Amino acid dipepetide frequency for Proteiniphilum saccharofermentans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.969AlaAla: 4.969 ± 0.087	0.638AlaCys: 0.638 ± 0.025	3.826AlaAsp: 3.826 ± 0.056	4.382AlaGlu: 4.382 ± 0.061	3.08AlaPhe: 3.08 ± 0.056	5.181AlaGly: 5.181 ± 0.074	1.217AlaHis: 1.217 ± 0.034	4.765AlaIle: 4.765 ± 0.07	3.486AlaLys: 3.486 ± 0.058	6.113AlaLeu: 6.113 ± 0.083	1.657AlaMet: 1.657 ± 0.037	3.015AlaAsn: 3.015 ± 0.061	2.168AlaPro: 2.168 ± 0.042	2.348AlaGln: 2.348 ± 0.041	3.002AlaArg: 3.002 ± 0.054	4.143AlaSer: 4.143 ± 0.057	3.408AlaThr: 3.408 ± 0.049	4.505AlaVal: 4.505 ± 0.071	0.822AlaTrp: 0.822 ± 0.028	2.833AlaTyr: 2.833 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.471CysAla: 0.471 ± 0.023	0.123CysCys: 0.123 ± 0.01	0.495CysAsp: 0.495 ± 0.021	0.464CysGlu: 0.464 ± 0.021	0.446CysPhe: 0.446 ± 0.018	0.71CysGly: 0.71 ± 0.029	0.228CysHis: 0.228 ± 0.015	0.611CysIle: 0.611 ± 0.023	0.412CysLys: 0.412 ± 0.019	0.715CysLeu: 0.715 ± 0.025	0.218CysMet: 0.218 ± 0.014	0.438CysAsn: 0.438 ± 0.017	0.368CysPro: 0.368 ± 0.018	0.217CysGln: 0.217 ± 0.014	0.448CysArg: 0.448 ± 0.02	0.516CysSer: 0.516 ± 0.021	0.493CysThr: 0.493 ± 0.018	0.487CysVal: 0.487 ± 0.021	0.135CysTrp: 0.135 ± 0.011	0.349CysTyr: 0.349 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.784AspAla: 3.784 ± 0.057	0.432AspCys: 0.432 ± 0.018	2.948AspAsp: 2.948 ± 0.062	3.979AspGlu: 3.979 ± 0.056	3.121AspPhe: 3.121 ± 0.051	4.253AspGly: 4.253 ± 0.071	0.993AspHis: 0.993 ± 0.028	4.602AspIle: 4.602 ± 0.068	3.83AspLys: 3.83 ± 0.054	4.929AspLeu: 4.929 ± 0.061	1.464AspMet: 1.464 ± 0.033	3.111AspAsn: 3.111 ± 0.05	2.504AspPro: 2.504 ± 0.046	1.526AspGln: 1.526 ± 0.035	2.763AspArg: 2.763 ± 0.048	2.914AspSer: 2.914 ± 0.054	2.687AspThr: 2.687 ± 0.046	3.342AspVal: 3.342 ± 0.051	0.938AspTrp: 0.938 ± 0.027	2.854AspTyr: 2.854 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	4.399GluAla: 4.399 ± 0.063	0.433GluCys: 0.433 ± 0.019	3.234GluAsp: 3.234 ± 0.054	5.303GluGlu: 5.303 ± 0.083	2.582GluPhe: 2.582 ± 0.048	4.26GluGly: 4.26 ± 0.064	1.029GluHis: 1.029 ± 0.024	5.296GluIle: 5.296 ± 0.062	5.643GluLys: 5.643 ± 0.073	5.915GluLeu: 5.915 ± 0.075	2.013GluMet: 2.013 ± 0.036	4.188GluAsn: 4.188 ± 0.059	1.907GluPro: 1.907 ± 0.038	2.468GluGln: 2.468 ± 0.049	3.295GluArg: 3.295 ± 0.053	3.445GluSer: 3.445 ± 0.054	3.67GluThr: 3.67 ± 0.05	4.178GluVal: 4.178 ± 0.059	