Amino acid dipepetide frequency for archaeon HR03

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.97AlaAla: 9.97 ± 0.362
0.717AlaCys: 0.717 ± 0.106
3.75AlaAsp: 3.75 ± 0.194
6.892AlaGlu: 6.892 ± 0.324
3.242AlaPhe: 3.242 ± 0.195
6.692AlaGly: 6.692 ± 0.258
1.199AlaHis: 1.199 ± 0.104
4.15AlaIle: 4.15 ± 0.196
4.758AlaLys: 4.758 ± 0.21
9.008AlaLeu: 9.008 ± 0.295
1.989AlaMet: 1.989 ± 0.138
1.834AlaAsn: 1.834 ± 0.138
2.415AlaPro: 2.415 ± 0.133
1.798AlaGln: 1.798 ± 0.114
4.767AlaArg: 4.767 ± 0.264
4.931AlaSer: 4.931 ± 0.218
3.841AlaThr: 3.841 ± 0.182
8.899AlaVal: 8.899 ± 0.278
0.717AlaTrp: 0.717 ± 0.082
2.888AlaTyr: 2.888 ± 0.157
0.0AlaXaa: 0.0 ± 0.0
Cys
0.472CysAla: 0.472 ± 0.077
0.109CysCys: 0.109 ± 0.032
0.445CysAsp: 0.445 ± 0.054
0.636CysGlu: 0.636 ± 0.084
0.272CysPhe: 0.272 ± 0.059
1.135CysGly: 1.135 ± 0.122
0.136CysHis: 0.136 ± 0.039
0.518CysIle: 0.518 ± 0.074
0.263CysLys: 0.263 ± 0.049
0.726CysLeu: 0.726 ± 0.078
0.218CysMet: 0.218 ± 0.043
0.209CysAsn: 0.209 ± 0.053
0.636CysPro: 0.636 ± 0.088
0.245CysGln: 0.245 ± 0.057
0.627CysArg: 0.627 ± 0.083
0.599CysSer: 0.599 ± 0.065
0.409CysThr: 0.409 ± 0.069
0.599CysVal: 0.599 ± 0.077
0.1CysTrp: 0.1 ± 0.03
0.363CysTyr: 0.363 ± 0.058
0.0CysXaa: 0.0 ± 0.0
Asp
3.314AspAla: 3.314 ± 0.164
0.372AspCys: 0.372 ± 0.056
2.043AspAsp: 2.043 ± 0.149
4.113AspGlu: 4.113 ± 0.206
1.943AspPhe: 1.943 ± 0.133
3.768AspGly: 3.768 ± 0.203
0.708AspHis: 0.708 ± 0.075
2.978AspIle: 2.978 ± 0.167
2.279AspLys: 2.279 ± 0.15
3.85AspLeu: 3.85 ± 0.208
1.09AspMet: 1.09 ± 0.104
1.208AspAsn: 1.208 ± 0.105
2.443AspPro: 2.443 ± 0.142
0.844AspGln: 0.844 ± 0.089
2.325AspArg: 2.325 ± 0.164
1.934AspSer: 1.934 ± 0.148
2.098AspThr: 2.098 ± 0.129
4.722AspVal: 4.722 ± 0.217
0.599AspTrp: 0.599 ± 0.084
1.861AspTyr: 1.861 ± 0.144
0.0AspXaa: 0.0 ± 0.0
Glu
6.756GluAla: 6.756 ± 0.288
0.418GluCys: 0.418 ± 0.066
2.706GluAsp: 2.706 ± 0.166
6.338GluGlu: 6.338 ± 0.324
2.306GluPhe: 2.306 ± 0.124
3.932GluGly: 3.932 ± 0.179
1.217GluHis: 1.217 ± 0.12
4.359GluIle: 4.359 ± 0.21
6.774GluLys: 6.774 ± 0.282
7.173GluLeu: 7.173 ± 0.283
2.125GluMet: 2.125 ± 0.133
2.815GluAsn: 2.815 ± 0.165
3.133GluPro: 3.133 ± 0.159
1.88GluGln: 1.88 ± 0.122
4.013GluArg: 4.013 ± 0.185
2.924GluSer: 2.924 ± 0.167
4.277GluThr: 4.277 ± 0.205
6.066GluVal: 6.066 ± 0.254
0.772GluTrp: 0.772 ± 0.087
