Amino acid dipepetide frequency for Geomonas soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.463AlaAla: 17.463 ± 0.13	1.354AlaCys: 1.354 ± 0.028	6.696AlaAsp: 6.696 ± 0.076	6.118AlaGlu: 6.118 ± 0.073	4.097AlaPhe: 4.097 ± 0.051	10.26AlaGly: 10.26 ± 0.086	2.678AlaHis: 2.678 ± 0.042	5.031AlaIle: 5.031 ± 0.053	4.248AlaLys: 4.248 ± 0.061	13.901AlaLeu: 13.901 ± 0.124	3.725AlaMet: 3.725 ± 0.05	3.136AlaAsn: 3.136 ± 0.067	5.942AlaPro: 5.942 ± 0.079	5.765AlaGln: 5.765 ± 0.061	8.496AlaArg: 8.496 ± 0.08	7.507AlaSer: 7.507 ± 0.067	6.294AlaThr: 6.294 ± 0.107	9.05AlaVal: 9.05 ± 0.071	1.985AlaTrp: 1.985 ± 0.038	2.392AlaTyr: 2.392 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.152CysAla: 1.152 ± 0.026	0.121CysCys: 0.121 ± 0.009	0.567CysAsp: 0.567 ± 0.016	0.521CysGlu: 0.521 ± 0.016	0.304CysPhe: 0.304 ± 0.013	0.94CysGly: 0.94 ± 0.027	0.263CysHis: 0.263 ± 0.011	0.412CysIle: 0.412 ± 0.016	0.257CysLys: 0.257 ± 0.012	0.808CysLeu: 0.808 ± 0.02	0.213CysMet: 0.213 ± 0.011	0.219CysAsn: 0.219 ± 0.012	0.455CysPro: 0.455 ± 0.018	0.244CysGln: 0.244 ± 0.01	0.606CysArg: 0.606 ± 0.019	0.548CysSer: 0.548 ± 0.018	0.486CysThr: 0.486 ± 0.016	0.701CysVal: 0.701 ± 0.021	0.128CysTrp: 0.128 ± 0.009	0.178CysTyr: 0.178 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.606AspAla: 7.606 ± 0.08	0.446AspCys: 0.446 ± 0.017	3.131AspAsp: 3.131 ± 0.049	3.48AspGlu: 3.48 ± 0.052	2.025AspPhe: 2.025 ± 0.03	4.891AspGly: 4.891 ± 0.078	1.285AspHis: 1.285 ± 0.024	2.39AspIle: 2.39 ± 0.031	1.943AspLys: 1.943 ± 0.036	5.312AspLeu: 5.312 ± 0.066	1.183AspMet: 1.183 ± 0.023	1.262AspAsn: 1.262 ± 0.026	3.043AspPro: 3.043 ± 0.048	1.646AspGln: 1.646 ± 0.03	3.494AspArg: 3.494 ± 0.047	2.59AspSer: 2.59 ± 0.037	2.835AspThr: 2.835 ± 0.103	4.295AspVal: 4.295 ± 0.064	0.998AspTrp: 0.998 ± 0.023	1.29AspTyr: 1.29 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.645GluAla: 6.645 ± 0.072	0.397GluCys: 0.397 ± 0.016	2.227GluAsp: 2.227 ± 0.039	2.531GluGlu: 2.531 ± 0.043	1.855GluPhe: 1.855 ± 0.031	3.656GluGly: 3.656 ± 0.045	1.441GluHis: 1.441 ± 0.028	2.442GluIle: 2.442 ± 0.037	1.792GluLys: 1.792 ± 0.035	5.909GluLeu: 5.909 ± 0.072	1.248GluMet: 1.248 ± 0.023	1.171GluAsn: 1.171 ± 0.027	2.651GluPro: 2.651 ± 0.046	2.488GluGln: 2.488 ± 0.035	4.699GluArg: 4.699 ± 0.064	2.719GluSer: 2.719 ± 0.042	2.478GluThr: 2.478 ± 0.036	4.184GluVal: 4.184 ± 0.057	0.697GluTrp: 0.697 ± 0.021	0.989GluTyr: 0.989 ± 0.027	0.001GluXaa: 0.001 ± 0.001