0.965GluTrp: 0.965 ± 0.033	2.62GluTyr: 2.62 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.914PheAla: 2.914 ± 0.054	0.468PheCys: 0.468 ± 0.02	3.026PheAsp: 3.026 ± 0.046	2.722PheGlu: 2.722 ± 0.046	2.566PhePhe: 2.566 ± 0.047	3.343PheGly: 3.343 ± 0.054	0.931PheHis: 0.931 ± 0.031	3.414PheIle: 3.414 ± 0.062	2.279PheLys: 2.279 ± 0.043	4.338PheLeu: 4.338 ± 0.068	1.23PheMet: 1.23 ± 0.036	2.606PheAsn: 2.606 ± 0.047	1.946PhePro: 1.946 ± 0.037	1.35PheGln: 1.35 ± 0.034	2.409PheArg: 2.409 ± 0.048	3.763PheSer: 3.763 ± 0.054	2.937PheThr: 2.937 ± 0.046	2.856PheVal: 2.856 ± 0.047	0.679PheTrp: 0.679 ± 0.026	2.092PheTyr: 2.092 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.328GlyAla: 4.328 ± 0.073	0.683GlyCys: 0.683 ± 0.025	3.764GlyAsp: 3.764 ± 0.057	4.4GlyGlu: 4.4 ± 0.059	3.4GlyPhe: 3.4 ± 0.054	4.937GlyGly: 4.937 ± 0.079	1.301GlyHis: 1.301 ± 0.034	5.812GlyIle: 5.812 ± 0.064	5.119GlyLys: 5.119 ± 0.071	5.889GlyLeu: 5.889 ± 0.069	2.059GlyMet: 2.059 ± 0.047	4.048GlyAsn: 4.048 ± 0.066	1.436GlyPro: 1.436 ± 0.034	2.191GlyGln: 2.191 ± 0.046	3.178GlyArg: 3.178 ± 0.055	4.383GlySer: 4.383 ± 0.063	4.309GlyThr: 4.309 ± 0.062	4.67GlyVal: 4.67 ± 0.064	1.1GlyTrp: 1.1 ± 0.027	3.498GlyTyr: 3.498 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.099HisAla: 1.099 ± 0.032	0.199HisCys: 0.199 ± 0.013	0.93HisAsp: 0.93 ± 0.026	0.981HisGlu: 0.981 ± 0.032	1.051HisPhe: 1.051 ± 0.027	1.257HisGly: 1.257 ± 0.033	0.463HisHis: 0.463 ± 0.024	1.492HisIle: 1.492 ± 0.036	0.949HisLys: 0.949 ± 0.025	1.749HisLeu: 1.749 ± 0.046	0.37HisMet: 0.37 ± 0.016	0.994HisAsn: 0.994 ± 0.028	1.093HisPro: 1.093 ± 0.033	0.65HisGln: 0.65 ± 0.022	0.959HisArg: 0.959 ± 0.031	1.196HisSer: 1.196 ± 0.03	1.038HisThr: 1.038 ± 0.031	0.975HisVal: 0.975 ± 0.028	0.27HisTrp: 0.27 ± 0.015	0.935HisTyr: 0.935 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.183IleAla: 5.183 ± 0.066	0.681IleCys: 0.681 ± 0.025	4.78IleAsp: 4.78 ± 0.058	4.848IleGlu: 4.848 ± 0.067	3.208IlePhe: 3.208 ± 0.052	5.054IleGly: 5.054 ± 0.068	1.497IleHis: 1.497 ± 0.039	5.071IleIle: 5.071 ± 0.09	3.807IleLys: 3.807 ± 0.063	6.462IleLeu: 6.462 ± 0.08	1.517IleMet: 1.517 ± 0.034	3.59IleAsn: 3.59 ± 0.062	3.513IlePro: 3.513 ± 0.047	2.252IleGln: 2.252 ± 0.047	3.872IleArg: 3.872 ± 0.059	5.129IleSer: 5.129 ± 0.065	4.409IleThr: 4.409 ± 0.067	4.499IleVal: 4.499 ± 0.065	0.858IleTrp: 0.858 ± 0.028	2.907IleTyr: 2.907 