2.143GluTyr: 2.143 ± 0.168
0.0GluXaa: 0.0 ± 0.0
Phe
3.151PheAla: 3.151 ± 0.204
0.345PheCys: 0.345 ± 0.07
1.843PheAsp: 1.843 ± 0.139
2.597PheGlu: 2.597 ± 0.155
2.052PhePhe: 2.052 ± 0.158
3.124PheGly: 3.124 ± 0.19
0.627PheHis: 0.627 ± 0.072
2.688PheIle: 2.688 ± 0.158
1.662PheLys: 1.662 ± 0.119
4.359PheLeu: 4.359 ± 0.212
1.044PheMet: 1.044 ± 0.113
1.035PheAsn: 1.035 ± 0.099
1.489PhePro: 1.489 ± 0.118
0.963PheGln: 0.963 ± 0.082
2.661PheArg: 2.661 ± 0.178
2.733PheSer: 2.733 ± 0.171
2.561PheThr: 2.561 ± 0.155
3.305PheVal: 3.305 ± 0.156
0.672PheTrp: 0.672 ± 0.093
1.317PheTyr: 1.317 ± 0.113
0.0PheXaa: 0.0 ± 0.0
Gly
5.948GlyAla: 5.948 ± 0.236
0.953GlyCys: 0.953 ± 0.097
3.396GlyAsp: 3.396 ± 0.212
5.457GlyGlu: 5.457 ± 0.241
3.469GlyPhe: 3.469 ± 0.169
6.175GlyGly: 6.175 ± 0.303
1.389GlyHis: 1.389 ± 0.124
4.15GlyIle: 4.15 ± 0.204
4.086GlyLys: 4.086 ± 0.169
8.354GlyLeu: 8.354 ± 0.315
1.979GlyMet: 1.979 ± 0.125
1.78GlyAsn: 1.78 ± 0.123
2.878GlyPro: 2.878 ± 0.177
1.88GlyGln: 1.88 ± 0.127
5.13GlyArg: 5.13 ± 0.234
3.941GlySer: 3.941 ± 0.195
3.105GlyThr: 3.105 ± 0.186
7.945GlyVal: 7.945 ± 0.254
1.017GlyTrp: 1.017 ± 0.107
3.214GlyTyr: 3.214 ± 0.165
0.0GlyXaa: 0.0 ± 0.0
His
1.162HisAla: 1.162 ± 0.105
0.154HisCys: 0.154 ± 0.041
0.808HisAsp: 0.808 ± 0.087
1.09HisGlu: 1.09 ± 0.101
0.627HisPhe: 0.627 ± 0.074
1.916HisGly: 1.916 ± 0.136
0.463HisHis: 0.463 ± 0.081
0.981HisIle: 0.981 ± 0.113
0.554HisLys: 0.554 ± 0.066
2.098HisLeu: 2.098 ± 0.142
0.354HisMet: 0.354 ± 0.058
0.499HisAsn: 0.499 ± 0.074
1.153HisPro: 1.153 ± 0.113
0.436HisGln: 0.436 ± 0.063
1.335HisArg: 1.335 ± 0.118
0.99HisSer: 0.99 ± 0.094
0.808HisThr: 0.808 ± 0.081
1.789HisVal: 1.789 ± 0.146
0.109HisTrp: 0.109 ± 0.034
0.699HisTyr: 0.699 ± 0.079
0.0HisXaa: 0.0 ± 0.0
Ile
4.885IleAla: 4.885 ± 0.225
0.536IleCys: 0.536 ± 0.077
2.661IleAsp: 2.661 ± 0.161
4.141IleGlu: 4.141 ± 0.189
2.588IlePhe: 2.588 ± 0.187
4.349IleGly: 4.349 ± 0.194
1.308IleHis: 1.308 ± 0.112
4.068IleIle: 4.068 ± 0.207
2.697IleLys: 2.697 ± 0.157
5.938IleLeu: 5.938 ± 0.264
1.453IleMet: 1.453 ± 0.11
1.989IleAsn: 1.989 ± 0.145
3.378IlePro: 3.378 ± 0.188
1.426IleGln: 1.426 ± 0.097
3.505IleArg: 3.505 ± 0.198
3.505IleSer: 3.505 ± 0.195
3.078IleThr: 3.078 ± 0.177
5.412IleVal: 5.412 ± 0.22
0.581IleTrp: 0.581 ± 0.089
1.807IleTyr: 1.807 ± 0.139