Phe	4.058PheAla: 4.058 ± 0.05	0.343PheCys: 0.343 ± 0.014	2.582PheAsp: 2.582 ± 0.039	2.166PheGlu: 2.166 ± 0.035	1.388PhePhe: 1.388 ± 0.032	3.298PheGly: 3.298 ± 0.054	0.792PheHis: 0.792 ± 0.022	1.639PheIle: 1.639 ± 0.031	1.243PheLys: 1.243 ± 0.027	2.707PheLeu: 2.707 ± 0.041	0.799PheMet: 0.799 ± 0.021	1.132PheAsn: 1.132 ± 0.027	1.426PhePro: 1.426 ± 0.025	1.065PheGln: 1.065 ± 0.024	1.893PheArg: 1.893 ± 0.032	2.188PheSer: 2.188 ± 0.035	2.086PheThr: 2.086 ± 0.047	2.839PheVal: 2.839 ± 0.043	0.508PheTrp: 0.508 ± 0.018	0.819PheTyr: 0.819 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.63GlyAla: 8.63 ± 0.077	0.868GlyCys: 0.868 ± 0.025	4.266GlyAsp: 4.266 ± 0.056	4.328GlyGlu: 4.328 ± 0.054	3.223GlyPhe: 3.223 ± 0.042	6.84GlyGly: 6.84 ± 0.095	1.99GlyHis: 1.99 ± 0.03	3.789GlyIle: 3.789 ± 0.049	3.199GlyLys: 3.199 ± 0.051	8.496GlyLeu: 8.496 ± 0.073	2.22GlyMet: 2.22 ± 0.036	2.215GlyAsn: 2.215 ± 0.062	3.076GlyPro: 3.076 ± 0.045	3.292GlyGln: 3.292 ± 0.043	5.458GlyArg: 5.458 ± 0.062	4.961GlySer: 4.961 ± 0.074	4.853GlyThr: 4.853 ± 0.115	6.513GlyVal: 6.513 ± 0.058	1.439GlyTrp: 1.439 ± 0.034	2.124GlyTyr: 2.124 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	3.071HisAla: 3.071 ± 0.044	0.275HisCys: 0.275 ± 0.014	1.347HisAsp: 1.347 ± 0.027	1.415HisGlu: 1.415 ± 0.032	0.908HisPhe: 0.908 ± 0.022	2.245HisGly: 2.245 ± 0.037	0.686HisHis: 0.686 ± 0.021	0.889HisIle: 0.889 ± 0.02	0.545HisLys: 0.545 ± 0.015	2.355HisLeu: 2.355 ± 0.036	0.533HisMet: 0.533 ± 0.02	0.492HisAsn: 0.492 ± 0.015	1.415HisPro: 1.415 ± 0.027	0.763HisGln: 0.763 ± 0.019	1.705HisArg: 1.705 ± 0.031	1.135HisSer: 1.135 ± 0.023	1.038HisThr: 1.038 ± 0.023	1.71HisVal: 1.71 ± 0.027	0.446HisTrp: 0.446 ± 0.015	0.562HisTyr: 0.562 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.949IleAla: 5.949 ± 0.063	0.348IleCys: 0.348 ± 0.014	3.175IleAsp: 3.175 ± 0.042	3.117IleGlu: 3.117 ± 0.044	1.162IlePhe: 1.162 ± 0.025	4.079IleGly: 4.079 ± 0.047	0.915IleHis: 0.915 ± 0.02	1.423IleIle: 1.423 ± 0.029	1.403IleLys: 1.403 ± 0.034	2.831IleLeu: 2.831 ± 0.047	0.628IleMet: 0.628 ± 0.02	1.306IleAsn: 1.306 ± 0.029	1.872IlePro: 1.872 ± 0.036	1.255IleGln: 1.255 ± 0.027	2.514IleArg: 2.514 ± 0.037	2.235IleSer: 2.235 ± 0.037	2.49IleThr: 2.49 ± 0.044	3.527IleVal: 3.527 ± 0.053	0.44IleTrp: 0.44 ± 0.016	0.874IleTyr: 0.874 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.399LysAla: 