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	3.984LysAla: 3.984 ± 0.054	0.333LysCys: 0.333 ± 0.02	3.396LysAsp: 3.396 ± 0.055	5.489LysGlu: 5.489 ± 0.074	2.04LysPhe: 2.04 ± 0.043	4.247LysGly: 4.247 ± 0.064	1.015LysHis: 1.015 ± 0.026	4.514LysIle: 4.514 ± 0.07	4.604LysLys: 4.604 ± 0.078	4.86LysLeu: 4.86 ± 0.071	1.744LysMet: 1.744 ± 0.036	3.612LysAsn: 3.612 ± 0.054	2.248LysPro: 2.248 ± 0.043	2.37LysGln: 2.37 ± 0.045	3.008LysArg: 3.008 ± 0.05	3.438LysSer: 3.438 ± 0.051	3.579LysThr: 3.579 ± 0.057	3.889LysVal: 3.889 ± 0.057	0.793LysTrp: 0.793 ± 0.028	2.64LysTyr: 2.64 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	5.706LeuAla: 5.706 ± 0.073	0.815LeuCys: 0.815 ± 0.028	4.68LeuAsp: 4.68 ± 0.074	5.257LeuGlu: 5.257 ± 0.063	4.917LeuPhe: 4.917 ± 0.072	5.49LeuGly: 5.49 ± 0.075	1.749LeuHis: 1.749 ± 0.04	6.057LeuIle: 6.057 ± 0.073	5.811LeuLys: 5.811 ± 0.072	8.912LeuLeu: 8.912 ± 0.109	2.194LeuMet: 2.194 ± 0.045	4.817LeuAsn: 4.817 ± 0.069	3.963LeuPro: 3.963 ± 0.057	3.403LeuGln: 3.403 ± 0.051	4.17LeuArg: 4.17 ± 0.051	7.067LeuSer: 7.067 ± 0.078	5.096LeuThr: 5.096 ± 0.065	4.944LeuVal: 4.944 ± 0.071	1.057LeuTrp: 1.057 ± 0.031	3.683LeuTyr: 3.683 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.837MetAla: 1.837 ± 0.035	0.159MetCys: 0.159 ± 0.011	1.446MetAsp: 1.446 ± 0.034	1.751MetGlu: 1.751 ± 0.037	0.914MetPhe: 0.914 ± 0.029	1.82MetGly: 1.82 ± 0.046	0.47MetHis: 0.47 ± 0.022	1.679MetIle: 1.679 ± 0.039	2.083MetLys: 2.083 ± 0.042	2.202MetLeu: 2.202 ± 0.045	0.721MetMet: 0.721 ± 0.024	1.487MetAsn: 1.487 ± 0.035	1.106MetPro: 1.106 ± 0.027	1.048MetGln: 1.048 ± 0.027	1.21MetArg: 1.21 ± 0.032	1.415MetSer: 1.415 ± 0.038	1.331MetThr: 1.331 ± 0.03	1.523MetVal: 1.523 ± 0.033	0.283MetTrp: 0.283 ± 0.015	0.831MetTyr: 0.831 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.451AsnAla: 3.451 ± 0.064	0.399AsnCys: 0.399 ± 0.018	2.946AsnAsp: 2.946 ± 0.048	3.237AsnGlu: 3.237 ± 0.05	2.477AsnPhe: 2.477 ± 0.045	3.94AsnGly: 3.94 ± 0.065	0.973AsnHis: 0.973 ± 0.031	4.329AsnIle: 4.329 ± 0.069	3.0AsnLys: 3.0 ± 0.054	4.568AsnLeu: 4.568 ± 0.067	1.276AsnMet: 1.276 ± 0.029	3.142AsnAsn: 3.142 ± 0.051	2.925AsnPro: 2.925 ± 0.047	1.69AsnGln: 1.69 ± 0.032	2.972AsnArg: 2.972 ± 0.055	3.281AsnSer: 3.281 ± 0.057	2.812AsnThr: 2.812 ± 0.048	3.096AsnVal: 3.096 ± 0.05	0.758AsnTrp: 0.758 ± 0.029	2.526AsnTyr: 2.526 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.803ProAla: 