0.0IleXaa: 0.0 ± 0.0
Lys
4.349LysAla: 4.349 ± 0.183
0.436LysCys: 0.436 ± 0.066
1.898LysAsp: 1.898 ± 0.131
3.296LysGlu: 3.296 ± 0.175
1.562LysPhe: 1.562 ± 0.131
3.687LysGly: 3.687 ± 0.183
1.081LysHis: 1.081 ± 0.104
4.504LysIle: 4.504 ± 0.214
3.541LysLys: 3.541 ± 0.223
5.475LysLeu: 5.475 ± 0.253
1.544LysMet: 1.544 ± 0.125
1.798LysAsn: 1.798 ± 0.112
3.523LysPro: 3.523 ± 0.174
1.798LysGln: 1.798 ± 0.124
3.423LysArg: 3.423 ± 0.196
2.724LysSer: 2.724 ± 0.149
3.914LysThr: 3.914 ± 0.193
4.649LysVal: 4.649 ± 0.214
0.599LysTrp: 0.599 ± 0.08
1.462LysTyr: 1.462 ± 0.125
0.0LysXaa: 0.0 ± 0.0
Leu
9.589LeuAla: 9.589 ± 0.369
0.763LeuCys: 0.763 ± 0.096
4.912LeuAsp: 4.912 ± 0.212
7.991LeuGlu: 7.991 ± 0.326
3.777LeuPhe: 3.777 ± 0.197
8.227LeuGly: 8.227 ± 0.337
1.689LeuHis: 1.689 ± 0.115
5.439LeuIle: 5.439 ± 0.231
5.866LeuLys: 5.866 ± 0.227
11.368LeuLeu: 11.368 ± 0.386
2.542LeuMet: 2.542 ± 0.161
3.569LeuAsn: 3.569 ± 0.178
4.667LeuPro: 4.667 ± 0.232
2.27LeuGln: 2.27 ± 0.14
7.409LeuArg: 7.409 ± 0.249
7.064LeuSer: 7.064 ± 0.264
5.439LeuThr: 5.439 ± 0.234
8.69LeuVal: 8.69 ± 0.277
0.953LeuTrp: 0.953 ± 0.095
3.178LeuTyr: 3.178 ± 0.181
0.0LeuXaa: 0.0 ± 0.0
Met
2.207MetAla: 2.207 ± 0.165
0.173MetCys: 0.173 ± 0.043
1.026MetAsp: 1.026 ± 0.096
1.471MetGlu: 1.471 ± 0.11
0.854MetPhe: 0.854 ± 0.101
1.989MetGly: 1.989 ± 0.132
0.463MetHis: 0.463 ± 0.067
1.426MetIle: 1.426 ± 0.112
1.417MetLys: 1.417 ± 0.115
2.815MetLeu: 2.815 ± 0.16
0.736MetMet: 0.736 ± 0.078
0.672MetAsn: 0.672 ± 0.077
1.18MetPro: 1.18 ± 0.096
0.627MetGln: 0.627 ± 0.074
1.789MetArg: 1.789 ± 0.133
1.807MetSer: 1.807 ± 0.118
1.371MetThr: 1.371 ± 0.115
2.715MetVal: 2.715 ± 0.148
0.2MetTrp: 0.2 ± 0.042
0.645MetTyr: 0.645 ± 0.074
0.0MetXaa: 0.0 ± 0.0
Asn
2.061AsnAla: 2.061 ± 0.137
0.363AsnCys: 0.363 ± 0.056
0.953AsnAsp: 0.953 ± 0.088
1.589AsnGlu: 1.589 ± 0.127
1.126AsnPhe: 1.126 ± 0.102
2.043AsnGly: 2.043 ± 0.138
0.545AsnHis: 0.545 ± 0.08
2.424AsnIle: 2.424 ± 0.15
1.335AsnLys: 1.335 ± 0.114
3.278AsnLeu: 3.278 ± 0.189
0.881AsnMet: 0.881 ± 0.099
0.872AsnAsn: 0.872 ± 0.093
2.306AsnPro: 2.306 ± 0.15
0.59AsnGln: 0.59 ± 0.072
1.871AsnArg: 1.871 ± 0.12
1.58AsnSer: 1.58 ± 0.117
1.48AsnThr: 1.48 ± 0.105
2.742AsnVal: 2.742 ± 0.182
0.481AsnTrp: 0.481 ± 0.071
1.035AsnTyr: 1.035 ± 0.099
0.0AsnXaa: 0.0 ± 0.0
Pro
3.305ProAla: 3.305 ± 0.164
