.317 ± 0.027	0.416ProTrp: 0.416 ± 0.008	1.373ProTyr: 1.373 ± 0.015	0.014ProXaa: 0.014 ± 0.001
Gln	2.17GlnAla: 2.17 ± 0.024	0.822GlnCys: 0.822 ± 0.016	1.576GlnAsp: 1.576 ± 0.016	2.568GlnGlu: 2.568 ± 0.022	1.826GlnPhe: 1.826 ± 0.015	1.626GlnGly: 1.626 ± 0.018	1.006GlnHis: 1.006 ± 0.013	2.401GlnIle: 2.401 ± 0.017	3.067GlnLys: 3.067 ± 0.021	3.845GlnLeu: 3.845 ± 0.023	1.367GlnMet: 1.367 ± 0.015	2.28GlnAsn: 2.28 ± 0.019	2.082GlnPro: 2.082 ± 0.026	2.817GlnGln: 2.817 ± 0.053	2.224GlnArg: 2.224 ± 0.018	2.852GlnSer: 2.852 ± 0.022	2.193GlnThr: 2.193 ± 0.015	2.184GlnVal: 2.184 ± 0.018	0.494GlnTrp: 0.494 ± 0.008	1.326GlnTyr: 1.326 ± 0.014	0.012GlnXaa: 0.012 ± 0.001
Arg	2.962ArgAla: 2.962 ± 0.021	0.977ArgCys: 0.977 ± 0.012	2.715ArgAsp: 2.715 ± 0.019	3.548ArgGlu: 3.548 ± 0.027	2.362ArgPhe: 2.362 ± 0.016	2.591ArgGly: 2.591 ± 0.023	1.378ArgHis: 1.378 ± 0.015	3.277ArgIle: 3.277 ± 0.02	4.111ArgLys: 4.111 ± 0.021	4.481ArgLeu: 4.481 ± 0.028	1.457ArgMet: 1.457 ± 0.013	2.893ArgAsn: 2.893 ± 0.018	2.361ArgPro: 2.361 ± 0.023	2.293ArgGln: 2.293 ± 0.017	4.193ArgArg: 4.193 ± 0.026	3.946ArgSer: 3.946 ± 0.03	2.767ArgThr: 2.767 ± 0.02	3.095ArgVal: 3.095 ± 0.023	0.568ArgTrp: 0.568 ± 0.009	1.605ArgTyr: 1.605 ± 0.014	0.013ArgXaa: 0.013 ± 0.001
Ser	4.808SerAla: 4.808 ± 0.026	1.466SerCys: 1.466 ± 0.016	4.347SerAsp: 4.347 ± 0.026	5.129SerGlu: 5.129 ± 0.036	3.433SerPhe: 3.433 ± 0.022	4.422SerGly: 4.422 ± 0.026	1.663SerHis: 1.663 ± 0.015	4.734SerIle: 4.734 ± 0.026	4.522SerLys: 4.522 ± 0.024	6.397SerLeu: 6.397 ± 0.025	1.921SerMet: 1.921 ± 0.016	3.774SerAsn: 3.774 ± 0.021	4.028SerPro: 4.028 ± 0.036	3.024SerGln: 3.024 ± 0.022	4.041SerArg: 4.041 ± 0.029	8.675SerSer: 8.675 ± 0.067	5.596SerThr: 5.596 ± 0.048	4.779SerVal: 4.779 ± 0.026	0.82SerTrp: 0.82 ± 0.011	2.193SerTyr: 2.193 ± 0.017	0.022SerXaa: 0.022 ± 0.002
Thr	3.733ThrAla: 3.733 ± 0.027	1.233ThrCys: 1.233 ± 0.015	2.982ThrAsp: 2.982 ± 0.038	3.657ThrGlu: 3.657 ± 0.026	2.562ThrPhe: 2.562 ± 0.02	3.104ThrGly: 3.104 ± 0.024	1.18ThrHis: 1.18 ± 0.011	3.79ThrIle: 3.79 ± 0.02	3.219ThrLys: 3.219 ± 0.02	4.705ThrLeu: 4.705 ± 0.023	1.439ThrMet: 1.439 ± 0.012	2.635ThrAsn: 2.635 ± 0.018	3.6ThrPro: 3.6 ± 0.031	1.999ThrGln: 1.999 ± 0.016	2.765ThrArg: 2.765 ± 0.02	5.376ThrSer: 5.376 ± 0.042	5.05ThrThr: 5.05 ± 0.089	4.236ThrVal: 4.236 ± 0.029	0.642ThrTrp: 0.642 ± 0.008	1.634ThrTyr: 1.634 ± 0.016	0.017ThrXaa: 0.017 ± 0.001
Val	4.072ValAla: 4.072 ± 0.022	1.267ValCys: 1.267 ± 0.016	3.583ValAsp: 3.583 ± 0.019	4.527ValGlu: 4.527 ± 0.028	3.126ValPhe: 3.126 ± 0.022	3.005ValGly: 3.005 ± 0.021	1.461ValHis: 1.461 ± 0.012	3.798ValIle: 3.798 ± 0.023	3.758ValLys: 3.758 ± 0.027	5.421ValLeu: 5.421 ± 0.029	1.568ValMet: 1.568 ± 0.014	2.824ValAsn: 2.824 ± 0.018	3.241ValPro: 3.241 ± 0.023	2.413ValGln: 2.413 ± 0.017	2.96ValArg: 2.96 ± 0.022	4.685ValSer: 4.685 ± 0.026	3.75ValThr: 3.75 ± 0.023	4.43ValVal: 4.43 ± 0.028	0.679ValTrp: 0.679 ± 0.009	1.953ValTyr: 1.953 ± 0.018	0.013ValXaa: 0.013 ± 0.001
Trp	0.577TrpAla: 0.577 ± 0.008	0.229TrpCys: 0.229 ± 0.006	0.542TrpAsp: 0.542 ± 0.009	0.619TrpGlu: 0.619 ± 0.009	0.534TrpPhe: 0.534 ± 0.008	0.444TrpGly: 0.444 ± 0.008	0.251TrpHis: 0.251 ± 0.005	0.813TrpIle: 0.813 ± 0.011	0.946TrpLys: 0.946 ± 0.011	0.977TrpLeu: 0.977 ± 0.011	0.384TrpMet: 0.384 ± 0.008	0.717TrpAsn: 0.717 ± 0.009	0.393TrpPro: 0.393 ± 0.007	0.422TrpGln: 0.422 ± 0.007	0.652TrpArg: 0.652 ± 0.009	0.818TrpSer: 0.818 ± 0.011	0.695TrpThr: 0.695 ± 0.01	0.57TrpVal: 0.57 ± 0.009	0.162TrpTrp: 0.162 ± 0.005	0.371TrpTyr: 0.371 ± 0.007	0.004TrpXaa: 0.004 ± 0.001
Tyr	1.689TyrAla: 1.689 ± 0.015	0.768TyrCys: 0.768 ± 0.011	1.753TyrAsp: 1.753 ± 0.014	1.965TyrGlu: 1.965 ± 0.015	1.65TyrPhe: 1.65 ± 0.016	1.929TyrGly: 1.929 ± 0.017	0.832TyrHis: 0.832 ± 0.011	1.746TyrIle: 1.746 ± 0.018	1.681TyrLys: 1.681 ± 0.017	2.772TyrLeu: 2.772 ± 0.02	0.809TyrMet: 0.809 ± 0.01	1.482TyrAsn: 1.482 ± 0.015	1.431TyrPro: 1.431 ± 0.019	1.373TyrGln: 1.373 ± 0.013	1.724TyrArg: 1.724 ± 0.015	2.404TyrSer: 2.404 ± 0.02	1.671TyrThr: 1.671 ± 0.016	1.836TyrVal: 1.836 ± 0.014	0.422TyrTrp: 0.422 ± 0.008	1.264TyrTyr: 1.264 ± 0.014	0.008TyrXaa: 0.008 ± 0.001
Xaa	0.016XaaAla: 0.016 ± 0.002	0.004XaaCys: 0.004 ± 0.001	0.017XaaAsp: 0.017 ± 0.001	0.021XaaGlu: 0.021 ± 0.002	0.011XaaPhe: 0.011 ± 0.001	0.014XaaGly: 0.014 ± 0.001	0.007XaaHis: 0.007 ± 0.001	0.015XaaIle: 0.015 ± 0.001	0.018XaaLys: 0.018 ± 0.002	0.023XaaLeu: 0.023 ± 0.002	0.006XaaMet: 0.006 ± 0.001	0.013XaaAsn: 0.013 ± 0.001	0.013XaaPro: 0.013 ± 0.001	0.014XaaGln: 0.014 ± 0.001	0.012XaaArg: 0.012 ± 0.001	0.02XaaSer: 0.02 ± 0.002	0.015XaaThr: 0.015 ± 0.001	0.016XaaVal: 0.016 ± 0.001	0.003XaaTrp: 0.003 ± 0.001	0.007XaaTyr: 0.007 ± 0.001	0.039XaaXaa: 0.039 ± 0.011

Statistics based on 25394 proteins (9829288 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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