2.803 ± 0.057	0.237ProCys: 0.237 ± 0.012	2.922ProAsp: 2.922 ± 0.044	3.645ProGlu: 3.645 ± 0.053	1.995ProPhe: 1.995 ± 0.039	2.93ProGly: 2.93 ± 0.049	0.803ProHis: 0.803 ± 0.03	2.257ProIle: 2.257 ± 0.048	1.869ProLys: 1.869 ± 0.041	3.393ProLeu: 3.393 ± 0.05	0.864ProMet: 0.864 ± 0.025	1.751ProAsn: 1.751 ± 0.034	1.064ProPro: 1.064 ± 0.03	1.422ProGln: 1.422 ± 0.031	1.488ProArg: 1.488 ± 0.032	2.47ProSer: 2.47 ± 0.045	1.872ProThr: 1.872 ± 0.036	3.455ProVal: 3.455 ± 0.052	0.522ProTrp: 0.522 ± 0.02	1.791ProTyr: 1.791 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.154GlnAla: 2.154 ± 0.042	0.222GlnCys: 0.222 ± 0.014	1.604GlnAsp: 1.604 ± 0.036	2.223GlnGlu: 2.223 ± 0.043	1.55GlnPhe: 1.55 ± 0.034	2.097GlnGly: 2.097 ± 0.042	0.683GlnHis: 0.683 ± 0.025	2.454GlnIle: 2.454 ± 0.041	2.323GlnLys: 2.323 ± 0.044	3.341GlnLeu: 3.341 ± 0.059	0.977GlnMet: 0.977 ± 0.028	1.839GlnAsn: 1.839 ± 0.044	1.299GlnPro: 1.299 ± 0.034	1.709GlnGln: 1.709 ± 0.038	1.666GlnArg: 1.666 ± 0.035	2.157GlnSer: 2.157 ± 0.044	1.956GlnThr: 1.956 ± 0.043	1.976GlnVal: 1.976 ± 0.041	0.514GlnTrp: 0.514 ± 0.023	1.427GlnTyr: 1.427 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.729ArgAla: 2.729 ± 0.05	0.317ArgCys: 0.317 ± 0.018	2.557ArgAsp: 2.557 ± 0.043	3.425ArgGlu: 3.425 ± 0.063	2.545ArgPhe: 2.545 ± 0.051	2.711ArgGly: 2.711 ± 0.047	0.913ArgHis: 0.913 ± 0.028	3.896ArgIle: 3.896 ± 0.053	3.473ArgLys: 3.473 ± 0.06	4.518ArgLeu: 4.518 ± 0.064	1.385ArgMet: 1.385 ± 0.038	2.882ArgAsn: 2.882 ± 0.048	1.612ArgPro: 1.612 ± 0.036	1.794ArgGln: 1.794 ± 0.046	2.347ArgArg: 2.347 ± 0.05	2.706ArgSer: 2.706 ± 0.05	2.436ArgThr: 2.436 ± 0.038	2.826ArgVal: 2.826 ± 0.046	0.748ArgTrp: 0.748 ± 0.029	2.381ArgTyr: 2.381 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.15SerAla: 4.15 ± 0.064	0.645SerCys: 0.645 ± 0.026	3.725SerAsp: 3.725 ± 0.054	3.895SerGlu: 3.895 ± 0.052	3.481SerPhe: 3.481 ± 0.057	5.23SerGly: 5.23 ± 0.07	1.172SerHis: 1.172 ± 0.031	4.441SerIle: 4.441 ± 0.059	3.207SerLys: 3.207 ± 0.059	6.17SerLeu: 6.17 ± 0.071	1.417SerMet: 1.417 ± 0.032	2.881SerAsn: 2.881 ± 0.052	2.67SerPro: 2.67 ± 0.044	1.991SerGln: 1.991 ± 0.036	2.99SerArg: 2.99 ± 0.047	4.152SerSer: 4.152 ± 0.065	3.229SerThr: 3.229 ± 0.055	4.392SerVal: 4.392 ± 0.059	0.868SerTrp: 0.868 ± 0.027	2.989SerTyr: 2.989 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.806ThrAla: 3.806 ± 0.055	