0.281ProCys: 0.281 ± 0.051
2.397ProAsp: 2.397 ± 0.141
3.541ProGlu: 3.541 ± 0.183
1.816ProPhe: 1.816 ± 0.126
3.105ProGly: 3.105 ± 0.16
1.244ProHis: 1.244 ± 0.115
2.37ProIle: 2.37 ± 0.177
1.889ProLys: 1.889 ± 0.138
5.04ProLeu: 5.04 ± 0.206
1.153ProMet: 1.153 ± 0.101
1.326ProAsn: 1.326 ± 0.118
2.679ProPro: 2.679 ± 0.204
1.244ProGln: 1.244 ± 0.101
3.196ProArg: 3.196 ± 0.164
3.133ProSer: 3.133 ± 0.154
2.461ProThr: 2.461 ± 0.147
4.186ProVal: 4.186 ± 0.17
0.608ProTrp: 0.608 ± 0.094
1.979ProTyr: 1.979 ± 0.131
0.0ProXaa: 0.0 ± 0.0
Gln
2.225GlnAla: 2.225 ± 0.135
0.127GlnCys: 0.127 ± 0.035
0.799GlnAsp: 0.799 ± 0.085
1.289GlnGlu: 1.289 ± 0.134
0.772GlnPhe: 0.772 ± 0.075
1.516GlnGly: 1.516 ± 0.111
0.508GlnHis: 0.508 ± 0.064
1.417GlnIle: 1.417 ± 0.114
1.444GlnLys: 1.444 ± 0.129
3.115GlnLeu: 3.115 ± 0.162
0.699GlnMet: 0.699 ± 0.088
0.863GlnAsn: 0.863 ± 0.09
1.162GlnPro: 1.162 ± 0.106
0.944GlnGln: 0.944 ± 0.113
1.898GlnArg: 1.898 ± 0.148
1.199GlnSer: 1.199 ± 0.105
1.389GlnThr: 1.389 ± 0.121
2.007GlnVal: 2.007 ± 0.11
0.163GlnTrp: 0.163 ± 0.047
0.617GlnTyr: 0.617 ± 0.074
0.0GlnXaa: 0.0 ± 0.0
Arg
4.422ArgAla: 4.422 ± 0.197
0.69ArgCys: 0.69 ± 0.09
2.942ArgAsp: 2.942 ± 0.154
4.731ArgGlu: 4.731 ± 0.205
2.842ArgPhe: 2.842 ± 0.18
4.458ArgGly: 4.458 ± 0.173
1.126ArgHis: 1.126 ± 0.102
3.796ArgIle: 3.796 ± 0.159
3.832ArgLys: 3.832 ± 0.183
7.046ArgLeu: 7.046 ± 0.257
1.871ArgMet: 1.871 ± 0.116
2.125ArgAsn: 2.125 ± 0.137
2.86ArgPro: 2.86 ± 0.168
1.998ArgGln: 1.998 ± 0.126
5.021ArgArg: 5.021 ± 0.264
2.815ArgSer: 2.815 ± 0.134
2.606ArgThr: 2.606 ± 0.138
5.539ArgVal: 5.539 ± 0.229
0.717ArgTrp: 0.717 ± 0.082
2.17ArgTyr: 2.17 ± 0.142
0.0ArgXaa: 0.0 ± 0.0
Ser
4.304SerAla: 4.304 ± 0.2
0.581SerCys: 0.581 ± 0.079
2.334SerAsp: 2.334 ± 0.161
3.432SerGlu: 3.432 ± 0.176
2.897SerPhe: 2.897 ± 0.167
4.985SerGly: 4.985 ± 0.222
1.226SerHis: 1.226 ± 0.105
3.45SerIle: 3.45 ± 0.18
2.842SerLys: 2.842 ± 0.173
6.492SerLeu: 6.492 ± 0.245
1.489SerMet: 1.489 ± 0.125
1.553SerAsn: 1.553 ± 0.108
2.842SerPro: 2.842 ± 0.156
1.371SerGln: 1.371 ± 0.095
3.432SerArg: 3.432 ± 0.188
3.687SerSer: 3.687 ± 0.221
2.742SerThr: 2.742 ± 0.162
4.785SerVal: 4.785 ± 0.218
0.835SerTrp: 0.835 ± 0.096
1.989SerTyr: 1.989 ± 0.132
0.0SerXaa: 0.0 ± 0.0
Thr
4.704ThrAla: 4.704 ± 0.246
0.463ThrCys: 0.463 ± 0.06
1.852ThrAsp: 1.852 ± 0.144