4.399 ± 0.061	0.165LysCys: 0.165 ± 0.01	1.757LysAsp: 1.757 ± 0.038	1.527LysGlu: 1.527 ± 0.033	0.989LysPhe: 0.989 ± 0.023	2.46LysGly: 2.46 ± 0.047	0.734LysHis: 0.734 ± 0.02	1.312LysIle: 1.312 ± 0.032	1.442LysLys: 1.442 ± 0.044	3.629LysLeu: 3.629 ± 0.05	0.767LysMet: 0.767 ± 0.02	0.944LysAsn: 0.944 ± 0.026	2.271LysPro: 2.271 ± 0.04	1.279LysGln: 1.279 ± 0.03	2.338LysArg: 2.338 ± 0.039	1.853LysSer: 1.853 ± 0.033	1.978LysThr: 1.978 ± 0.034	2.672LysVal: 2.672 ± 0.044	0.378LysTrp: 0.378 ± 0.015	0.677LysTyr: 0.677 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.19LeuAla: 14.19 ± 0.123	0.978LeuCys: 0.978 ± 0.024	5.966LeuAsp: 5.966 ± 0.061	4.818LeuGlu: 4.818 ± 0.062	3.251LeuPhe: 3.251 ± 0.048	8.149LeuGly: 8.149 ± 0.081	2.416LeuHis: 2.416 ± 0.04	3.904LeuIle: 3.904 ± 0.05	3.793LeuLys: 3.793 ± 0.052	10.327LeuLeu: 10.327 ± 0.116	2.588LeuMet: 2.588 ± 0.04	2.772LeuAsn: 2.772 ± 0.045	5.853LeuPro: 5.853 ± 0.068	3.917LeuGln: 3.917 ± 0.05	7.782LeuArg: 7.782 ± 0.078	6.566LeuSer: 6.566 ± 0.059	5.16LeuThr: 5.16 ± 0.055	7.846LeuVal: 7.846 ± 0.077	1.314LeuTrp: 1.314 ± 0.029	1.869LeuTyr: 1.869 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.046MetAla: 3.046 ± 0.044	0.178MetCys: 0.178 ± 0.009	1.234MetAsp: 1.234 ± 0.027	1.025MetGlu: 1.025 ± 0.022	0.727MetPhe: 0.727 ± 0.02	1.796MetGly: 1.796 ± 0.035	0.597MetHis: 0.597 ± 0.016	0.84MetIle: 0.84 ± 0.021	1.1MetLys: 1.1 ± 0.027	2.715MetLeu: 2.715 ± 0.049	0.557MetMet: 0.557 ± 0.017	0.923MetAsn: 0.923 ± 0.02	1.619MetPro: 1.619 ± 0.032	1.1MetGln: 1.1 ± 0.026	1.885MetArg: 1.885 ± 0.033	1.816MetSer: 1.816 ± 0.027	1.455MetThr: 1.455 ± 0.028	1.775MetVal: 1.775 ± 0.033	0.238MetTrp: 0.238 ± 0.01	0.369MetTyr: 0.369 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.342AsnAla: 3.342 ± 0.05	0.251AsnCys: 0.251 ± 0.011	1.602AsnAsp: 1.602 ± 0.073	1.263AsnGlu: 1.263 ± 0.027	0.969AsnPhe: 0.969 ± 0.023	2.393AsnGly: 2.393 ± 0.055	0.552AsnHis: 0.552 ± 0.017	1.15AsnIle: 1.15 ± 0.03	0.82AsnLys: 0.82 ± 0.028	2.603AsnLeu: 2.603 ± 0.041	0.546AsnMet: 0.546 ± 0.016	0.808AsnAsn: 0.808 ± 0.027	1.719AsnPro: 1.719 ± 0.03	0.919AsnGln: 0.919 ± 0.023	1.637AsnArg: 1.637 ± 0.027	1.248AsnSer: 1.248 ± 0.032	1.534AsnThr: 1.534 ± 0.036	2.001AsnVal: 2.001 ± 0.043	0.408AsnTrp: 0.408 ± 0.016	0.687AsnTyr: 0.687 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.071ProAla: 7.071 ± 0.093	0.382ProCys: 0.382 ± 0.013	3.068ProAsp: 3.068 ± 0.044	3.08ProGlu: 3.08 ± 0.048	1.722ProPhe: 1.722 ± 0.032	4.393ProGly: 4.393 ± 0.056	1.154ProHis: 1.154 ± 0.025	1.901ProIle: 1.901 ± 0.031	1.63ProLys: 1.63 ± 0.029	5.012ProLeu: 5.012 ± 0.061	1.387ProMet: 1.387 ± 0.031	1.3ProAsn: 1.3 ± 0.028	2.75ProPro: 2.75 ± 0.055	2.171ProGln: 2.171 ± 0.041	3.014ProArg: 3.014 ± 0.042	3.124ProSer: 3.124 ± 0.043	2.753ProThr: 2.753 ± 0.042	4.325ProVal: 4.325 ± 0.048	0.802ProTrp: 0.802 ± 0.021	1.059ProTyr: 1.059 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	5.796GlnAla: 5.796 ± 0.065	0.3GlnCys: 0.3 ± 0.014	1.609GlnAsp: 1.609 ± 0.031	1.616GlnGlu: 1.616 ± 0.031	1.236GlnPhe: 1.236 ± 0.025	3.097GlnGly: 3.097 ± 0.045	0.949GlnHis: 0.949 ± 0.024	1.556GlnIle: 1.556 ± 0.03	1.045GlnLys: 1.045 ± 0.025	4.108GlnLeu: 4.108 ± 0.052	1.029GlnMet: 1.029 ± 0.022	0.728GlnAsn: 0.728 ± 0.022	2.251GlnPro: 2.251 ± 0.042	1.881GlnGln: 1.881 ± 0.034	3.549GlnArg: 3.549 ± 0.055	2.189GlnSer: 2.189 ± 0.037	1.826GlnThr: 1.826 ± 0.035	3.211GlnVal: 3.211 ± 0.036	0.707GlnTrp: 0.707 ± 0.02	0.731GlnTyr: 0.731 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.432ArgAla: 7.432 ± 0.07	0.64ArgCys: 0.64 ± 0.02	3.806ArgAsp: 3.806 ± 0.048	4.254ArgGlu: 4.254 ± 0.057	2.848ArgPhe: 2.848 ± 0.044	4.643ArgGly: 4.643 ± 0.051	2.019ArgHis: 2.019 ± 0.035	3.499ArgIle: 3.499 ± 0.041	2.047ArgLys: 2.047 ± 0.03	7.82ArgLeu: 7.82 ± 0.085	2.017ArgMet: 2.017 ± 0.031	1.739ArgAsn: 1.739 ± 0.031	3.102ArgPro: 3.102 ± 0.041	2.991ArgGln: 2.991 ± 0.048	5.393ArgArg: 5.393 ± 0.071	3.922ArgSer: 3.922 ± 0.056	3.38ArgThr: 3.38 ± 0.048	5.225ArgVal: 5.225 ± 0.062	1.273ArgTrp: 1.273 ± 0.03	1.728ArgTyr: 1.728 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.899SerAla: 6.899 ± 0.072	0.481SerCys: 0.481 ± 0.018	2.937SerAsp: 2.937 ± 0.039	2.655SerGlu: 2.655 ± 0.036	2.291SerPhe: 2.291 ± 0.035	5.438SerGly: 5.438 ± 0.086	1.307SerHis: 1.307 ± 0.026	2.504SerIle: 2.504 ± 0.036	1.707SerLys: 1.707 ± 0.036	6.174SerLeu: 6.174 ± 0.064	1.468SerMet: 1.468 ± 0.028	1.49SerAsn: 1.49 ± 0.032	3.153SerPro: 3.153 ± 0.04	2.097SerGln: 2.097 ± 0.04	3.936SerArg: 3.936 ± 0.049	3.586SerSer: 3.586 ± 0.051	3.416SerThr: 3.416 ± 0.059	4.387SerVal: 4.387 ± 0.047	0.842SerTrp: 0.842 ± 0.022	1.347SerTyr: 1.347 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	6.207ThrAla: 6.207 ± 0.089	0.464ThrCys: 0.464 ± 0.018	2.649ThrAsp: 2.649 ± 0.054	2.41ThrGlu: 2.41 ± 0.049	1.748ThrPhe: 1.748 ± 0.042	4.797ThrGly: 4.797 ± 0.096	1.235ThrHis: 1.235 ± 0.029	2.158ThrIle: 2.158 ± 0.05	1.344ThrLys: 1.344 ± 0.035	6.317ThrLeu: 6.317 ± 0.086	1.212ThrMet: 1.212 ± 0.028	1.328ThrAsn: 1.328 ± 0.037	3.586ThrPro: 3.586 ± 0.047	2.023ThrGln: 2.023 ± 0.034	3.377ThrArg: 3.377 ± 0.047	3.075ThrSer: 3.075 ± 0.056	3.072ThrThr: 3.072 ± 0.063	4.423ThrVal: 4.423 ± 0.073	0.761ThrTrp: 0.761 ± 0.022	1.186ThrTyr: 1.186 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	9.328ValAla: 9.328 ± 0.09	0.742ValCys: 0.742 ± 0.017	4.536ValAsp: 4.536 ± 0.048	4.188ValGlu: 4.188 ± 0.056	2.756ValPhe: 2.756 ± 0.044	5.622ValGly: 5.622 ± 0.059	1.712ValHis: 1.712 ± 0.03	3.361ValIle: 3.361 ± 0.044	2.807ValLys: 2.807 ± 0.049	8.277ValLeu: 8.277 ± 0.087	1.995ValMet: 1.995 ± 0.036	2.341ValAsn: 2.341 ± 0.039	4.121ValPro: 4.121 ± 0.05	3.026ValGln: 3.026 ± 0.04	5.14ValArg: 5.14 ± 0.06	4.711ValSer: 4.711 ± 0.056	4.204ValThr: 4.204 ± 0.066	6.526ValVal: 6.526 ± 0.078	1.022ValTrp: 1.022 ± 0.025	1.56ValTyr: 1.56 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.404TrpAla: 1.404 ± 0.029	0.168TrpCys: 0.168 ± 0.012	0.702TrpAsp: 0.702 ± 0.016	0.56TrpGlu: 0.56 ± 0.018	0.581TrpPhe: 0.581 ± 0.018	0.915TrpGly: 0.915 ± 0.02	0.396TrpHis: 0.396 ± 0.016	0.638TrpIle: 0.638 ± 0.017	0.549TrpLys: 0.549 ± 0.019	1.957TrpLeu: 1.957 ± 0.04	0.472TrpMet: 0.472 ± 0.017	0.525TrpAsn: 0.525 ± 0.019	0.754TrpPro: 0.754 ± 0.022	0.74TrpGln: 0.74 ± 0.021	1.212TrpArg: 1.212 ± 0.032	0.926TrpSer: 0.926 ± 0.021	0.842TrpThr: 0.842 ± 0.022	1.095TrpVal: 1.095 ± 0.022	0.321TrpTrp: 0.321 ± 0.015	0.288TrpTyr: 0.288 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.451TyrAla: 2.451 ± 0.04	0.219TyrCys: 0.219 ± 0.01	1.291TyrAsp: 1.291 ± 0.071	1.147TyrGlu: 1.147 ± 0.027	0.891TyrPhe: 0.891 ± 0.021	1.868TyrGly: 1.868 ± 0.038	0.413TyrHis: 0.413 ± 0.016	0.707TyrIle: 0.707 ± 0.02	0.655TyrLys: 0.655 ± 0.019	2.2TyrLeu: 2.2 ± 0.035	0.405TyrMet: 0.405 ± 0.014	0.618TyrAsn: 0.618 ± 0.024	1.038TyrPro: 1.038 ± 0.028	0.752TyrGln: 0.752 ± 0.019	1.653TyrArg: 1.653 ± 0.029	1.216TyrSer: 1.216 ± 0.033	1.192TyrThr: 1.192 ± 0.043	1.672TyrVal: 1.672 ± 0.031	0.338TyrTrp: 0.338 ± 0.014	0.551TyrTyr: 0.551 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5762 proteins (1976155 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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