0.393ThrCys: 0.393 ± 0.017	3.52ThrAsp: 3.52 ± 0.056	3.331ThrGlu: 3.331 ± 0.049	2.7ThrPhe: 2.7 ± 0.045	4.967ThrGly: 4.967 ± 0.069	1.032ThrHis: 1.032 ± 0.034	4.088ThrIle: 4.088 ± 0.056	2.634ThrLys: 2.634 ± 0.048	5.174ThrLeu: 5.174 ± 0.058	1.157ThrMet: 1.157 ± 0.033	2.539ThrAsn: 2.539 ± 0.051	2.763ThrPro: 2.763 ± 0.046	1.786ThrGln: 1.786 ± 0.042	2.291ThrArg: 2.291 ± 0.044	3.383ThrSer: 3.383 ± 0.054	3.097ThrThr: 3.097 ± 0.059	3.918ThrVal: 3.918 ± 0.059	0.663ThrTrp: 0.663 ± 0.025	2.316ThrTyr: 2.316 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.13ValAla: 4.13 ± 0.07	0.624ValCys: 0.624 ± 0.023	3.628ValAsp: 3.628 ± 0.051	4.1ValGlu: 4.1 ± 0.065	2.911ValPhe: 2.911 ± 0.053	3.928ValGly: 3.928 ± 0.062	1.017ValHis: 1.017 ± 0.03	4.596ValIle: 4.596 ± 0.066	3.96ValLys: 3.96 ± 0.063	5.373ValLeu: 5.373 ± 0.065	1.611ValMet: 1.611 ± 0.035	3.419ValAsn: 3.419 ± 0.051	2.532ValPro: 2.532 ± 0.047	1.921ValGln: 1.921 ± 0.038	2.996ValArg: 2.996 ± 0.049	4.504ValSer: 4.504 ± 0.06	3.868ValThr: 3.868 ± 0.067	4.233ValVal: 4.233 ± 0.062	0.775ValTrp: 0.775 ± 0.027	2.565ValTyr: 2.565 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.776TrpAla: 0.776 ± 0.027	0.132TrpCys: 0.132 ± 0.01	0.898TrpAsp: 0.898 ± 0.029	0.958TrpGlu: 0.958 ± 0.032	0.633TrpPhe: 0.633 ± 0.024	1.046TrpGly: 1.046 ± 0.027	0.274TrpHis: 0.274 ± 0.016	0.94TrpIle: 0.94 ± 0.029	0.898TrpLys: 0.898 ± 0.026	1.198TrpLeu: 1.198 ± 0.03	0.4TrpMet: 0.4 ± 0.017	0.874TrpAsn: 0.874 ± 0.03	0.34TrpPro: 0.34 ± 0.017	0.552TrpGln: 0.552 ± 0.021	0.655TrpArg: 0.655 ± 0.022	0.735TrpSer: 0.735 ± 0.028	0.758TrpThr: 0.758 ± 0.022	0.773TrpVal: 0.773 ± 0.024	0.228TrpTrp: 0.228 ± 0.014	0.577TrpTyr: 0.577 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.885TyrAla: 2.885 ± 0.059	0.411TyrCys: 0.411 ± 0.017	2.65TyrAsp: 2.65 ± 0.05	2.454TyrGlu: 2.454 ± 0.053	2.254TyrPhe: 2.254 ± 0.047	3.103TyrGly: 3.103 ± 0.053	0.888TyrHis: 0.888 ± 0.027	2.82TyrIle: 2.82 ± 0.053	2.418TyrLys: 2.418 ± 0.049	3.967TyrLeu: 3.967 ± 0.067	1.041TyrMet: 1.041 ± 0.029	2.566TyrAsn: 2.566 ± 0.049	2.096TyrPro: 2.096 ± 0.037	1.484TyrGln: 1.484 ± 0.041	2.48TyrArg: 2.48 ± 0.045	2.9TyrSer: 2.9 ± 0.052	2.571TyrThr: 2.571 ± 0.051	2.155TyrVal: 2.155 ± 0.045	0.668TyrTrp: 0.668 ± 0.026	2.096TyrTyr: 2.096 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3381 proteins (1306952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---