2.878ThrGlu: 2.878 ± 0.198
1.807ThrPhe: 1.807 ± 0.129
4.649ThrGly: 4.649 ± 0.191
1.099ThrHis: 1.099 ± 0.086
2.851ThrIle: 2.851 ± 0.189
1.952ThrLys: 1.952 ± 0.122
5.657ThrLeu: 5.657 ± 0.253
1.444ThrMet: 1.444 ± 0.108
1.317ThrAsn: 1.317 ± 0.095
3.115ThrPro: 3.115 ± 0.16
1.008ThrGln: 1.008 ± 0.095
2.86ThrArg: 2.86 ± 0.183
2.842ThrSer: 2.842 ± 0.162
2.788ThrThr: 2.788 ± 0.182
5.257ThrVal: 5.257 ± 0.23
0.617ThrTrp: 0.617 ± 0.071
1.78ThrTyr: 1.78 ± 0.163
0.0ThrXaa: 0.0 ± 0.0
Val
8.081ValAla: 8.081 ± 0.315
0.844ValCys: 0.844 ± 0.1
5.548ValAsp: 5.548 ± 0.229
7.936ValGlu: 7.936 ± 0.283
4.386ValPhe: 4.386 ± 0.202
6.674ValGly: 6.674 ± 0.254
1.235ValHis: 1.235 ± 0.114
4.867ValIle: 4.867 ± 0.211
6.256ValLys: 6.256 ± 0.245
8.644ValLeu: 8.644 ± 0.287
1.88ValMet: 1.88 ± 0.125
2.842ValAsn: 2.842 ± 0.158
2.96ValPro: 2.96 ± 0.176
1.671ValGln: 1.671 ± 0.106
4.749ValArg: 4.749 ± 0.219
5.957ValSer: 5.957 ± 0.254
4.277ValThr: 4.277 ± 0.215
8.98ValVal: 8.98 ± 0.304
0.926ValTrp: 0.926 ± 0.096
3.596ValTyr: 3.596 ± 0.18
0.0ValXaa: 0.0 ± 0.0
Trp
0.826TrpAla: 0.826 ± 0.098
0.054TrpCys: 0.054 ± 0.019
0.472TrpAsp: 0.472 ± 0.075
0.645TrpGlu: 0.645 ± 0.068
0.454TrpPhe: 0.454 ± 0.069
0.79TrpGly: 0.79 ± 0.089
0.218TrpHis: 0.218 ± 0.054
0.663TrpIle: 0.663 ± 0.077
0.527TrpLys: 0.527 ± 0.067
1.199TrpLeu: 1.199 ± 0.109
0.427TrpMet: 0.427 ± 0.058
0.39TrpAsn: 0.39 ± 0.049
0.445TrpPro: 0.445 ± 0.065
0.272TrpGln: 0.272 ± 0.05
1.171TrpArg: 1.171 ± 0.102
0.799TrpSer: 0.799 ± 0.085
0.554TrpThr: 0.554 ± 0.07
0.817TrpVal: 0.817 ± 0.092
0.218TrpTrp: 0.218 ± 0.045
0.3TrpTyr: 0.3 ± 0.055
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.733TyrAla: 2.733 ± 0.155
0.336TyrCys: 0.336 ± 0.053
1.707TyrAsp: 1.707 ± 0.117
2.061TyrGlu: 2.061 ± 0.134
1.435TyrPhe: 1.435 ± 0.129
3.033TyrGly: 3.033 ± 0.146
0.545TyrHis: 0.545 ± 0.068
2.207TyrIle: 2.207 ± 0.158
1.289TyrLys: 1.289 ± 0.116
3.768TyrLeu: 3.768 ± 0.169
0.654TyrMet: 0.654 ± 0.078
0.863TyrAsn: 0.863 ± 0.079
1.689TyrPro: 1.689 ± 0.125
0.89TyrGln: 0.89 ± 0.082
2.424TyrArg: 2.424 ± 0.166
2.107TyrSer: 2.107 ± 0.171
1.743TyrThr: 1.743 ± 0.133
3.205TyrVal: 3.205 ± 0.164
0.354TyrTrp: 0.354 ± 0.07
1.09TyrTyr: 1.09 ± 0.124
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 434 proteins (110130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski